Revista Fitos
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description: e-ISSN: 2446-4775 A Revista Fitos é um periódico científico interdisciplinar, em acesso aberto, sem custos para autores e de difusão gratuita, com periodicidade trimestral, editado pelo Centro de Inovação em Biodiversidade e Saúde (CIBS) do Instituto de Tecnologia em Fármacos (Farmanguinhos), da Fundação Oswaldo Cruz. Indexações CrossRef Google Acadêmico Microsoft Academic BVS - Biblioteca Virtual de Saúde Fiocruz OASIS / IBICT ARCA / FIOCRUZ Portal de Periódicos da Fiocruz Portal de Periódicos Capes Journals4Free Latindex Diadorim / IBICT Qualis B4 – Interdisciplinar, Medicina Veterinária e Odontologia B5 – Biotecnologia, Ciências Agrárias, Ciências Ambientais, Engenharia II e Saúde Coletiva C – Biodiversidade, Ciências Biológicas II, Ciências Biológicas III, Farmácia e Química Para submeter seu artigo, leia as instruções aos autores e cadastre-se.
publisher: Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
language: pt-BR
publication name: Revista Fitos
issn: 1808-9569
copyright: 1. DIREITOS CEDIDOS - A cessão total não exclusiva, permanente e irrevogável dos direitos autorais patrimoniais não comerciais de utilização de que trata este documento inclui, exemplificativamente, os direitos de disponibilização e comunicação pública da OBRA, em qualquer meio ou veículo, inclusive em Repositórios Digitais, bem como os direitos de reprodução, exibição, execução, declamação, recitação, exposição, arquivamento, inclusão em banco de dados, preservação, difusão, distribuição, divulgação, empréstimo, tradução, dublagem, legendagem, inclusão em novas obras ou coletâneas, reutilização, edição, produção de material didático e cursos ou qualquer forma de utilização não comercial. 2. AUTORIZAÇÃO A TERCEIROS - A cessão aqui especificada concede à FIOCRUZ - FUNDAÇÃO OSWALDO CRUZ o direito de autorizar qualquer pessoa – física ou jurídica, pública ou privada, nacional ou estrangeira – a acessar e utilizar amplamente a OBRA, sem exclusividade, para quaisquer finalidades não comerciais, nos termos deste instrumento. 3. USOS NÃO COMERCIAIS - Usos não comerciais são aqueles em que a OBRA é disponibilizada gratuitamente, sem cobrança ao usuário e sem intuito de lucro direto por parte daquele que a disponibiliza e utiliza. 4. NÃO EXCLUSIVIDADE - A não exclusividade dos direitos cedidos significa que tanto o AUTOR como a FIOCRUZ - FUNDAÇÃO OSWALDO CRUZ ou seus autorizados poderão exercê-los individualmente de forma independente de autorização ou comunicação, prévia ou futura. 5. DIREITOS RESERVADOS - São reservados exclusivamente ao(s) AUTOR(es) os direitos morais sobre as obras de sua autoria e/ou titularidade, sendo os terceiros usuários responsáveis pela atribuição de autoria e manutenção da integridade da OBRA em qualquer utilização. Ficam reservados exclusivamente ao(s) AUTOR(es) e/ou TITULAR(es) os usos comerciais da OBRA incluída no âmbito deste instrumento. 6. AUTORIA E TITULARIDADE - O AUTOR declara ainda que a obra é criação original própria e inédita, respo…
items: Quantification of bioactive compounds and evaluation of antioxidant capacity in lalo (Corchorus olitorius L.) cultivated in western Santa Catarina
items: Review of the Chemical and Biological Properties of the Genus Dalechampia sp.
items: Evaluation of the volatile composition of purple basil (Ocimum basilicum var. purpurascens) subjected to steam distillation
items: Cytotoxicity assessment and molecular diversity through mass spectrometry analysis of Costus spicatus
items: Fórmulas magistrais fitoterápicas na prática clínica do profissional Nutricionista
items: O desafio da inovação em biodiversidade e saúde na perspectiva ecológica: o papel do Centro de Inovação em Biodiversidade e Saúde (CIBS)
items: Petiveria alliacea L. (Phytolaccaceae) against Acinetobacter baumannii, Burkholderia cepacia and Staphylococcus aureus
items: ANALYSIS OF TOTAL AND THERMOTOLERANT COLIFORMS IN CASSAVA GUMS MANUFACTURED IN A MUNICIPALITY IN THE INTERIOR OF ACRE
items: Gallic Acid and Its Derivatives: Promising Candidates in Combating SARS-CoV-2 Viral Proteases
items: Development and Stability of a Topical Curcuma longa Emulsion for Veterinary Use in Hyperimmune Serum Horses
items: Antimycobacterial and antibiofilm activity of Bauhinia forficata subsp. pruinosa leaf extract
items: The use of Phytotherapeutic Treatment in the SUS in São Paulo, a survey with health professionals.
items: RENISUS and the Biodiversity of the Recôncavo Region: A Study on Medicinal Plants with Therapeutic Potential
items: History, organizational evolution and perspectives of RedesFito: strengthening Local Ecoproductive Arrangements for Medicinal Plants and Phytoproducts
items: Exploring the Functional Properties of Pumpkin Seed Oil (Cucurbita maxima) for moisturizer formulation.
items: Farmácias Vivas (Living Pharmacies) and the valorization of Brazilian sociobiodiversity: challenges and potential for their consolidation in the SUS
items: Potential of Erigeron bonariensis L. essential oil and its polyacetylene 2-cis-lachnophyllum acid methyl ester as neutralizers of bothropic venoms in vitro
items: Eficácia da Cordia salicifolia Cham (Boraginaceae) contra o biofilme de Enterococcus faecium
items: Compostos bioativos presentes em frutos da Amazônia
items: Composição química e atividade antifúngica do óleo essencial de flores de Cantinoa carpinifolia (Lamiaceae)
items: Spasmolytic and antidiarrheal effects of leaves and stem bark extracts from Cenostigma pyramidale (Fabaceae)
items: Guidelines for Ethical Access to Traditional Knowledge: A Case Report from the Lagoa Quieta Village, Tenterhar-Guajajara Community, Amarante do Maranhão, Brazil
items: Shelf life and composition determination of hydrolates: experimental evidence in aromatic species
items: Quality Control and Regulation of Medicinal Cannabis Products in Brazil
items: Response of Solidago chilensis Meyen (Brazilian Arnica) to Different Water Regimes: Productive and Phytochemical Aspects
items: Chemical composition and in vitro antifungal activity of essential oils from Lippia alba and Lippia turbinata

