Bioprospecting of anticancer activity of genera Garcinia and Clusia: a brief review

Lavínia de Carvalho Brito
OrcID
Maria Raquel Figueiredo

    Lavínia de Carvalho Brito

    Universidade do Estado do Rio de Janeiro (UERJ), Instituto de Química/Central Analítica Fernanda Coutinho. Av São Francisco Xavier, 524, Pavilhão Haroldo Lisboa da Cunha, sala 109, terreo, Maracanã, CEP 20550-013, Rio de Janeiro, RJ, Brasil.

    OrcID http://orcid.org/0000-0003-4448-1275

    Graduada em Química Industrial - Faculdades Reunidas Nuno Lisboa (1985), com mestrado em Química Orgânica pela Universidade Federal do Rio de Janeiro (1992) e doutorado em Química Orgânica pela Universidade Federal Fluminense (2003). Desde 1984 é química da Universidade do Estado do Rio de Janeiro com experiência na área de Química Orgänica, Química de Produtos Naturais, Espectroscopia de Ressonäncia Magnética Nuclear, Radiofarmácia, Medicina Nuclear e Radioecologia. Desde 2009 trabalha na Central Analítica Fernanda Coutinho - UERJ e desenvolve projeto de pesquisa em Fitomedicamentos, na área de Química de Produtos Naturais, na Fundação Oswaldo Cruz (FIOCRUZ).

    Maria Raquel Figueiredo

    Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, Química de Produtos Naturais. Rua Sizenando Nabuco, 100, Manguinhos, Laboratório de Química de Produtos Naturais-PN3, CEP 21041-250, Rio de Janeiro, RJ, Brasil.

    Possui graduação em Química Industrial pela Universidade Federal Fluminense (1981), mestrado em Química de Produtos Naturais pela Universidade Federal do Rio de Janeiro (1985) e doutorado em Química Orgânica pela Universidade de São Paulo (1991). Atualmente é pesquisador titular da Fundação Oswaldo Cruz. Tem experiência na área de Química, com ênfase em Química dos Produtos Naturais, atuando principalmente nos seguintes temas: Quimiossistemática, Fitoquímica e Desenvolvimento Tecnológico.

Keywords

Bioprospecting
Clusiaceae
Clusia studartiana
Cancer
Garcinia

Abstract

Bioprospecting is a way to extract economic value from Brazilian biodiversity, comprising mainly the pharmaceutical industry. Cancer is one of the main causes of mortality in the world and 64.9% of anticancer drugs approved from 1946 to 2019 were extracted from natural sources. The Clusiaceae family has several bioactive secondary metabolites, highlighting the antineoplastic action of species from the genera Garcinia and Clusia. The objective of this work was to carry out a brief review on anticancer activity of the Clusia and Garcinia genera, belonging to the Clusiaceae family. The bibliographic search was carried out from 2000 to 2021, in the Scifinder, Pubmed, Scopus and Web of Science databases. In vitro and in vivo studies of both genera were selected, on anticancer activity of some of the most representative isolated substances, and the action mechanisms involved. Duplicates, questionable or insufficient data were excluded. This review reinforces the importance of bioprospecting anticancer molecules from the Clusiaceae family, which could contribute to drug discovery from natural sources and a sustainable technological development in Brazil.

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  • Lavínia de Carvalho Brito
    Universidade do Estado do Rio de Janeiro (UERJ), Instituto de Química/Central Analítica Fernanda Coutinho. Av São Francisco Xavier, 524, Pavilhão Haroldo Lisboa da Cunha, sala 109, terreo, Maracanã, CEP 20550-013, Rio de Janeiro, RJ, Brasil.
    http://orcid.org/0000-0003-4448-1275
  • Maria Raquel Figueiredo
    Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, Química de Produtos Naturais. Rua Sizenando Nabuco, 100, Manguinhos, Laboratório de Química de Produtos Naturais-PN3, CEP 21041-250, Rio de Janeiro, RJ, Brasil.

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Bioprospecting of anticancer activity of genera Garcinia and Clusia: a brief review. Rev Fitos [Internet]. 2022 Mar. 4 [cited 2024 Nov. 22];16(Supl. 2):247-66. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1227
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