Development and preliminary stability evaluation of serum with Aloe vera and Matricaria chamomilla extracts

Nicole Kananda Almeida Maia
OrcID
Ana Carolina Gomes de Albuquerque de Freitas
OrcID
José Otávio Carréra Silva Júnior
OrcID
Tais Vanessa Gabbay Alves
OrcID

    Nicole Kananda Almeida Maia

    University of the Amazon (UFAM), Campus Ananindeua. Unama Coqueiro, CEP 67113-901, Ananindeua, PA, Brazil.

    OrcID https://orcid.org/0009-0004-1655-3926

    He is currently a student at the University of Amazônia and a pibic at the University of Amazônia

    Ana Carolina Gomes de Albuquerque de Freitas

    Federal University of Pará, Rua Augusto Corrêa, 01, Bairro Guamá, CEP 66075-110, Belém, PA, Brazil.

    OrcID https://orcid.org/0000-0002-9034-7512

    He has a Bachelor's degree in Industrial Chemistry and a Master's degree in Organic Chemistry, both from the Federal University of Pará and a Degree in Chemistry. He participated as a DTI fellow at the National Agricultural Laboratory-PA, working with validation of chromatographic methodologies according to NBR ISO / IEC 17025: 2005. He has experience in teaching Higher Education, working as an External Professor at UFPA / Campus Soure. He has experience in the area of Chemistry, with an emphasis on Chemistry of Natural Products, working mainly on the following topics: phytochemistry and classic and modern chromatography (CCD, CCVU, CLAE and CCDAE). She is currently a laboratory technician-Chemistry area, at the Federal University of Pará-campus Guamá and substitute professor of higher education, at the Federal University of Pará-Campus Universitário do Marajó, Breves.

    José Otávio Carréra Silva Júnior

    Federal University of Pará, Rua Augusto Corrêa, 01, Bairro Guamá, CEP 66075-110, Belém, PA, Brazil.

    OrcID https://orcid.org/0000-0003-1691-1039

    He has a degree in Pharmacy from the Federal University of Pará (1990), a Master's degree (2000) and a PhD (2006) in Pharmaceutical Sciences from the Faculty of Pharmaceutical Sciences of Ribeirão Preto at the University of São Paulo. Productivity Scholarship in Technological Development and Innovative Extension from CNPq Level 2 (2013 - Current). Member of the Thematic Technical Committee on PHARMACEUTICAL INPUTS of the Brazilian Pharmacopoeia / ANIVISA. He is currently a Full Professor and Researcher at the Federal University of Pará-UFPA. He held the following positions: Deputy Director of the Faculty of Pharmacy (2007 -2009), Coordinator of the Postgraduate Program in Pharmaceutical Sciences - PPGCF (2009 - 2011 and 2011 - 2013), Coordinator of the Postgraduate Program in Pharmaceutical Innovation - PPGIF Doctoral Level (2013 - 2015 and 2015 - 2017), where he works as Permanent Professor in both Programs. He has experience in the field of Pharmacy, with an emphasis on Drugs and Medicines, working mainly on the following topics: a) Research, development and innovation of pharmaceutical and cosmetic products; b) Technological development of herbal medicines; c) Study of the pharmacotechnical functionality of excipients in formulations; d) Development and evaluation of micro and nanostructured systems and pharmaceutical applications; e) Research and development of innovative cosmetic formulations using oils from Amazonian plant species; f) Standardization of plant extracts (liquid and dried by nebulization - Spray Drying).

    Tais Vanessa Gabbay Alves

    University of the Amazon (UFAM), Campus Ananindeua. Unama Coqueiro, CEP 67113-901, Ananindeua, PA, Brazil.

    OrcID https://orcid.org/0000-0002-7112-8074

    Graduated in Pharmacy (2009), qualified in Biochemistry (2011), Master's degree in Pharmaceutical Sciences (2011) from the Federal University of Pará. PhD in Pharmaceutical Innovation (2017) from the Federal University of Pará (UFPA) with a sandwich period at Università Degli Studi di Genova (UNIGE), Italy. It works in the development of the pharmacy area with an emphasis on pharmaceutical and cosmetic products, highlighting the following themes: Development of microstructured systems, Physicochemical quality control, Reuse of agro-industrial waste, Spray drying, Thermogravimetric analysis and Modified release systems . With teaching experience in the generalist Pharmacy course teaching the subjects: Physicochemical quality control of medicines, Pharmaceutical Technology, Pharmacotechnics and Cosmetology. He is currently a Professor in the Pharmacy Course at Instituto Campinense de Ensino Superior Ltda. (Unama Ananindeua) and Postgraduate Professor in Advanced Aesthetics and Cosmetology.

Keywords

Phytocosmetic
Preliminary stability
Quality control

Abstract

The use of phytocosmetics has been increasing in the beauty industry, in various treatments such as anti-aging, whitening and anti-acne. Serum is a pharmaceutical form similar to a gel, with greater fluidity, as well as soothing and anti-inflammatory actives, which can be suitable candidates for acne-prone skin. Thus, the objective of this study was to carry out the development of formulations based on Natrosol® serum containing extracts of aloe vera and chamomile in five different concentrations and to evaluate their preliminary stability. For this, tests were carried out in 6 ice-thaw cycles in which the samples were subjected to temperatures of 45±2°C and 5±2°C, each for 24 hours, totaling one cycle. During the end of each cycle, the samples were evaluated according to organoleptic characteristics, pH and density, being compared with the control (which remained at room temperature). All analyzed parameters remained according to specifications throughout the test, except for odor, which showed a slight change. It is suggested that during the conditions of this study, the stability was maintained, according to the stability guide and therefore the formulations can proceed to further steps such as the long-term stability test.

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Development and preliminary stability evaluation of serum with Aloe vera and Matricaria chamomilla extracts. Rev Fitos [Internet]. 2024 Jun. 5 [cited 2024 Nov. 20];18:e1602. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1602
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