Quantification of bioactive compounds and evaluation of antioxidant capacity in lalo (Corchorus olitorius L.) cultivated in western Santa Catarina
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description: The plant known as Lalo (Corchorus olitorius L.), also called ‘fruit jute’, ‘shrub okra’ or ‘jute mallow’, is a tropical leafy vegetable found in Africa, Asia, the Middle East and Latin America. It is used for food and therapeutic purposes and is considered an unconventional food plant (PANC) in Brazil, predominantly in the Amazon. However, there are no studies on its cultivation in Santa Catarina and its characteristics under local edaphoclimatic conditions. This study aimed to quantify the total phenolic content (TPC) and antioxidant potential of Lalo under the conditions of Santa Catarina. Whole plant samples were collected 180 days after sowing in Nova Erechim (SC). Results indicated that C. olitorius L. at the end of its growth cycle contained bioactive compounds, including total phenolics ranging from 7.70 to 20.89 mg GAE/g and antioxidant activity from 13.23 to 62.82 μmol TE/g. Compounds such as quercetin, epigallocatechin, p-coumaric acid, and syringic acid were identified, with variations depending on the assay conditions used. The findings highlight the importance of Lalo as a source of bioactive compounds and its potential in future food and therapeutic research and applications.
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creator: Bachelor Louis
creator: Aline Perin Dresch
creator: Bruna Caline Sampaio dos Santos
creator: João Paulo Bender
creator: Vanessa Neumann Silva
creator: Guilherme Martinez Mibielli
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 02/02/2026
publication date: 02/02/2026
starting page: e1850
ending page: e1850
doi: 10.32712/2446-4775.2025.1850

Review of the Chemical and Biological Properties of the Genus Dalechampia sp.
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description: The Euphorbiaceae family comprises plants possessing significant therapeutic potential, exemplified by the genera Dalechampia, Euphorbia, and Croton, recognized for their bioactive compounds and established applications in traditional medicine. Dalechampia, despite being comparatively less investigated, exhibits a remarkable phytochemical diversity, encompassing diterpenes, triterpenes, flavonoids, alkaloids, and phenolic compounds. These constituents demonstrate notable antioxidant, anti-inflammatory, antimicrobial, and neuroprotective activities. This review aims to examine the pharmacological potential of Dalechampia, highlighting both its commonalities and distinctive characteristics when compared to other genera within the family. While Euphorbia and Croton feature extensively investigated species, comprehensive studies on the species of the genus Dalechampia remain limited. Nevertheless, its isolated compounds, such as triterpenes and flavonoids, indicate promising therapeutic capabilities. Furthermore, the resin production in Dalechampia, integral to its defense mechanisms and pollinator attraction, underscores an ecological role that largely awaits thorough exploration. Comparisons with more extensively studied genera underscore the necessity for further pharmacological and toxicological investigations to elucidate the full spectrum of Dalechampia's potential applications. Future research endeavors should integrate chemical, biological, and ecological analyses to enhance the understanding of this genus, thereby contributing to the discovery of novel therapeutic agents and the sustainable management of its natural resources.
subject: Critical Review
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subject: Validação Farmacológica I
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creator: Ana Carla Rangel Rosa
creator: Leonardo Bindelli Verly
creator: Gabriel Finotti Alves Vieira
creator: Cecília Fernandes Patta Muller Marques
creator: Maria Eduarda Dan Macedo
creator: João Victor Andrade
creator: Gabriel Azevedo Carvalho
creator: Mário Ferreira da Conceição Santos
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 20/04/2026
publication date: 20/04/2026
doi: 10.32712/2446-4775.2026.1900

Evaluation of the volatile composition of purple basil (Ocimum basilicum var. purpurascens) subjected to steam distillation
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description: Basil (Ocimum basilicum) is used in cooking and industry for its essential oil (EO). The purple variety (O. basilicum var. purpurascens) stands out for the presence of anthocyanidins, compounds with recognized antioxidant activity and characteristic colors. EOs are usually obtained by distillation, a process in which a portion of the volatile compounds remains dissolved or emulsified in the distillation water, resulting in the hydrosol. Given the scarcity of studies on the volatile fraction of purple basil hydrosol, this work aimed to evaluate its chemical composition after steam distillation. The distillation did not yield the EO, only the hydrosol, with a yield of volatile compounds of 0.173 g/L. Analysis of the volatile fraction by gas chromatography coupled with mass spectrometry identified eight compounds, with linalool predominating (62.71%). The absence of EO suggests that anatomical and structural variations among cultivars may influence its development, requiring further studies for confirmation.
subject: [SILOE] Comunicação Breve
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creator: Glauce Cardoso Desmarais
creator: Daniel Luiz Reis Simas
creator: Ellen Tanus Rangel
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 23/03/2026
publication date: 23/03/2026
starting page: e1981
ending page: e1981
doi: 10.32712/2446-4775.2026.1981

