Production and evaluation of tablets containing high amount of Maytenus ilicifolia dried extract

Luiz Alberto Lira Soares
Magda Rhayanne Assunção Ferreira

    Luiz Alberto Lira Soares

    Federal University of Pernambuco-UFPE, Department of Pharmaceutical Sciences, Laboratory of Pharmacognosy. Rua Professor Artur de Sá, s / n, Cidade Universitária, CEP 50740-521, Recife-PE, Brazil.

    Graduated in Pharmacy from the Federal University of Pernambuco (1994), holds a master's degree (1997) and a PhD in Pharmaceutical Sciences from the Federal University of Rio Grande do Sul (2002). CAPES-DAAD fellow at the Department of Pharmaceutical Technology - Eberhard Karls Universität, Tübingen (2000-2001),. He acted as Adjunct Professor in the Department of Pharmacy at UFRN (JUL / 2002-DEC / 2008), deputy coordinator of PPGCF-UFRN (2005-2008) and deputy head of department (2008). Member of the Brazilian Pharmacopoeia Commission (2008-2013): Thematic Technical Committee on Medicinal Plants (since 2008), and Thematic Technical Committee on Markers and Herbal Patterns (2012-2013). Member of the Brazilian Society of Pharmacognosy (secretary: 2009-2011; and vice-president 2013-2015) and of the Brazilian Association of Pharmaceutical Sciences - ABCF (1st treasurer: 2012-2013; and, fiscal council 2013-2015). He is currently an Associate Professor in the Department of Pharmaceutical Sciences at UFPE (DEC / 2008) and deputy coordinator of the Postgraduate Program in Therapeutic Innovation PPGIT / CCB / UFPE (2013-2015). Scholarship holder PQ2 / CNPq (since 2009) and PDE CAPES / DAAD (Uni-Tübingen, 2015), has experience in the areas of Pharmaceutical Technology and Quality Control, with an emphasis on analytical and technological development of herbal medicines.

    Magda Rhayanne Assunção Ferreira

    Federal University of Pernambuco-UFPE, Department of Pharmaceutical Sciences, Laboratory of Pharmacognosy. Rua Professor Artur de Sá, s / n, Cidade Universitária, CEP 50740-521, Recife-PE, Brazil.

Keywords

Maytenus ilicifolia
Espinheira-santa
Dried extract
Tablets
Formulation
Phytopharmaceutical

Abstract

The aim of this work was the evaluation of influence from excipients on the properties of tablets containing high-dose of granules from spray-dried product of Maytenus ilicifolia leaves. Thus several excipients were studied such as filler/binder (microcrystalline cellulose; microcrystalline cellulose co-processed with α-lactose monohydrated; α-lactose monohydrated co-processed with polyvinylpyrrolidone and cross-linked polyvinylpyrrolidone; or, calcium phosphate); superdisintegrants (sodium starch glycolate, sodium cellulose glycolate or cross-linked polyvinylpyrrolidone); and, lubricants/glidants (colloidal silicon dioxide and magnesium stearate). The crushing strength and disintegration times of tablets were preliminarily evaluated, and the results showed that formulation containing microcrystalline cellulose and sodium cellulose glycolate produced tablets with appropriate crushing strength and disintegration time. The final tablets prepared by the selected excipients, showed crushing strength of 88.0 ± 5.2 N, absence of friability or weight variation, maximum disintegration time of 13.2 minutes and total dissolution at 25 minutes. The total tannin content evaluated by spectrophotometric assay, showed that the chemical constituents were stable during the technological transformations of the extractive solutions.

