O gênero Croton e Aspectos Relevantes de Diterpenos Clerodanos

Referências

1. ABDON, A.P.V.; CARDOSO, J.H.L.; SOUZA, A.N.C.; MORAIS, S.M.; SANTOS, C.F. Antinociceptive effects of the essential oil of Croton nepetaefolius on mice. Brazilian Journal of Medical and Biological Research, v.35, n.10, p.1215-1219, 2002.
2. ABO, K.A.; OGUNLEYE, V.O.; ASHIDI, J.S. Antimicrobial potential of Spondias mombin, Croton zambesicus and Zygotritonia crocea. Phytotherapy Research, v.13, n.6, p.494-497, 1999.
3. ADDAE-MENSAH, I.; WAIBEL, R.; ACHENBACH, H.; MURIUKI, G.; PEARCE, C.; SANDERS, J.K.M. Constituents of tropical medicinal plants. Part 37. A clerodane diterpene and other constituents of Croton megalocarpus. Phytochemistry, v.28, n.10, p.2759-2761, 1989.
4. ADDAE-MENSAH, I.; ACHENBACH, H.; THOITHI, G.N.; WAIBEL, R.; MWANGI, J.W. Constituents of tropical medicinal plants. 51. Epoxychiromodine and other constituents of Croton megalocarpus. Phytochemistry, v.31, n.6, p.2055-2058, 1992.
5. AGNER, A.R.; MACIEL, M.A.M.; PINTO, A.C.; PAMPLONA, S.G.S.R.; CÓLUS, I.M.S. Investigation of genotoxicity activity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara. Teratogenesis Carcinogenesis and Mutagenesis, v.19, n.6, p.377-384, 1999.
6. AGNER, A.R.; MACIEL, M.A.M.; PINTO, A.C.; CÓLUS, I.M.S., Antigenotoxicity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara. Planta Medica, v.67, n.9, p.815-819, 2001.
7. AKHILA, A.; RANI, K.; THAKUR, R.S. Biosynthesis of the clerodane furano-diterpene lactone skeleton in Tinospora cordifolia. Phytochemistry, v.30, n.8, p.2573-2576, 1991.
8. ALBUQUERQUE, A.A.C.; SORENSON, A.L.; LEALCARDOSO, J.H. Effects of essential oil of Croton zehntner, and of anethole and estragole on skeletal muscles. Journal of Ethnopharmacology, v.49, n.1, p.41-49, 1995.
9. ALEXANDER, I.C.; PASCOE, K.O.; MANCHARD, P.; WILLIAMS, L.A.D. An insecticidal diterpene from Croton linearis. Phytochemistry, v.30, n.6, p.1801-1803, 1991.
10. ALMEIDA, A.B.A.; MELO, P.S.; HIRUMA-LIMA, C.A.; GRACIOSO, J.S.; CARLI, L.; NUNES, D.S.; HAUN, M.; SOUZA-BRITO, A.R.M. Antiulcerogenic effect and cytotoxic activity of semi-synthetic crotonin obtained from Croton cajucara Benth. European Journal of Pharmacology, v.472, n.3, p.205-212, 2003.
12. ANAZETTI, M.C.; MELO, P.S.; DURÁN, N.; HAUN M. Comparative cytotoxicity of dimethylamide-crotonin in the promyelocytic leukemia cell line (HL60) and human peripheral blood mononuclear cells. Toxicology, v.188, n.2-3, p.261-274, 2003.
13. ANAZETTI, M.C.; MELO, P.S.; DURÁN, N.; HAUN M. Dehydrocrotonin and its derivative, dimethylamide-crotonin induce apoptosiswith lipid peroxidation and activation of caspases-2, -6, and -9 in human leukemic cells HL60. Toxicology, v.203, n.1-3, p.123-137, 2004.
14. APPENDINO, G.; BORRELLI, F.; CAPASSO, R.; CAMPAGNUOLO, C.; FATTORUSSO, E.; PETRUCCI, F.; TAGLIALATELA-SCAFATI, O. Minor diterpenoids from Cascarilla (Croton eluteria Bennett) and evaluation of the cascarilla extract and cascarillin effects on gastric acid secretion. Journal of Agricultural and Food Chemistry, v.51, n.24, p.6970-6974, 2003.
15. ARROYO, E.R.; HOLCOMB, J. Structural studies of an active principle from Croton tiglium. Journal of Medicine Chemistry, v.8, n.5, p.672-675, 1965.
16. ASADA, T.; TSUKAMOTO, M.; IIO, H.; TOKOROYAMA, T. Synthetic studies on clerodane diterpenoids. One-pot stereospecific construction of cis-clerodan skeleton by multiply stereocontrolled cyclization and total syntheses of natural products. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu, v.28, p.377-384, 1986.
