Estudo de Revisão da Eficácia Clínica do Vitex agnus-castus na Saúde Feminina

Isaia, C.F. Perini

doi:10.32712/2446-4775.2007.73

Estudo de Revisão da Eficácia Clínica do Vitex agnus-castus na Saúde Feminina

v. 3 n. 02 (2007)
43-50
18/10/2013
01/06/2007
https://doi.org/10.32712/2446-4775.2007.73

Isaia, C.F. Perini

Palavras-chave

Vitex agnus-castus

Síndrome Pré-Menstrual

Hiperprolactinemia

Mastodinia

Menopausa

Resumo

O extrato seco da fruta Vitex agnus-castus (VAC) é popularmente usado no tratamento de sintomas pré-menstruais como mastodinia cíclica e hiperprolactinemia, e outros sintomas somáticos e físicos da Síndrome Pré-Menstrual (PMS), além de também haver relatos sobre seu uso em deficiências da fase lútea do ciclo menstrual e nos sintomas da menopausa. Poucas informações estão disponíveis a respeito da ação do VAC nos distúrbios da PMS e em outras condições femininas. Portanto, este levantamento bibliográfico tem como objetivo buscar melhores esclarecimentos quanto ao mecanismo de ação do extrato da planta VAC, sua eficácia clínica e efeitos farmacológicos, sua ação no alívio dos sintomas da PMS, principalmente da mastodinia e hiperprolactinemia, nos defeitos da fase lútea e na menopausa. Como resultado, verificamos maior número de estudos sobre a utilização e eficácia da planta no alívio de sintomas da mastodinia cíclica e hiperprolactinemia da PMS, que comprovaram boa tolerância e inibição das dores moderadas pelos agentes dopaminérgicos do VAC.

