Fungos Endofíticos. Potencial para a Produção de Substâncias Bioativas

M. A. Ferrara

doi:10.32712/2446-4775.2006.43

Endophytic Fungi. Potential for the Production of Bioactive Substances

Vol. 2 No. 01 (2006)
73-79
15/10/2013
01/06/2006
https://doi.org/10.32712/2446-4775.2006.43

M. A. Ferrara

Keywords

endophytic fungi

medicinal plants

bioactive natural products

secondary metabolites

Abstract

Microorganisms, in special fungi, have been a most significant source of drugs for therapeutic use. Endophytic fungi, which reside in the tissues of virtually all living plants and present important interaction with the host, because of what appears to be their contribution to the host plant, may produce a plethora of substances of potential use as medicine. Medicinal plants have been recently subject of investigations related to their endophytic fungi and their secondary metabolites. Besides the possibility of producing the same substance as the host plant or a bioactive analogous, these microorganisms may synthesize novel molecules with antibiotic, antimycotic, immunosuppressant, anticancer, and other activities.

References

ARAGÃO, T.V.G.; FREITAS, A.; FERRARA, M.A.; SIANI, A.C.; BEHRENS, M.D. Atividade antimicrobiana de metabólitos obtidos por fermentação de fungos endofíticos de Lippia sidoides e Phoradendron sp. Anais da III Bienal de Pesquisa da FIOCRUZ, Fundação Oswaldo Cruz. p.301, 2002a.
ARAGÃO, T.V.G.; FREITAS, A.; FERRARA, M.A.; SIANI, A.C. Isolamento de microrganismos endofíticos de Lippia sidoides e avaliação da atividade antimicrobiana de metabólitos obtidos por fermentação. XVII Simpósio Brasileiro de Plantas Medicinais. Universidade de Mato Grosso, 2002b.
ARAÚJO, W.L.; LIMA, A.O.S.; AZEVEDO, J.L.; MARCON, J.; SOBRAL, J.K.; LAÇAVA, P.T. Manual: Isolamento de microrganismos endofíticos. Departamento de Genética, Escola Superior de Agricultura Luiz de Queiroz - ESALQ/USP, Piracicaba, SP, 86 p., 2002.
ARNOLD, A.E.; MAYNARD, Z.; GILBERT, G.S.; COLEY, P.D.; KURSAR, T.A. Are tropical fungal endophytes hyperdiverse? Ecology Letters v.3, n.4, p.267-274, 2000.
BACON, C. W. Procedure for isolating endophytic from tall fescue and screening isolates for ergot alkaloids. Applied and Environmental Microbiology v.54, n.11, p.2615-2618, 1988.
BILLS, G.; DOMBROWSKI, A.; PELAEZ, F.; POLISHOOK, J.; AN, Z. Recent and future discoveries of pharmacologically active metabolites from tropical fungi. In: WATLING, R.; FRANKLAND, J. C.; AINSWORTH, A. M.; ISSAC, S.; ROBINSON, C. H. (ed.) Tropical Mycology: Micromycetes, vol. 2 CABI Publishing, New York, p.165-194, 2002 apud Microbiology and Molecular Biology Reviews, v.67, n.4, p.491- 502, 2003.
BULL, A. T.; GOODFELLOW, M.; SLATER, J.H. Biodiversity as a source in innovation in biotechnology. Annual Review of Microbiology, v.46, p.219-258, 1992.
CARROL, G. Forest endophytic: Pattern and process. Canadian journal of Botanic. v.73, n.1, p.1316-1324, 1995.
CARVALHO, C.M.; SALEM, J.I.; ASTOLFI FILHO, S. Bioativos com antagonismo para Mycobacterium tuberculosis em microrganismos endofíticos da Amazônia. Anais do XXIII Congresso Brasileiro de Microbiologia, Sociedade Brasileira de Microbiologia, 2005.
