Economic and therapeutic potential of essential oils most used in Brazil

Isanete Geraldini Costa Bieski
Juliana Lima Urbano dos Santos
Míria de Lima Ferreira
Polliana Conceição Garcia
Suzy Hellen Alves Dourado
Aline Bispo Januário
Teresa Elizabete Messias
Joelma Maria dos Santos da Silva Apolinario

    Isanete Geraldini Costa Bieski

    Instituto do Saber Ativo-Isa, Laurinda Maria de Oliveira 111-N, Module 05, Juína, CEP 78320-000, MT, Brazil.

    President of Instituto do Saber Ativo (Instituto Isa) - www.institutoisa.com.br. Graduations in Pharmacy (UNIC-1997), Biochemistry (UNIC-2006), Degree in Chemistry (UAB/IFMT-2019) and Biology (Claretian-2019). Experience in designing, raising and executing project resources in various areas. Member of the International Society for Ethnopharmacology, (ISE: https://www.ethnopharmacology.org/). Brazilian Society of Pharmacognosy - SBFGNOSIA, among others. Completed Specializations:   1. TEACHING OF CHEMISTRY - EAD; 2. Biological Sciences with an emphasis on Botany and Ecology; 3. Didactics of Higher Education; 4. Hospital Pharmacy; 5. Pharmacology: Update and New Perspectives; 6. Medicinal Plants, Handling, Use and Handling; 7.Management in Public Service. Ongoing Specialization by AJES: Tutoring in EAD. Master's Degree in Health Sciences, area of ​​Pharmacology of Natural Products, (UFMT-2010); Sandwich Doctorate in Health Sciences, Natural Products Pharmacology area, with Sandwich Internship by the Science without Borders Program at the University of Ottawa, Ontario, Canada; coordinated by Prof. Dr. Domingos Tabajara de Oliveira Martins and John Thor Arnason, PhD Professor of Biology University of Ottawa (UFMT-2015). Post-doctorate by the Department of Botany and Ecology. Flora, Vegetation and Ethnobotany Research Group ? FLOVET, under the supervision of Prof. Dr. Germano Guarin Neto (UFMT-2017-2018). She was coordinator of the Pharmacy and Aesthetics and Cosmetics Course at Faculdade Noroeste de Mato Grosso (AJES) from 2016-2020. Editor-in-Chief of the Revista de Saúde Viva Multidisciplinar at AJES (REVISAJES). Coordinator of several projects of her authorship and/or participation. Expertise in fundraising for various projects. Partnership with the Rikbaktsa Indigenous Women's Association (AIMURIK) Research Lines: Ethnopharmacology; Ethnobotany; Medicinal Plants and Herbal Medicines; Clinical Pharmacy. It is currently part of the Center for Ethnobotanical and Ethnopharmacological Studies (CEE). Participates as a researcher in the CNPq Research Groups:  1.Pharmacology of Natural Products, Coordinated by Prof. Dr. Domingos Tabajara de Oliveira Martins; 2. Probability and Statistics, Coordinated by Prof. Dr. Mariano Martinez Espinosa; 3. Flora, Vegetation and Ethnobotany, Coordinated by Prof. Dr. Germano Guarim Neto, Medicinal Plants coordinated by Prof. Dr. Germano Guarim Neto. I was a professor at the AJES Post-Graduate Course; President of the NDE course in Pharmacy at AJES and Technology Course in Aesthetics and Cosmetics. Clinical Pharmacist with title granted by SBRAFH, practice at Clínica Escola and Hospital São Lucas in Juína-MT. Participated in the Work Group on Phytotherapy of the Federal Council of Pharmacy (2015). He participated in the MEC Evaluation Committee for approval of the undergraduate courses at the AJES Faculty (Pharmacy, Nursing, Physiotherapy, Psychology, Dentistry, Aesthetics and Cosmetics) in Juína, Campo Novo and Guarantã do Norte. Mentor of the Medicinal Plants Program. FITOVIVA, in Cuiabá-MT (2003-2008). Evaluator of several scientific journals. Advisor and Consultant in the area of ​​Medicinal Plants and Herbal Medicines, for the implementation of the Viva Pharmacy. He has experience in Pharmacy with an emphasis on Living Pharmacies, acting on the following topics: Pharmacobotany, Ethnobotany and Ethnopharmacology, Phytotherapy and Living Pharmacy, Bromatology, Pharmaceutical Assistance, Public Health, Semiology, Phytotherapy and Living Pharmacy, Homeopathy, Pharmacology, Pharmacotechnics, Analysis Clinics, Pharmaceutical Care and Assistance, Drug Dispensing, Magisterial Pharmacy, Clinical Pharmacy and Pharmaceutical Office and Clinical Analysis. She was the owner of Pharmacy and Drugstore. I worked at the Carlos Chagas Laboratory (1993-1996; 2009).

