Brazilian peppertree (Schinus terebinthifolius Raddi) as a possible source of human health products

Jéssica Hellen Souza da Silva
OrcID
Mayara de Azeredo Rezende
OrcID

    Jéssica Hellen Souza da Silva

    Estácio de Sá University, Estácio de Sá College of Rio de Janeiro. Rua André Rocha, 1005, Taquara, CEP 22710-560, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0000-0002-6054-8903

    Graduated in Pharmacy from the Federal University of Rio de Janeiro (UFRJ)(2009), master's and doctorate in Sciences from the Postgraduate Program in Chemistry of Natural Products of the Institute for Research of Natural Products (IPPN-UFRJ)(2017). He served as contract professor of Pharmacognosy, Pharmacobotany and Organic Chemistry at the University Center Foundation of the West Zone of Rio de Janeiro (UEZO) (2013-2014). He has a Lato sensu postgraduate degree in Phytotherapy from Faculdade UnYLeYa (420h)(2020) and Specialization in Innovation in Biodiversity Medicines from the Center for Innovation in Biodiversity and Health (CIBS) in Farmanguinhos/Fiocruz (2022). He worked as a professor at Estácio de Sá University (UNESA) (2016-2020), teaching Pharmacognosy, Phytotherapy, Biochemistry, Organic Chemistry and other related subjects, with experience in teaching practical classes in physical and virtual laboratories, and teaching through of active methodologies. He was a member of the National Structuring Teaching Nucleus (NDE) of the undergraduate courses in Pharmacy On-site, Blended and Distance Learning Estácio (2017-2020), being responsible for updating and adjusting the curriculum matrices of the undergraduate courses in Pharmacy, Onsite, Blended Learning and Distance Learning Estácio referring to the area of Pharmacognosy, Phytotherapy and Chemistry of Natural Products (2017-2020). She is currently an EAD content specialist in Organic Chemistry, Pharmacognosy and Phytotherapy at the company EnsineMe and works as a Temporary Volunteer Hospital Pharmacist at PMERJ. In the area of research, he has experience in Phytochemistry with an emphasis on identification, purification, isolation and structural elucidation of secondary plant metabolites of medicinal plants, with a focus on the species Schinus terebinthifolius Raddi, Anacardiaceae (Aroeira- Vermelha). He also has experience in Biochemistry, with emphasis on isolation and biocatalytic application of plant lipases.

    Mayara de Azeredo Rezende

    FIOCRUZ, Institute of Pharmaceutical Technology - Farmanguinhos, Center for Innovation in Biodiversity and Health (CIBS). Avenida Comandante Guaranys, 447, Jacarepaguá, CEP 22775-903, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0000-0002-1287-0316

    Pharmacist, specialist in Innovation Management in Phytomedicines and Regulatory Affairs, Master in Oncology with emphasis in Molecular Biology and PhD student in Public Health at the National School of Public Health (ENSP/FIOCRUZ). She has experience in the segments of hospital pharmacy (acting as an on-call doctor and temporary employee of the National Institute of Cardiology), oncology (in the field of diagnosis by flow cytometry and immunophenotyping and assistance), herbal medicines, regulation and Intellectual Property. She is currently General Advisor for the Coordination of the Center for Innovation in Biodiversity Medicines (CIBS/Farmanguinhos / Fiocruz), Consultant in the area of Innovation in Biodiversity Medicines, Professor in the regulatory affairs area of the specialization course in Biodiversity Medicines and Research analyst , Development and Innovation in Medicines from Biodiversity. She develops her doctoral thesis in the onco-regulatory segment, analyzing the insertion of data and evidence from the real world (Real World Data and Real World Evidence) in the incorporation of new drugs in the onco-hematological segment.

Keywords

Schinus terebinthifolius Raddi
Pink pepper
Health products
Patents
Prospection

Abstract

The plant species Schinus terebinthifolius Raddi is native to Brazil and, popularly, almost every part of the plant is used for medicinal purposes, including the fruit, known as “pink pepper” or “Brazilian pepper”. In this sense, studies that point to the development of technological innovation associated with the production and use of S. terebinthifolius for health are importan. The objective of this study was to carry out a prospection of health products based on S. terebinthifolius Raddi and/or pink pepper, through literature research and patent database searches. The results reveal proposals for pharmaceutical formulations based on S. terebinthifolius and its fruits for use in human health. Patent applications have shown that S. terebinthifolius has many uses within the context of formulating products for human health worldwide, but that in the Brazilian context, there is no investment in technological innovation associated with the production and use of S. terebinthifolius. This research proposes pink pepper as one more candidate to produce pharmaceutical ingredients through the Research and Development of new innovative herbal products, stimulating the Brazilian technology park and the innovation chain in medicines from biodiversity.

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Author(s)

  • Jéssica Hellen Souza da Silva
    Estácio de Sá University, Estácio de Sá College of Rio de Janeiro. Rua André Rocha, 1005, Taquara, CEP 22710-560, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0000-0002-6054-8903
  • Mayara de Azeredo Rezende
    FIOCRUZ, Institute of Pharmaceutical Technology - Farmanguinhos, Center for Innovation in Biodiversity and Health (CIBS). Avenida Comandante Guaranys, 447, Jacarepaguá, CEP 22775-903, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0000-0002-1287-0316

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Brazilian peppertree (Schinus terebinthifolius Raddi) as a possible source of human health products. Rev Fitos [Internet]. 2024 Jan. 4 [cited 2024 Dec. 27];18(Suppl. 1):e1485. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1485
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