Plant species described in an Atlantic Forest biosphere reserve area as a source for new bioactive compounds

Mr. Fernando Vítor de Vasconcelos Rodrigues Silva
OrcID
Dr. Gloria Narjara Santos da Silva
OrcID

    Mr. Fernando Vítor de Vasconcelos Rodrigues Silva

    Federal University of Bahia, Faculty of Pharmacy. Barão de Jeremoabo Street, Ondina, CEP 40170-115, Salvador, BA, Brazil.

    OrcID https://orcid.org/0009-0005-9425-2712

    Graduation in progress in Pharmacy from the Federal University of Bahia (UFBA)

    Dr. Gloria Narjara Santos da Silva

    Federal University of Bahia, Faculty of Pharmacy. Barão de Jeremoabo Street, Ondina, CEP 40170-115, Salvador, BA, Brazil.

    OrcID https://orcid.org/0000-0002-6584-201X

    He holds a degree in Pharmacy (2008) and a Master's degree in Pharmaceutical Sciences (2010) from the Federal University of Santa Maria (UFSM). He holds a PhD in Pharmaceutical Sciences (2014) from the Federal University of Rio Grande do Sul (UFRGS), with a sandwich internship at the Laboratory of Molecular and Cellular Biology of Plasmodium at the University of São Paulo (USP) (2011) and at the Department of Pharmacology and Physiology at Rutgers, The University of New Jersey, Newark, NJ, USA, (2013). Post-doctorate in the Graduate Program in Pharmaceutical Sciences - UFRGS (2014-2015) and Queen Mary University of London (QMUL), UK, (2016-2017). Advisor and professor in undergraduate and graduate courses at Universidade Regional Integrada (URI), Campus Frederico Westphalen, RS, (2014-2018) and at Universidade Federal de Goiás (UFG) as a substitute professor (2019-2021). Post-doctorate in the Postgraduate Program in Biological Sciences - PPGCB / UFG (2020-2021). Currently, she works as a Professor of Higher Education, Adjunct A, Class A, level II, in an Exclusive Dedication regime, in the Department of Medicine of the Faculty of Pharmacy of the Federal University of Bahia (UFBA). Main experience in research in the areas of medicinal chemistry and pharmacognosy, with emphasis on isolation, semi-synthesis, structural elucidation and evaluation of biological activity of plant chemical constituents and derivatives, especially of the terpene class.

Keywords

Parque das Dunas
Plant species
Atlantic Forest
Pharmacological Properties
Toxic Profile
In silico prediction
Secondary metabolites

Abstract

 This work consists of a systematic review of the literature related to the plant species cataloged in Parque das Dunas, Salvador-BA, a region acclaimed by the title of Atlantic Forest biosphere reserve by UNESCO (United Nations Educational, Scientific and Cultural Organization). We included studies containing data on pharmacological activity, phytochemical and toxic profile of the species, from PUBMED, SCIELO and SCIENCE DIRECT databases, in Portuguese and English, without a delimited period. The scientific names of the thirty cataloged species were used as descriptors. The physicochemical parameters and prediction in silico toxicity were evaluated for the isolated and active compounds. As a result, it was verified that of the thirty species, twelve were investigated for pharmacological activity and/or phytochemical and toxic profile, and 33% of the studies involving Chrysobalanus icaco L. (Chrysobalanaceae). Twenty-five bioactive compounds isolated predominantly of the terpene and flavonoid classes, and in eighteen studies the safety of seven species was evaluated. The in silico analysis showed ten compounds did not violate the Lipinski and Veber rules, and only three with high toxic potential. This review gathers data that point to the use of natural products from Brazilian territory in research that may culminate in development of innovative drugs. 

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Author(s)

  • Mr. Fernando Vítor de Vasconcelos Rodrigues Silva
    Federal University of Bahia, Faculty of Pharmacy. Barão de Jeremoabo Street, Ondina, CEP 40170-115, Salvador, BA, Brazil.
    https://orcid.org/0009-0005-9425-2712
  • Dr. Gloria Narjara Santos da Silva
    Federal University of Bahia, Faculty of Pharmacy. Barão de Jeremoabo Street, Ondina, CEP 40170-115, Salvador, BA, Brazil.
    https://orcid.org/0000-0002-6584-201X

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Plant species described in an Atlantic Forest biosphere reserve area as a source for new bioactive compounds. Rev Fitos [Internet]. 2024 Oct. 9 [cited 2024 Nov. 21];18. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1731
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