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  • Resumo

    Annona squamosa is a source of bioactive compounds, with several pharmacological activities. However, tests are needed to confirm its safety in terms of cytogenotoxic potential and its possible medicinal activity. Thus, the aims of the present study were to isolate the bioactive compounds of sugar apple peel and determine their antiproliferative activity in human tumor cell lines and mutagenic activity in germinating Aspergillus nidulans conidia. Chemical extraction resulted in the isolation of kaurenoic acid, a terpene that demonstrated a cytostatic effect at concentrations of 25 µg mL-1 and 250 µg mL-1 and antiproliferative at a concentration of 250 µg mL-1. The germination test showed that this compound can activate apoptosis, since there was an increase in dead conidia and a decrease in malformed individuals in all treatments. These results indicate its antiproliferative effect and apoptosis activation, representing a useful tool in the development of new chemotherapy drugs.

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    Palavras-chave

    Diterpene
    Cytostatic Effect
    Cytocidal Effect
    Sugar Apple
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