Potencial terapêutico da camomila (Matricaria chamomilla L., Asteraceae) no manejo da mucosite oral: : revisão integrativa

Emmanuelle de Siqueira Leal Capellini
OrcID

    Emmanuelle de Siqueira Leal Capellini

    Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos/Farmanguinhos. Rio de Janeiro, RJ, Brasil. CEP: 22775-903

    OrcID https://orcid.org/0000-0001-8922-4622

    061981314841

    Lattes: Não encontrado.

    Cirurgiã-dentista, servidora pública no Hospital REgional de Taguatinga, Preceptora do Programa de REsidencia em terapia intensiva da SES/FEPECS/DF, intensivista, paliativista, odontologia hospitalar e oncologia.

Palavras-chave

Matricaria chamomilla
Camomila
Estomatite
Mucosite oral
Quimioterapia
Radioterapia

Resumo

O câncer é a doença que mais cresce no mundo, e o seu tratamento é às custas de diversos efeitos colaterais, dentre eles a mucosite oral. A mucosite oral impacta na qualidade de vida, podendo levar a hospitalização. Dentre os tratamentos para a mucosite oral estão a indicação de fitoterápicos para uso tópico e redução da sintomatologia. A Matricaria chamomilla L. Asteraceae, é uma das plantas medicinais mais promissoras para o manejo da mucosite oral, com potencial terapêutico significativo no tratamento desta e de outras afecções orais. Este trabalho tem o objetivo de investigar o potencial terapêutico da camomila (Matricaria chamomilla L. Asteraceae) no manejo da mucosite oral a fim de contribuir para a inovação de uma formulação farmacêutica para aplicação clínica. Foram analisados 48 estudos numa revisão integrativa.  Dentre estes, 70,8% demonstraram que esta planta medicinal possui ação antiinflamatória e com significativa redução na intensidade, severidade e duração das lesões orais. No entanto, os estudos não comprovaram a eficácia na prevenção ou incidência da mucosite oral, e a limitação se dá pela falta de um protocolo embasada e numa formulação farmacêutica padronizada que seja eficaz também no surgimento desta manifestação como efeito colateral a terapia antineoplásica.