CRAGG, G.M.; NEWMAN, D.J. Medicinals for the millennia: the historical record. Annuals of the New York Academy of Science, v.953, p.3-25, 2001.
GUIMARÃES, A.C., SARKIS, M.I, AMARAL, A.C.F., SIANI A.C., KUSTER, R.M. Isolamento de fungos endofíticos das espécies vegetais da Amazônia Cladocolea micrantha e Anacardium occidenatale. IV Congresso Brasileiro de Micologia. Ouro Preto, MG, Livro de Resumos AGR 031, 2004.
GUNATILAKA, A.A.L. Natural products from plant-associated microorganisms: Distribution, structural diversity, bioactivity, and implications of their occurrence. Journal of Natural Products, v.69, p.509-526, 2006.
HAWKSWORTH, D.L. The fungal dimension of biodiversity: magnitude, significance, and conservation. Mycology Research v.95, p. 641-655, 1991.
HUANG, Y.; WANG, J.; LI, G.; ZHENG, Z.; SU, W. Antitumor and antifungal activities in endophytic fungi isolated from pharmaceutical plants Taxus mairei, Cephalataxus fortunei and Torreya grandis. FEMS Immunoogy and Medical Microbioliology, v.31, n.2, p.163-7, 2001.
KONGSAEREE, P.; PRABPAI, S.; SRIUBOLMAS, N.; VONGVEIN, C.; WIYAKRUTTA, S. Antimalarial dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of Crassocephalum crepidioides. Journal of Natural Products, v.66, p.709-711, 2003.
LEE, J.; LOBKOVSKY, E.; PLIAM, N.B.; STROBEL, G.A.; CLARDY,J. Subglutinols A and B: immunosuppressive compounds from the endophytic fungus Fusarium subglutinans. Journal of Organic Chemistry, v.60, p.7076-7077, 1995.
LI, J.Y.; STROBEL, G.; SIDHU, R.S.; HESS, W.M.; FORD, E.J. Endophytic taxol producing fungi from bald cypress, Taxodium distichum. Microbilogy, v.142, p.2223-2226, 1996.
LI, J.Y.; SIDHU, R.S.; BOLLON, A. STROBEL, G. Stimulation of taxol production in liquid cultures of Pestalotiopsis microspora. Mycology Research, v.102, n.4, p.461-464, 1998.
LIU, J.Y.; SONG, Y.C.; ZHANG, Z.; WANG, L.; GUO, Z.J.; ZOU, W.X.; TAN, R.X. Aspergillus fumigatus CY018, an endophytic fungus in Cynodon dactylon as a versatile producer of new and bioactive metabolites. Journal of Biotechnology, v.114, n.3, p.279-287, 2004.
LU, H; ZOU, WX; MENG, J.C.; HU, J.; TAN, R.X. New antibiotic metabolites produced by Colletotrichum sp., an endophytic fungus in Artemisia annua. Plant Science, v.151, p.67-73, 2000
MA, Y.M.; LI, Y.; LIU, J.Y.; SONG, Y.C.; TAN, R.X. Anti-Helicobacter pylori metabolites from Rhizoctonia sp. Cy064, an endophytic fungus in Cynodon dactylon. Fitoterapia, v.75, n.5, p.451-456, 2004.
MARINHO, A.M.R.; RODRIGUES-FILHO, E.; MOITINHO, M.L.R.; SANTOS, L.S. Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach. Journal of the Brazilian Chemical Society, v.16, n.2, p.280-283, 2005.
PEARCE, C. Biologically active fungal metabolites. Advances in Applied Microbiology, v.44, p.1-80, 1997.
PEREIRA, N.O.; ROSA, L.H.; TEIXEIRA, L.C.R.S.; ALVES, T.M.A.; ZANI, C.L.; ROSA, C.A. Fungos endofíticos associados a planta Trixis vauthieri (Asteraceae) produtores de substâncias tripanosomicidas. Anais do XXIII Congresso Brasileiro de Microbiologia, Sociedade Brasileira de Microbiologia, 2005.
PETRINI, O. Taxonomy of endophytic fungi of aerial plant tissues. In Microbiology of the Phyllosphere. Fokkema, N. J. & Van den Heuvel (eds.), Cambridge University Press, 1986.