Cytotoxicity assessment and molecular diversity through mass spectrometry analysis of Costus spicatus
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description: Costus spicatus Swartz exhibits notable biological properties due to its rich content of flavonoids and saponins, suggesting promising anti-inflammatory, antinociceptive, and antimicrobial properties. This study investigated the cytotoxic effects and molecular diversity of Costus spicatus extracts. Cytotoxicity assays revealed varying sensitivities across leaf, stem, and rhizome extracts, with ethanolic extracts generally exhibiting higher potency. Tandem mass spectrometry analysis identified eleven metabolites, including polyphenols like quercetin and rutin. Higher levels of polyphenols were observed in leaf and stem extracts compared to rhizomes. Among these plant parts, the leaves emerged as the richest source of flavonoids, constituting 45.83% of the total flavonoid content. Hierarchical clustering analysis highlighted dissimilarities between extract types. Overall, Costus spicatus extracts displayed cytotoxic effects against tested cell lines, with ethanolic extracts showing greater potency. This comprehensive analysis provides valuable insights into the potential medicinal applications of Costus spicatus and its molecular composition.
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creator: Gracimério José Guarneire
creator: Nerilson Marques Lima
creator: Giovanna Duarte Silva
creator: Naará da Silva Balbino
creator: Teresinha de Jesus Aguiar dos Santos Andrade
creator: Beatriz Joia Tabai
creator: Rebeca Rocha Rodrigues
creator: Salva Asghar
creator: Samuel Gouveia Silva Neres Cardoso
creator: Alessandra de Paula Carli
creator: Sandra Bertelli Ribeiro de Castro
creator: Caio Cesar de Souza Alves
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 12/01/2026
publication date: 12/01/2026
starting page: e1851
ending page: e1851
doi: 10.32712/2446-4775.2025.1851

Fórmulas magistrais fitoterápicas na prática clínica do profissional Nutricionista
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description: A fitoterapia pode ser definida como uma terapêutica caracterizada pelo uso de plantas medicinais em suas diferentes formas farmacêuticas, sem a utilização de substâncias ativas isoladas, ainda que de origem vegetal. Este estudo buscou compreender a inserção das fórmulas magistrais fitoterápicas na prática clínica de Nutricionistas, com foco na região Sul de Santa Catarina. A pesquisa, de caráter descritivo e exploratório, envolveu 36 profissionais egressos de um curso de Nutrição, utilizando um questionário digital para coletar dados sobre a prescrição de fitoterápicos. Os resultados revelaram que, embora a maioria dos Nutricionistas ainda não prescreva fitoterápicos regularmente, há um grupo significativo que o faz, principalmente de forma ocasional. As plantas mais utilizadas incluem Espinheira-santa (Maytenus ilicifolia Mart. ex Reiss., Celastraceae), Cúrcuma (Curcuma longa L., Zingiberaceae) e Mulungu (Erythrina mulungu Mart. ex Benth., Fabaceae), sendo empregadas para diversas condições, como controle de peso, melhora da digestão e redução da ansiedade. A percepção geral é de que os fitoterápicos são eficazes e bem tolerados pelos pacientes, com poucos relatos de efeitos adversos. Os achados sugerem um crescente interesse e a necessidade de aprofundamento na área para otimizar a capacitação do profissional Nutricionista e aprimorar a prática clínica.
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creator: Larissa Pereira Bem
creator: Paula Rosane Vieira Guimarães
creator: Fabiane Maciel Fabris
creator: Maria Cristina Gonçalves de Souza
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 18/05/2026
publication date: 18/05/2026
starting page: e1904
ending page: e1904
doi: 10.32712/2446-4775.2026.1904

O desafio da inovação em biodiversidade e saúde na perspectiva ecológica: o papel do Centro de Inovação em Biodiversidade e Saúde (CIBS)
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description: Palestra proferida na abertura da Reunião de Planejamento Estratégico do CIBS para 2026, em 11 de dezembro de 2025.
subject: Perspective piece
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creator: Glauco de Kruse Villas Bôas
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 12/02/2026
publication date: 12/02/2026
starting page: e1982
ending page: e1982
doi: 10.32712/2446-4775.2026.1982

Petiveria alliacea L. (Phytolaccaceae) against Acinetobacter baumannii, Burkholderia cepacia and Staphylococcus aureus
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description: In this study, the antibacterial activity of Petiveria alliacea L. (Phytolaccaceae) leaves was evaluated, using it's hydroalcoholic extract on strains of Acinetobacter baumannii, Burkholderia cepacia and Staphylococcus aureus in an in vitro experiment. The extract produced and control antibiotics (Ampicillin, Chloramphenicol and Sulfamethazol + Trimethopim) were evaluated for Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The susceptibility profile of microorganisms to commercial antibacterials was established. MIC analyses demonstrated that the Petiveria alliacea extract has antimicrobial activity against the A. baumanni and B. cepacia strains evaluated, with MIC determined at 250 µg mL-1. For 56% of the S. aureus strains evaluated (9 out of 16), there was no inhibition with MIC > 250 µg mL-1, however, there was inhibition against the other strains (7 out of 16). The S. aureus 1 strain showed the best result, with a MIC of 15 µg mL-1, followed by strains 10 and 66, with a MIC of 62.5 µg mL-1 and, finally, strains 13, 15, 21 and ATCC 6538, with a MIC of 125 µg mL-1. The results of the CBM analysis demonstrate the bacteriostatic activity of the hydroalcoholic solution of Petiveria alliacea leaves, while the MIC analyses confirm its antimicrobial potential.
subject: Article
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creator: Giulia Maria Câmara Leme
creator: Mariana de Oliveira Silva
creator: Talita Thomaz Nader
creator: André Pitondo da Silva
creator: Juliana da Silva Coppede
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 25/02/2026
publication date: 25/02/2026
starting page: e1810
ending page: e1810
doi: 10.32712/2446-4775.2025.1810