Referências

  1. Smith RA, Andrews KS, Brooks D, Fedewa SA, Manassaram‐Baptiste D, Saslow D et al. Cancer screening in the United States, 2019: a review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J Clin. 2019 May; 69(3): 184–210. [https://doi.org/10.3322/caac.21557] [https://pubmed.ncbi.nlm.nih.gov/30875085/].
  2. Soares RG. Treatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study. Lasers Med Sci. 2018 Nov; 33(8): 1813-1819. [https://doi.org/10.1007/s10103-018-2549-y]
  3. Valduga F, Oltramari E, Lemes LTO, Mattos CE, Stefenon L, Mozzini CB. Prevenção da Mucosite Oral em Pacientes submetidos à Quimioterapia. Rev Bras Cancerol. 2018; 64(2): 189-194. Disponível em: [https://doi.org/10.32635/2176-9745.RBC.2018v64n2.77].
  4. Almeida EM, Ferreira HJ, Alves DR, Silva WMB. Therapeutic potential of medicinal plants indicated by the Brazilian public health system in treating the collateral effects induced by chemotherapy, radiotherapy, and chemoradiotherapy: a systematic review. Complement Ther Med. 2020 Mar; 49: 102293. [https://doi.org/10.1016/j.ctim.2019.102293] [https://pubmed.ncbi.nlm.nih.gov/32147034/].
  5. Organization WH. WHO traditional medicine strategy: 2014-2023. Who.int. World Health Organization; 2014. Available from: [https://apps.who.int/iris/handle/10665/92455].
  6. Inca 2020. Estimativa-2020-Incidencia-de-cancer-no-brasil. Instituto nacional de câncer José Alencar Gomes da Silva. Disponível em: [https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2020-incidencia-de-cancer-no-brasil.pdf]. [acesso em: 16 jan. 2023].
  7. Beech N, Robinson S, Porceddu S, Batstone M. Dental management of patients irradiated for head and neck cancer. Australian Dental J. 2014 Mar; 59(1): 20-8. [https://doi.org/10.1111/adj.12134] [https://pubmed.ncbi.nlm.nih.gov/24495127/].
  8. Bezinelli LM, Eduardo FP, Lopes RMG, Biazevic MGH, Eduardo CP, Correa L et al. Cost-effectiveness of the introduction of specialized oral care with laser therapy in hematopoietic stem cell transplantation. Hematol Oncol. 2014; 32(1): 31–9. [https://doi.org/10.1002/hon.2050] [https://pubmed.ncbi.nlm.nih.gov/23625880/].
  9. Peterson DE, Boers-Doets CB, Bensadoun RJ, Herrstedt J. Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up. Annals Oncol. 2015 Sep 1; 26 (Suppl 5): 139–51. [https://doi.org/10.1093/annonc/mdv202] [https://pubmed.ncbi.nlm.nih.gov/26142468/].
  10. Braga FTMM, Santos ACF, Bueno PCP, Silveira RCCP, Santos CB, Bastos JK et al. Use of Chamomilla recutita in the prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized, controlled, phase II clinical trial. Cancer Nurs. 2015 Jul/ago 2; 38(4): 322–9. [https://doi.org/10.1097/NCC.0000000000000194].
  11. Yarom N, Hovan A, Bossi P, Ariyawardana A, Jensen SB, Gobbo M et al. Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and clinical practice guidelines — part 2: honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents. Support Care Cancer. 2020 May; 28(5): 2457–72. [https://doi.org/10.1007/s00520-019-05256-4] [https://pubmed.ncbi.nlm.nih.gov/32056010/].
  12. Bonomo P, Elad S, Kataoka T, Bosso P. The impact of the COVID-19 outbreaks on supportive care for oral mucositis: current concepts and practice. Support Care Cancer. 2021May; 29(5): 2255-2258. [https://doi.org/10.1007/s00520-020-05966-0] [https://pubmed.ncbi.nlm.nih.gov/33392774/].
  13. Paiva MDEB et al. Complicações orais decorrentes da terapia antineoplásica. Arq Odontol. 2010; 46(01): 48–55. ISSN 1516-0939. [http://revodonto.bvsalud.org/pdf/aodo/v46n1/a08v46n1.pdf].
  14. Schirmer EM, Ferrari A, Trindade LCT. Evolução da mucosite oral após intervenção nutricional em pacientes oncológicos no serviço de cuidados paliativos. Rev Dor São Paulo. 2012; 13(2): 141-6.[https://doi.org/10.1590/S1806-00132012000200009].
  15. Andishe Tadbir A, Pourshahidi S, Ebrahimi H, Hajipour Z, Memarzade MR, Shirazian S. The effect of Matricaria chamomilla (chamomile) extract in Orabase on minor aphthous stomatitis, a randomized clinical trial. J Herb Med. 2015 Jun 1; 5(2): 71-6. [https://doi.org/10.1016/j.hermed.2015.05.001].