    Juliana Lima Urbano dos Santos

    Universidade Federal da Paraíba (UFPB), Departamento de Ciências Farmacêuticas, Centro e Ciência da Saúde (DCF/CCS), Cidade Universitária, CEP 58051-900, João Pessoa, PB, Brasil.

    Student in Pharmacy at the Federal University of Paraíba (UFPB). She is actively involved in academic community events in the Health Sciences area, with a primary focus on Integrative and Complementary Practices (PICs). She participated in teaching initiation and scientific initiation projects as a scholarship holder and volunteer. She has several short courses in different areas as she seeks to expand her range of knowledge. She is currently participating in the scientific initiation project "Phytochemical study of two species of Malvaceae sensu lato" and in the extension project? Health Education for the Rational Use of Herbal Medicines?, both at UFPB.

    Míria de Lima Ferreira

    Federal University of Paraíba (UFPB), Department of Pharmaceutical Sciences, Health Science Center (DCF/CCS), University City, CEP 58051-900, João Pessoa, PB, Brazil.

    Polliana Conceição Garcia

    Municipal Health Department of the municipality of Diorama, Technical Coordination of the APL Project of Medicinal Plants and Phytotherapics of Avenida Deputado José de Assis, s/n, Centro, CEP 76260-000, Diorama, GO, Brazil.

    Degree in Pharmacy with specialization in Clinical Analysis, by the Federal University of Mato Grosso (2007). Specialization in Phytotherapy from the Federal University of Goiás (2010). Master's Degree in Applied Health Sciences from the Federal University of Goiás (2015). Specialization in Epidemiology & Health at the Federal University of Goiás (2017). He has experience in Good Production Practices and Quality Assurance of Medicinal Plants and Herbal Medicines. Professor at the Faculty of Iporá - Graduate Course in Pharmacy in the Disciplines: Epidemiology & Health Surveillance; Pharmacognosy (2019). She is currently the Technical Responsible for Basic Pharmacy and Technical Coordinator of the APL Project of Medicinal Plants and Herbal Medicines in the municipality of Diorama-GO.

    Suzy Hellen Alves Dourado

    Federal University of Mato Grosso (UFMT), Sinop campus, Avenida Alexandre Ferronato, 1200, Res. Cidade Jardim, CEP 78550-728, MT, Brazil.

    Graduated in pharmacy from the Federal University of Mato Grosso, campus of Sinop (2016). During his graduation, he performed scientific initiation activities in the area of pharmaceutical chemistry and toxicology. She is currently a Masters student at UFMT / Sinop in Health Sciences with a research line on pharmacological and toxicological evaluation of natural and synthetic products.

    Aline Bispo Januário

    Instituto do Saber Ativo-Isa, Laurinda Maria de Oliveira 111-N, Module 05, Juína, CEP 78320-000, MT, Brazil.

    Master in Forest and Environmental Sciences, graduated in Forest Engineering from the Federal University of Mato Grosso (2008).

    Teresa Elizabete Messias

    Instituto do Saber Ativo-Isa, Laurinda Maria de Oliveira 111-N, Module 05, Juína, CEP 78320-000, MT, Brazil.

