O uso de plantas medicinais e fitoterápicos durante a gravidez: uma revisão integrativa

Luciana Bortoli Sartori; Chana de Medeiros da Silva

doi:10.32712/2446-4775.2023.1467

The use of medicinal plants and phytotherapics during pregnancy: an integrative review

Vol. 17 No. 3 (2023)
425-444
05/06/2022
30/09/2023
https://doi.org/10.32712/2446-4775.2023.1467

Luciana Bortoli Sartori
Chana de Medeiros da Silva

Keywords

Medicinal plants

Phytotherapy

Pregnancy

Abstract

It is known that the use of products based on natural resources are harmless and its use does not require a follow-up to a qualified healthcare professional, but this thought must be demystify, regardless the geographical, socioeconomics, ethnic and cultural variables that are likely to distinguish them, pregnant women make use of medicinal plants or phytotherapics. This article aims to carry out a literature integrative review of brazilian scientific publications about the use of medicinal plants as well as phytotherapics during pregnancy. A research was made to find out publications in the last 20 years, on databases as PubMed, SciELO, Science Direct and Virtual Health Library with the descriptors in English “medicinal plants AND pregnancy” and “phytotherapy AND pregnancy” and their correspondents in Portuguese “plantas medicinais e gravidez” and “fitoterapia e gravidez” from July to October 2020. 27 articles were inserted which were published between 2000 and 2019 and met the inclusion and exclusion criteria. To sum up, it was verified that three major themes have been discussed: adverse reactions, embryotoxicity, teratogenic and abortive effects of medicinal plants; safety and efficacy of the use of medicinal plants; and behaviors and beliefs regarding the use of medicinal plants.

