Potential use of organic residues from the industrial production of Citrus sinensis orange juice to obtain essential oil to control Aedes aegypti

Juliana Pereira Welbert
OrcID
Fernando Ariel Genta
OrcID
Bruno Gomes
OrcID
Maria Helena Durães Alves Monteiro
OrcID

    Juliana Pereira Welbert

    Oswaldo Cruz Foundation (Fiocruz), Oswaldo Cruz Institute, Insect Biochemistry and Physiology Laboratory. Avenida Brasil, 4365, pavilion Leônidas Deane, Manguinhos, CEP 21040-900, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0009-0005-5133-5294

    Chemistry technician from Colégio Mercúrio (2012), pharmacist from the Federal University of Rio de Janeiro (2019), specialist in Innovation Management in Phytomedicines from Farmanguinhos from FIOCRUZ/RJ (2020). Master in Cellular and Molecular Biology from the Oswaldo Cruz Institute of FIOCRUZ/RJ (2023). PhD student in Parasitic Biology at the Oswaldo Cruz Institute of FIOCRUZ/RJ. Experience in the application of natural products to control Aedes aegypti larvae and their biochemical effects. Currently, she studies the metabolism of Lutzomyia longipalpis by feeding it with an artificial diet at the Laboratory of Biochemistry and Insect Physiology-IOC / FIOCRUZ.

    Fernando Ariel Genta

    Oswaldo Cruz Foundation (Fiocruz), Oswaldo Cruz Institute, Insect Biochemistry and Physiology Laboratory. Avenida Brasil, 4365, pavilion Leônidas Deane, Manguinhos, CEP 21040-900, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0000-0001-9558-1116

    He is a senior researcher at the Oswaldo Cruz Foundation (FIOCRUZ) in Rio de Janeiro. Currently studying the digestive system of triatomines, sandflies and culicids, focused on the enzymology of digestion and the interactions between trypanosomatids and their insect vectors, in the area of Parasitology - subarea Entomology and Malacology of Parasites and Vectors. Graduated in Biological Sciences from the University of São Paulo (1998), master's degree in Biochemistry from the University of São Paulo (2000), PhD in Biochemistry from the University of São Paulo (2004), post-doctorate in Biochemistry from the University of São Paulo (2006 ) Liverpool School of Tropical Medicine (2010), University of Notre Dame (2015) and MBA in Business Management from Fundação Getúlio Vargas (2020). He has experience in the area of Biochemistry, with an emphasis on Biochemistry and Molecular Biology of Insects and Enzymology, having worked on the study of digestive enzymes of insect vectors and their relationship with the vectorial capacity and establishment of infection by parasites. He coordinates the Enzyme Kinetics and Advanced Biochemistry disciplines in the postgraduate course in Cellular and Molecular Biology at the Oswaldo Cruz Institute. He is head of the Insect Biochemistry and Physiology Laboratory, coordinator of the Postgraduate Program in Vector Surveillance and Control at the Oswaldo Cruz Foundation, member of the INCT management committee in Molecular Entomology, full member of the Deliberative Council of the Oswaldo Cruz Institute, and editor of the journal Frontiers in Physiology (Invertebrate Physiology).

    Bruno Gomes

    Oswaldo Cruz Foundation (Fiocruz), Oswaldo Cruz Institute, Insect Biochemistry and Physiology Laboratory. Avenida Brasil, 4365, pavilion Leônidas Deane, Manguinhos, CEP 21040-900, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0000-0003-3877-2359

    Maria Helena Durães Alves Monteiro

    Oswaldo Cruz Foundation (Fiocruz), Institute of Technology in Pharmaceuticals-Farmanguinhos, Center for Innovation in Biodiversity and Health (CIBS). Avenida Comandante Guaranys, 447, building 10, Jacarepaguá, CEP 22775-903, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0000-0001-7434-5544

    Degree in Biological Sciences (Universidade Santa Úrsula) and in Dentistry (Universidade Federal Fluminense), master's degree in Public Health from the Oswaldo Cruz Foundation (1996) and doctorate in Biological Sciences (Botany) from the National Museum / Federal University of Rio de Janeiro. Currently works as a development technologist at the Center for Innovation in Biodiversity and Health (CIBS) / Farmanguinhos-FIOCRUZ, professor and advisor of the Lato Sensu postgraduate course in Phytomedicine Innovation (CIBS/Farmanguinhos/Fiocruz) and as scientific editor of the Magazine Ribbons from Farmanguinhos/Fiocruz. She works on research, development and innovation (RD&I) projects in the area of natural products and phytomedicines, especially in Dentistry. Areas of activity: Botany (taxonomy and morphology), medicinal plants and natural products, oral health, integrative practices.

