Preclinical gastroprotective activity of an Eugenia brasiliensis Lam. (Myrtaceae) extract

Ana Júlia Campos
OrcID
Matheus Henrique Ruela Mews
OrcID
Debora Delwing Dal Magro
OrcID
Michele Debiasi Alberton
OrcID
Daniela Delwing de Lima
OrcID
Eduardo Manoel Pereira
OrcID

    Ana Júlia Campos

    University of Joinville Region, University of Joinville Region. Rua Paulo Malschitzki, 10, Zona Industrial Norte, CEP 89219-700, Joinville, SC, Brazil.

    OrcID https://orcid.org/0000-0002-7388-4359

    Farmacêutica com experiência na integração e suporte das diversas áreas técnicas e administrativas da indústria farmacêutica, com habilidades para gerenciar e executar projetos que envolvem desenvolvimento de produtos e melhorias de processos. Dinâmica, pragmática e organizada, sou movida por desafios. Gosto de trabalhar em ambientes que estimulem o aprendizado e projetos que envolvem ideias ou problemas amplamente relevantes. 

    Matheus Henrique Ruela Mews

    Universidade da Região de Joinville

    OrcID https://orcid.org/0000-0001-6314-8588

    Graduated in Pharmacy (2018) from the University of Joinville Region - Univille. He is currently a professor at the Instituto Pró-Rim de Educação e Pesquisa em Saúde - IPREPS, in the disciplines of Pharmacology and Calculus. Postgraduate in Quality and Productivity Management. He has experience in Pharmacy Industry, working in quality control.

    Debora Delwing Dal Magro

    Regional University of Blumenau Foundation (FURB), Department of Pharmaceutical Sciences. Department of Pharmaceutical Sciences, Campus III, Rua São Paulo, 2171, Itoupava Seca, CEP 89030-001, Blumenau, SC, Brazil.

    OrcID https://orcid.org/0000-0003-4459-1562

    Graduated in Pharmacy and Biochemistry from the Lutheran University of Brazil, Master's and Doctorate in Biological Sciences (Biochemistry) from the Federal University of Rio Grande do Sul. She is currently a full professor at undergraduate level and advisor/researcher of the Graduate Program in Biodiversity at the Regional University of Blumenau Foundation. He works in scientific research with the themes: Inborn Errors of Metabolism, metabolic diseases, diseases/conditions that affect the Central Nervous System (autism, epilepsy, depression, Parkinson's Disease), pain, oxidative stress, behavior, energy metabolism and bioprospecting.

    Michele Debiasi Alberton

    Regional University of Blumenau Foundation (FURB), Department of Pharmaceutical Sciences. Department of Pharmaceutical Sciences, Campus III, Rua São Paulo, 2171, Itoupava Seca, CEP 89030-001, Blumenau, SC, Brazil.

    OrcID https://orcid.org/0000-0003-3490-9936

    She holds a Master's degree in Pharmacy from the Federal University of Santa Catarina (2001) and a PhD in Chemistry from the Federal University of Santa Catarina (2008). He is currently a professor at the Regional University of Blumenau Foundation. He has experience in the area of Natural Products, with an emphasis on Phytochemistry and evaluation of biological activity. She works in the Graduate Program in Chemistry and in the Graduate Program in Biodiversity at the same institution, as a permanent professor. She was coordinator of the Graduate Program in Chemistry at FURB during two terms (2019-2022). She is currently the Dean of Research, Graduate Studies, Extension and Culture at FURB, with a mandate between 2023-2026. 

    Daniela Delwing de Lima

    University of Joinville Region, University of Joinville Region. Rua Paulo Malschitzki, 10, Zona Industrial Norte, CEP 89219-700, Joinville, SC, Brazil.

    OrcID https://orcid.org/0000-0001-5335-5102

    Graduated in Pharmacy and specialized in Clinical Analysis from the Lutheran University of Brazil. Master and PhD in Biological Sciences (Biochemistry) from the Federal University of Rio Grande do Sul. She served as a university professor at the University of Frederico Westphalen-URI and the University of Chapecó-UNOCHAPECÓ. Graduation professor and advisor/researcher of the Graduate Program in Health and Environment at the University of Joinville Region (UNIVILLE). Experience in Pharmacy and Biochemistry, works in scientific research with the themes: Inborn Errors of Metabolism, metabolic diseases, diseases/conditions that affect the Central Nervous System, pain, oxidative stress, behavior, energy metabolism and bioprospecting.