PETRINI, O.; SIEBER, T.N.; TOTI, L.; VIRET, O. Ecology, metabolite production and substrate utilization in endophytic fungi. Natural Toxins, v.1, p.185-196, 1992.
PURI, S.C.; NAZIR, A. CHAWLA, R.; ARORA, R.; RIYAZ-ULHASAN, S.; AMNA, T.; AHMED, B.; VERMA, V.; SINGH, SHIKHA.; SAGAR, R.; SHARMA, A.; KUMAR, R.; SHARMA, R.K.; QAZI, G.N. The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans. Journal of Biotechnology, 2006. Em publicação. (disponível em http://www.sciencedirect.com/)
RODRIGUES, K.F.; PETRINI, O. Biodiversity of endophytic fungi in tropical regions. In: Diversity of tropical microfungi. Hyde, K. D. (ed.), University of Hong Kong press. p.57-69, 1997.
RODRIGUES, K.F.; HESSE, M.E WERNER, C. Antimicrobial activities of secondary metabolites produced by endophytic fungi from Spondias monbin. Journal of Basic Microbiology, v.40, p.261-267, 2000.
ROSA, L.H.; VAZ, A.B.M.; ALVES, T.M.A.; ROMANHA, A.J.; RABELLO, A.L.T.; ROSA, C.A.; ZANI, C. L. Atividade tripanosomicida de fungos endofíticos da planta Palicourea sp. Anais do XXIII Congresso Brasileiro de Microbiologia, Sociedade Brasileira de Microbiologia, 2005.
SAIKKONEN, K.; FAETH, S.H.; HELANDER, M.; SULLIVAN, T.J. Fungal endophytes: A continuum of interactions with host plants. Annual Review of Ecology and Systematics, v.29, p.319-345, 1998.
SELOSSE, M.-A.; BAUDOIN, E.; VANDENKOORNHUYSE, P. Symbiotic microorganisms, a key for ecological success and protection of plants. Comptes Rendus Biologies v.327, p.639-648, 2004.
SILVA, G.H.; TELES, H.L.; TREVISAN, H.C.; YOUNG, M.C.M; PFENNING,L.H.; EBERLIN, M.N.; HADDAD, R.; BOLZANI, V.S.; ARAÃšJO, A.R. Antifungal metabolites produced by the endophytic fungus Phomopsis cassia isolated from Cassia spectabilis. Journal of the Brazilian Chemical Society, v.16, n.6B, p.1463-1466, 2005
STROBEL, G.; HESS, W. M.; FORD, E.; SIDHU, R. S.; E YANG, X. Taxol from fungal endophytes and the issue of biodiversity. Journal of Industrial Microbiology and Biotechnology, v.17, n.5-6, p.417-424, 1996a.
STROBEL, G.; YANG, X. SEARS, J. KRAMER, R.; SIDHU, R. S. E HESS, W. M. Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana. Microbilogy, v.142, p.435-440, 1996b.
STROBEL, G.; LONG, D. M. Endophytic microbes embody pharmaceutical potencial. ASM News, v.64, n.5, p.263-268, 1998.
STROBEL, G.A; MILLER, R.V.; MARTINEZ-MILLER, C.; CONDRON, M.M.; TEPLOW, D.B.; HESS, W.M. Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Microbiology, v.145, p.1919-26, 1999.
STROBEL, G.A. Rainforest endophytes and bioactive products. Critical Reviews in Biotechnology, v.22, n.4, p.315-333, 2002.
STROBEL, G.; DAISY, B. Bioprospecting for microbial endophytes and their natural products. Microbiology and Molecular Biology Reviews, v.67, n.4, p.491-502, 2003
WAGENAAR, M.M; CORWIN, J.; STROBEL, G.; CLARDY. J. Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella. Journal of Natural Products v.63, n.12, p.1692-1695, 2000.
WEBER, D.; STERNER, O.; ANKE, T.; GORZALCZANCY, S.; MARTINO, V.; ACEVEDO, C. Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli. Journal of Antibiotics (Tokyo), v.57, n.9, p.559-563, 2004.