    Joelma Maria dos Santos da Silva Apolinario

    Instituto do Saber Ativo-Isa, Laurinda Maria de Oliveira 111-N, Module 05, Juína, CEP 78320-000, MT, Brazil.

    Undergraduate in PHARMACY at the Maurício de Nassau University Center - UNINASSAU - Campina Grande-PB, Undergraduate in CHEMISTRY at UEPB - State University of Paraíba - Campina Grande -PB. Clinical Analyst, Post-Graduate Lato Sensu in ONCOLOGICAL PHARMACY, CLINICAL AND HOSPITAL PHARMACY, MICROBIOLOGY by FAVENI. Lato Sensu Post-Graduate Student in CLINICAL AND FORENSIC TOXICOLOGY, MBA in DRUG AND PHARMACY MANAGEMENT from FACEMINAS, Lato Sensu Post-Graduate Student in FORENSIC INVESTIGATION AND CRIMINAL EXPERTISE from FARESE. Phytotherapy Tutor at Instituto do Saber Ativo - ISA - Mato Grosso - MT, TRAINING IN HOLISTIC THERAPY at Instituto Saber Consciente São Paulo - SP, with emphasis on Aromatherapy, Phytotherapy, Bach Flowers, Essential Oils and Integrative Practices. TRAINING IN INTEGRATIVE HOMEOPATHIC THERAPY at Instituto Terapia dos Astros São Paulo - SP, with emphasis on Consultation, Prescription and Homeopathic Medicines. Member of the CHEMICAL AND BIOLOGICAL STUDY OF NATURAL AND DERIVATIVE PRODUCTS RESEARCH Project by UFPR - FEDERAL UNIVERSITY OF PARANÁ, Department of Pharmacy, Laboratory of Pharmacognosy. MONITORS of the I CONGRESS OF INFECTOLOGY AND TROPICAL MEDICINE - COIMET by UniBH - Centro Universitário de Belo Horizonte. MONITORS of the II National Science and Health Congress (MULTIPROFESSIONAL PERFORMANCE IN ONCOLOGY). Member of the Clinical Hematology League at FACSUL - Faculdade Sucesso de Campina Grande - PB. Member of OFAC UNIVERSITY - Women's Organization of Clinical Analysis - MA. MEMBER OF THE ACADEMIC LEAGUE OF MOLECULAR BIOLOGY - LABIOMOL of the NOBLE FACULTY OF FEIRA DE SANTANA - FAN/BA and HIGHER EDUCATION UNIT OF FEIRA DE SANTANA - UNEF/BA. Member of the LAFARMA Pharmacology League at UNIVERSIDADE FEDERAL DE GOIÁS - UFG. SCIENTIFIC DIRECTOR of the League of Clinical Analysis -LAAC of the NOBLE FACULTY OF FEIRA DE SANTANA - FAN/BA and HIGHER EDUCATION UNIT OF FEIRA DE SANTANA - UNEF/BA. He has experience in the pharmaceutical area with an emphasis on Biodiagnosis, Clinical Analysis, Interpretation of Laboratory Tests, Manipulation Pharmacy, Medical Entomology, Health Biotechnology, Laboratory Analysis of Microbial Growth with Aspects of Clinical Biochemistry, Microorganism isolation techniques in Microbiology and Applied Molecular Biology à Oncology - SPOM Sociedad Peruana de Oncología Médica Lima - PERU, Virtual Course on Multidisciplinary Approach to Breast Cancer - SPM Sociedad Peruana de Mastología, Lima PERÙ, I International Course on Pharmacology - SOCIEMSA, Lima - PERÚ, Training Course on Active and Aging Healthy - Guidelines for better management in Health and Disease - Faculty of Medicine University of Coimbra - PORTUGAL.