References

  1. Santos-Oliveira R, Coulaud-Cunha S, Colaço W. Revisão da Maytenus ilicifolia Mart. ex Reissek, Celastraceae. Contribuição ao estudo das propriedades farmacológicas. Braz J Pharmacogn. 2009; 19 (2b): 650-659. ISSN 1981-528X. [CrossRef].
  2. Calou IBF, Lima LAR, Ferreira JAN, Cerqueira GS. A atividade gastroprotetora da Maytenus ilicifolia e Maytenus aquifolium. Rev Saude Cienc. 2014; 3(2): 33-42. [Link].
  3. Leme TSV, Prando TBL, Gasparotto FM, Souza P, Crestani S, Souza LM et al. Role of prostaglandin/Camp pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae). J Ethnopharmacol. 2013; 150(1): 154-161. ISSN 0378-8741. [CrossRef] [PubMed].
  4. Veloso CC, Soares GL, Perez AC, Rodrigues VG, Silva FC. Pharmacological potential of Maytenus species and isolated constituents, especially tingenone, for treatment of painful inflammatory diseases. Braz J Pharmacogn. 2017; 27(4): 533-540. ISSN 0102-695X. ISSN 1981-528X. [CrossRef].
  5. Dutra RC, Campos MM, Santos ARS, Calixto JB. Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives. Pharmacol Res. 2016; 112: 4-29. ISSN 1043-6618. [CrossRef].
  6. Soares LAL, Ferreira MRA. Standardization and Quality Control of Herbal Medicines. In: De Freitas LAP; Teixeira CCC; Zamarioli CM (Org.). Recent Developments in Phytomedicine Technology. 1ª ed. New York: Nova Science Publishers; 2017, p. 243-278.
  7. Petrovick PR, Knorst MT. Characterization of a concentrated extract from Achyrocline satureioides as an intermediary product for the preparation of an ointment. Phytother Res. 1991; 5: 237-238. [CrossRef].
  8. De Souza KCB, Petrovick, PR, Bassani, VL, González Ortega G. The adjuvants aerosil 200 and gelita-sol-P influence on the technological characteristics of spray-dried powder from Passiflora edulis var. flavicarpa. Drug Dev Ind Pharm. 2000; 26(3): 331-336. [CrossRef].
  9. Bassani VL, Gonzáles OG, Petrovick PR. Desenvolvimento Tecnológico de Produtos Fitoterápicos. Rev Fitos. 2005; 1(1): 14-17. [Link].
  10. Baccarin T, Ferreira RA, Gazoni VF, Yunes RA, Malheiros A, Lucinda-Silva RM. Influence of Extraction Parameters on Hydroalcohol Extracts of the Stem Bark of Rapanea ferruginea Mez Using Myrsinoic Acid B as Marker. Tropical J Pharm Res. 2014; 13(7): 1113-1119. [CrossRef].
  11. De Souza TP, González Ortega G, Petrovick PR, Bassani VL. Avaliação da viabilidade de compressão direta de formulações contendo alto teor de produto seco nebulizado de Maytenus ilicifolia. Acta Farm Bonaer. 2000; 19(2): 91-98.
  12. Linden R, Gonzáles Ortega G, Petrovick PR, Bassani VL. Response surface analysis applied to the preparation of tablets containing a high concentration of vegetable spray-dried extract. Drug Dev Ind Pharm. 2000; 26(4): 441-446. [CrossRef].
  13. Soares LAL, Schmidt PC, González Ortega G, Petrovick PR. Efeito da força e da velocidade de compressão sobre as propriedades de comprimidos contendo alta concentração de extrato seco vegetal. Acta Farm Bonaer. 2003; 22(2): 147-154.
  14. Tank D, Karan K, Gajera BY, Dave RH. Investigate the effect of solvents on wet granulation of microcrystalline cellulose using hydroxypropyl methylcellulose as a binder and evaluation of rheological and thermal characteristics of granules. Saudi Pharm J. 2018; 26(4): 593-602. [CrossRef].
  15. Maltais M, Vargas R, DiPaolo T. Development of a new formulation for direct compression of a natural product. J Pharm Technol & Drug Res. 2015; 4(2): 1-6. ISSN 2050-120X. [CrossRef].
  16. Sarabandi K, Peighambardoust SH, Sadeghi Mahoonak AR, Samaei SP. Effect of different carriers on microstructure and physical characteristics of spray dried apple juice concentrate. J Food Sci Technol. 2018; 55(8): 3098-3109. [CrossRef].
  17. Soares LAL, González Ortega G, Petrovick PR, Schmidt PC. Dry granulation and compression of spray-dried plant extracts. AAPS PharmSciTech. 2005; 6(3): E359-E366. [CrossRef].
  18. Von Eggelkraut-Gottanka SG, Abu Abeb S, Müller W, Schmidt PC. Roller compaction and tabletting of St. John’s wort plant dry extract using gap width and force controlled roller compactor. I. Granulation and tabletting of eight different extract batches. Pharm Dev Technol. 2002a; 7(4): 433-445. [CrossRef].
