Aspectos sobre Produtos Naturais na Descoberta de Novos Agentes Antitumorais e Antimutagênicos

M. A. M. Maciel
F. E. S. Gomes
A. C. Pinto
I. M. S. Cólus
N. S. S. Magalhães
N. F. Grynberg
A. Echevarria

Palavras-chave

Plantas Medicinais
Produtos Naturais
Atividade Antitumoral
Atividade Antimutagênica

Resumo

O presente estudo traz um breve histórico sobre produtos naturais anticarcinogênicos, bem como aspectos relevantes de pesquisas quimiofarmacológicas onde agentes anticancerígenos são o alvo principal de investigações. Neste contexto, mostra uma abordagem geral sobre quimioterapia e mutagenicidade. Focaliza ainda, aspectos químicos e propriedades anticâncer e antimutagênica de uma das mais importantes plantas medicinais brasileiras da atualidade: Croton cajucara Benth, uma euforbiácea, muito utilizada na medicina popular da região Amazônica, de onde se isola a promissora substância trans-desidrocrotonina, cujo uso vem sendo difundido por todo o país, e que poderia representar uma substância a ser mais bem explorada como agente anticâncer. Sua incorporação em sistemas de liberação controlada também é abordada.

 

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Autor(es)

  • M. A. M. Maciel
    Departamento de Química, Universidade Federal do Rio Grande do Norte, Campus Universitário, 59078-970 Natal, RN, Brasil
  • F. E. S. Gomes
    Departamento de Química, Universidade Federal do Rio Grande do Norte, Campus Universitário, 59078-970 Natal, RN, Brasil
  • A. C. Pinto
    Instituto de Química, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Cidade Universitária, 21945- 970 Rio de Janeiro, RJ, Brasil
  • I. M. S. Cólus
    Departamento de Biologia Geral, Centro de Ciências Biológicas, Universidade Estadual de Londrina, 86051-970 Londrina, PR, Brasil
  • N. S. S. Magalhães
    Departamento de Bioquímica, Laboratório de Imunopatologia Keizo-Asami (LIKA), Universidade Federal de Pernambuco, Cidade Universitária, 50670-901 Recife, PE, Brasil
  • N. F. Grynberg
    Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, 23851-970 Seropédica, RJ, Brasil
  • A. Echevarria
    Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, 23851-970 Seropédica, RJ, Brasil

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1.
Aspectos sobre Produtos Naturais na Descoberta de Novos Agentes Antitumorais e Antimutagênicos. Rev Fitos [Internet]. 1º de março de 2007 [citado 22º de novembro de 2024];3(01):38-59. Disponível em: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/66
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