  16. Pacífico DM et al. Prospecção científica e tecnológica de Matricaria recutita L. (Camomila). Rev GEINTEC–Aracaju/SE. 2018; 8(2): 4339–56. [https://repositorio.ufc.br/handle/riufc/36056].
  17. Batista ALA, Lins RDAU, Coelho RS, Barbosa DN, Belém NM, Celestino FJA. Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction. Complement Ther Clin Pract. 2014 Feb; 20:93–8. [https://doi.org/10.1016/j.ctcp.2013.08.002] [https://pubmed.ncbi.nlm.nih.gov/24439653/].
  18. Monteiro MHDA, Fraga SAPM. Fitoterapia na prática clínica odontológica: produtos de origem vegetal e fitoterápicos. Rev Fitos. Rio de Janeiro. 2021; 15(1): 58–77. [https://doi.org/10.32712/2446-4775.2021.1102].
  19. Ministério da Saúde Brasil. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Política nacional de práticas integrativas e complementares no SUS: atitude de ampliação de acesso. Diário da República, 2.a série – nº 102 (27-05-2015). 2015. 96 p. Available from: [http://bvsms.saude.gov.br/bvs/publicacoes/politica_nacional_praticas_integrativas_complementares_2ed.pdf].
  20. Resolução CFO-82, de 25 de setembro de 2008. Available from: [https://sistemas.cfo.org.br/visualizar/atos/RESOLU/SEC/2008/82].
  21. Porto PF, Bragança MLBM, Oliveira BR, Coelho CCNS, Serra HCOA, Muniz AKOA et al. The trends on plants in the prevention and treatment of the COVID-19. Rev Fitos. 2021 Mar 31; 15(1): 115–9. [https://doi.org/10.32712/2446-4775.2021.1026].
  22. Caires JS, Andrade TA, Amaral JB, Calasans MTA, Rocha MD S. A Utilização das terapias complementares nos cuidados paliativos: benefícios e finalidades. Cogitare Enferm. 2014; 19(3): 514–20. ISSN 1414-8536. [http://www.revenf.bvs.br/scielo.php?script=sci_arttext&pid=S1414-85362014000300012].
  23. Aleluia CM et al. Fitoterápicos na odontologia. Rev Odontol Univ Cid São Paulo. 2015; 27(2): 126–34. ISSN 1983-5183.
  24. Bohneberger G, Machado MA, Debiasi MM, Dirschnabel AJ, Ramos GO. Fitoterápicos na odontologia, quando podemos utilizá-los? Braz J Health Rev. 2019; 2(4): 3504–17. [https://doi.org/10.34119/bjhrv2n4-114].
  25. Santos ARFC, Cruz JHA, Guênes GMT, Filho AAO, Alves MASG. Matricaria chamomilla L.: propriedades farmacológicas. Arch Health Invest. 2019; 8(12): 846–52. [https://doi.org/10.21270/archi.v8i12.4654].
  26. Bôas GKV. Inovação em medicamentos da biodiversidade: uma adaptação necessária (ou útil) nas políticas públicas. 2013. 174 f. Tese de Doutorado [Programa de Pós-Graduação em Saúde Pública] - Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, 2013. [https://www.arca.fiocruz.br/handle/icict/13796].
  27. Brasil RF. Lei No 10.973, de 2 de dezembro de 2004. Diário Oficial [República Federativa do Brasil] [Internet]. 2004;17. Available from: [www.planalto.gov.br/ccivil_03/_Ato2004-2006/2004/Lei/L10.973.htm#art16].
  28. Brasil. Ministério da Saúde. Política e Programa nacional de Plantas Medicinais e Fitoterápicos. [Internet]. Available from: [http://editora.saude.gov.br].
  29. Silva KO, Coutinho KF, Messias GC, Santos GS, Souza ÉP. Conduta de pacientes oncológicos com mucosites orais quanto ao tratamento farmacológico e não farmacológico. Rev Ciênc Méd Biol. 2016 Dec 15; 15(3): 375-381. [https://doi.org/10.9771/cmbio.v15i3.17354].
  30. el Mobadder M, Farhat F, el Mobadder W, Nammour S. Photobiomodulation therapy in the treatment of oral mucositis, dysgeusia and oral dryness as side-effects of head and neck radiotherapy in a cancer patient: a case report. Dent J (Basel). 2018 Dec 1; 6(4): 64. [https://doi.org/10.3390/dj6040064] [https://pubmed.ncbi.nlm.nih.gov/30423851/].
  31. Ardakani MT, Ghassemi S, Mehdizadeh M, Mojab F, Salamzadeh J, Ghassemi S et al. Evaluating the effect of Matricaria recutita and Mentha piperita herbal mouthwash on management of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized, double blind, placebo controlled clinical trial. Complement Ther Med. 2016 Dec 1; 29: 29–34. [https://doi.org/10.1016/j.ctim.2016.08.001].
  32. Souza BCDE. Bochecho de camomila (Chamomilla recutita) como auxiliar no tratamento da mucosite oral. Braz J Surgery Clinic Res - BJSCR. 2019; 29(1): 68–74. [https://www.mastereditora.com.br/periodico/20191208_114225.pdf].