References

Rangel M, Bragança FCR. Representações de gestantes sobre o uso de plantas medicinais. Rev Bras Pl Med. 2009; 11(1): 100-109. [https://doi.org/10.1590/S1516-05722009000100016].
Mengue SS, Mentz LA, Schenkel EP. Uso de plantas medicinais da gravidez. Rev Bras Farmacogn. 2001; 11(1): 21-35. [https://doi.org/10.1590/S0102-695X2001000100004].
Brasil. Ministério da Saúde. Política Nacional de Práticas Integrativas e Complementares no SUS - PNPICs-SUS. Brasília, DF: MS. 2006. 92p. [https://bvsms.saude.gov.br/bvs/publicacoes/pnpic.pdf].
Brasil. Ministério da Saúde. Política nacional de plantas medicinais e fitoterápicos. Brasília, DF: MS. 2006. 60p. [https://bvsms.saude.gov.br/bvs/publicacoes/politica_nacional_fitoterapicos.pdf].
Brasil. Ministério da Saúde. Programa Nacional de Plantas Medicinais e Fitoterápicos. Brasília, DF: MS. 2009. 136p. [https://bvsms.saude.gov.br/bvs/publicacoes/programa_nacional_plantas_medicinais_fitoterapicos.pdf].
Turolla MSR, Nascimento ES. Informações toxicológicas de alguns fitoterápicos utilizados no Brasil. Rev Bras Ciênc Farm. 2006; 42(2): 289-306. [https://doi.org/10.1590/S1516-93322006000200015].
Cardoso BS, Amaral VCS. O uso da fitoterapia durante a gestação: um panorama global. Ciênc Saúde Colet. 2019; 24(4): 1439-1450. [https://doi.org/10.1590/1413-81232018244.07472017].
Izzo AA. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data. Med Princ Pract. 2012; 21(5): 404–428. [https://doi.org/10.1159/000334488].
Mendes KDS, Silveira RCCP, Galvão CM. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na Enfermagem. Texto Cont Enferm. 2008; 17(4): 758-764. [https://doi.org/10.1590/S0104-07072008000400018].
Bardin L. Análise de conteúdo. São Paulo: Edições 70, 2012. ISBN-13: 9788562938047.
Almeida FCG, Lemonica IP. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. J Ethnopharmacol. 2000; 73: 53-60. [https://doi.org/10.1016/S0378-8741(00)00275-0].
Monteiro MHD, Gomes-Carneiro MR, Felzenszwalb I, Chahoud I, Paumgartten FJR. Toxicological evaluation of a tea from leaves of Vernonia condensata. J Ethnopharmacol. 2001; 74(2): 149-157. [https://doi.org/10.1016/S0378-8741(00)00363-9].
Montanari T, Bevilacqua E. Effect of Maytenus ilicifolia Mart. on pregnant mice. Contraception. 2002; 65(2): 171-175. [https://doi.org/10.1016/S0010-7824(01)00301-8].
Damasceno DC, Volpato GT, Sartori TCF, Rodrigues PF, Perin EA, Calderon IMP et al. Effects of Annona squamosa extract on early pregnancy in rats. Phytomedicine. 2002; 9: 667-672. [https://doi.org/10.1078/094471102321616508].
Damasceno DC, Volpato GT, Calderon IMP, Aguiar R, Rudge MVC. Effect of Bauhinia forficata extract in diabetic pregnant rats: maternal repercussions. Phytomedicine. 2004; 11: 196-201. [https://doi.org/10.1078/0944-7113-00348].
Freitas TG, Augusto PM, Montanari T. Effect of Ruta graveolens L. on pregnant mice. Contraception. 2005; 71(1): 74-77. [https://doi.org/10.1016/j.contraception.2004.07.014].
Ruiz ALTG, Taffarello D, Souza VHS, Carvalho JE. Farmacologia e Toxicologia de Peumus boldus e Baccharis genistelloides. Rev Bras Farmacog. 2008; 18(2): 295-300. [https://doi.org/10.1590/S0102-695X2008000200025].
Lanini J, Duarte-Almeida JM, Nappo S, Carlini EA. “O que vêm da terra não faz mal” - relatos de problemas relacionados ao uso de plantas medicinais por raizeiros de Diadema/SP. Rev Bras Farmacogn. 2009; 19(1): 121-129. [https://doi.org/10.1590/S0102-695X2009000100022].
Lourenço ACS, Miguel LK, Guarido KL, Sensiate LA, Salles MJS. Óleo de copaíba (Copaifera langsdorfii Desf.) em padrões reprodutivos de camundongos e no desenvolvimento embriofetal. Rev Bras Pl Med. 2009; 11(4): 407-413. [https://doi.org/10.1590/S1516-05722009000400008].
Rodrigues HG, Meireles CG, Lima JTS, Toledo GP, Cardoso JL, Gomes SL. Efeito embriotóxico, teratogênico e abortivo de plantas medicinais. Rev Bras Pl Med. 2011; 13(3): 359-366. [ https://doi.org/10.1590/S1516-05722011000300016].
