Pharmacological evidence regarding medicinal plants used for the treatment of rheumatoid arthritis and osteoarthritis (osteoarthrosis)

Prof. Leopoldo Clemente Baratto
OrcID
Mrs. Katharine Augusto da Silva Monteiro
OrcID
Mrs. Beatriz Prata Pereira
OrcID

    Prof. Leopoldo Clemente Baratto

    Federal University of Rio de Janeiro, Rectory, CCS, Faculty of Pharmacy, DPNA. Av. Carlos Chagas Filho, 373, CCS, Block A, 2nd floor, Room 30, Ilha do Fundão - Cidade Universitária, CEP 21941-590, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0000-0002-7125-7431

    Adjunct Professor at the Federal University of Rio de Janeiro-UFRJ, Faculty of Pharmacy, Department of Natural Products and Food-DPNA. Current Vice-President of the Brazilian Society of Pharmacognosy (SBFgnosia) in the 2023-2025 term; he was President of SBFgnosia in the 2017-2019 and 2019-2021 biennia and Vice-President in the 2021-2023 term. From August 2014 to December 2015 he was Adjunct Professor at the Federal University of Western Pará-UFOPA, Institute of Public Health, Pharmacy Course, on the Santarém-PA Campus. He has a degree in Pharmacy from the Federal University of Santa Catarina (UFSC) and Master's (2010) and Doctor (2013) titles in Pharmaceutical Sciences from the Federal University of Paraná (UFPR). From April 2012 to March 2013 he completed a doctoral internship abroad (sandwich period), at the Martin-Luther-Universität in Halle (Saale) - Germany, in the research group of Prof. Dr Reinhard Paschke. He works in the areas of Pharmacognosy and Natural History, and coordinates research projects on Natural History, Historical Ethnobotany, Ethnopharmacology and evidence-based Phytotherapy. He is a collaborating professor linked to the Postgraduate Programs in Pharmaceutical Science and Technology at UFRJ (CETECFAR / UFRJ) and in Health Sciences at UFOPA (PPGCSA / UFOPA). He works in the area of Scientific Dissemination, focusing on social media. He coordinates an extension project that has a scientific dissemination channel about medicinal plants on social media, PlantaCiência (@plantaciencia / www.plantaciencia.com), with more than 32 thousand followers (Instagram, Facebook, Twitter and YouTube).

    Mrs. Katharine Augusto da Silva Monteiro

    Federal University of Rio de Janeiro, Rectory, CCS, Faculty of Pharmacy, DPNA. Av. Carlos Chagas Filho, 373, CCS, Block A, 2nd floor, Room 30, Ilha do Fundão - Cidade Universitária, CEP 21941-590, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0009-0009-7305-5639

    Bachelor's degree in pharmacy from the Federal University of Rio de Janeiro.

    Mrs. Beatriz Prata Pereira

    Federal University of Rio de Janeiro (UFRJ), Applied Pharmacognosy Laboratory, Rectory, CCS, Faculty of Pharmacy, DPNA. Av. Carlos Chagas Filho, 373, CCS, Bloco A, 2nd floor, Room 30, Ilha do Fundão, Cidade Universitária, CEP 21941-590, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0009-0003-1617-5315

    Studying Pharmacy at the Federal University of Rio de Janeiro (UFRJ). Technician in Industrial Automation with completed high school from CEFET/RJ Campus Maria da Graça.

Keywords

Harpagophytum procumbens
Hypericum perforatum
Miconia albicans
Uncaria tomentosa
Varronia curassavica

Abstract

Rheumatoid arthritis (RA) and osteoarthritis (OA) are social impact disorders that lead to intense pain, deformities, and inability to perform daily and work-related activities. In Brazil, despite the National Policies for Integrative and Complementary Practices (PNPIC) and Medicinal Plants and Phytotherapies (PNPMF) that have expanded access to Phytotherapy, the incorrect dissemination of the use of medicinal plants remains common, often without any scientific evidence of efficacy. The aim of this study was to select some plants popularly recommended on the internet for treating RA and OA and to gather data on their efficacy and safety. These plants include Harpagophytum procumbens, Hypericum perforatum, Miconia albicans, Uncaria tomentosa, and Varronia curassavica. A literature review covering in vitro, preclinical, and clinical trials revealed promising results regarding the action of these plants on RA and OA. Most studies emphasize the anti-inflammatory, anti-arthritic, and analgesic effects of these species. However, as the mechanisms are not yet fully understood, further studies, particularly clinical trials, are necessary to reach a more definitive conclusion. This literature review can contribute to and alert healthcare professionals and patients seeking these products for the treatment of rheumatic diseases.

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Author(s)

  • Prof. Leopoldo Clemente Baratto
    Federal University of Rio de Janeiro, Rectory, CCS, Faculty of Pharmacy, DPNA. Av. Carlos Chagas Filho, 373, CCS, Block A, 2nd floor, Room 30, Ilha do Fundão - Cidade Universitária, CEP 21941-590, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0000-0002-7125-7431
  • Mrs. Katharine Augusto da Silva Monteiro
    Federal University of Rio de Janeiro, Rectory, CCS, Faculty of Pharmacy, DPNA. Av. Carlos Chagas Filho, 373, CCS, Block A, 2nd floor, Room 30, Ilha do Fundão - Cidade Universitária, CEP 21941-590, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0009-0009-7305-5639
  • Mrs. Beatriz Prata Pereira
    Federal University of Rio de Janeiro (UFRJ), Applied Pharmacognosy Laboratory, Rectory, CCS, Faculty of Pharmacy, DPNA. Av. Carlos Chagas Filho, 373, CCS, Bloco A, 2nd floor, Room 30, Ilha do Fundão, Cidade Universitária, CEP 21941-590, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0009-0003-1617-5315

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Pharmacological evidence regarding medicinal plants used for the treatment of rheumatoid arthritis and osteoarthritis (osteoarthrosis). Rev Fitos [Internet]. 2024 Jul. 2 [cited 2025 Mar. 10];18:e1635. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1635
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