  33. Zadik Y, Arany PR, Fregnani ER, Bossi P, Antunes HS, Bensadoun RJ et al. Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 2019 Oct 1; 27(10): 3969–83. [https://doi.org/10.1007/s00520-019-04890-2].
  34. Watters AL, Epstein JB, Agulnik M. Oral complications of targeted cancer therapies: a narrative literature review. Oral Oncol. 2011; 47: 441–8. [https://doi.org/10.1016/j.oraloncology.2011.03.028].
  35. WHO handbook for reporting results of cancer treatment. Vol. 48. WHO; 1979.
  36. Magnani C, Mastroianni C, Giannarelli D, Stefanelli MC, di Cienzo V, Valerioti T et al. Oral hygiene care in patients with advanced disease: an essential measure to improve oral cavity conditions and symptom management. American J Hospice Palliat Med. 2019 Sep 1; 36(9): 815–9. [https://doi.org/10.1177/1049909119829411].
  37. Hong CHL, Gueiros LA, Fulton JS, Cheng KKF, Kandwal A, Galiti D et al. Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 2019 Oct 1; 27(10): 3949–67. [https://doi.org/10.1007/s00520-019-04848-4].
  38. Jones JA et al. MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer. Support Care Cancer. 2022. [https://doi.org/10.1007/s00520-022-07211-2].
  39. Charalambous A, Lambrinou E, Katodritis N, Vomvas D, Raftopoulos V, Georgiou M et al. The effectiveness of thyme honey for the management of treatment-induced xerostomia in head and neck cancer patients: A feasibility randomized control trial. Europ J Oncol Nursing. 2017 Apr 1; 27: 1–8. [https://doi.org/10.1016/j.ejon.2017.01.001].
  40. Giafferis RBL et al. Estratégias terapêuticas disponíveis para xerostomia e hipossalivação em pacientes irradiados de cabeça e pescoço: manual para profissionais da saúde. Rev UNINGÁ, Maringá. 2017; 54(1): 45–58. [https://doi.org/10.46311/2318-0579.54.eUJ6].
  41. Gomes VTS, Gomes RNS, Gomes MS, Joaquim WM, Lago EC, Nicolau RA. Effects of Matricaria Recutita L. in the Treatment of Oral Mucositis. he Scient World J. 2018; 2018: 1–8. [https://doi.org/10.1155/2018/4392184].
  42. Elad S, Cheng KKF, Lalla R v, Yarom N, Hong C, Logan RM et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2020 Oct 1; 126(19): 4423–31. [https://doi.org/10.1002/cncr.33100].
  43. Lopes LD, Rodrigues AB, Brasil DRM, Moreira MMC, Amaral JG, Oliveira PP. Prevenção e tratamento da mucosite em ambulatório de oncologia: uma construção coletiva. Texto Contexto Enferm. 2016; 25(1): e2060014. [https://doi.org/10.1590/0104-070720160002060014].
  44. Jales SMCP. Avaliação da efetividade de um protocolo de cuidados odontológicos no alívio da dor, sintomas bucais, melhora da qualidade de vida em pacientes com câncer de cabeça e pescoço em cuidados paliativos: ensaio clínico não controlado. São Paulo. 2011. Tese de Doutorado [em Neurologia] - Faculdade de Medicina, Universidade de São Paulo, São Paulo. 2011. [https://doi.org/10.11606/T.5.2011.tde-08122011-161547].
  45. Reis PED, Ciol MA, Melo NS, Figueiredo PTS, Leite AF, Manzi NM. Chamomile infusion cryotherapy to prevent oral mucositis induced by chemotherapy: a pilot study. Support Care Cancer. 2016 Oct 1; 24(10): 4393–8. [https://doi.org/10.1007/s00520-016-3279-y]
  46. Riley P, Glenny AM, Worthington H v, Littlewood A, Clarkson JE, Mccabe MG. Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy. Cochr Database System Rev. 2015; 2015(2): 1465-1858. [https://doi.org/10.1002/14651858.CD011552].
  47. Eduardo FP, Bezinelli LM, Lopes RMG, Sobrinho JJN, Hamerschlak N, Correa L. Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan-induced oral mucositis during hematological stem-cell transplantation: a prospective clinical study. Hematol Oncol. 2015 Sep; 33(3): 152-8. [https://doi.org/10.1002/hon.2133] [https://pubmed.ncbi.nlm.nih.gov/24519448/].
  48. Soileau K, Elster N. The hospice patient’s right to oral care: making time for the mouth. J Palliat Care. 2018; 3(2): 65-69. [https://doi.org/10.1177/0825859718763283].
  49. Brito CA, Araujo DS, Granja JG, Souza SM, Lima MAG, Oliveira MC. Efeito da clorexidina e do laser de baixa potência na prevenção e no tratamento da mucosite oral. Rev Odontol UNESP. 2012 July-Aug; 41(4): 236. ISSN 1807-2577.