Keywords

Oils volatile
Brazil
Importation of products
Exportation of products

Abstract

Essential oils are highly concentrated and volatile aromatic extracts obtained from plants. The present work sought to optimize information about the economic potential of essential oils in Brazil. By reviewing the literature and updating the existing commercial data, it was possible to identify relevant scientific studies that were selected in searches through the eletronic databases National Library of Medicine (PubMed), Scientific Eletronic Library Online (SciElo), Google Scholar, The Cochrane Library, according to the degree of adequacy to the proposed theme. As the country is one of the major producers of essential oils, it’s exports and imports are responsible for handling millions of dollars. Realizing the importance of this product both for health and for the country’s economy, the most studied essential oils stand out: Citrus limon (L.) Burm.f.; Eucalyptus citriodora Hook; Eucalyptus urograndis; Eucalyptus microcoris; Mentha arvensis L.; Mentha piperita L.; Cedrus atlantica (Endl.) Manetti ex Carrière; Cymbopogon winterianus Jowitt ex Bor; Cymbopogon citratus (DC.) Stapf; Myrocarpus frondosus Allemão; Citrus sinensis (L.) Osbeck; Citrus bergamia Risso; Pelargonium graveolens L’Hér. The results obtained demonstrate that the production of essential oils in the country is viable and has a great economic and therapeutic potential.