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M. A. Ferrara
Instituto de Tecnologia em Fármacos, Far-Manguinhos - Fundação Oswaldo Cruz Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 Rio de Janeiro, RJ, Brasil

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Endophytic Fungi. Potential for the Production of Bioactive Substances. Rev Fitos [Internet]. 2006 Jun. 1 [cited 2024 Nov. 22];2(01):73-9. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/43

This work is licensed under a Creative Commons Attribution 4.0 International License.

[1] ARAGÃO, T.V.G.; FREITAS, A.; FERRARA, M.A.; SIANI, A.C.; BEHRENS, M.D. Atividade antimicrobiana de metabólitos obtidos por fermentação de fungos endofíticos de Lippia sidoides e Phoradendron sp. Anais da III Bienal de Pesquisa da FIOCRUZ, Fundação Oswaldo Cruz. p.301, 2002a.

[2] ARAGÃO, T.V.G.; FREITAS, A.; FERRARA, M.A.; SIANI, A.C. Isolamento de microrganismos endofíticos de Lippia sidoides e avaliação da atividade antimicrobiana de metabólitos obtidos por fermentação. XVII Simpósio Brasileiro de Plantas Medicinais. Universidade de Mato Grosso, 2002b.

[3] ARAÚJO, W.L.; LIMA, A.O.S.; AZEVEDO, J.L.; MARCON, J.; SOBRAL, J.K.; LAÇAVA, P.T. Manual: Isolamento de microrganismos endofíticos. Departamento de Genética, Escola Superior de Agricultura Luiz de Queiroz - ESALQ/USP, Piracicaba, SP, 86 p., 2002.

[4] ARNOLD, A.E.; MAYNARD, Z.; GILBERT, G.S.; COLEY, P.D.; KURSAR, T.A. Are tropical fungal endophytes hyperdiverse? Ecology Letters v.3, n.4, p.267-274, 2000.

[5] BACON, C. W. Procedure for isolating endophytic from tall fescue and screening isolates for ergot alkaloids. Applied and Environmental Microbiology v.54, n.11, p.2615-2618, 1988.

[6] BILLS, G.; DOMBROWSKI, A.; PELAEZ, F.; POLISHOOK, J.; AN, Z. Recent and future discoveries of pharmacologically active metabolites from tropical fungi. In: WATLING, R.; FRANKLAND, J. C.; AINSWORTH, A. M.; ISSAC, S.; ROBINSON, C. H. (ed.) Tropical Mycology: Micromycetes, vol. 2 CABI Publishing, New York, p.165-194, 2002 apud Microbiology and Molecular Biology Reviews, v.67, n.4, p.491- 502, 2003.

[7] BULL, A. T.; GOODFELLOW, M.; SLATER, J.H. Biodiversity as a source in innovation in biotechnology. Annual Review of Microbiology, v.46, p.219-258, 1992.

[8] CARROL, G. Forest endophytic: Pattern and process. Canadian journal of Botanic. v.73, n.1, p.1316-1324, 1995.

[9] CARVALHO, C.M.; SALEM, J.I.; ASTOLFI FILHO, S. Bioativos com antagonismo para Mycobacterium tuberculosis em microrganismos endofíticos da Amazônia. Anais do XXIII Congresso Brasileiro de Microbiologia, Sociedade Brasileira de Microbiologia, 2005.

[10] CRAGG, G.M.; NEWMAN, D.J. Medicinals for the millennia: the historical record. Annuals of the New York Academy of Science, v.953, p.3-25, 2001.

[11] GUIMARÃES, A.C., SARKIS, M.I, AMARAL, A.C.F., SIANI A.C., KUSTER, R.M. Isolamento de fungos endofíticos das espécies vegetais da Amazônia Cladocolea micrantha e Anacardium occidenatale. IV Congresso Brasileiro de Micologia. Ouro Preto, MG, Livro de Resumos AGR 031, 2004.