  50. Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014; 120: 1453–61. [https://doi.org/10.1002/cncr.28592].
  51. Riley P, Glenny AM, Worthington HV, Littlewood A, Fernandez Mauleffinch LM, Clarkson JE et al. Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors. 2017; 2017(11): 1465-1858. Cochr Database System Rev. [https://doi.org/10.1002/14651858.CD011990.pub2].
  52. Neto APA et al. Fitoterapia como opção de tratamento para a mucosite oral: uma revisão da literatura. Anais III CIOPB - III Congresso Interdisciplinar de Odontologia da Paraíba / Arch Health Invest. 2018; (7):. [https://www.archhealthinvestigation.com.br/ArcHI/article/view/3972].
  53. Neves L de J, Boldrini É, Tanimoto HM, Trevisani DM, Lopes LF, Macari KSM. Avaliação do efeito do laser preventivo na mucosite oral quimioinduzida em pacientes submetidos a altas doses de Metotrexato. Rev Bras Cancerol. 2020 Dec 28; 67(1). [https://doi.org/10.32635/2176-9745.RBC.2021v67n1.1128].
  54. Lin YS, Lin LC, Lin SW, Chang CP. Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study. Nutr Cancer. 2010; 62(5): 682–91. [https://doi.org/10.1080/01635581003605532].
  55. Machado A, Freitas A, Sales-Peres SH. Atividade anti-inflamatória de produtos naturais em odontologia: uma revisão sistemática. Rev Fitos. Rio de Janeiro. 2016; 10(1): 1–93. [https://doi.org/10.5935/2446-4775.20160005].
  56. Yang C, Gong G, Jin E, Han X, Zhuo Y, Yang S et al. Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: a systematic review and network meta-analysis. Int J Nurs Stud. 2019 Jan; 89: 80-87. [https://doi.org/10.1016/j.ijnurstu.2018.08.007].
  57. Pequeno MA et al. Matricaria Recutita Extract (Chamomile) to reduce Candida albicans and entrobacter cloacae biofilms: in vitro study. RGO - Rev Gaúch Odontol. Porto Alegre. 2018; 66(2): 122–8. [https://doi.org/10.1590/1981-863720180002000033328].
  58. Braga AS, Simas LLM, Pires JG, Souza BM, Melo FPSR, Saldanha LL et al. Antibiofilm and anti-caries effects of an experimental mouth rinse containing Matricaria chamomilla L. extract under microcosm biofilm on enamel. J Dent. 2020 Aug 1; 99. [https://doi.org/10.1016/j.jdent.2020.103415].
  59. Schmidt TR, Curra M, Wagner VP, Martins MAT, de Oliveira AC, Batista AC et al. Mucoadhesive formulation containing Curcuma longa L. reduces oral mucositis induced by 5-fluorouracil in hamsters. Phytother Res. 2019 Apr 1; 33(4): 881–90. [https://doi.org/10.1002/ptr.6279].
  60. Brasil. Ministério da Saúde. Agência Nacional de Vigilância Sanitária-Anvisa. Farmacopeia Brasileira. Memento Fitoterápico da Farmacopeia Brasileira. 1ª Ed. Brasília. 2016. [https://www.gov.br/saude/pt-br/composicao/sectics/daf/pnpmf/publicacoes/memento-fitoterapico-da-farmacopeia-brasileira/view].
  61. Monteiro MHDA. Fitoterapia na odontologia: levantamento dos principais produtos de origem vegetal para saúde bucal. 2014. 218 f. Trabalho de Conclusão de Curso (Especialização) [Programa Pós-Graduação em Gestão da Inovação em Fitomedicamentos] - Instituto de Tecnologia em Fármacos/Farmanguinhos, Fundação Oswaldo Cruz, Rio de Janeiro, 2014. [https://doi.org/10.5935/2446-4775.20150021].
  62. Dantas IC de M, Lucena EES, Lima ÁMP. Avaliação do conhecimento e uso de plantas medicinais e fitoterápicos por dentistas do Seridó Potiguar/RN. Rev Fitos. 2020; 14(3): 372–81. [https://doi.org/10.32712/2446-4775.2019.1097].
  63. Brasil. Ministério da Saúde. Agência Nacional de Vigilância Sanitária-Anvisa. Brasileira F. Formulário de Fitoterápicos. 2a Ed. 2021. Disponível em: [https://www.gov.br/anvisa/pt-br].
  64. Shetty SB, Mahin-Syed-Ismail P, Varghese S, Thomas-George B, Kandathil-Thajuraj P, Baby D et al. Antimicrobial effects of Citrus sinensis peel extracts against dental caries bacteria: an in vitro study. J Clin Exp Dent. 2016; 8(1): e71–7. [https://doi.org/10.4317/jced.52493].
  65. Domingues SA, Paiva LF. Atividade antifúngica de Cymbopogon citratus (DC) Stapf frente à leveduras do gênero Candida sp. Rev Fitos. Rio de Janeiro. 2021; 15(1): 22–31. [https://doi.org/10.32712/2446-4775.2021.958].
  66. Marmitt DJ, Rempel C, Goettert MI, Silva AC. Plantas Medicinais da RENISUS Com potencial anti-inflamatório: revisão sistemática em três bases de dados científicas. Rev Fitos, Rio de Janeiro. 2015; 9(2): 73–159. [https://doi.org/10.5935/2446-4775.20150011].
