Espécies vegetais descritas em área de reserva da biosfera da Mata Atlântica como fonte para novos compostos bioativos

Fernando Vítor de Vasconcelos Rodrigues Silva
OrcID
Gloria Narjara Santos da Silva
OrcID

    Fernando Vítor de Vasconcelos Rodrigues Silva

    Universidade Federal da Bahia

    OrcID https://orcid.org/0009-0005-9425-2712

    Graduação em curso em Farmácia pela Universidade Federal da Bahia (UFBA)

    Gloria Narjara Santos da Silva

    Universidade Federal da Bahia

    OrcID https://orcid.org/0000-0002-6584-201X

    Possui graduação em Farmácia (2008) e Mestrado em Ciências Farmacêuticas (2010) pela Universidade Federal de Santa Maria (UFSM). Doutorado em Ciências Farmacêuticas (2014) pela Universidade Federal do Rio Grande do Sul (UFRGS), com estágio sandwich no Laboratório de Biologia Molecular e Celular do Plasmodium da Universidade de São Paulo (USP) (2011) e no Departamento de Farmacologia e Fisiologia da Rutgers, The University of New Jersey, Newark, NJ, USA, (2013). Pós-Doutorado no Programa de Pós-Graduação em Ciências Farmacêuticas- UFRGS (2014-2015) e Queen Mary University of London (QMUL), UK, (2016-2017). Atuação como orientadora e docente em disciplinas nível graduação e pós-graduação na Universidade Regional Integrada (URI), Campus Frederico Westphalen, RS, (2014-2018) e na Universidade Federal de Goiás (UFG) como professora substituta (2019-2021). Pós-doutorado no Programa de Pós-Graduação em Ciências Biológicas- PPGCB/UFG (2020-2021). Atualmente, atua como Professora do Magistério Superior, denominação Adjunto A, Classe A, nível II, em regime de Dedicação Exclusiva, no Departamento do Medicamento da Faculdade de Farmácia da Universidade Federal da Bahia (UFBA). Principal experiência na pesquisa nas áreas de química medicinal e farmacognosia, com ênfase em isolamento, semissíntese, elucidação estrutural e avaliação de atividade biológica de constituintes químicos vegetais e derivados, especialmente da classe dos terpenos.

Palavras-chave

Parque das Dunas
Espécies vegetais
Mata Atlântica
Propriedades Farmacológicas
Perfil Tóxico
Predição in silico
Metabólitos secundários

Resumo

Esse trabalho consistiu na revisão sistemática da literatura referente às espécies vegetais catalogadas no Parque das Dunas de Salvador - BA, região aclamada com o título de reserva da biosfera da Mata Atlântica pela UNESCO (United Nations Educational, Scientific and Cultural Organization). O critério de inclusão foram pesquisas sobre atividade farmacológica, perfil fitoquímico e tóxico das espécies, das bases de dados PubMed, SciELO e Science Direct, em português e inglês, sem período delimitado. Como descritores foram utilizados os nomes científicos das trinta espécies catalogadas. Os metabólitos secundários isolados e ativos tiveram os parâmetros físico-químicos e predição da toxicidade in silico avaliados. Verificou-se que, das trinta espécies doze foram investigadas quanto à atividade farmacológica e/ou perfil fitoquímico e tóxico, com maioria dos estudos envolvendo Chrysobalanus icaco L. (Chrysobalanaceae). Encontrou-se vinte cinco compostos bioativos, predominantemente das classes terpeno e flavonoide, e dezoito estudos com avaliação da segurança de sete espécies. A análise in silico mostrou que dez compostos não violaram as regras de Lipinski e Veber, e apenas três com alto potencial tóxico. Essa revisão reuniu dados que apontaram para a utilização de produtos naturais do território brasileiro em pesquisas que poderão culminar no desenvolvimento de fármacos inovadores. 

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Espécies vegetais descritas em área de reserva da biosfera da Mata Atlântica como fonte para novos compostos bioativos. Rev Fitos [Internet]. 9º de outubro de 2024 [citado 14º de novembro de 2024];18. Disponível em: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1731
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