References

  1. Empresa Brasileira de Pesquisa Agropecuária – EMBRAPA. Óleos essenciais. [Link].
  2. Silva J, Abebe W, Sousa SM, Duarte VG, Machado MIL, Matos FJA. Analgesic and anti-inflammatory effects of essential oils of Eucalyptus. J Ethnopharmacol. 2003; 89: 277-283. ISSN 0378-8741. [CrossRef].
  3. Hajhashemi V, Ghannadi A, Sharif B. Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. J Ethnopharmacol. 2003; 89: 67-71. ISSN 0378-8741. [CrossRef].
  4. Perry NS. Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav. 2003; 75: 651-659. ISSN 0091-3057. [CrossRef].
  5. Amaral F. Técnicas de aplicação de óleos essenciais: terapias de saúde e beleza. 256p. ISBN: 9788522122141.
  6. Simões CMO, Schenkel EP, de Mello JCP, Mentz LA, Petrovick PR. Farmacognosia - do produto natural ao medicamento. 1ª ed. Porto Alegre: Artmed, 2017. 502p. ISBN: 9788582713594.
  7. National Association for Holistic Aromatherapy. What is aromatherapy? [Link]
  8. Farrar AJ, Farrar FC. Clinical Aromatherapy. Nurs Clin North Am. 2020; 55(4): 489-504. ISSN 0029-6465. [CrossRef].
  9. Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils - a review. Food Chem Toxicol. 2008; 46(2): 446-475. [CrossRef].
  10. Buckle J. Clinical aromatherapy: essential oils in healthcare. 3ª ed. St. Louis, MO: Elsevier, 2014. 432p. ISBN: 9780702054402.
  11. Reis D, Jones T. Aromatherapy: using essential oils as a supportive therapy. Clin J Oncol Nurs. 2017; 21(1): 16-19. ISSN 1092-1095. [CrossRef].
  12. Comex Stat. [Link].
  13. What is UN Comtrade? United Nations International Trade Statistics Knowledge base. [Link].
  14. Rozza AL, Moraes Tde M, Kushima H et al. Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E₂. Chem Biol Interact. 2011; 189(1-2): 82-89. ISSN 0009-2797. [CrossRef].
  15. Dosoky NS, Setzer WN. Biological Activities and Safety of Citrus spp. Essential Oils. Int J Mol Sci. 2018; 19(7): 1966. ISSN 1422-0067. [CrossRef].
  16. Zu Y, Yu H, Liang L, Fu Y, Efferth T, Liu X et al. Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells. Molecules. 2010; 15(5): 3200-3210. ISSN 1420-3049. [CrossRef].
  17. Yavari Kia P, Safajou F, Shahnazi M, Nazemiyeh H. The effect of lemon inhalation aromatherapy on nausea and vomiting of pregnancy: a double-blinded, randomized, controlled clinical trial. Iran Red Crescent Med J. 2014; 16(3): e14360. ISSN 2074-1804. [CrossRef].
  18. Akpinar B. The effects of olfactory stimuli on scholastic performance. Ir J Educ. 2005; 36: 86-90. ISSN 0883-0355.
  19. Gomes SP, Favero S. Assessment of the insecticidal potential of Eucalyptus urograndis essential oil against Rhodnius neglectus Lent (Hemiptera: Reduviidae). Neotrop Entomol. 2013; 42(4): 431-435. ISSN 1678-8052. [CrossRef].
  20. Oliveira FN, Fortes GA, Paula JR, Ferri PH, Santos SC. Seasonal influence on the essential oil of Eucalyptus microcorys. Nat Prod Commun. 2014; 9(4): 575-580. ISSN 1934-578X.
  21. Pinheiro REE, Chaves TP, Melo ES, Ali S, Ali SW, Umer M et al. Modulatory-antibiotic activity of the essential oil from Eucalyptus citriodora against MDR bacterial strains. Cell Mol Biol (Noisy-le-grand). 2020; 66(4): 60-64. ISSN 1165-158X.
  22. Cermelli C, Fabio A, Fabio G, Quaglio P. Effect of eucalyptus essential oil on respiratory bacteria and viruses. Curr Microbiol. 2008; 56(1): 89-92. ISSN 1432-0991. [CrossRef].
  23. Boukef MK. Médicine traditionnelle et pharmacopée, les plantes dans la médicine traditionnelle tunisienne. 1986: Agence de Coopération Culturelle et Technique. ISBN: 9290280859.
  24. Chagas AC, Oliveira MC, Giglioti R et al. Efficacy of 11 Brazilian essential oils on lethality of the cattle tick Rhipicephalus (Boophilus) microplus. Ticks Tick Borne Dis. 2016; 7(3): 427-432. ISSN 1877-959X. [CrossRef].
  25. Kumar P, Mishra S, Malik A, Satya S. Insecticidal properties of Mentha species: A review. Ind Crops Prod. 2011; 34: 802-817. ISSN 0926-6690. [CrossRef].
  26. Park YJ, Baek SA, Choi Y, Kim JK, Park SU. Metabolic Profiling of Nine Mentha Species and Prediction of Their Antioxidant Properties Using Chemometrics. Molecules. 2019; 24(2): 258. ISSN 1420-3049. [CrossRef].
  27. Pazinato R, Volpato A, Baldissera MD et al. In vitro effect of seven essential oils on the reproduction of the cattle tick Rhipicephalus microplus. J Adv Res. 2016; 7(6): 1029-1034. ISSN 2090-1232. [CrossRef].
  28. Huang XF, Chang KF, Lee SC et al. Extract derived from Cedrus atlantica acts as an antitumor agent on hepatocellular carcinoma growth in vitro and in vivo. Molecules. 2020; 25(20): 4608. ISSN 1420-3049. [CrossRef].
  29. Dakir M, El Hanbali F, Mellouki F et al. Antibacterial diterpenoids from Cedrus atlantica. Nat Prod Res. 2005; 19(7): 719-722. ISSN 1478-6427. [CrossRef].
  30. Martins DF, Emer AA, Batisti AP, Donatello N, Carlesso MG, Mazzardo-Martins L et al. Inhalation of Cedrus atlantica essential oil alleviates pain behavior through activation of descending pain modulation pathways in a mouse model of postoperative pain. J Ethnopharmacol. 2015; 175: 30-38. ISSN 0378-8741. [CrossRef].
  31. Rodrigues KA, Dias CN, do Amaral FM, Moraes DF, Mouchrek Filho VE, Andrade EH et al. Molluscicidal and larvicidal activities and essential oil composition of Cymbopogon winterianus. Pharm Biol. 2013; 51(10): 1293-1297. ISSN 1388-0209. [CrossRef].
  32. de Mello V, Prata MC, da Silva MR, Daemon E, da Silva LS, Guimarães Fdel G et al. Acaricidal properties of the formulations based on essential oils from Cymbopogon winterianus and Syzygium aromaticum plants. Parasitol Res. 2014; 113(12): 4431-4437. ISSN 1432-1955. [CrossRef].