  67. Brasil. Ministério da Saúde. B. Monografia da Espécie Matricaria chamomilla L. (= Chamomilla recutita (L.) Rauschert, CAMOMILA). Brasília. 2015. [https://www.gov.br/saude/pt-br/acesso-a-informacao/participacao-social/consultas-publicas/2017/arquivos/MonografiaCamomila.pdf].
  68. Organization WH, Plants WHOC on SM, WHO Consultation on Selected Medicinal Plants (2nd 1999: Ravello-Salerno I), WHO Consultation on Selected Medicinal Plants (3rd: 2001: Ottawa Ont), WHO Consultation on Selected Medicinal Plants (4th: 2005: Salerno-Paestum I). WHO monographs on selected medicinal plants [Internet]. Geneva PP - Geneva: World Health Organization; Available from: [https://apps.who.int/iris/handle/10665/42052].
  69. Pereira SV et al. Dynamic maceration of Matricaria chamomilla inflorescences: optimal conditions for flavonoids and antioxidant activity. Rev Bras Farmacog. 2018; 28: 111–7. [https://doi.org/10.1016/j.bjp.2017.11.006].
  70. Al-Dabbagh B, Elhaty IA, Elhaw M, Murali C, al Mansoori A, Awad B et al. Antioxidant and anticancer activities of chamomile (Matricaria recutita L.). BMC Res Notes. 2019 Jan 3; 12(1). [https://doi.org/10.1186/s13104-018-3960-y].
  71. Balbinot S, Velasquez PG, Düsman E. Reconhecimento e uso de plantas medicinais pelos idosos do Município de Marmeleiro – Paraná. Rev Bras Pl Med. Campinas. 2013; 15(4 supl. I): 632–8. [https://doi.org/10.1590/S1516-05722013000500002].
  72. Lins R, Vasconcelos, Leite, Coelho-Soares, Barbosa. Avaliação clínica de bochechos com extratos de aroeira (Schinus terebinthifolius) e Camomila (Matricaria recutita L.) sobre a placa bacteriana e a gengivite. Rev Bras Pl Med. 2013. [https://doi.org/10.1590/S1516-05722013000100016].
  73. Amaral W, Deschamps C, Machado MP, Côcco LC, Koeler HS, Scheer AP. Desenvolvimento da camomila, rendimento e qualidade do óleo essencial em diferentes idades de colheita. Rev Bras Pl Med. Campinas. 2014; 16(2): 237–42. [https://doi.org/10.1590/S1516-05722014000200011].
  74. Avonto C, Rua D, Lasonkar PB, Chittiboyina AG, Khan IA. Identification of a compound isolated from German chamomile (Matricaria chamomilla) with dermal sensitization potential. Toxicol Appl Pharmacol. 2017; 318: 16–22. [https://doi.org/10.3390/biom9030106].
  75. Salehi B et al. Plant-Derived bioactives in oral mucosal lesions: a key emphasis to Curcumin, Lycopene, Chamomile, Aloe vera, Green Tea and Coffee Properties. Biomolecules. 2019; 9(106): 2-23. [https://doi.org/10.3390/biom9030106].
  76. Flemming M, Kraus B, Rascle A, Jürgenliemk G, Fuchs S, Fürst R et al. Revisited anti-inflammatory activity of matricine in vitro: comparison with chamazulene. Fitoterapia. 2015; 106: 122–8. Available from: [https://doi.org/10.1016/j.fitote.2015.08.010].
  77. Monteiro MHDA, Fraga SAPM. Fitoterapia na odontologia: levantamento dos principais produtos de origem vegetal para saúde bucal. Rev Fitos. Rio de Janeiro. 2015; 9(4): 253–303. [https://doi.org/10.5935/2446-4775.20150021].
  78. Morales-Bozo I, Ortega-Pinto A, Rojas Alcayaga G, Aitken Saavedra JP, Salinas Flores O, Lefimil Puente C et al. Evaluation of the effectiveness of a chamomile (Matricaria chamomilla) and linseed (Linum usitatissimum) saliva substitute in the relief of xerostomia in elders. Gerodontology. 2017 Mar 1; 34(1): 42–8. [https://doi.org/10.1111/ger.12220].
  79. Goes P, Dutra CS, Lisboa MRP, Gondim D V, Leitão R, Brito GAC et al. Clinical efficacy of a 1% Matricaria chamomile L. Mouthwash and 0.12% chlorhexidine for gingivitis control in patients undergoing orthodontic treatment with fixed appliances. J Oral Sci. 2016 Dec 1; 58(4): 569–74. [https://doi.org/10.2334/josnusd.16-0280].
  80. Whittemore R, Knafl K. Methodological issues in nursing research. The integrative review: updated methodology. J Adv Nurs. 52(5): 546– 553. [https://doi.org/10.1111/j.1365-2648.2005.03621.x].
  81. Galvão CM. Níveis de evidência. ACTA Paulista Enferm. 2006; 19(2): 2006. [https://doi.org/10.1590/S0103-21002006000200001].
