Croton Genus and Relevant Aspects of Clerodane Diterpenes

M. A. M. Maciel
J. K. P. C. Cortez
F. E. S. Gomes

Keywords

Croton
Clerodanes
Chemistry
Pharmacology
Croton cajucara
trans-Desidrocrotonin

Abstract

The genus Croton (Euphorbiaceae) is widely distributed around the world, with significant concentration in Africa, Brazil, and México. The species Croton zambesicus Muell Arg. (Africa), Croton lechleri Muell Arg. (USA), and Croton tiglium Klotzsch (Asia), lead the international researches with 58 papers. Among the native species from Brazil, Croton cajucara Benth, Croton zehntneri Pax et Hoffm., and Croton sonderianus Müll Arg. are distinguished for being the most representatives with 86 papers. The Croton cajucara was investigated in a multidisciplinary scientific context representing the most studied specie with 60 published papers. The most abundant source of clerodane-type diterpenes are plants from genus Teucrium (Labiatae). However, the genus Ajuga, Scutellaria, Clerodendrum, and Croton also represents a rich source of clerodanes. The species Croton schiedeanus Schlecht, Croton sonderianus, and Croton cajucara Benth are rich sources of clerodanes. Actually, the ditepene-type 19-nor-clerodane trans-dehydrocrotonin (DCTN) is one of the most representative diterpene-type clerodane since it is correlated with the main biological properties of Croton cajucara. This paper focuses relevants aspects about the genus Croton and clerodane, with special emphasizes on chemical and pharmacological results obtained with the medicinal specie Croton cajucara.

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  • M. A. M. Maciel
    Universidade Federal do Rio Grande do Norte, Departamento de Química, Campus Universitário, 59072-970 Natal, RN, Brasil
  • J. K. P. C. Cortez
    Universidade Federal do Rio Grande do Norte, Departamento de Química, Campus Universitário, 59072-970 Natal, RN, Brasil
  • F. E. S. Gomes
    Universidade Federal do Rio Grande do Norte, Departamento de Química, Campus Universitário, 59072-970 Natal, RN, Brasil

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Croton Genus and Relevant Aspects of Clerodane Diterpenes. Rev Fitos [Internet]. 2006 Dec. 1 [cited 2026 May 7];2(03):54-73. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/59
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