Costa KCS, Bezerra SB, Norte CM, Nunes LMN, Olinda TM. Medicinal plants with teratogenic potential: current considerations. Braz J Pharm Sci. 2012; 48(3): 427-433. [https://doi.org/10.1590/S1984-82502012000300009].
Arruda JT, Approbato FC, Maia MCS, Silva TM, Approbato MS. Efeito do extrato aquoso de camomila (Chamomilla recutita L.) na prenhez de ratas e no desenvolvimento dos filhotes. Rev Bras Pl Med. 2013; 15(1): 66-71. [https://doi.org/10.1590/S1516-05722013000100009].
Gonçalves CA, Siqueira JM, Carollo CA, Mauro MO, Davi N, Cunha-Laura AL et al. Gestational exposure to Byrsonima verbascifolia: Teratogenicity, mutagenicity and immunomodulation evaluation in female Swiss mice. J Ethnopharmacol. 2013; 150(3): 843–850. [https://doi.org/10.1016/j.jep.2013.09.012].
Souza MNCV, Tangerina MMP, Silva VC, Vilegas W, Sannomiya M. Plantas medicinais abortivas utilizadas por mulheres de UBS: etnofarmacologia e análises cromatográficas por CCD e CLAE. Rev Bras Pl Med. 2013; 15(4): 763-773. [https://doi.org/10.1590/S1516-05722013000500018].
Cunha-Laura AL, Oliveira RJ, Barros ALC, Siqueira JM, Vieira MC, Auharek SA. Maternal exposure to Cochlospermum regium: a toxicological evaluation. Rev Bras Farmacogn. 2013; 23(2): 374-378. [https://doi.org/10.1590/S0102-695X2013005000005].
Gonçalves CA, Silva NL, Mauro MO, David N, Cunha-Laura AL, Auharek SA et al. Evaluation of mutagenic, teratogenic, and immunomodulatory effects of Annona nutans hydromethanolic fraction on pregnant mice. Genet Molec Res. 2014; 13(2): 4392-4405. [https://geneticsmr.com/year2014/vol13-2/pdf/gmr3941.pdf].
David N, Mauro MO, Gonçalves CA, Pesarini JR, Strapasson RLB, Kassuya CAL et al. Gochnatia polymorpha ssp. floccosa: Bioprospecting of an anti-inflammatory phytotherapy for use during pregnancy. J Ethnopharmacol. 2014; 154(2): 370-379. [https://doi.org/10.1016/j.jep.2014.04.005].
Leitão F, Leitão SG, Fonseca-Kruel VS, Silva IM, Martins K. Medicinal plants traded in the open-air markets in the State of Rio de Janeiro, Brazil: an overview on their botanical diversity and toxicological potential. Rev Bras Farmacog. 2014; 24: 225-247. [https://doi.org/10.1016/j.bjp.2014.04.005].
Fulanetti FB, Camargo GGR, Ferro MC, Randazzo-Moura P. Toxic effects of the administration of Mikania glomerata Sprengel during the gestational period of hypertensive rats. Open Vet J. 2016; 6(1): 23-29. [https://doi.org/10.4314/ovj.v6i1.4] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756170/].
Araújo CRF, Santiago FG, Peixoto MI, Oliveira JOD, Coutinho MS. Use of Medicinal Plants with Teratogenic and Abortive Effects by Pregnant Women in a City in Northeastern Brazil. Rev Bras Ginecol Obstetr. 2016; 38(3): 127-131. [https://doi.org/10.1055/s-0036-1580714].
Silva PLN, Oliveira JS, Santos APO, Vaz MDT. Cuidados pré-natais e puerperais às gestantes de um centro de saúde de Minas Gerais quanto ao risco de pré-eclâmpsia: aspectos clínicos, nutricionais e terapêuticos. J Health Biol Sci. 2017; 5(4): 346-351. [https://doi.org/10.12662/2317-3076jhbs.v5i4.1222.p346-351.2017].
Pessato LR, Auharek SA, Gonçalves CA, David N, Monreal ACD, Kassuya CAL et al. Effects of dichloromethane and butanol fractions of Gochnatia polymorpha subsp. floccosa in maternal reproductive outcome, embryo-fetal development and DNA integrity in mice. J Ethnopharmacol. 2017; 200: 205-208. [https://doi.org/10.1016/j.jep.2017.02.042].
Volpato GT, Moraes-Souza RQ, Soares TS, Leal-Silva T, Damasceno DC. Medicinal plants for diabetes treatment during pregnancy. Curr Med Chem. 2017; 24(4): 404-410. [http://dx.doi.org/10.2174/0929867323666161003122914].
Zampirolli ACD, Oliveira MVL, Mariani NAP, Meira EF, Meira FDMS. Utilização de medicamentos e plantas medicinais por gestantes atendidas na unidade de saúde da mulher em Alegre, ES, Brasil. Infarma. 2017; 29(4): 349-356. [http://dx.doi.org/10.14450/2318-9312.v29.e4.a2017.pp349-356].
Silva ACA, Santana LLB. Os riscos do uso de plantas medicinais durante o período gestacional: uma revisão bibliográfica. Acta Toxicol Argentina. 2018; 26(3): 118-125. [http://www.scielo.org.ar/pdf/ata/v26n3/v26n3a04.pdf].