  82. Howick J, Chalmers I, Lind J, Glasziou P, Greenhalgh T, Heneghan C et al. Oxford Centre for Evidence-Based Medicine 2011. Levels Evid. Available from: http://www.cebm.net/index.aspx?o=5653
  83. Zhang X, Sun D, Qin N, Liu M, Zhang J, Li X. Comparative prevention potential of 10 mouthwashes on intolerable oral mucositis in cancer patients: A Bayesian network analysis. Oral Oncol. 2020; 107:104751. [https://doi.org/10.1016/j.oraloncology.2020.104751].
  84. Marucci L, Farneti A, di Ridolfi P, Pinnaro P, Pellini R, Giannarelli D et al. Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer. Head Neck. 2017 Sep 1; 39(9): 1761-9. [https://doi.org/10.1002/hed.24832].
  85. Eubank PLC, Abreu LG, Violante IP, Volpato LER. Medicinal plants used for the treatment of mucositis induced by oncotherapy: a systematic review. Support Care Cancer. 2021; 29: 6981-6993. [https://doi.org/10.1007/s00520-021-06247-0].
  86. Oliveira BV, de Barros Silva PG, Nojosa JDS, Brizeno LAC, Ferreira JM, Sousa FB et al. Tnf-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats. J Applied Oral Sci. 2016 May 1; 24(3): 278–90. [https://doi.org/10.1590/1678-775720150481].
  87. Elhadad MA, El-Negoumy E, Taalab MR, Ibrahim RS, Elsaka RO. The effect of topical Chamomile in the prevention of chemotherapy induced oral mucositis: a randomized clinical t. Oral Dis. 2022; 28: 164-72. Available from: [https://doi.org/10.1016/j.oooo.2013.12.338].
  88. Sampaio TPD. Matricaria recutita Linn. In the prevention and control of radio-induced oral mucositis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014; 117(2): E215. [https://doi.org/10.1016/j.oooo.2013.12.338].
  89. Tadbir AA et al. The effect of Matricaria chamomilla (chamomile) extract in Orabase on minor aphthous stomatitis, a randomized clinical trial. HERMED/ J Herb Med. June 2015; 5(2): 71-76. [https://doi.org/10.1016/j.hermed.2015.05.001].
  90. Valenzuela S, Pons-Fuster A, López-Jornet P. Effect of a 2% topical Chamomile application for treating burning mouth syndrome: a controlled clinical trial. J Oral Pathol Med. 2016; 45(7): 528–33. [https://doi.org/10.1111/jop.12412].
  91. Holmes TSV, Pereira JV, Gomes DQC, Pereira MSV, Nóbrega DRM, Santos MGC. Evaluation of the effectiveness of Matricaria recutita Linn. in the prevention and control of radiation-induced oral mucositis. Rev Odonto Cienc. 2013; 28(4): 89–93. Available from: [https://revistaseletronicas.pucrs.br/index.php/fo/article/view/12488].
  92. Biolab Sanus Farmacêutica Ltda. AD-MUC: Bula original, obtida diretamente da ANVISA. Disponível em: [https://buladeremedio.net/biolab_sanus_farmaceutica_ltda/1/ad_muc/profissional].
  93. Ltda HDBB. Traumeel S | Bulas Med. Disponível em: [https://www.bulas.med.br/p/bulas-de-medicamentos/bula/1365168/traumeel+s.htm]. [acesso em: 16 jan. 2023].
  94. Sencer SF, Zhou T, Freedman LS, Ives JA, Chen Z, Wall D et al. Traumeel S.® in preventing and treating mucositis in young patients undergoing SCT: a report of the Children’s Oncology Group. Bone Marrow Transplant. 2012 Nov; 47(11): 1409–14. [https://doi.org/10.1038/bmt.2012.30].
  95. Kato S, Saito A, Matsuda N, Suzuki H, Ujiie M, Sato S et al. Management of afatinib-induced stomatitis. Mol Clin Oncol. 2017 Apr; 6(4): 603–5. [https://doi.org/10.3892/mco.2017.1184].
  96. Ministério da Saúde. Agência Nacional de Vigilância Sanitária, ANVISA. Resolução da Diretoria Colegiada-RDC N° 26, de 13 de maio de 2014. [https://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2014/rdc0026_13_05_2014.pdf].
  97. Silva ACA et al. Effect of Chamomilla Recutita in the oncology patient with oral mucositis: a systematic review. Enferm Global. 2021; 20(2): 614-652. [https://doi.org/10.6018/eglobal.426451].
  98. Brasil. Ministério da Saúde. ANVISA. Farmacopeia Brasileira. 6ª ed. Vol. 1. Anvisa. 2019; 1: 874. [https://fitoterapiabrasil.com.br/biblioteca-virtual/farmacopeia-brasileira-6a-edicao2019-volume-i].
  99. Bigagli E, Cinci L, D’Ambrosio M, Luceri C. Pharmacological activities of an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts in UVB-induced oxidative stress and inflammation of human corneal cells. J Photochem Photobiol B. 2017 Aug 1; 173: 618–25. [https://doi.org/10.1016/j.jphotobiol.2017.06.031].
