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Preclinical evaluation of the interference of Conocarpus erectus L. (Combretaceae) tea on routine hematological and biochemical profile

    Allane Patricia Santos da Paz

    Federal University of Pará, Institute of Biological Sciences, Laboratory of Pharmacology and Toxicology of Natural Products. Rua Augusto Correa, S/N, Guamá, CEP 66075-110, Belém, PA, Brazil.

    OrcID https://orcid.org/0000-0001-6084-6989

    Master's student in Pharmaceutical Sciences (Biological Assessment of Natural and Synthetic Products) and Bachelor's degree in Nutrition from the Federal University of Pará (UFPA). Member of the Research, Teaching and Extension Laboratory in Clinical Analysis (LACPEE) of the Institute of Biological Sciences (ICB) of the Federal University of Pará (UFPA).

    Gisely Santiago Santos

    Federal University of Pará, UFPA. Faculty of Medicine, Avenida Generalíssimo Deodoro, until 1257 - odd side, Umarizal, CEP 66050-160, Belém, PA, Brazil.

    OrcID https://orcid.org/0000-0001-6143-3588

    Graduated in Physiotherapy from the State University of Pará (2016). Summary: Mandatory internship at the University of the State of Pará in the Outpatient area (UEAFTO-Physiotherapy and Occupational Therapy Teaching and Assistance Unit; Occupational Physiotherapy at PRODEPA; Community Health at NASF-Águas Lindas/Ananindeua) and in the Hospital area (University Hospital João de Barros Barreto; Metropolitan Urgency and Emergency Hospital; Santa Casa de Misericórdia do Pará Foundation). Internship at the Body and Health Physiotherapy Clinic in the Kinesiotherapy sector.

    Michael Eduardo Melo do Vale

    Federal University of Pará, UFPA. Faculty of Medicine, Avenida Generalíssimo Deodoro, 1257, Umarizal, CEP 66050-160, Belém, PA, Brazil.

    OrcID https://orcid.org/0009-0001-9170-2918

    Medical student at the Federal University of Pará (UFPA-Belém). In addition to knowledge of languages: Portuguese; English and French.

    Izabela Nascimento Galvão

    Federal University of Pará, UFPA. Faculty of Medicine, Avenida Generalíssimo Deodoro, 1257, Umarizal, CEP 66050-160, Belém, PA, Brazil.

    OrcID https://orcid.org/0000-0003-3595-240X

    Doctor graduated from the Federal University of Pará (2023).

    Lara Gabriele Silva da Silva

    Federal University of Pará, UFPA. Faculty of Medicine, Avenida Generalíssimo Deodoro, 1257, Umarizal, CEP 66050-160, Belém, PA, Brazil.

    OrcID https://orcid.org/0009-0004-9428-5242

    Medical student at the Federal University of Pará.

    Tamara Ingrid dos Santos Negrão

    Federal University of Pará, UFPA. Faculty of Medicine, Avenida Generalíssimo Deodoro, 1257, Umarizal, CEP 66050-160, Belém, PA, Brazil.

    OrcID https://orcid.org/0009-0009-6701-3360

    Graduated in biomedicine from Escola Superior da Amazônia (2015). He is currently coordinator of laboratory surveillance - Ananindeua Municipal Health Secretary. He has experience in the area of General Biology, with an emphasis on clinical analysis

    Moises Hamoy

    Federal University of Pará, Institute of Biological Sciences, Laboratory of Pharmacology and Toxicology of Natural Products. Rua Augusto Correa, S/N, Guamá, CEP 66075-110, Belém, PA, Brazil.

    OrcID https://orcid.org/0000-0002-2931-4324

    He has a degree in Veterinary Medicine from the Federal Rural University of Amazônia (1998) and a master's degree in Neuroscience from the Federal University of Pará (2002), a doctorate in neuroscience and molecular biology. He is currently a professor at the Federal University of Pará. He has experience in the area of Pharmacology, with an emphasis on health areas, working mainly on the following topics: Medical Pharmacology, Screening of herbal medicines for therapeutic use. Professor of Medical Pharmacology at the UFPA Faculty of Medicine.

    Vanessa Jóia de Mello

    Federal University of Pará, Institute of Biological Sciences, Laboratory of Pharmacology and Toxicology of Natural Products. Rua Augusto Correa, S/N, Guamá, CEP 66075-110, Belém, PA, Brazil.

    OrcID https://orcid.org/0000-0003-0359-9760

    He holds a Sandwich Doctorate in Pharmacology from the Federal University of Minas Gerais - Institute of Biological Sciences - ICB UFMG and Universidad Complutense de Madrid - UCM (2005). She is currently an assistant professor at the Institute of Biological Sciences UFPA-Pharmacology area. She has experience in Teaching, Research and extension mainly in the areas of Pharmacology, Physiology and Biochemistry. With great emphasis on the biological activity of Natural Products.