ANALYSIS OF TOTAL AND THERMOTOLERANT COLIFORMS IN CASSAVA GUMS MANUFACTURED IN A MUNICIPALITY IN THE INTERIOR OF ACRE
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description: Cassava plays an important economic and social role in the state of Acre. Several of its derivatives are produced by small-scale producers and sold in commercial establishments and street markets in the state. One of the main products derived from cassava is gum, which is used in the preparation of various culinary products, the main use being in the preparation of tapioca. Due to the food applicability and importance of gum in the region's culture, the aim of this study was to microbiologically evaluate samples of gum produced and sold in a municipality in the interior of Acre. The presence of total and thermotolerant coliforms was investigated using the most probable number (MPN) technique. The results showed that of the four samples tested, two showed positive results in the presumptive and confirmatory test, indicating the need to improve hygiene practices in the manufacture and/or storage of the product.
subject: Article
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creator: Aline Dias de Oliveira
creator: Alex da Silva Santos
creator: Erlane da Rocha Fernandes
creator: Gabriela Moysés Pereira
creator: Regiane Ribeiro dos Santos
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 09/03/2026
publication date: 09/03/2026
doi: 10.32712/2446-4775.2026.1871

Gallic Acid and Its Derivatives: Promising Candidates in Combating SARS-CoV-2 Viral Proteases
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description: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the importance of seeking new therapeutic approaches, especially in light of the rapid spread of the virus, the limited availability of effective treatments, and the emergence of new variants. SARS-CoV-2 uses cell entry mechanisms mediated by the Spike (S) protein and, after infection, depends on the action of essential viral proteases—such as Mpro (main protease) and PLpro (papain-like protease)—for its replication. These targets have become strategic for the development of new antiviral drugs. In this context, natural products and their derivatives, such as gallic acid (GA), emerge as promising alternatives, as they are widely recognized for their antioxidant, anti-inflammatory, and antiviral properties. This review article explores the replication mechanisms of SARS-CoV-2 proteases and discusses the therapeutic potential of GA and its derivatives as promising candidates for viral inhibitors against SARS-CoV-2 proteases. Significant data were collected from different databases (PubMed, Scopus, Science Direct, and Web of Science) using keywords such as gallic acid, SARS-CoV-2, and protease inhibitors. In silico and in vitro studies have shown that GA and its derivatives can act as potential inhibitors of the Mpro and PLpro proteases of SARS-CoV-2.
subject: Critical Review
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creator: Maryélle Gobatto de Carvalho
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 04/05/2026
publication date: 04/05/2026
starting page: e1932
ending page: e1932
doi: 10.32712/2446-4775.2026.1932

Development and Stability of a Topical Curcuma longa Emulsion for Veterinary Use in Hyperimmune Serum Horses
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description: Horses used for hyperimmune serum production frequently develop local inflammatory reactions at injection sites. The dry extract of Curcuma longa L. (DECL) exhibits anti-inflammatory and wound-healing properties; however, its topical veterinary use requires pharmaceutical standardization. In this study, a 3% DECL oil-in-water emulsion was developed and its physicochemical, microbiological, and stability characteristics were evaluated using a validated HPLC method for total curcuminoids. Diethylene glycol monoethyl ether was selected as a pre-solvent based on solvent-screening assays. DECL-loaded and blank emulsions were prepared using a mixed nonionic emulsifying system and evaluated at 0, 30, and 90 days under room (25 ± 2°C) and accelerated (45 ± 2°C) conditions. The formulations remained homogeneous, with no phase separation or precipitation, and showed pH values compatible with equine skin, with only a slight decrease over time. Total curcuminoid content remained stable under both storage conditions. The HPLC-DAD method demonstrated adequate selectivity, linearity, accuracy, and precision according to regulatory guidelines. Microbiological analyses confirmed the absence of contamination. Overall, the 3% DECL emulsion met essential pharmaceutical quality attributes and maintained stability for 90 days, supporting its potential as a standardized topical herbal medicinal product for veterinary use in horses.
subject: Article
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creator: Leide Lene Coelho Ferreira
creator: Deise Cristina Drummond Xavier Paes Lopes
creator: Luis Eduardo Ribeiro da Cunha
creator: Priscilla Farinhas Cardoso
creator: Igor Cunha Cardoso
creator: Sérgio Kazumasa Fujimori
creator: Isadora Guimarães da Silva
creator: Ana Beatriz Souza Soares
creator: Maria das Dores Dutra Behrens
creator: Elisabete Pereira dos Santos
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 10/08/2026
publication date: 10/08/2026
starting page: e1991
ending page: e1991
doi: 10.32712/2446-4775.2026.1991

Antimycobacterial and antibiofilm activity of Bauhinia forficata subsp. pruinosa leaf extract
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description: This study investigated the effect of Bauhinia forficata subsp. pruinosa leaf extract on four mycobacterial species and their biofilms, as well as its phenolic content. Phytochemical assays (total phenolic and flavonoid content, chromatographic analysis) and microbiological evaluations (minimum inhibitory concentration – MIC; minimum bactericidal concentration – MBC, time-kill curve, checkerboard assay, and antibiofilm assessment) were performed. Rutin was identified as the major compound. The extract exhibited an MIC of 0.31 mg/mL-1 for all tested strains; however, Mycobacteroides massiliense showed lower susceptibility, considering its MBC value and behavior in the time-kill curve. Additionally, the extract inhibited and eradicated biofilms of M. massiliense and Mycolicibacterium fortuitum and eradicated those of Mycobacteroides abscessus and Mycolicibacterium smegmatis when applied at the MIC value. Furthermore, the extract displayed an additive effect against M. abscessus and M. smegmatis in combination with clarithromycin and against M. massiliense when combined with imipenem. This study is the first to report the in vitro antimycobacterial and antibiofilm activity of B. forficata subsp. pruinosa leaf extract. The positive effects observed are partially attributed to the flavonol rutin. Our findings suggest its potential use as an adjuvant in the treatment of mycobacterial infections, addressing antibiotic resistance issues.
subject: Article
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creator: Maiara Oliveira Jantsch
creator: Vanessa Amaral Ribeiro
creator: Gustavo Andrade Ugalde
creator: Janice de Fátima Facco
creator: Marli Matiko Anraku de Campos
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 12/01/2026
publication date: 12/01/2026
starting page: e1836
ending page: e1836
doi: 10.32712/2446-4775.2025.1836

