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Biological Activity of Some Diterpenics Acids and its Semi-Synthetic Derivatives

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Abstract

This work presents bioassays complementary results obtained from some natural diterpenes as (-)-ozic acid (1a), (-)-abietic acid (2a), (±)- copalic acid (3a) and (+)-hardwickic acid (4a), and some of their semi-synthetic derivatives Compound 1a was isolated from the epicarp resin of Hymenaea sp. (collected in Campinas, SP); (-)-Abietic acid (2a) was obtained from commercial resin of Pinus elliottii, and copalic and hardwickic acids (3a and 4a) were isolated from commercial resin of Copaifera sp. In a first approach, brine shrimp (Artemia salina) mortality and bioautographic assays were carried out. The compounds, which presented the better results in these former tests, were submitted to assays for their inhibitory ability on carcinogenic cells and Mycobacterium tuberculosis bacillus growth.

References

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Author(s)

  • P. M. Imamura
    Instituto de Química, C. P. 6154 UNICAMP, 13084-971, Campinas, SP
  • R. M.; Ide
    Instituto de Química, C. P. 6154 UNICAMP, 13084-971, Campinas, SP
  • M. P. del C. Soriano
    Instituto de Química, C. P. 6154 UNICAMP, 13084-971, Campinas, SP
  • I. Lunardi
    Instituto de Química, C. P. 6154 UNICAMP, 13084-971, Campinas, SP
  • J. E. Carvalho
    Centro de Pesquisa CPQBA-UNICAMP
  • R. T. Nogueira
    Instituto de Química, USP, Ribeirão Preto, SP.
  • C. Santos
    UNIMAR, Universidade de Marília, Marília, SP
  • R. A. Giacomini
    Laboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense, Campos dos Goytacazes, RJ

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1.
Biological Activity of Some Diterpenics Acids and its Semi-Synthetic Derivatives. Rev Fitos [Internet]. 2005 Jun. 30 [cited 2025 Apr. 5];1(01):60-6. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/9
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