Genotoxicidade de Helianthus annuus Linné, 1753 (Asteraceae): novas perspectivas e tendências

Marcelo Fabiano Gomes Boriollo, Thaísla Andriele da Silva, Jeferson Júnior Silva, Manoel Francisco Rodrigues Netto, José Francisco Höfling, Jorge Kleber Chavasco

DOI: http://dx.doi.org/10.5935/2446-4775.20170026

Resumo


A presente revisão reúne informações acerca dos aspectos genotóxicos de Helianthus annuus Linné (girassol), até o presente momento na literatura. O girassol é uma importante fonte de óleo natural e sua ampla aplicabilidade é atribuível ao variável repertório fitoquímico. A ação preventiva da diurese, diarreia e doenças inflamatórias, além dos efeitos de alívio dos sintomas asmáticos, proteção gástrica, cicatrização, ação anti-inflamatória e antimicrobiana foram reconhecidas quanto às propriedades farmacológicas do girassol. Com um grande potencial fitoquímico, é importante também analisarmos seu potencial tóxico e genotóxico. Vários resultados inconclusivos a respeito da correlação entre a carcinogênese e o óleo de girassol foram observados na literatura. Por outro lado, um número limitado de informações sobre a mutagênese ou antimutagênese do extrato hidroalcoólico e distintas fontes do óleo de sementes de girassol, submetido ou não ao estresse térmico, foi relatado. Esta revisão apresentará os atuais trabalhos envolvendo a ação genotóxica ou anti genotóxica de H. annuus L., colaborando com a implantação de limites ao consumo, potenciais riscos à saúde ou medidas estratégicas quimiopreventivas.


Palavras-chave


Aspectos bioquímicos. Farmacologia. Fitoterapia. Genética toxicológica. Girassol.

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Referências


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