The use of Phytotherapeutic Treatment in the SUS in São Paulo, a survey with health professionals.
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description: The specialized procedure Phytotherapeutic Treatment was included in the SUS Procedure, Medication and OPM Table Management System (SIGTAP), by SAS Ordinance No. 1,988 of December 2018. The São Paulo Municipal Health Department (SMS-SP) adopted this integrative and complementary health practice (PICS) in 2020. This study sought to evaluate the skills and experiences of health professionals, aiming to offer phytotherapeutic treatment to the population served in their units. A qualitative-quantitative study used a structured questionnaire for acquisition and subsequent analysis of data in the characteristics of interest. The study obtained ninety-eight (98) valid participations and among the findings, it showed that 78.6% of the respondents would like to serve the population with this treatment; however only 14.3% did so. The respondents indicated which diseases in which they would like to apply medicinal plants, presented indications of plant species and suggestions to improve the offer of phytotherapy in the municipality. The research concluded that there is a positive attitude among professionals towards the use of medicinal plants. To this end, it is necessary to expand their training and the presence of plant inputs as stock items in the pharmacies of health units.
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creator: Luiz Eduardo Chaves Caiado
creator: Francine Julian Oliveira Campos
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 04/03/2026
publication date: 04/03/2026
starting page: e1880
ending page: e1880
doi: 10.32712/2446-4775.2026.1880

RENISUS and the Biodiversity of the Recôncavo Region: A Study on Medicinal Plants with Therapeutic Potential
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description: Studies on medicinal plants are essential for preserving and transmitting traditional knowledge, as well as offering effective therapeutic alternatives. The National List of Medicinal Plants of Interest to the Brazilian Unified Health System (RENISUS), created in 2009, includes 98 species with therapeutic potential, prioritizing native plants and guiding research aimed at the development of herbal medicines. This study carried out a survey of medicinal plant species from the Recôncavo region of Bahia that are listed in RENISUS, seeking to understand their use and relevance to local health. Information was obtained from the platforms SpeciesLink, Plants of the World Online, Reflora, and the International Plant Names Index (IPNI), which compile records from botanical collections. Of the 98 species listed, 40 were confirmed in the region, representing about 41% of the national list. This result highlights the importance of the Recôncavo for the valorization and conservation of plant genetic resources. The study emphasizes the potential of local biodiversity for public health and identifies challenges such as underreporting of species and taxonomic gaps. The integration of scientific knowledge and traditional wisdom is fundamental for the conservation and sustainable use of these plants, strengthening regional development and collective health.
subject: Article
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creator: Lucas Roberto Fagundes dos Santos
creator: Everton Hilo Souza
creator: Lidyanne Yuriko Saleme Aona Pinheiro
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 11/05/2026
publication date: 11/05/2026
starting page: e1940
ending page: e1940
doi: 10.32712/2446-4775.2026.1940

History, organizational evolution and perspectives of RedesFito: strengthening Local Ecoproductive Arrangements for Medicinal Plants and Phytoproducts
type: item
description: The National System of RedesFito (Networks of Innovation in Biodiversity-Based Medicines) represents a unique Brazilian experience integrating public health, biodiversity, innovation, and territorial development. Established within the framework of the National Policy on Medicinal Plants and Herbal Medicines, the system emerged as an institutional response to the need for articulating traditional knowledge, scientific research, public policies, and local productive chains focused on the sustainable use of sociobiodiversity. This article analyzes the historical trajectory, organizational evolution, and current model of RedesFito through a qualitative historical-analytical and documentary review. The results highlight the transition from an initially centralized structure to a decentralized and territorialized network organized around Local Management Hubs and Ecoproductive Local Arrangements. These arrangements function as sociotechnical innovation platforms, integrating agroecology, environmental justice, solidarity economy, and the valorization of traditional knowledge. The RedesFito experience demonstrates significant potential to strengthen Brazil’s Unified Health System, enhance health sovereignty, and promote alternative development pathways grounded in territorial diversity. Nevertheless, challenges remain regarding long-term financing, regulatory alignment, and the consolidation of polycentric governance mechanisms. The article concludes that RedesFito constitutes an innovative paradigm of biodiversity-based health innovation, offering relevant contributions to public health policy and sustainable development debates in Brazil and beyond.
subject: Perspective piece
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creator: Jefferson Pereira Caldas dos Santos
creator: Helen Paredes Souza
creator: Glauco de Kruse Villas Bôas
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 27/04/2026
publication date: 27/04/2026
starting page: e1996
ending page: e1996
doi: 10.32712/2446-4775.2026.1996

Exploring the Functional Properties of Pumpkin Seed Oil (Cucurbita maxima) for moisturizer formulation.
type: item
description: Considering the current needs of the National Cosmetics Industry for products that serve women with dry skin and the global mobilization to promote care for the Environment through the reuse of waste, this article aims to reuse Pumpkin seeds (Curcubita maxima), study its physical-chemical and microbiological characteristics to develop a dermocosmetic product. To this end, the methodology proceeds with oil extraction using the soxhlet method, followed by physical-chemical and microbiological analyses, proceeding to formulate a body moisturizer with components that help in recovering the characteristics of healthy skin, carrying out new physical analyzes -chemical and microbiological tests to ensure product quality. In this way, it is observed that all the results obtained were shown to be in compliance when compared to the parameters of inspection bodies, such as ANVISA, which allows us to conclude that there is the possibility of reusing easily accessible waste that would be discarded in nature (the Seeds of Pumpkin). Proving the potential for reuse through its return in the production chain.
subject: Article
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creator: Ana Paula Santana de Brito
creator: Aylana dos Santos Assis
creator: Cintia Evelyn da Paixão Santos
creator: Júlia Maria Amaral da Conceição
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 16/02/2026
publication date: 16/02/2026
starting page: e1843
ending page: e1843
doi: 10.32712/2446-4775.2025.1843