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Author(s)

Luciana Bortoli Sartori
Centro Universitário Univates. Rua Avelino Tallini, 171, Universitário, CEP 95900-000, Lajeado, RS, Brasil.
https://orcid.org/0000-0003-1218-1331
Chana de Medeiros da Silva
Universidade de Santa Cruz do Sul, Departamento de Biologia e Farmácia. Avenida Independência, 2293, sala 3504, Universitário, CEP 96815-900, Santa Cruz do Sul, RS, Brasil.
https://orcid.org/0000-0002-2231-5121

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How to Cite

The use of medicinal plants and phytotherapics during pregnancy: an integrative review. Rev Fitos [Internet]. 2023 Sep. 30 [cited 2026 Jan. 18];17(3):425-44. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1467

This work is licensed under a Creative Commons Attribution 4.0 International License.

[1] Rangel M, Bragança FCR. Representações de gestantes sobre o uso de plantas medicinais. Rev Bras Pl Med. 2009; 11(1): 100-109. [https://doi.org/10.1590/S1516-05722009000100016].

[2] Mengue SS, Mentz LA, Schenkel EP. Uso de plantas medicinais da gravidez. Rev Bras Farmacogn. 2001; 11(1): 21-35. [https://doi.org/10.1590/S0102-695X2001000100004].

[3] Brasil. Ministério da Saúde. Política Nacional de Práticas Integrativas e Complementares no SUS - PNPICs-SUS. Brasília, DF: MS. 2006. 92p. [https://bvsms.saude.gov.br/bvs/publicacoes/pnpic.pdf].

[4] Brasil. Ministério da Saúde. Política nacional de plantas medicinais e fitoterápicos. Brasília, DF: MS. 2006. 60p. [https://bvsms.saude.gov.br/bvs/publicacoes/politica_nacional_fitoterapicos.pdf].

[5] Brasil. Ministério da Saúde. Programa Nacional de Plantas Medicinais e Fitoterápicos. Brasília, DF: MS. 2009. 136p. [https://bvsms.saude.gov.br/bvs/publicacoes/programa_nacional_plantas_medicinais_fitoterapicos.pdf].

[6] Turolla MSR, Nascimento ES. Informações toxicológicas de alguns fitoterápicos utilizados no Brasil. Rev Bras Ciênc Farm. 2006; 42(2): 289-306. [https://doi.org/10.1590/S1516-93322006000200015].

[7] Cardoso BS, Amaral VCS. O uso da fitoterapia durante a gestação: um panorama global. Ciênc Saúde Colet. 2019; 24(4): 1439-1450. [https://doi.org/10.1590/1413-81232018244.07472017].

[8] Izzo AA. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data. Med Princ Pract. 2012; 21(5): 404–428. [https://doi.org/10.1159/000334488].

[9] Mendes KDS, Silveira RCCP, Galvão CM. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na Enfermagem. Texto Cont Enferm. 2008; 17(4): 758-764. [https://doi.org/10.1590/S0104-07072008000400018].

[10] Bardin L. Análise de conteúdo. São Paulo: Edições 70, 2012. ISBN-13: 9788562938047.

[11] Almeida FCG, Lemonica IP. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. J Ethnopharmacol. 2000; 73: 53-60. [https://doi.org/10.1016/S0378-8741(00)00275-0].

[12] Monteiro MHD, Gomes-Carneiro MR, Felzenszwalb I, Chahoud I, Paumgartten FJR. Toxicological evaluation of a tea from leaves of Vernonia condensata. J Ethnopharmacol. 2001; 74(2): 149-157. [https://doi.org/10.1016/S0378-8741(00)00363-9].