  33. Silva CF, Moura FC, Mendes MF, Pessoa FLP. Extraction of citronella (Cymbopogon nardus) essential oil using supercritical co2: experimental data and mathematical modeling. Braz J Chem. 2011; 28(2): 343-350. ISSN 1678-4790. [CrossRef].
  34. Devi K, Patar L, Modi MK, Sen P. An insight into structure, function, and expression analysis of 3-Hydroxy-3-Methylglutaryl-CoA reductase of Cymbopogon winterianus. Bioinform Biol Insights. 2017; 11. ISSN 1177-9322. [CrossRef].
  35. Nakahara K, Alzoreky N, Yoshihashi T, Nguyen T. Chemical composition and antifungal activity of essential oil from Cymbopogon nardus (Citronella Grass). JARQ. 2003; 37(4): 249-252. ISSN 2185-8896. [CrossRef].
  36. WebMD. Citronella Oil. [Link].
  37. Abe S, Sato Y, Inoue S, Ishibashi H, Maruyama N, Takizawa T et al. Anti-Candida albicans activity of essential oils including Lemongrass (Cymbopogon citratus) oil and its component, citral. Japan J Med Mycol. 2003; 44(4): 285-91. ISSN 0916-4804. [CrossRef].
  38. Tyagi AK, Malik A. Morphostructural damage in food-spoiling bacteria due to the lemon grass oil and its vapour: SEM, TEM, and AFM investigations. Evid Based Compl Altern Med. 2012; 2012. ISSN 1741-4288. [CrossRef].
  39. Negrelle RRB, Gomes EC. Cymbopogon citratus DC. Stapf: chemical composition and biological activities. Rev Bras Pl Med. 2006; 9(1): 80-92. ISSN 1983-084X.
  40. Silva Cde B, Guterres SS, Weisheimer V, Schapoval EE. Antifungal activity of the lemongrass oil and citral against Candida spp. Braz J Infect Dis. 2008; 12(1): 63-66. ISSN 1413-8670. [CrossRef].
  41. Tyagi AK, Malik A. Liquid and vapour-phase antifungal activities of selected essential oils against Candida albicans: microscopic observations and chemical characterization of Cymbopogon citratus. BMC Complement Altern Med. 2010; 10: 65. ISSN 1472-6882. [CrossRef].
  42. Boukhatem MN, Kameli A, Ferhat MA, Saidi F, Tayebi K. The food preservative potential of essential oils: is lemongrass the answer? J Verbr Lebensm. 2013; 9(1): 1-9. ISSN 1661-5751. [CrossRef].
  43. Cabrera DC, Gomes GL, Flach A, da Costa LA, Rosa GR, de Moura NF. Evaluation of climatic factors on the yield and chemical composition of the essential oil of Myrocarpus frondosus. Nat Prod Res. 2015; 29(7): 667-70. ISSN 1478-6427. [CrossRef].
  44. Ao Y, Satoh K, Shibano K, Kawahito Y, Shioda S. Singlet oxygen scavenging activity and cytotoxicity of essential oils from rutaceae. J Clin Biochem Nutr. 2008; 43(1): 6-12. ISSN 0912-0009. [CrossRef].
  45. Sarrou E, Chatzopoulou P, Dimassi-Theriou K, Therios I. Volatile constituents and antioxidant activity of peel, flowers and leaf oils of Citrus aurantium L. growing in Greece. Molecules. 2013; 18(9): 10639-10647. ISSN 1420-3049. [CrossRef].
  46. Yu L, Yan J, Sun Z. D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways. Mol Med Rep. 2017; 15(4): 2339-2346. ISSN 1791-3004. [CrossRef].
  47. Roberto D, Micucci P, Sebastian T, Graciela F, Anesini C. Antioxidant activity of limonene on normal murine lymphocytes: relation to H2O2 modulation and cell proliferation. Basic Clin Pharmacol Toxicol. 2010; 106(1): 38-44. ISSN 1742-7843. [CrossRef].
  48. Russo R, Cassiano MG, Ciociaro A, Adornetto A, Varano GP, Chiappini C et al. Role of D-Limonene in autophagy induced by bergamot essential oil in SH-SY5Y neuroblastoma cells. PLoS One. 2014; 9(11): e113682. ISSN 1932-6203. [CrossRef].
  49. Rombolà L, Amantea D, Russo R, Adornetto A, Berliocchi L, Tridico L et al. Rational basis for the use of bergamot essential oil in complementary medicine to treat chronic pain. Mini Rev Med Chem. 2016; 16(9): 721-728. ISSN 1875-5607. [CrossRef].
  50. Filomena L, Ilari S, Giancotti LA, Morabito C, Malafoglia V, Gliozzi M et al. The protective role of bergamot polyphenolic fraction on several animal models of pain. PharmaNutrition. 2016; 4: S35-S40. ISSN 2213-4344. [CrossRef].
  51. Sakurada T, Mizoguchi H, Kuwahata H, Katsuyama S, Komatsu T, Morrone LA et al. Intraplantar injection of bergamot essential oil induces peripheral antinociception mediated by opioid mechanism. Pharmacol Biochem Behav. 2011; 97(3): 436-443. ISSN 0091-3057. [CrossRef].
  52. Boukhatem MN, Kameli A, Ferhat MA, Saidi F, Mekarnia M. Rose geranium essential oil as a source of new and safe anti-inflammatory drugs. Libyan J Med. 2013; 8: 22520. ISSN 1819-6357. [CrossRef].
  53. Zeljkovic SC, Maksimović M. Antioxidant activity of essential oil and aqueous extract of Pelargonium graveolens L’Her. Food Control. 2012; 23(1): 263-267. ISSN 0956-7135. [CrossRef].
  54. Hsouna A, Hamdi N. Phytochemical composition and antimicrobial activities of the essential oils and organic extracts from Pelargonium graveolens growing in Tunisia. Lipids Dealth Dis. 2012; 11(1): 167. ISSN 1476-511X. [CrossRef].
  55. Jinukuti MG, Giri A. Antimicrobial activity of phytopharmaceuticals for prevention and cure of diseases. Ann Phytomed. 2013; 2(2): 28-46. ISSN 2393-9885.
  56. Boukhatem MN, Kameli A, Saidi F. Essential oil of Algerian rose-scented geranium (Pelargonium graveolens): chemical composition and antimicrobial activity against food spoilage pathogens. Food Control. 2013; 34(1): 208-213. ISSN 0956-7135. [CrossRef].
  57. Sociedade Nacional de Agricultura. Óleos essenciais: uma fonte de divisas a ser mais explorada no Brasil. 2017. [Link].
PDF (Portuguese)
HTML (Portuguese)
XML (Portuguese)
Save bookmark