    Eduardo Manoel Pereira

    University of Joinville Region, Department of Pharmacy. Rua Paulo Malchitzki 10, Bom Retiro, CEP 89219-710, Joinville, SC, Brazil

    OrcID https://orcid.org/0000-0002-5734-626X

    Graduated in Pharmacy-Biochemistry from the Federal University of Alfenas (2002) and Master in Pharmacology from the Federal University of Paraná (2006). Professor at the University of Joinville Region for 15 years, responsible for the disciplines of Basic and Clinical Pharmacology in the Pharmacy course and Clinical Pharmacology in the Medicine course. He conducts preclinical lines of research on the action of substances of natural origin in models of gastritis, pain, inflammation, diabetes and oxidative stress in rats and mice, and clinics on the evaluation of prescription errors in public and private institutions and pharmacotherapeutic follow-up. . Professor of the Multiprofessional Residency at the Municipal Hospital São José de Joinville, of the Postgraduate Courses in Clinical Oncology and Clinical Pharmacy and Pharmaceutical Prescription at the University of Joinville Region and of the Postgraduate Course in Hospital Pharmacy at Hospital Santa Catarina de Blumenau. Member of the Committee for Ethics in Research on the Use of Animals at the University of Joinville Region. Graduating from the third year of Psychology at the University of Joinville Region.

Keywords

Eugenia brasiliensis
Phytomedicines
Phytotherapy
Gastritis
Gastric ulcer

Abstract

Gastric ulcers are lesions of the mucous coating membrane of the stomach characterized by burning and epigastric pain as symptoms, which are empirically relieved by Eugenia brasiliensis Lam. (Myrtaceae) extracts. However, there are no studies which evaluated sistematically its gastroprotector potential. Thus, this study aimed to assess the gastroprotector effectiveness of an acetonic extract obtained from leaves of Eugenia brasiliensis in reducing gastric ulcers in rats. Animals were divided in groups and submitted to alcohol and indomethacin models of gastric lesion after previous treatment with the extract and to acetic acid-induced ulcer followed by six days exposure to the extract. Ethanol-induced gastric lesion was reduced by 30 and 100 mg/Kg of the extract in 36% and 68%, respectively. Indomethacin-induced gastric lesion area was reduced by 30, 100 and 300 mg/Kg of the extract in 66%, 88% and 73%, respectively. Acetic acid-induced gastric ulcer was reduced in 72% by 100 mg/Kg extract. Data indicate that Eugenia brasiliensis acetonic extract was effective in reducing gastric lesion in all models tested, which can be attributed to modulation of the inflammatory response and antioxidant activity enhancement by polyphenols, resulting in direct contribution to decrease cell damage which brings consequent gastric ulcer reduction.

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Author(s)

  • Ana Júlia Campos
    University of Joinville Region, University of Joinville Region. Rua Paulo Malschitzki, 10, Zona Industrial Norte, CEP 89219-700, Joinville, SC, Brazil.
    https://orcid.org/0000-0002-7388-4359
  • Matheus Henrique Ruela Mews
    Universidade da Região de Joinville
    https://orcid.org/0000-0001-6314-8588
  • Debora Delwing Dal Magro
    Regional University of Blumenau Foundation (FURB), Department of Pharmaceutical Sciences. Department of Pharmaceutical Sciences, Campus III, Rua São Paulo, 2171, Itoupava Seca, CEP 89030-001, Blumenau, SC, Brazil.
    https://orcid.org/0000-0003-4459-1562
  • Michele Debiasi Alberton
    Regional University of Blumenau Foundation (FURB), Department of Pharmaceutical Sciences. Department of Pharmaceutical Sciences, Campus III, Rua São Paulo, 2171, Itoupava Seca, CEP 89030-001, Blumenau, SC, Brazil.
    https://orcid.org/0000-0003-3490-9936
  • Daniela Delwing de Lima
    University of Joinville Region, University of Joinville Region. Rua Paulo Malschitzki, 10, Zona Industrial Norte, CEP 89219-700, Joinville, SC, Brazil.
    https://orcid.org/0000-0001-5335-5102
  • Eduardo Manoel Pereira
    University of Joinville Region, Department of Pharmacy. Rua Paulo Malchitzki 10, Bom Retiro, CEP 89219-710, Joinville, SC, Brazil
    https://orcid.org/0000-0002-5734-626X

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Preclinical gastroprotective activity of an Eugenia brasiliensis Lam. (Myrtaceae) extract. Rev Fitos [Internet]. 2023 Dec. 20 [cited 2025 Dec. 19];17(4):540-5. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1555
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