[13] Montanari T, Bevilacqua E. Effect of Maytenus ilicifolia Mart. on pregnant mice. Contraception. 2002; 65(2): 171-175. [https://doi.org/10.1016/S0010-7824(01)00301-8].

[14] Damasceno DC, Volpato GT, Sartori TCF, Rodrigues PF, Perin EA, Calderon IMP et al. Effects of Annona squamosa extract on early pregnancy in rats. Phytomedicine. 2002; 9: 667-672. [https://doi.org/10.1078/094471102321616508].

[15] Damasceno DC, Volpato GT, Calderon IMP, Aguiar R, Rudge MVC. Effect of Bauhinia forficata extract in diabetic pregnant rats: maternal repercussions. Phytomedicine. 2004; 11: 196-201. [https://doi.org/10.1078/0944-7113-00348].

[16] Freitas TG, Augusto PM, Montanari T. Effect of Ruta graveolens L. on pregnant mice. Contraception. 2005; 71(1): 74-77. [https://doi.org/10.1016/j.contraception.2004.07.014].

[17] Ruiz ALTG, Taffarello D, Souza VHS, Carvalho JE. Farmacologia e Toxicologia de Peumus boldus e Baccharis genistelloides. Rev Bras Farmacog. 2008; 18(2): 295-300. [https://doi.org/10.1590/S0102-695X2008000200025].

[18] Lanini J, Duarte-Almeida JM, Nappo S, Carlini EA. “O que vêm da terra não faz mal” - relatos de problemas relacionados ao uso de plantas medicinais por raizeiros de Diadema/SP. Rev Bras Farmacogn. 2009; 19(1): 121-129. [https://doi.org/10.1590/S0102-695X2009000100022].

[19] Lourenço ACS, Miguel LK, Guarido KL, Sensiate LA, Salles MJS. Óleo de copaíba (Copaifera langsdorfii Desf.) em padrões reprodutivos de camundongos e no desenvolvimento embriofetal. Rev Bras Pl Med. 2009; 11(4): 407-413. [https://doi.org/10.1590/S1516-05722009000400008].

[20] Rodrigues HG, Meireles CG, Lima JTS, Toledo GP, Cardoso JL, Gomes SL. Efeito embriotóxico, teratogênico e abortivo de plantas medicinais. Rev Bras Pl Med. 2011; 13(3): 359-366. [ https://doi.org/10.1590/S1516-05722011000300016].

[21] Costa KCS, Bezerra SB, Norte CM, Nunes LMN, Olinda TM. Medicinal plants with teratogenic potential: current considerations. Braz J Pharm Sci. 2012; 48(3): 427-433. [https://doi.org/10.1590/S1984-82502012000300009].

[22] Arruda JT, Approbato FC, Maia MCS, Silva TM, Approbato MS. Efeito do extrato aquoso de camomila (Chamomilla recutita L.) na prenhez de ratas e no desenvolvimento dos filhotes. Rev Bras Pl Med. 2013; 15(1): 66-71. [https://doi.org/10.1590/S1516-05722013000100009].

[23] Gonçalves CA, Siqueira JM, Carollo CA, Mauro MO, Davi N, Cunha-Laura AL et al. Gestational exposure to Byrsonima verbascifolia: Teratogenicity, mutagenicity and immunomodulation evaluation in female Swiss mice. J Ethnopharmacol. 2013; 150(3): 843–850. [https://doi.org/10.1016/j.jep.2013.09.012].

[24] Souza MNCV, Tangerina MMP, Silva VC, Vilegas W, Sannomiya M. Plantas medicinais abortivas utilizadas por mulheres de UBS: etnofarmacologia e análises cromatográficas por CCD e CLAE. Rev Bras Pl Med. 2013; 15(4): 763-773. [https://doi.org/10.1590/S1516-05722013000500018].