Keywords

Citrus sinensis
Larvicide
Essential oil
Aedes aegypti
Scientific disclosure

Abstract

The Aedes aegypti mosquito, from the Culicidae family, is an important vector of endemic arboviruses in Brazil. Vector control is one of the main strategies for controlling diseases caused by arboviruses. The development of alternative tools is necessary to reduce dependence on synthetic insecticides and the limitations caused by the increasing incidence of resistance in Aedes aegypti. The essential oil of sweet orange, Citrus sinensis (Rutaceae), has insecticidal activity and can be a valid choice to develop new control tools, due to its low toxicity to mammals and low cost, as it is a by-product of juice production. The production of orange juice in Brazil's citrus belt discards tons of organic waste yearly, such as the peel, which is often not properly applied or disposed of, causing environmental damage at the disposal sites. This work suggests the reuse of these residues, discarded by the juice industry in the citrus region of São Paulo and Minas Gerais, in the production of essential oil from Citrus sinensis, due to its potential in the development of products applied in the control of Aedes aegypti, according to activity reported in the literature, which would boost technological and social progress in the region.

References

  1. Pavela R. Essential oils for the development of eco-friendly mosquito larvicides: a review. Ind Crops Prod. Dec 2015; 76: 174-187. ISSN 0926-6690. Available at: [https://doi.org/10.1016/j.indcrop.2015.06.050].
  2. Liu NN. Insecticide resistance in mosquitoes: impact, mechanisms, and research directions. In: Berenbaum MR. (Ed.). Annual Rev Entomol. Palo Alto: Annual Reviews. 2015; 60: 537-559. ISBN 978-0-8243-0160-6. [https://doi.org/10.1146/annurev-ento-010814-020828].
  3. Wolffenbuttel AN et al. Chemical components of Citrus essential oils from Brazil. Nat Prod J. 2015; 5(1): 14-27. ISSN 2210- 3155. Available at: [https://doi.org/10.2174/221031550501150414095331].
  4. Workman MJ et al. Yeast-encapsulated essential oils: a new perspective as an environmentally friendly larvicide. Paras Vect. Jan 2020; 13(1): 9. ISSN 1756-3305. Available at: [https://doi.org/10.1186/s13071-019-3870-4].
  5. Moyes CL et al. Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans. Plos Neglec Trop Dis. Jul 2017; 11(7): 20. ISSN 1935-2735. Available at: [https://doi.org/10.1371/journal.pntd.0005625].
  6. Brasil. Ministério da Saúde, Secretaria de Vigilância em Saúde. Boletim Epidemiológico 33: Óbito por arboviroses no Brasil, 2008 a 2019. Volume 51. Brasília, 2020a. [http://plataforma.saude.gov.br/anomalias-congenitas/boletim-epidemiologico-SVS-33-2020.pdf].
  7. FUNDECITRUS. Fundo de Defesa da Citricultura. Safra de laranja 2019/20 em SP e MG se encerra em 386,79 milhões de caixas, 2020. Disponível em: [https://www.fundecitrus.com.br/comunicacao/noticias/integra/safra-de-laranja201920-em-sp-e-mg-se-encerra-em-38679-milhoes-de-caixas/910]. [acesso em: 18 out. 2020].
  8. CITRUSBR. Associação Nacional dos Exportadores de Sucos Cítricos. Release: Comunicado ao Mercado. [s.d.]. Disponível em: [https://citrusbr.com/imprensa/releases/release-comunicado-ao-mercado-3/]. [acesso em: 18 out. 2020].
  9. Gonzalez-Mas MC et al. Volatile compounds in Citrus essential oils: a comprehensive review. Front Pl Sci. Feb 2019; 10: 18. ISSN 1664-462X. Available at: [https://doi.org/10.3389/fpls.2019.00012].
  10. Mamma D, Christakopoulos P. Biotransformation of Citrus By-Products into value added products. Waste and Biomass Valorization. Aug 2014; 5(4): 529-549. ISSN 1877-2641. Available at: [https://doi.org/10.1007/s12649-013-9250-y].
  11. CITRUSBR. Associação Nacional dos Exportadores de Sucos Cítricos. Produtos e Subprodutos. [s.d.]. Disponível em: [http://www.citrusbr.com/laranjaesuco/?ins=19]. [acesso em: 18 out. 2020]. [http://www.citrusbr.com/laranjaesuco/?ins=19].
  12. Jimenez-Castro MP et al. Two-stage anaerobic digestion of orange peel without pre-treatment: experimental evaluation and application to São Paulo state. J Environ Chem Engineer. Aug 2020; 8(4): 10. Available at: [https://doi.org/10.1016/j.jece.2020.104035].
  13. Zema DA et al. Anaerobic digestion of orange peel in a semi-continuous pilot plant: an environmentally sound way of citrus waste management in agroecosystems. Sci Total Environ. Jul 2018; 630: 401-408. ISSN 0048-9697. Available at: [https://doi.org/10.1016/j.scitotenv.2018.02.168].
  14. Brasil. Ministério do Meio Ambiente. Política Nacional de Resíduos Sólidos, Lei nº 12.305, de agosto de 2010. Brasília, DF, 2010. [http://www.planalto.gov.br/ccivil_03/_ato2007-2010/2010/lei/l12305.htm].
  15. Ruiz B, Flotats X. Effect of limonene on batch anaerobic digestion of citrus peel waste. Biochem Engineer J. May 2016; 109: 9-18. ISSN 1369-703X. Available at: [https://doi.org/10.1016/j.bej.2015.12.011].
  16. Oyedeji AO et al. Insecticidal and biochemical activity of essential oil from Citrus sinensis peel and constituents on Callosobrunchus maculatus and Sitophilus zeamais. Pestic Biochem Physiol. Sep 2020; 168(8):. ISSN 0048-3575. Available at: [https://doi.org/10.1016/j.pestbp.2020.104643].
  17. Vera SS et al. Essential oils with insecticidal activity against larvae of Aedes aegypti (Diptera: Culicidae). Parasitol Res. Jul 2014; 113(7): 2647-2654. ISSN 0932-0113. Available at: [https://doi.org/10.1007/s00436-014-3917-6].