Farmácias Vivas (Living Pharmacies) and the valorization of Brazilian sociobiodiversity: challenges and potential for their consolidation in the SUS
type: item
description: The article aims to analyze the Farmácias Vivas as an instrument of the National Policy on Medicinal Plants and Herbal Medicines in Brazil. They represent innovative forms of organization and articulation between actors with different types of knowledge and capacities, as well as mechanisms to promote the value of Brazilian sociobiodiversity through the production and dispensing of medicinal plants and herbal medicines to the Unified Health System. A qualitative study was conducted using secondary sources of information to develop five categories: total number of initiatives, types of Farmácias Vivas, stages of implementation or operation, profile of the actors involved, and registration and authorization of operation. The results reveal two key elements in the context of the national policy: diversity of actor profiles across biomes, which supports adaptation to changes in the institutional environment but also requires the development of strategies that account for local specificities; and weak registration and regulatory framework of these initiatives within the Ministry of Health, compromising their oversight and monitoring. Thus, a scenario emerges that is marked by a wide diversity of initiatives with potential to contribute to Primary Health Care, while also revealing the persistence of fragile institutional foundations that limit their implementation and consolidation.
subject: Article
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creator: Nataly Cubides Zuñiga
creator: Maria Beatriz Machado Bonacelli
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 11/03/2026
publication date: 11/03/2026
starting page: e1881
ending page: e1881
doi: 10.32712/2446-4775.2026.1881

Potential of Erigeron bonariensis L. essential oil and its polyacetylene 2-cis-lachnophyllum acid methyl ester as neutralizers of bothropic venoms in vitro
type: item
description: Snake envenoming causes human organic multisystem failures and local effects (LEs: hemorrhage, edema and necrose). The antivenom serum is not always effective, generating in extreme cases anaphylaxis and being useless against LEs. An alternative under research is the treatment with alexiteric medicinal plants containing metabolites able to interact and inactivate/neutralize the venom 's components. As, in this context, Erigeron bonariensis L. is a promising species, we aimed to study the alexiteric potential of its essential oil from Uruguay. As assessed by GC/MS, the main components were: 2-cis-lachnophyllum acid methyl ester (cis-LAME,32.8%), 4R-(+)-limonene (22.6%), germacrene D (8.1%), trans-β-ocimene (6.9%) and 1S-(-)-β-pinene (4.8%). cis-LAME was isolated (column chromatography) and identified by spectroscopic methods. The oil and cis-LAME were incubated with Bothrops diporus and B. alternatus venoms, indicating alexiteric potential based on a screening performed by 1D-SDS-PAGE. For B. diporus venom (which causes more envenoming cases in Argentina) were conducted other in vitro tests (inhibition of proteolysis, hemolysis and procoagulant activity). The samples inhibited proteolysis and hemolysis (26.3% and 57.9% for the oil and cis-LAME, respectively), whereas only cis-LAME inhibited procoagulant activity (60.6%). The results obtained confirmed the potential of E. bonariensis to neutralize bothropic venoms, highlighting cis-LAME as a key bioactive component.
subject: [SILOE] Artigo de Pesquisa
  topic: section
subject: Validação Farmacológica I
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creator: Minteguiaga Manuel
creator: Ana María Torres
creator: María Noelia Umpiérrez
creator: César Atilio Nazareno Catalán
creator: Eduardo Dellacassa
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 25/05/2026
publication date: 25/05/2026
starting page: e1950
ending page: e1950
doi: 10.32712/2446-4775.2026.1950

Eficácia da Cordia salicifolia Cham (Boraginaceae) contra o biofilme de Enterococcus faecium
type: item
description: Enterococcus faecium apresenta resistência às principais classes de antimicrobianos, sendo essencial a descoberta de novas opções terapêuticas. Um dos mecanismos que promove resistência à ação de antimicrobianos é o biofilme. O objetivo deste estudo foi avaliar a eficácia da Cordia salicifolia Cham (Boraginaceae), uma planta medicinal popular no Brasil, sobre o biofilme de E. faecium. Foram avaliados isolados de E. faecium (n=12) obtidos de pacientes hospitalizados. O perfil de sensibilidade a antimicrobianos foi determinado. A atividade antibacteriana dos extratos aquoso e etanólico, obtidos das folhas e talos da planta, foi avaliada pela determinação da concentração inibitória mínima e a atividade sobre o biofilme foi avaliada pelo método de quantificação de biomassa por cristal violeta, após 24 horas de incubação na presença dos extratos. A maioria dos isolados foi classificada como forte produtora de biofilme (83,3%) e apresentou resistência à vancomicina (91,6%), ampicilina (91,6%), gentamicina (83,3%) e estreptomicina (50%). Não foi observada inibição do crescimento ou do biofilme pelos extratos de C. salicifolia, apesar do uso de concentração igual a dose tóxica para macrófagos. Concluindo, os extratos, aquoso e etanólico de C. salicifolia não apresentam atividade antibacteriana e nem anti-biofilme sobre isolados clínicos de E. faecium.
subject: Article
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creator: Karolayne Piedade Camargos
creator: Karina Ferrazzoli Devienne Vicentine
creator: Thaís Soares Farnesi de Assunção
creator: Thais Vilela de Almeida Silveira
creator: Sthefânia Dalva da Cunha Rezende
creator: Adriana Gonçalves de Oliveira
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 18/02/2026
publication date: 18/02/2026
starting page: e1844
ending page: e1844
doi: 10.32712/2446-4775.2025.1844

Compostos bioativos presentes em frutos da Amazônia
type: item
description: A região amazônica é rica em árvores frutíferas e muitos de seus frutos são utilizados como matéria-prima para produção de produtos alimentícios e com finalidades medicinais. Devido a sua grande aplicabilidade, os frutos amazônicos são usados como fonte de renda pela população, além disso eles são ricos em compostos bioativos que trazem inúmeros benefícios para a saúde. Dessa forma, esse artigo tem por objetivo contribuir com a divulgação de espécies vegetais amazônicas, trazendo uma revisão integrativa sobre a composição química e principais atividades biológicas de frutos nativos conhecidos por sua aceitação no mercado e/ou pela cultura local. Para o desenvolvimento deste trabalho, foram consultadas as bases de dados ScienceDirect, Periódicos CAPES e PubMed, utilizando descritores nas línguas portuguesa e inglesa. Os resultados obtidos evidenciam o potencial desses frutos como fontes naturais de substâncias bioativas, com destaque para atividade antioxidante.
subject: Critical Review
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creator: Gabriela Moysés Pereira
creator: Maria de Fátima Simão Jucá Cruz
creator: Alex da Silva Santos
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 09/02/2026
publication date: 09/02/2026
starting page: e1882
ending page: e1882
doi: 10.32712/2446-4775.2025.1882