17. BACCELLI, C.; BLOCK, S.; VAN HOLLE, B.; SCHANCK, A.; CHAPON, D.; TINANT, B.; VAN MEERVELT, L.; MOREL, N.; QUETIN-LeCLERCQ, J. Diterpenes isolated from Croton zambesicus inhibit KCl-induced contraction. Planta Medica, v.71, n.11, p.1036-1039, 2005.
18. BANERJEE, K.K.; SEN, A. Purification and properties of a lectin from the seeds of Croton tiglium with hemolytic activity toward rabbit red cells. Archives of Biochemistry and Biophysics, v.212, n.2, p.740-753, 1981.
19. BANERJEE, K.K.; SEN, A. Glycolipid-dependent agglutination of liposomes by Croton tiglium lectin. FEBS Letters, v.162, n.2, p.248-251, 1983.
20. BARRETO Jr., A.G.; BISCAIA Jr., E.C.; VEIGA Jr., V.F.; PINTO, A.C.; CARVALHAES, S.F.; MACIEL, M.A.M. Ion-exchange chromatography applied to the isolation of acidic fraction from copaiba (Copaifera multijuga) oil and from sacaca (Croton cajucara). Química Nova, v.28, n.4, p.719-722, 2005.
21. BARKOVICH, R.; LIAO, J.C. Metabolic engineering of isoprenoids. Metabolic Engineering, v.3, n.1, p.27-39, 2001.
22. BATATINHA, M.J.M.; SOUZA-SPINOSA, H.; BERNARDI, M.M. Croton zehntneri: Possible central nervous system effects of the essential oil in rodents. Journal of Ethnopharmacology, v.45, n.1, p.53-57, 1995.
23. BERNARDI, M.M.; SOUZA-SPINOSA, H.; BATATINHA, M.J.M.; GIORGI, R. Croton zehntneri: possible central nervous systems effects in rodents. Journal of Ethnopharmacology, v.33, n.3, p.285-287, 1991.
24. BIGHETTI, E.J.B.; HIRUMA-LIMA, C.A.; GRACIOSO, J.S.; SOUZA-BRITO, A.R.M. Anti-inflammatory and antinociceptive effects in rodents of the essential oil of Croton cajucara Benth. Journal of Pharmacy and Pharmacology, v.51, n.12, p.1447-1453, 1999.
25. BIGHETTI, E.J.B.; SOUZA-BRITO, A.R.M.; FARIA, E.C.; OLIVEIRA, H.C.F. Chronic treatment with bark infusion from Croton cajucara lowers plasma triglyceride levels in genetic hyperlipidemic mice. Canadian Journal of Physiology and Pharmacology, v.82, n.6, p.387-392, 2004.
26. BLOCK, S.; STEVIGNY, C.; PAUW-GILLET, M.C.; HOFFMANN, E.; LLABRÈS, G.; ADJAKIDJE, V.; QUETINLeCLERCQ, J. ent-Trachyloban-3â-ol, a new cytotoxic diterpene from Croton zambesicus. Planta Medica, v.68, n.7, p.647-649, 2002.
27. BLOCK, S.; BACCELLI, C.; TINANT, B.; VAN MEERVELT, L.; ROZENBERG, R.; JIWAN, J.L.-H.; LLABRÈS, G.; PAUWGILLET, M.-C.; QUETIN-LeCLERCQ, J. Diterpenes from the leaves of Croton zambesicus. Phytochemistry, v.65, n.8, p.1165-1171, 2004.
28. BLOCK, S.; GERKENS, P.; PEULEN, O.; JOLOIS, O.; MINGEOT-LeCLERCQ, M.P.; PAUW-GILLET, M.-C.; QUETIN-LeCLERCQ, J. Induction of apoptosis in human promyelocytic leukemia cells by a natural trachylobane diterpene. Anticancer Research, v.25, n.1A, p.363-368, 2005a.
29. BLOCK, S.; BRKIC, D.; HUBERT, P.; QUETIN-LeCLERCQ, J. A validated method for the quantification of primarane and trachylobane diterpenes in the leaves of Croton zambesicus by capillary gas chromatography. Phytochemical Analysis, v.16, n.5, p.342-348, 2005b.
30. BLOCK, S.; FLAMINI, G.; BRKIC, D.; MORELLI, I.; QUETINLeCLERCQ, J. Analysis of the essential from leaves of Croton zambesicus Muell. Arg. growing in Benin. Flavour and Fragrance Journal, v.21, n.2, p.222-224, 2006.
31. BOONYARATHANAKORNKIT, L.; CHE, C.T.; FONG, H.H.; FARNSWORTH, N.R. Constituents of Croton crassifolius roots. Planta Medica, v.54, n.1, p.61-63, 1988.
32. BOYOM, F.F.; KEUMEDJIO, F.; DONGMO, P.M.J.; NGADJUI, B.T.; ZOLLO, P.H.A.; MENUT, C.; BESSIERE, J.M. Essential oils from Croton zambesicus Muell. Arg. growing in Cameroon. Flavour and Fragance Journal, v.17, n.3, p.215-217, 2002.