[12] GUNATILAKA, A.A.L. Natural products from plant-associated microorganisms: Distribution, structural diversity, bioactivity, and implications of their occurrence. Journal of Natural Products, v.69, p.509-526, 2006.

[13] HAWKSWORTH, D.L. The fungal dimension of biodiversity: magnitude, significance, and conservation. Mycology Research v.95, p. 641-655, 1991.

[14] HUANG, Y.; WANG, J.; LI, G.; ZHENG, Z.; SU, W. Antitumor and antifungal activities in endophytic fungi isolated from pharmaceutical plants Taxus mairei, Cephalataxus fortunei and Torreya grandis. FEMS Immunoogy and Medical Microbioliology, v.31, n.2, p.163-7, 2001.

[15] KONGSAEREE, P.; PRABPAI, S.; SRIUBOLMAS, N.; VONGVEIN, C.; WIYAKRUTTA, S. Antimalarial dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of Crassocephalum crepidioides. Journal of Natural Products, v.66, p.709-711, 2003.

[16] LEE, J.; LOBKOVSKY, E.; PLIAM, N.B.; STROBEL, G.A.; CLARDY,J. Subglutinols A and B: immunosuppressive compounds from the endophytic fungus Fusarium subglutinans. Journal of Organic Chemistry, v.60, p.7076-7077, 1995.

[17] LI, J.Y.; STROBEL, G.; SIDHU, R.S.; HESS, W.M.; FORD, E.J. Endophytic taxol producing fungi from bald cypress, Taxodium distichum. Microbilogy, v.142, p.2223-2226, 1996.

[18] LI, J.Y.; SIDHU, R.S.; BOLLON, A. STROBEL, G. Stimulation of taxol production in liquid cultures of Pestalotiopsis microspora. Mycology Research, v.102, n.4, p.461-464, 1998.

[19] LIU, J.Y.; SONG, Y.C.; ZHANG, Z.; WANG, L.; GUO, Z.J.; ZOU, W.X.; TAN, R.X. Aspergillus fumigatus CY018, an endophytic fungus in Cynodon dactylon as a versatile producer of new and bioactive metabolites. Journal of Biotechnology, v.114, n.3, p.279-287, 2004.

[20] LU, H; ZOU, WX; MENG, J.C.; HU, J.; TAN, R.X. New antibiotic metabolites produced by Colletotrichum sp., an endophytic fungus in Artemisia annua. Plant Science, v.151, p.67-73, 2000

[21] MA, Y.M.; LI, Y.; LIU, J.Y.; SONG, Y.C.; TAN, R.X. Anti-Helicobacter pylori metabolites from Rhizoctonia sp. Cy064, an endophytic fungus in Cynodon dactylon. Fitoterapia, v.75, n.5, p.451-456, 2004.

[22] MARINHO, A.M.R.; RODRIGUES-FILHO, E.; MOITINHO, M.L.R.; SANTOS, L.S. Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach. Journal of the Brazilian Chemical Society, v.16, n.2, p.280-283, 2005.

[23] PEARCE, C. Biologically active fungal metabolites. Advances in Applied Microbiology, v.44, p.1-80, 1997.

[24] PEREIRA, N.O.; ROSA, L.H.; TEIXEIRA, L.C.R.S.; ALVES, T.M.A.; ZANI, C.L.; ROSA, C.A. Fungos endofíticos associados a planta Trixis vauthieri (Asteraceae) produtores de substâncias tripanosomicidas. Anais do XXIII Congresso Brasileiro de Microbiologia, Sociedade Brasileira de Microbiologia, 2005.

[25] PETRINI, O. Taxonomy of endophytic fungi of aerial plant tissues. In Microbiology of the Phyllosphere. Fokkema, N. J. & Van den Heuvel (eds.), Cambridge University Press, 1986.

[26] PETRINI, O.; SIEBER, T.N.; TOTI, L.; VIRET, O. Ecology, metabolite production and substrate utilization in endophytic fungi. Natural Toxins, v.1, p.185-196, 1992.