  19. De Souza TP, Gómez-Amoza JL, Pacheco RM, Petrovick PR. Development of granules from Phyllanthus niruri spray-dried extract. Braz J Pharm Sci. 2009; 45(4): 669-675. [CrossRef].
  20. Von Eggelkraut-Gottanka SG, Abu Abeb S, Müller W, Schmidt PC. Roller compaction and tabletting of St. John’s wort plant dry extract using gap width and force controlled roller compactor. II. Study of roller compaction variables on granule and tablet properties by a 33 factorial design. Pharm Dev Technol. 2002b; 7(4): 447-455. [CrossRef].
  21. Thoorens G, Krier F, Leclercq B, Carlin B, Evrard B. Microcrystalline cellulose, a direct compression binder in a quality by design environment-A review. Int J Pharmac. 2014; 473(1-2): 64-72. ISSN 0378-5173. [CrossRef].
  22. Quodbach J, Kleinebudde P. A critical review on tablet disintegration. Pharm Develop Technol. 2016; 21(6): 763-774. [CrossRef].
  23. Carvalho ELS. Desenvolvimento de extrato seco nebulizado de Maytenus ilicifolia Martius ex. Reiss. (Espinheira-santa). 1998. Dissertação de Mestrado [Programa de Pós-graduação em Ciências Farmacêuticas]. Universidade Federal do Rio Grande do Sul. Porto Alegre. 1998.
  24. European Pharmacopeia (Ph. Eur.) 9th Edition. Council of Europe: Strasbourg, France, 2018.
  25. González Ortega G, Schmidt PC. Obtención de Comprimidos Conteniendo Extractos Atomizados de Flor de la Pasión (Passiflora incarnata L.). Acta Farm Bonaer. 1995; 14(3): 173-180.
  26. Gallo L, RamíreZ-Rigo MV, Piña J, Palma S, Allemandi D, Bucalá V. Valeriana officinalis Dry Plant Extract for Direct Compression: Preparation and Characterization. Sci Pharm. 2012; 80(4): 1013-1026. [CrossRef].
  27. Chaerunisa AY, Sriwidodo S, Abdassah M. Microcrystalline Cellulose as Pharmaceutical Excipient [Online First]. IntechOpen, [CrossRef]. Jul. 2019. Disponível em: [Link]. Acesso em: 30 out. 2019.
  28. Corá LA, Fonseca PR, Américo MF, Oliveira RB, Baffa O, Miranda JRA. Influence of compression forces on tablets disintegrationby AC Biosusceptometry. European J Pharm Biopharm. 2008; 69(1): 372–379. ISSN 0939-6411. [CrossRef].
  29. Pratik J, Rupesh T, Raosaheb S. A brief review on Kollidon. Journal of Drug Delivery & Therapeutics. 2019; 9(2): 493-500. [CrossRef].
  30. Desai PM, Liew CV, Heng PWS. Review of Disintegrants and the Disintegration Phenomena. J Pharm Sci. 2016; 105(9): 2545-2555. [CrossRef].
  31. Brasil. Agência Nacional de Vigilância Sanitária-ANVISA. Resolução RDC nº 26, de 13 de maio de 2014. Dispõe sobre o registro de medicamentos fitoterápicos e o registro e a notificação de produtos tradicionais fitoterápicos. Diário Oficial [da República Federativa do Brasil]. Brasília. [Link].
  32. Carvalho ACB, Ramalho LS, Marques RFO, Perfeito JPS. Regulation of herbal medicines in Brazil. J Ethnopharmacol. 2014; 158(3): 503-506. ISSN 2175-9790. [CrossRef].
  33. Martins AG. Influência de fatores tecnológicos na avaliação analítica e farmacológicos de extratos secos de Maytenus ilicifolia Martius ex. Reiss. 1998. 99 f. Dissertação de Mestrado [Programa de Pós-graduação em Ciências Farmacêuticas]. Universidade Federal do Rio Grande do Sul, UFRGS. Porto Alegre. 1998.
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Author(s)

  • Luiz Alberto Lira Soares
    Federal University of Pernambuco-UFPE, Department of Pharmaceutical Sciences, Laboratory of Pharmacognosy. Rua Professor Artur de Sá, s / n, Cidade Universitária, CEP 50740-521, Recife-PE, Brazil.
  • Magda Rhayanne Assunção Ferreira
    Federal University of Pernambuco-UFPE, Department of Pharmaceutical Sciences, Laboratory of Pharmacognosy. Rua Professor Artur de Sá, s / n, Cidade Universitária, CEP 50740-521, Recife-PE, Brazil.

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Production and evaluation of tablets containing high amount of Maytenus ilicifolia dried extract. Rev Fitos [Internet]. 2020 Aug. 20 [cited 2025 Jan. 29];14(2):191-206. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/881
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