    Lucimar Di Paula dos Santos Madeira

    Federal University of Pará, UFPA. Institute of Biological Sciences, Research, teaching and extension laboratory in Clinical Analysis. Rua Augusto Correa, S/N, Guamá, CEP 66075-110, Belém, PA, Brazil.

    OrcID https://orcid.org/0000-0001-7708-7640

    He has a degree in Biomedicine from the Federal University of Pará (2005), a master's degree in Biology of Infectious and Parasitic Agents from the Federal University of Pará (2008) and a PhD in Biology of Infectious and Parasitic Agents from the Federal University of Pará (2013). She is currently an adjunct professor II (class C) in the Bacteriology position at the Federal University of Pará and works in the research areas of Urinary Tract Infections and Sexually Transmitted Infections. She has experience from 2012 to the present day, in the following areas: Microbiology with an emphasis on Bacteriology. Coordinator of the Clinical Analysis Research and Extension Teaching Laboratory (LACPEE), located at the Institute of Biological Sciences of the Federal University of Pará.

Keywords

Abstract

The Conocarpus erectus L, known as “button mangrove”, is a plant with great ethnopharmacological applicability in diabetes, gastric ulcer, and diarrhea, widely used as a single treatment, or associated with allopathy. Using a preclinical model, the present work evaluated possible alterations in the hematological and biochemical tests of Wistar rats after consumption of lyophilized C. erectus L. tea for 40 days, at the dose traditionally used for digestive disorders. Exposure in repeated doses could not promote significant changes in body mass and routine hematological/biochemical parameters evaluated. Studies with these characteristics promote a greater understanding of the use of traditional medicine, the possible interactions on diagnostic laboratory parameters, and the impact on patient follow-up.

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Author(s)

  • Allane Patricia Santos da Paz
    Federal University of Pará, Institute of Biological Sciences, Laboratory of Pharmacology and Toxicology of Natural Products. Rua Augusto Correa, S/N, Guamá, CEP 66075-110, Belém, PA, Brazil.
    https://orcid.org/0000-0001-6084-6989
  • Gisely Santiago Santos
    Federal University of Pará, UFPA. Faculty of Medicine, Avenida Generalíssimo Deodoro, until 1257 - odd side, Umarizal, CEP 66050-160, Belém, PA, Brazil.
    https://orcid.org/0000-0001-6143-3588
  • Michael Eduardo Melo do Vale
    Federal University of Pará, UFPA. Faculty of Medicine, Avenida Generalíssimo Deodoro, 1257, Umarizal, CEP 66050-160, Belém, PA, Brazil.
    https://orcid.org/0009-0001-9170-2918
  • Izabela Nascimento Galvão
    Federal University of Pará, UFPA. Faculty of Medicine, Avenida Generalíssimo Deodoro, 1257, Umarizal, CEP 66050-160, Belém, PA, Brazil.
    https://orcid.org/0000-0003-3595-240X
  • Lara Gabriele Silva da Silva
    Federal University of Pará, UFPA. Faculty of Medicine, Avenida Generalíssimo Deodoro, 1257, Umarizal, CEP 66050-160, Belém, PA, Brazil.
    https://orcid.org/0009-0004-9428-5242
  • Tamara Ingrid dos Santos Negrão
    Federal University of Pará, UFPA. Faculty of Medicine, Avenida Generalíssimo Deodoro, 1257, Umarizal, CEP 66050-160, Belém, PA, Brazil.
    https://orcid.org/0009-0009-6701-3360
  • Moises Hamoy
    Federal University of Pará, Institute of Biological Sciences, Laboratory of Pharmacology and Toxicology of Natural Products. Rua Augusto Correa, S/N, Guamá, CEP 66075-110, Belém, PA, Brazil.
    https://orcid.org/0000-0002-2931-4324
  • Vanessa Jóia de Mello
    Federal University of Pará, Institute of Biological Sciences, Laboratory of Pharmacology and Toxicology of Natural Products. Rua Augusto Correa, S/N, Guamá, CEP 66075-110, Belém, PA, Brazil.
    https://orcid.org/0000-0003-0359-9760
  • Lucimar Di Paula dos Santos Madeira
    Federal University of Pará, UFPA. Institute of Biological Sciences, Research, teaching and extension laboratory in Clinical Analysis. Rua Augusto Correa, S/N, Guamá, CEP 66075-110, Belém, PA, Brazil.
    https://orcid.org/0000-0001-7708-7640

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Preclinical evaluation of the interference of Conocarpus erectus L. (Combretaceae) tea on routine hematological and biochemical profile. Rev Fitos [Internet]. 2024 Jun. 14 [cited 2025 Apr. 5];18:e1559. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1559
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