[27] PURI, S.C.; NAZIR, A. CHAWLA, R.; ARORA, R.; RIYAZ-ULHASAN, S.; AMNA, T.; AHMED, B.; VERMA, V.; SINGH, SHIKHA.; SAGAR, R.; SHARMA, A.; KUMAR, R.; SHARMA, R.K.; QAZI, G.N. The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans. Journal of Biotechnology, 2006. Em publicação. (disponível em http://www.sciencedirect.com/)

[28] RODRIGUES, K.F.; PETRINI, O. Biodiversity of endophytic fungi in tropical regions. In: Diversity of tropical microfungi. Hyde, K. D. (ed.), University of Hong Kong press. p.57-69, 1997.

[29] RODRIGUES, K.F.; HESSE, M.E WERNER, C. Antimicrobial activities of secondary metabolites produced by endophytic fungi from Spondias monbin. Journal of Basic Microbiology, v.40, p.261-267, 2000.

[30] ROSA, L.H.; VAZ, A.B.M.; ALVES, T.M.A.; ROMANHA, A.J.; RABELLO, A.L.T.; ROSA, C.A.; ZANI, C. L. Atividade tripanosomicida de fungos endofíticos da planta Palicourea sp. Anais do XXIII Congresso Brasileiro de Microbiologia, Sociedade Brasileira de Microbiologia, 2005.

[31] SAIKKONEN, K.; FAETH, S.H.; HELANDER, M.; SULLIVAN, T.J. Fungal endophytes: A continuum of interactions with host plants. Annual Review of Ecology and Systematics, v.29, p.319-345, 1998.

[32] SELOSSE, M.-A.; BAUDOIN, E.; VANDENKOORNHUYSE, P. Symbiotic microorganisms, a key for ecological success and protection of plants. Comptes Rendus Biologies v.327, p.639-648, 2004.

[33] SILVA, G.H.; TELES, H.L.; TREVISAN, H.C.; YOUNG, M.C.M; PFENNING,L.H.; EBERLIN, M.N.; HADDAD, R.; BOLZANI, V.S.; ARAÃšJO, A.R. Antifungal metabolites produced by the endophytic fungus Phomopsis cassia isolated from Cassia spectabilis. Journal of the Brazilian Chemical Society, v.16, n.6B, p.1463-1466, 2005

[34] STROBEL, G.; HESS, W. M.; FORD, E.; SIDHU, R. S.; E YANG, X. Taxol from fungal endophytes and the issue of biodiversity. Journal of Industrial Microbiology and Biotechnology, v.17, n.5-6, p.417-424, 1996a.

[35] STROBEL, G.; YANG, X. SEARS, J. KRAMER, R.; SIDHU, R. S. E HESS, W. M. Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana. Microbilogy, v.142, p.435-440, 1996b.

[36] STROBEL, G.; LONG, D. M. Endophytic microbes embody pharmaceutical potencial. ASM News, v.64, n.5, p.263-268, 1998.

[37] STROBEL, G.A; MILLER, R.V.; MARTINEZ-MILLER, C.; CONDRON, M.M.; TEPLOW, D.B.; HESS, W.M. Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Microbiology, v.145, p.1919-26, 1999.

[38] STROBEL, G.A. Rainforest endophytes and bioactive products. Critical Reviews in Biotechnology, v.22, n.4, p.315-333, 2002.

[39] STROBEL, G.; DAISY, B. Bioprospecting for microbial endophytes and their natural products. Microbiology and Molecular Biology Reviews, v.67, n.4, p.491-502, 2003

[40] WAGENAAR, M.M; CORWIN, J.; STROBEL, G.; CLARDY. J. Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella. Journal of Natural Products v.63, n.12, p.1692-1695, 2000.

[41] WEBER, D.; STERNER, O.; ANKE, T.; GORZALCZANCY, S.; MARTINO, V.; ACEVEDO, C. Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli. Journal of Antibiotics (Tokyo), v.57, n.9, p.559-563, 2004.