Author(s)

  • Isanete Geraldini Costa Bieski
    Instituto do Saber Ativo-Isa, Laurinda Maria de Oliveira 111-N, Module 05, Juína, CEP 78320-000, MT, Brazil.
  • Juliana Lima Urbano dos Santos
    Universidade Federal da Paraíba (UFPB), Departamento de Ciências Farmacêuticas, Centro e Ciência da Saúde (DCF/CCS), Cidade Universitária, CEP 58051-900, João Pessoa, PB, Brasil.
  • Míria de Lima Ferreira
    Federal University of Paraíba (UFPB), Department of Pharmaceutical Sciences, Health Science Center (DCF/CCS), University City, CEP 58051-900, João Pessoa, PB, Brazil.
  • Polliana Conceição Garcia
    Municipal Health Department of the municipality of Diorama, Technical Coordination of the APL Project of Medicinal Plants and Phytotherapics of Avenida Deputado José de Assis, s/n, Centro, CEP 76260-000, Diorama, GO, Brazil.
  • Suzy Hellen Alves Dourado
    Federal University of Mato Grosso (UFMT), Sinop campus, Avenida Alexandre Ferronato, 1200, Res. Cidade Jardim, CEP 78550-728, MT, Brazil.
  • Aline Bispo Januário
    Instituto do Saber Ativo-Isa, Laurinda Maria de Oliveira 111-N, Module 05, Juína, CEP 78320-000, MT, Brazil.
  • Teresa Elizabete Messias
    Instituto do Saber Ativo-Isa, Laurinda Maria de Oliveira 111-N, Module 05, Juína, CEP 78320-000, MT, Brazil.
  • Joelma Maria dos Santos da Silva Apolinario
    Instituto do Saber Ativo-Isa, Laurinda Maria de Oliveira 111-N, Module 05, Juína, CEP 78320-000, MT, Brazil.