[25] Cunha-Laura AL, Oliveira RJ, Barros ALC, Siqueira JM, Vieira MC, Auharek SA. Maternal exposure to Cochlospermum regium: a toxicological evaluation. Rev Bras Farmacogn. 2013; 23(2): 374-378. [https://doi.org/10.1590/S0102-695X2013005000005].

[26] Gonçalves CA, Silva NL, Mauro MO, David N, Cunha-Laura AL, Auharek SA et al. Evaluation of mutagenic, teratogenic, and immunomodulatory effects of Annona nutans hydromethanolic fraction on pregnant mice. Genet Molec Res. 2014; 13(2): 4392-4405. [https://geneticsmr.com/year2014/vol13-2/pdf/gmr3941.pdf].

[27] David N, Mauro MO, Gonçalves CA, Pesarini JR, Strapasson RLB, Kassuya CAL et al. Gochnatia polymorpha ssp. floccosa: Bioprospecting of an anti-inflammatory phytotherapy for use during pregnancy. J Ethnopharmacol. 2014; 154(2): 370-379. [https://doi.org/10.1016/j.jep.2014.04.005].

[28] Leitão F, Leitão SG, Fonseca-Kruel VS, Silva IM, Martins K. Medicinal plants traded in the open-air markets in the State of Rio de Janeiro, Brazil: an overview on their botanical diversity and toxicological potential. Rev Bras Farmacog. 2014; 24: 225-247. [https://doi.org/10.1016/j.bjp.2014.04.005].

[29] Fulanetti FB, Camargo GGR, Ferro MC, Randazzo-Moura P. Toxic effects of the administration of Mikania glomerata Sprengel during the gestational period of hypertensive rats. Open Vet J. 2016; 6(1): 23-29. [https://doi.org/10.4314/ovj.v6i1.4] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756170/].

[30] Araújo CRF, Santiago FG, Peixoto MI, Oliveira JOD, Coutinho MS. Use of Medicinal Plants with Teratogenic and Abortive Effects by Pregnant Women in a City in Northeastern Brazil. Rev Bras Ginecol Obstetr. 2016; 38(3): 127-131. [https://doi.org/10.1055/s-0036-1580714].

[31] Silva PLN, Oliveira JS, Santos APO, Vaz MDT. Cuidados pré-natais e puerperais às gestantes de um centro de saúde de Minas Gerais quanto ao risco de pré-eclâmpsia: aspectos clínicos, nutricionais e terapêuticos. J Health Biol Sci. 2017; 5(4): 346-351. [https://doi.org/10.12662/2317-3076jhbs.v5i4.1222.p346-351.2017].

[32] Pessato LR, Auharek SA, Gonçalves CA, David N, Monreal ACD, Kassuya CAL et al. Effects of dichloromethane and butanol fractions of Gochnatia polymorpha subsp. floccosa in maternal reproductive outcome, embryo-fetal development and DNA integrity in mice. J Ethnopharmacol. 2017; 200: 205-208. [https://doi.org/10.1016/j.jep.2017.02.042].

[33] Volpato GT, Moraes-Souza RQ, Soares TS, Leal-Silva T, Damasceno DC. Medicinal plants for diabetes treatment during pregnancy. Curr Med Chem. 2017; 24(4): 404-410. [http://dx.doi.org/10.2174/0929867323666161003122914].

[34] Zampirolli ACD, Oliveira MVL, Mariani NAP, Meira EF, Meira FDMS. Utilização de medicamentos e plantas medicinais por gestantes atendidas na unidade de saúde da mulher em Alegre, ES, Brasil. Infarma. 2017; 29(4): 349-356. [http://dx.doi.org/10.14450/2318-9312.v29.e4.a2017.pp349-356].

[35] Silva ACA, Santana LLB. Os riscos do uso de plantas medicinais durante o período gestacional: uma revisão bibliográfica. Acta Toxicol Argentina. 2018; 26(3): 118-125. [http://www.scielo.org.ar/pdf/ata/v26n3/v26n3a04.pdf].