Composição química e atividade antifúngica do óleo essencial de flores de Cantinoa carpinifolia (Lamiaceae)
type: item
description: Popularmente conhecida como “rosmarinho” e “mata-pasto”, a espécie Cantinoa carpinifolia (CC) é um arbusto ramificado com inflorescências grandes e flores violetas. Sabendo-se que os óleos essenciais (OEs) de espécies do gênero possuem atividades biológicas, nosso objetivo foi avaliar a composição química e a atividade antifúngica (AAF) do OE de CC contra Botrytis cinerea e Rhizoctonia solani. As plantas foram coletadas em Rio Paranaíba – MG, o OE foi obtido das flores por hidrodestilação e analisado por cromatografia gasosa, e a AAF foi avaliada por ensaio de Poison food. O rendimento do OE foi de 1,27% e foram identificados 32 componentes, sendo α-Tujona (46,05 %), Espatulenol (6,72 %), Sabineno (6,06 %), Isocariofileno (5,09 %) e α-Copaeno (4,80 %) os compostos majoritários. O OE apresentou atividade antifúngica contra B. cinerea e contra R. solani. Após 102 horas de tratamento, o OE de CC à 0,1%, inibiu em 79% o crescimento de B. cinerea, e em 67% o crescimento de R. solani. Enquanto o controle positivo causou inibições de 52% e 72%, respectivamente. Assim, o OE de CC rico em monoterpenos se mostrou eficaz contra B. cinerea, indicando que a espécie pode ser considerada na pesquisa de novos antifúngicos naturais.
subject: [SILOE] Artigo de Pesquisa
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creator: Patrícia Moreira Valente
creator: Vânia Maria Moreira Valente
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 15/06/2026
publication date: 15/06/2026
starting page: e1954
ending page: e1954
doi: 10.32712/2446-4775.2026.1954

Spasmolytic and antidiarrheal effects of leaves and stem bark extracts from Cenostigma pyramidale (Fabaceae)
type: item
description: Cenostigma pyramidale (“catingueira” or ‘‘pau-de-rato’’) is widely used in Brazilian folk medicine to treat various illnesses, including diarrhea. This study aimed to evaluate the in vitro spasmolytic and in vivo antidiarrheal activities of the leaf and stem bark extracts of Cenostigma pyramidale and correlate them with traditional medicine. In the isolated guinea pig ileum, the trichloromethane fraction from the stem bark extract showed concentration-dependent spasmolytic activity in preparations pre-contracted with KCl 40 mM [logCE50 = 1,690 ± 0,09625 µg/mL]. In mice, stem bark extract at doses of 250 or 500 mg/kg reduced total stool mass, while leaf and stem bark extracts reduced intestinal transit at 250, 500, or 750 mg/kg, and 750 mg/kg of leaf extract reduced intestinal fluid accumulation. In conclusion, the antidiarrheal effect of Cenostigma pyramidale may be related to the inhibition of smooth muscle contraction, probably due to the presence of tannins and flavonoids in the extracts.
subject: Article
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creator: Bismarques Silva
creator: Pedro Menezes
creator: Eric Vieira
creator: Daniel da Silva Torres
creator: Murilo Soares da Silva
creator: David Silva
creator: Luiz Antonio Miranda de Souza Duarte Filho
creator: Deborah Lays Silva de Deus
creator: Gabriela Lemos de Azevedo Maia
creator: Fabrício Souza Silva
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 26/01/2026
publication date: 26/01/2026
starting page: e1845
ending page: e1845
doi: 10.32712/2446-4775.2025.1845

Guidelines for Ethical Access to Traditional Knowledge: A Case Report from the Lagoa Quieta Village, Tenterhar-Guajajara Community, Amarante do Maranhão, Brazil
type: item
description: This article explores the challenges and opportunities involved in accessing traditional knowledge within Indigenous communities, particularly the Tenterhar-Guajajara Indigenous community located in Amarante do Maranhão, Brazil. The entire bureaucratic process required to obtain the necessary authorizations for the research aimed at documenting the community’s use of medicinal plants, especially during the COVID-19 pandemic is described in detail, including submissions to Plataforma Brasil, SISBIO, SisGen, and FUNAI. Although documenting traditional knowledge is essential for scientific advancement and the valorization of Indigenous wisdom, the process is often hindered by the complexity and slowness of ethical and legal approvals, which can compromise the responsiveness of urgent research. Nevertheless, these procedures ensure that the study is conducted ethically and respectfully.Based on field experience and an analysis of the regulatory processes, the article proposes a flowchart to guide future researchers conducting ethno-oriented studies. The final reflections emphasize the importance of integrating this knowledge into public health and sustainability policies, reinforcing the role of Indigenous communities in biodiversity preservation.
subject: Article
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creator: Beatriz Ribeiro Ferreira
creator: Andrex Augusto Silva da Veiga
creator: Ana Beatriz de Lima
creator: Simony Carvalho Mendonça
creator: Flavia Maria Mendonça do Amaral
creator: Suzana Guimarães Leitão
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 25/02/2026
publication date: 25/02/2026
starting page: e1888
ending page: e1888
doi: 10.32712/2446-4775.2026.1888