  18. Araujo AFD et al. Larvicidal activity of Syzygium aromaticum (L.) Merr and Citrus sinensis (L.) Osbeck essential oils and their antagonistic effects with temephos in resistant populations of Aedes aegypti. Mem Inst Oswaldo Cruz. Jul 2016; 111(7): 443-449. ISSN 0074-0276. Available at: [https://doi.org/10.1590/0074-02760160075].
  19. Mithofer A, Boland W. Plant defense against herbivores: chemical aspects. In: Merchant SS. (Ed.). Annual Review of Plant Biology. Palo Alto: Annual Reviews. 2012; 63: 431-450. ISBN 978-0-8243-0663-2. [https://doi.org/10.1146/annurev-arplant-042110-103854].
  20. Dugo G et al. Characterization of oils from the fruits, leaves and flowers of the bitter orange tree. J Essent Oil Res. Mar-Apr 2011; 23(2): 45- 59. ISSN 1041-2905. Available at: [https://doi.org/10.1080/10412905.2011.9700446].
  21. Bourgou S et al. Changes of peel essential oil composition of four Tunisian Citrus during fruit maturation. Scient World J. 2012; 10:. ISSN 1537-744X. Available at: [https://doi.org/10.1100/2012/528593].
  22. Ayala JR et al. Extraction and characterization of orange peel essential oil from Mexico and United States of America. J Essent Oil Bearing Pl. 2017; 20(4): 897-914. ISSN 0972-060X. Available at: [https://doi.org/10.1080/0972060X.2017.1364173].
  23. Fakayode OA, Abobi KE. Optimization of oil and pectin extraction from orange (Citrus sinensis) peels: a response surface approach. J Analytical Sci Technol. Sep. 2018; 9: 16. ISSN 2093-3134. Available at: [https://doi.org/10.1186/s40543-018-0151-3].
  24. Giwa SO, Muhammad M, Giwa A. Utilizing orange peels for essential oil production. J Engineer Applied Sci. 2018; 13(1): 17-27. [https://doi.org/10.1016/j.heliyon.2018.e00893].
  25. Ayala-Zavala JF et al. Agro-industrial potential of exotic fruit byproducts as a source of food additives. Food Res Inter. Aug 2011; 44(7): 1866-1874. ISSN 0963-9969. Available at: [https://doi.org/10.1016/j.foodres.2011.02.021].
  26. Zhang QW, Lin LG, Ye WC. Techniques for extraction and isolation of natural products: a comprehensive review. Chinese Med. Apr 2018; 13(26):. ISSN 1749-8546. Available at: [https://doi.org/10.1186/s13020-018-0177-x].
  27. Gavahian M, Chu YH, Khaneghah AM. Recent advances in orange oil extraction: an opportunity for the valorisation of orange peel waste a review. Inter J Food Sci Technol. Apr 2019; 54(4): 925-932. ISSN 0950-5423. Available at: [https://doi.org/10.1111/ijfs.13987].
  28. Attard TM et al. Microwave assisted extraction as an important technology for valorising orange waste. New J Chem. Jun 2014; 38(6): 2278-2283. ISSN 1144-0546. Available at: [https://doi.org/10.1039/c4nj00043a].
  29. Bustamante J et al. Microwave assisted hydro-distillation of essential oils from wet citrus peel waste. J Cleaner Prod. Nov 2016; 137: 598-605. ISSN 0959-6526. Available at: [https://doi.org/10.1016/j.jclepro.2016.07.108].
  30. Mcclements DJ, Rao J. Food-Grade Nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Critical Rev Food Sci Nutr. 2011; 51(4): 285-330. ISSN 1040-8398. Available at: [https://doi.org/10.1080/10408398.2011.559558].
  31. Mcclements DJ. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter. 2012; 8(6): 1719-1729. ISSN 1744-683X. Available at: [https://doi.org/10.1039/c2sm06903b].
  32. Ghosh V, Mukherjee A, Chandrasekaran N. Formulation and characterization of plant essential oil based nanoemulsion: evaluation of its larvicidal activity against Aedes aegypti. Asian Journal of Chemistry. 2013; 25: S321-S323. ISSN 0970-7077. Available at: [https://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=6DkdTIOkvBcl2xaAQ1f&page=1&doc=1].
  33. Lucia A et al. Development of an environmentally friendly larvicidal formulation based on essential oil compound blend to control Aedes aegypti Larvae: correlations between physicochemical properties and insecticidal activity. Acs Sustainable Chem Engineer. Jul 2020; 8(29): 10995-11006. ISSN 2168-0485. Available at: [https://doi.org/10.1021/acssuschemeng.0c03778].
  34. Botas GD et al. Baccharis reticularia DC. and Limonene Nanoemulsions: promising larvicidal Agents for Aedes aegypti (Diptera: Culicidae) control. Molecules. Nov 2017; 22(11): 14. Available at: [https://doi.org/10.3390/molecules22111990].
  35. Ferreira TP et al. Prolonged mosquitocidal activity of Siparuna guianensis essential oil encapsulated in chitosan nanoparticles. Plos Neglec Trop Dis. Aug 2019; 13(8): 23. ISSN 1935-2735. Available at: [https://doi.org/10.1371/journal.pntd.0007624].
  36. Silva LS et al. Encapsulation of Piper aduncum and Piper hispidinervum essential oils in gelatin nanoparticles: a possible sustainable control tool of Aedes aegypti, Tetranychus urticae and Cerataphis lataniae. J Sci Food Agric. Jan 2019; 99(2): 685-695. ISSN 0022-5142. Available at: [https://doi.org/10.1002/jsfa.9233].
  37. Filly A et al. Solvent-free microwave extraction of essential oil from aromatic herbs: from laboratory to pilot and industrial scale. Food Chem. May 2014; 150: 193-198. ISSN 0308-8146. Available at: [https://doi.org/10.1016/j.foodchem.2013.10.139].
  38. Turek C, Stintzing FC. Stability of essential oils: a review. Comprehen Rev Food Sci Food Safety. Jan 2013; 12(1): 40-53. ISSN 1541-4337. Available at: [https://doi.org/10.1111/1541-4337.12006].
  39. Pavela R, Benelli G. Essential Oils as Ecofriendly Biopesticides? Challenges and Constraints. Trends Pl Sci. Dec 2016; 21(12): 1000- 1007. ISSN 1360-1385. Available at: [https://doi.org/10.1016/j.tplants.2016.10.005].
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Author(s)