Referências

BLUMENTHAL, M.; RUSSE, W.R.; GOLDBERG, A.; GRUENWALD, J.; HALL, T.; RIGGINS, C.W.; RISTER, R.S.; The Complete German Commission E Monographs - Therapeutic Guide to Herbal Medicines. Austin (TX): Americal Botanical Concil, Boston: Intregrative Medicine Communication; 1998.
BRUGISSER, R.; BURKARD, W.; SIMMEN, U.; SCHAFFNER, W. Untersuchungen an opioid-rezeptoren mit Vitex agnus-castus L. Zeitschrift fÃ¼r Phytotherapy, v.20, p.154, 1999 apud Complementary Therapies in Nursing & Midwifery, v.8, p.148-154, 2002.
DANIELE, C.; COON, J.T.; PITTLER, M.H.; ERNST. E. Vitex agnus castus: A Systematic Review of Adverse Events. Drug Safety, v.28, n.4, p.319-332, 2005.
FORD, O.; MOL, B.; ROBERTS, H. Progesterone for premenstrual syndrome [protocol]. The Cochrane Library, v.1, 2006.
GERHARD, I.; PATEK, A.; MANGA, B. et al. MastodynonÂ® bei weiblicher SterilitÃ¤t - Randomisierte, plazebokontollierte, klinische Doppelblindstudie. Forsch Komplementarmed, v.5, p.272-278, 1998.
HALASKA, M.; RAUSS, K.; BELES P. et al. Treatment of cyclical mastodynia using an extract of Vitex agnus-castus: results of a double-blind comparison with a placebo. Česká Gynekologie, v.63, p.388-392, 1998.
HALASKA, M.; BELES, P.; GORKOW, C.; SIEDER, C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus-castus extract: results of a placebo-controlled double-blind study. The Breast, v.8, p.175-181, 1999.
JARRY, H.; LEONHARDT, S.; GORKOW, C.; WUTTKE W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Experimental and Clinical Endocrinology, v.102, n.6, p.448-54, 1994.
LUCKS, B.C.; SORENSEN, J.; VEAL, L. Vitex agnus-castus essential oil and menopausal balance: a self-care survey. Complementary Therapies in Nursing & Midwifery, v.8, p.148-154, 2002.
LUCKS, B.C. Vitex agnus castus essential oil and menopausal balance: a research update. Complementary Therapies in Nursing and Midwifery, v.8, p.148-154, 2003.
MERZ P. G.; GORKOW, C.; SCHRODTER, A. et al. The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects. Experimental and Clinical Endocrinology & Diabetes, v.104, n.6, p.447-53, 1996.
MILEWICZ, A.; GEJDEL, E.; SWOREN, H. et al. Vitex agnus-castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study. Arzneimittelforschung, v.43, p.752-756, 1993.
MILEWICZ, A.; JEDRZEJUK, D. Premenstrual syndrome: From etiology to treatment. Maturitas, v.55, p.47-54, 2006.
NEUMANN-KUHNELT, B.; STIEF, G.; SCHMIADY, H.; KENTENICH, H. Investigations on possible effects of the phytotherapeutic agent Agnus-castus on the follicular and corpus luteum phases. Human Reproduction, v.8, p.110, 1993.
PETERS F, SCHUTH W, SCHEURICH B, BRECKWOLDT M. Serum prolactina levels in patients with fibrocystic breast disease. Obstetrics and Gynecology v.64, n.3, p.381-385, 1984.
PRILEPSKAYA, V.N.; LEDINA, A.V.; TAGIYEVA, A.V.; REVAZOVA, F.S. Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome. Maturitas, v.55, p.55-63, 2006.
ROEMHELD-HAMM, B. Chasteberry. American Family Physician, v.72, n.5, p.1, 2005.
SCHELLENBERG, R. Treatment for the premenstrual syndrome with Agnus Castus fruit extract: prospective, randomised, placebo controlled study. British Medical Journal: BMJ, v.322, p.134-137, 2001.
SLIUTZ, G.; SPEISER, P.; SCHULTZ, A. M. et al. Agnus-castus extracts inhibit prolactin secretion of rat pituitary cells. Hormone and Metabolic Research, v.25, p.253-255, 1993.
TESCH, B.J. Herbs commonly used bywomen. An evidence-based review. American Journal of Obstetrics & Gynecology, v.188, n.5, p.44-55, 2003.
WEBSTER, D.E.; LU, J.; CHEN, S.-N.; FARNSWORTH, N.R.; WANG, Z.J. Activation of the Âµ-opiate receptor by Vitex agnus-castus methanol extracts: Implication for its use in PMS. Journal of Ethnopharmacology v.106, p.216-221, 2006.
WUTTKE, W.; JARRY, H.; CHRISTOFFEL, B. et al. Chaste tree (Vitex agnus-castus) Pharmacology and clinical indications. Phytomedicine, v.10, p.348-357, 2003.

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Autor(es)

Isaia, C.F. Perini
Unidade de Pesquisa Clínica Carlos Isaia Filho, Rua Padre Chagas 66, Sala 704, Bairro Moinhos de Vento, 90570-080 Porto Alegre, RS, Brasil

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Estudo de Revisão da Eficácia Clínica do Vitex agnus-castus na Saúde Feminina. Rev Fitos [Internet]. 1º de junho de 2007 [citado 24º de novembro de 2024];3(02):43-50. Disponível em: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/73

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

[1] BLUMENTHAL, M.; RUSSE, W.R.; GOLDBERG, A.; GRUENWALD, J.; HALL, T.; RIGGINS, C.W.; RISTER, R.S.; The Complete German Commission E Monographs - Therapeutic Guide to Herbal Medicines. Austin (TX): Americal Botanical Concil, Boston: Intregrative Medicine Communication; 1998.

[2] BRUGISSER, R.; BURKARD, W.; SIMMEN, U.; SCHAFFNER, W. Untersuchungen an opioid-rezeptoren mit Vitex agnus-castus L. Zeitschrift fÃ¼r Phytotherapy, v.20, p.154, 1999 apud Complementary Therapies in Nursing & Midwifery, v.8, p.148-154, 2002.

[3] DANIELE, C.; COON, J.T.; PITTLER, M.H.; ERNST. E. Vitex agnus castus: A Systematic Review of Adverse Events. Drug Safety, v.28, n.4, p.319-332, 2005.