Shelf life and composition determination of hydrolates: experimental evidence in aromatic species
type: item
description: This study evaluated the microbiological stability of eleven hydrosols obtained from different aromatic species, with monthly monitoring of microbial load according to RDC 752/2022. Nine hydrosols were compliant at the initial evaluation, while two showed contaminations by E. coli. Shelf life varied substantially, ranging from 2 to 13 months, demonstrating that hydrosol stability is not uniform across species. Melaleuca alternifolia and Baccharis dracunculifolia exhibited the longest stability (13 months), whereas Aniba rosaeodora and Cordia verbenacea were the least stable. The most stable hydrosol (M. alternifolia) underwent chemical characterization, revealing a predominance of oxygenated monoterpenes and oxidative derivatives, with an oxidizable organic matter content of 0.07% (m/v). The results highlight the influence of chemical composition on microbiological stability and point to common shortcomings in production practices. The study contributes to the standardization of quality parameters and the development of specific analytical methods for hydrosols in Brazil.
subject: [SILOE] Artigo de Pesquisa
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creator: Marcos Aurelio Almeida Pereira
creator: Erika Costa Rudiger
creator: Rafaela Paschoal Brito Ribeiro
creator: Laiz Mocele Chalega de Sobral
creator: Anderson Amaral da Costa
creator: Rommel Alexandre Sauerbronn da Sauerbonn
creator: Fabiana Lima Silva
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 16/03/2026
publication date: 16/03/2026
starting page: e1974
ending page: e1974
doi: 10.32712/2446-4775.2026.1974

Quality Control and Regulation of Medicinal Cannabis Products in Brazil
type: item
description: Cannabis sativa is a complex plant native to Asia, rich in bioactive compounds called cannabinoids, and has significant medicinal interest. In Brazil, ANVISA regulates the importation of Cannabis extracts for therapeutic use and their artisanal production. Currently, nine C. sativa extracts and 14 cannabidiol-based products are available with a type B prescription, following RDC 327/2019, ensuring safety, efficacy, and quality. Products must meet strict quality standards, including good manufacturing practices, cannabinoid purity and potency, absence of contaminants and pesticides, and microbiological testing. Quality control from raw material to post-marketing monitoring ensures complete traceability. Gas chromatography is used for solvent residue analysis, while cannabinoid content is assessed through liquid chromatography. Inorganic analyses employ atomic absorption spectrometry with a graphite furnace and hydride generation. This article presents the current state of quality control testing for Cannabis-based products according to existing regulations.
subject: [O Uso da Cannabis no Brasil] Revisão
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creator: Carolina dos Reis Farias
creator: Ian Gardel Carvalho Barcellos Silva
creator: Bárbara da Conceição Coelho Cotta Cardoso
creator: Monica Costa Padilha
creator: Valdir Florencio Veiga-Junior
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 02/03/2026
publication date: 02/03/2026
starting page: e1847
ending page: e1847
doi: 10.32712/2446-4775.2025.1847

Response of Solidago chilensis Meyen (Brazilian Arnica) to Different Water Regimes: Productive and Phytochemical Aspects
type: item
description: Water availability is a key environmental factor influencing the cultivation of medicinal plants, as it affects both biomass yield and the biosynthesis of bioactive compounds, thereby modulating their pharmacological properties. Solidago chilensis Meyen (Brazilian arnica) was subjected to an agronomic trial aimed at assessing fresh and dry biomass production, flavonoid content, and foam index (as an indirect measure of saponin concentration) under distinct irrigation regimes. The experiment followed a completely randomized design (CRD), with treatments combining irrigation frequencies (daily, every 3.5 days, and every 7 days) and volumes (12%, 6%, and 3% of the soil’s water retention capacity). While no qualitative changes in phytochemical composition were observed, water availability significantly influenced productivity and secondary metabolite accumulation. Flavonoid levels were highest under frequent irrigation, whereas the foam index increased under less frequent watering, suggesting that water stress may enhance saponin biosynthesis. Overall, irrigation volume had a comparatively minor effect on the parameters assessed, with irrigation frequency being the primary driver of biomass production and phytochemical modulation. These findings indicate that frequent irrigation promotes biomass accumulation and flavonoid synthesis, whereas reduced irrigation frequency may trigger adaptive responses leading to increased saponin content in S. chilensis.
subject: Article
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creator: Júlio Cézar Borella
creator: Vinícius Mishima Rodrigues
creator: Raíssa Bonavina
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 15/04/2026
publication date: 15/04/2026
starting page: e1984
ending page: e1984
doi: 10.32712/2446-4775.2026.1894

Chemical composition and in vitro antifungal activity of essential oils from Lippia alba and Lippia turbinata
type: item
description: Fungal diseases are one of the most critical causes of postharvest losses in agricultural production, demanding safer and more sustainable control strategies. This study evaluated the chemical composition and in vitro antifungal activity of essential oils (EOs) from Lippia alba and Lippia turbinata against Botrytis cinerea, Monilinia fructicola, Rhizopus stolonifer, Colletotrichum nymphaeae, Fusarium hainanense, and Penicillium digitatum. The volatile method was applied using a concentration of 1000 ppm, with carbendazim as the chemical control. The EO of L. alba completely inhibited the growth of all fungi except P. digitatum (47.6 ± 1.4 %), while L. turbinata showed 100% inhibition for all tested species, without significant differences compared to the fungicide (p>0.05). Gas chromatography–mass spectrometry analysis revealed β-linalool (26.72%) and trans-dihydrocarvone (16.29 %) as major components in L. alba, and (−)-carvone (58.23 %) and D-limonene (27.72 %) in L. turbinata. The strong inhibitory activity and distinct chemical profiles suggest the potential of both species as sources of natural biofungicides for postharvest disease management.
subject: [SILOE] Artigo de Pesquisa
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creator: Norma Hortensia Alvarez
creator: María Inés Stegmayer
creator: Norma Guadalupe Micheloud
creator: Marcela Alejandra Buyatti
creator: Marcos Gabriel Derita
rights: Copyright (c) 2026 Revista Fitos https://creativecommons.org/licenses/by/4.0
date: 18/03/2026
publication date: 18/03/2026
starting page: e1977
ending page: e1977
doi: 10.32712/2446-4775.2026.1977