Metrics

  • Article viewed 832 time(s)

How to Cite

1.
Economic and therapeutic potential of essential oils most used in Brazil. Rev Fitos [Internet]. 2022 Jan. 31 [cited 2025 Dec. 7];15(Supl 1):125-37. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1203
Crossref
Scopus
Google Scholar
Europe PMC

1. DIREITOS CEDIDOS - A cessão total não exclusiva, permanente e irrevogável dos direitos autorais patrimoniais não comerciais de utilização de que trata este documento inclui, exemplificativamente, os direitos de disponibilização e comunicação pública da OBRA, em qualquer meio ou veículo, inclusive em Repositórios Digitais, bem como os direitos de reprodução, exibição, execução, declamação, recitação, exposição, arquivamento, inclusão em banco de dados, preservação, difusão, distribuição, divulgação, empréstimo, tradução, dublagem, legendagem, inclusão em novas obras ou coletâneas, reutilização, edição, produção de material didático e cursos ou qualquer forma de utilização não comercial.

2. AUTORIZAÇÃO A TERCEIROS - A cessão aqui especificada concede à FIOCRUZ - FUNDAÇÃO OSWALDO CRUZ o direito de autorizar qualquer pessoa – física ou jurídica, pública ou privada, nacional ou estrangeira – a acessar e utilizar amplamente a OBRA, sem exclusividade, para quaisquer finalidades não comerciais, nos termos deste instrumento.

3. USOS NÃO COMERCIAIS - Usos não comerciais são aqueles em que a OBRA é disponibilizada gratuitamente, sem cobrança ao usuário e sem intuito de lucro direto por parte daquele que a disponibiliza e utiliza.

4. NÃO EXCLUSIVIDADE - A não exclusividade dos direitos cedidos significa que tanto o AUTOR como a FIOCRUZ - FUNDAÇÃO OSWALDO CRUZ ou seus autorizados poderão exercê-los individualmente de forma independente de autorização ou comunicação, prévia ou futura.

5. DIREITOS RESERVADOS - São reservados exclusivamente ao(s) AUTOR(es) os direitos morais sobre as obras de sua autoria e/ou titularidade, sendo os terceiros usuários responsáveis pela atribuição de autoria e manutenção da integridade da OBRA em qualquer utilização. Ficam reservados exclusivamente ao(s) AUTOR(es) e/ou TITULAR(es) os usos comerciais da OBRA incluída no âmbito deste instrumento.

6. AUTORIA E TITULARIDADE - O AUTOR declara ainda que a obra é criação original própria e inédita, responsabilizando-se integralmente pelo conteúdo e outros elementos que fazem parte da OBRA, inclusive os direitos de voz e imagem vinculados à OBRA, obrigando-se a indenizar terceiros por danos, bem como indenizar e ressarcir a FIOCRUZ - FUNDAÇÃO OSWALDO CRUZ de eventuais despesas que vierem a suportar, em razão de qualquer ofensa a direitos autorais ou direitos de voz ou imagem, principalmente no que diz respeito a plágio e violações de direitos.

7. GRATUIDADE - A cessão e autorização dos direitos indicados e estabelecidos neste Instrumento será gratuita, não sendo devida qualquer remuneração, a qualquer título, ao autor e/ou titular, a qualquer tempo.

Report an error