  • Juliana Pereira Welbert
    Oswaldo Cruz Foundation (Fiocruz), Oswaldo Cruz Institute, Insect Biochemistry and Physiology Laboratory. Avenida Brasil, 4365, pavilion Leônidas Deane, Manguinhos, CEP 21040-900, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0009-0005-5133-5294
  • Fernando Ariel Genta
    Oswaldo Cruz Foundation (Fiocruz), Oswaldo Cruz Institute, Insect Biochemistry and Physiology Laboratory. Avenida Brasil, 4365, pavilion Leônidas Deane, Manguinhos, CEP 21040-900, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0000-0001-9558-1116
  • Bruno Gomes
    Oswaldo Cruz Foundation (Fiocruz), Oswaldo Cruz Institute, Insect Biochemistry and Physiology Laboratory. Avenida Brasil, 4365, pavilion Leônidas Deane, Manguinhos, CEP 21040-900, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0000-0003-3877-2359
  • Maria Helena Durães Alves Monteiro
    Oswaldo Cruz Foundation (Fiocruz), Institute of Technology in Pharmaceuticals-Farmanguinhos, Center for Innovation in Biodiversity and Health (CIBS). Avenida Comandante Guaranys, 447, building 10, Jacarepaguá, CEP 22775-903, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0000-0001-7434-5544

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Potential use of organic residues from the industrial production of Citrus sinensis orange juice to obtain essential oil to control Aedes aegypti. Rev Fitos [Internet]. 2024 Mar. 7 [cited 2025 Feb. 17];18(Suppl. 3):e1585. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1585
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