[4] FORD, O.; MOL, B.; ROBERTS, H. Progesterone for premenstrual syndrome [protocol]. The Cochrane Library, v.1, 2006.

[5] GERHARD, I.; PATEK, A.; MANGA, B. et al. MastodynonÂ® bei weiblicher SterilitÃ¤t - Randomisierte, plazebokontollierte, klinische Doppelblindstudie. Forsch Komplementarmed, v.5, p.272-278, 1998.

[6] HALASKA, M.; RAUSS, K.; BELES P. et al. Treatment of cyclical mastodynia using an extract of Vitex agnus-castus: results of a double-blind comparison with a placebo. Česká Gynekologie, v.63, p.388-392, 1998.

[7] HALASKA, M.; BELES, P.; GORKOW, C.; SIEDER, C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus-castus extract: results of a placebo-controlled double-blind study. The Breast, v.8, p.175-181, 1999.

[8] JARRY, H.; LEONHARDT, S.; GORKOW, C.; WUTTKE W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Experimental and Clinical Endocrinology, v.102, n.6, p.448-54, 1994.

[9] LUCKS, B.C.; SORENSEN, J.; VEAL, L. Vitex agnus-castus essential oil and menopausal balance: a self-care survey. Complementary Therapies in Nursing & Midwifery, v.8, p.148-154, 2002.

[10] LUCKS, B.C. Vitex agnus castus essential oil and menopausal balance: a research update. Complementary Therapies in Nursing and Midwifery, v.8, p.148-154, 2003.

[11] MERZ P. G.; GORKOW, C.; SCHRODTER, A. et al. The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects. Experimental and Clinical Endocrinology & Diabetes, v.104, n.6, p.447-53, 1996.

[12] MILEWICZ, A.; GEJDEL, E.; SWOREN, H. et al. Vitex agnus-castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study. Arzneimittelforschung, v.43, p.752-756, 1993.

[13] MILEWICZ, A.; JEDRZEJUK, D. Premenstrual syndrome: From etiology to treatment. Maturitas, v.55, p.47-54, 2006.

[14] NEUMANN-KUHNELT, B.; STIEF, G.; SCHMIADY, H.; KENTENICH, H. Investigations on possible effects of the phytotherapeutic agent Agnus-castus on the follicular and corpus luteum phases. Human Reproduction, v.8, p.110, 1993.

[15] PETERS F, SCHUTH W, SCHEURICH B, BRECKWOLDT M. Serum prolactina levels in patients with fibrocystic breast disease. Obstetrics and Gynecology v.64, n.3, p.381-385, 1984.

[16] PRILEPSKAYA, V.N.; LEDINA, A.V.; TAGIYEVA, A.V.; REVAZOVA, F.S. Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome. Maturitas, v.55, p.55-63, 2006.

[17] ROEMHELD-HAMM, B. Chasteberry. American Family Physician, v.72, n.5, p.1, 2005.

[18] SCHELLENBERG, R. Treatment for the premenstrual syndrome with Agnus Castus fruit extract: prospective, randomised, placebo controlled study. British Medical Journal: BMJ, v.322, p.134-137, 2001.

[19] SLIUTZ, G.; SPEISER, P.; SCHULTZ, A. M. et al. Agnus-castus extracts inhibit prolactin secretion of rat pituitary cells. Hormone and Metabolic Research, v.25, p.253-255, 1993.

[20] TESCH, B.J. Herbs commonly used bywomen. An evidence-based review. American Journal of Obstetrics & Gynecology, v.188, n.5, p.44-55, 2003.

[21] WEBSTER, D.E.; LU, J.; CHEN, S.-N.; FARNSWORTH, N.R.; WANG, Z.J. Activation of the Âµ-opiate receptor by Vitex agnus-castus methanol extracts: Implication for its use in PMS. Journal of Ethnopharmacology v.106, p.216-221, 2006.

[22] WUTTKE, W.; JARRY, H.; CHRISTOFFEL, B. et al. Chaste tree (Vitex agnus-castus) Pharmacology and clinical indications. Phytomedicine, v.10, p.348-357, 2003.