  100. Aghamohammadi A, Hosseinimehr SJ. Natural products for management of oral mucositis induced by radiotherapy and chemotherapy. Integr Cancer Ther. 2016; 15(1): 60–8. [https://doi.org/10.1177/1534735415596570].
  101. Curra M, Junior LAVS, Martins MD, Santos PSS. Protocolos quimioterápicos e incidência de mucosite bucal. Revisão integr. einstein (São Paulo). 2018; 16(1): 1–9. [https://doi.org/10.1590/s1679-45082018rw4007].
  102. Sharifi-Rad M et al. Matricaria genus as a source of antimicrobial agents: from farm to pharmacy and food applications. Microbiol Res. 2018; 215: 76–88. [https://doi.org/10.1016/j.micres.2018.06.010].
  103. Khayyal MT, Kreuter MH, Kemmler M, Altmann P, Abdel-Naby DH, El-Ghazaly MA. Effect of a chamomila extract in protecting against radiation-induced intestinal mucositis. Phytother Res. 2019 Mar 1; 33(3): 728–36. [https://doi.org/10.1002/ptr.6263].
  104. Singh O, Khanam Z, Misra N, Srivastava M. Chamomile (Matricaria chamomilla L.): An overview. Pharmacogn Rev. 2011; 5(9). [https://doi.org/10.4103/0973-7847.79103].
  105. Worthington H v., Clarkson JE, Bryan G, Furness S, Glenny AM, Littlewood A et al. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochr Database System Rev. 2011 Apr 13; 2021(3): [https://doi.org/10.1002/14651858.CD000978.pub5].
  106. Schönknecht K, Surdacka A, Rudenko L. Effectiveness of composed herbal extract in the treatment of gingivitis and oral and pharyngeal mucosa – review of studies. Wiad Lek Wiadomości Lekarskie. 2021; 74(7): 1737–49. [https://doi.org/10.36740/WLek202107131].
  107. Steinmann D, Babadağ Savaş B, Felber S, Joy S, Mertens I, Cramer H et al. Nursing procedures for the prevention and treatment of mucositis induced by cancer therapies: clinical practice guideline based on an interdisciplinary consensus process and a systematic literature search. Integr Cancer Ther. 2021; 20: [https://doi.org/10.1177/1534735420940412].
  108. López-González Á, García-Quintanilla M, Guerrero-Agenjo CM, Tendero JL, Guisado-Requena IM, Rabanales-Sotos J. Eficacy of cryotherapy in the prevention of oral mucosistis in adult patients with chemotherapy. Int J Environ Res Public Health. 2021; 18(3): 1–15. [https://doi.org/10.3390/ijerph18030994].
  109. Barreto RAB, Dantas JBL, Lima JB, Martins GB, Sanches ACB, Carrera M et al. Evaluation of the impact of oral hygiene and chamomila tea in the development of oral mucositis: pilot study. Rev Bras Cancerol7. 2020; 66(1): e-10777. [https://doi.org/10.32635/2176-9745.RBC.2020v66n1.777].
  110. Seyyedi SA, Sanatkhani M, Pakfetrat A, Olyaee P. The therapeutic effects of chamomilla tincture mouthwash on oral aphthae: a randomized clinical trial. J Clin Exp Dent. 2014; 6(5): e535–8. [https://doi.org/10.4317/jced.51472].
  111. Morais EF, Severo MLB, Martins HDD, Martins MAT, Martins MD, Freitas RA et al. Effectiveness of phytotherapeutics in the prevention and treatment of 5-fluorouracil-induced oral mucositis in animal models: a systematic review. Arch Oral Biol. 2021; 123:104998. [https://doi.org/10.1016/j.archoralbio.2020.104998].
  112. Dantas JBL, Freire TFC, Sanches ACB, Julião ELD, Medrado ARAP, Martins GB. Action of Matricaria recutita (chamomile) in the management of radiochemotherapy oral mucositis: a systematic review. Phytother Res. 2022; 36(3): 1115–25. [https://doi.org/10.1002/ptr.7378].
PDF
HTML
Salvar em favoritos

Autor(es)

  • Emmanuelle de Siqueira Leal Capellini
    Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos/Farmanguinhos. Rio de Janeiro, RJ, Brasil. CEP: 22775-903
    https://orcid.org/0000-0001-8922-4622

Categorias

Métricas

  • Artigo visto 118 vez(es)

Como Citar

1.
Potencial terapêutico da camomila (Matricaria chamomilla L., Asteraceae) no manejo da mucosite oral: : revisão integrativa. Rev Fitos [Internet]. 7º de março de 2024 [citado 7º de outubro de 2024];18(Suppl. 3):e1622. Disponível em: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1622
Crossref
Scopus
Google Scholar
Europe PMC
Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

Copyright (c) 2024 Revista Fitos

Informe um erro