33. CAI, Y.; EVANS, F.J.; ROBERTS, M.F.; PHILLIPSON, J.D.; ZENK, M.H.; GLEBA, Y.Y. Biological and chemical investigation of Dragon’s Blood from Croton species of South America. Part 1. Polyphenolic compounds from Croton lechleri. Phytochemistry, v.30, n.6, p.2033-2040, 1991.
34. CAI, Y.; CHEN, Z.P.; PHILLIPSON, J.D. Biological and chemical investigation of Dragon’s Blood from Croton species of South America. Part 2. Diterpenes from Croton lechleri. Phytochemistry, v.32, n.3, p.755-760, 1993a.
35. CAI, Y.; CHEN, Z.P.; PHILLIPSON, J.D. Biological and chemical investigation of Dragon’s Blood from Croton species of South America. Part 3. Clerodane diterpenoids from Croton lechleri. Phytochemistry, v.34, n.1, p.265-268, 1993b.
36. CAMPAGNUOLO, C.; FATTORUSSO, E.; PETRUCCI, F.; TAGLIALATELA-SCAFATI, O.; APPENDINO, G.; MARQUEZ, N.; MUÑOZ, E. A prenylbisabolane with NF-êB inhibiting properties from Cascarilla (Croton eluteria). Bioorganic & Medicinal Chemistry, v.13, n.13, p.4238-4242, 2005.
37. CAMPOS, A.R.; ALBUQUERQUE, F.A.A.; RAO, V.S.N; MACIEL, M.A.M.; PINTO, A.C. Investigations on the antinociceptive activity of crude extracts from Croton cajucara leaves in mice. Fitoterapia, v.73, n.2, p.116-120, 2002.
38. CARLIN, L.; VAISBERG, A.J.; HAMMOND, G.B. Isolation of sinoacutine from the leaves of Croton lechleri. Planta Medica, v.62, n.1, p.90-91, 1996.
39. CARVALHO, J.C.T.; SILVA, M.F.C.; MACIEL, M.A.M.; PINTO, A.C.; NUNES, D.S.; LIMA, R.M.; BASTOS, J.K.; SARTI, S.J. Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara. Part 1. Planta Medica, v.62, n.5, p.402-404, 1996.
40. CARVALHO, F.C.; ARAÚJO FILHO, J.A.; RÊGO, M.C.; TELES, F.F.F. Flutuações dos níveis dos carboidratos de reserva disponíveis nas raízes e no caule do marmeleiro (Croton sonderianus Muell.Arg.), ao longo dos diferentes estádios fenológicos. Revista Brasileira de Zootecnia, v.27, n.4, p.670-675, 1998.
41. CHATTERJEE, A.; BANERJEE, A.; BOHLMANN, F. Crotocaudin: a rearranged labdane type nor-diterpene from Croton caudatus Geisel. Tetrahedron, v.33, n.18, p.2407-2414, 1977.
42. CHATTERJEE, A.; BANERJEE, A.; BOHLMANN, F. Isocrotocaudin, a new nor-clerodane-type diterpene from Croton caudatus. Phytochemistry, v.17, n.10, p.1777-1779, 1978.
43. CORRÊA, D.H.A.; MELO, P.S.; CARVALHO, C.A.A.; AZEVEDO, M.B.M.; DURÁN, N.; HAUN, M. Dehydrocrotonin and its â-cyclodextrin complex: Cytotoxicity in V79 fibroblasts and rat cultured hepatocytes. European Journal of Pharmacology, v.510, n.1-2, p.17-24, 2005.
44. CHEI, Z.P.; CAI, Y.; PHILLIPSON, J.D. Studies on the antitumor, antibacterial, and wound-healing properties of dragon’s blood. Planta Medica, v.60, n.6, p.541-545, 1994.
45. CHEN, M.-H.; ZHOU, K.-J.; FU, Z.-J.; PAN, K.-Z. Preliminary crystallographic studies of crotin II. Journal of Molecular Biology, v.234, n.3, p.908-909, 1993.
46. COSENTINO, R.M.; NORTE, M.C.B.; LAZARINI, C.A. Estragole-induced behavioral changes in rats. Phytotherapy Research, v.18, n.11, p.921-928, 2004.
47. COSTA, A.M.; PERLES, E.C.; FUJIWARA, F.Y.; IMAMURA, P.M. Synthesis of methyl dihydrohardwickiate and its C-4 epimer. Structural amendment of natural crolechinic acid. Phytochemistry, v.53, n.8, p.851-854, 2000.
48. CRAVEIRO, A.A.; ANDRADE, C.H.S.; MATOS, F.J.A.; ALENCAR, J.W. Anise-like flavor of Croton aff. Zehntneri Pax et Hoffm. Journal of Agricultural and Food Chemistry, v.26, n.3, p.772-773, 1978a.
49. CRAVEIRO, A.A.; SILVEIRA, E.R.; MATOS, F.J.A.; ALENCAR, J.W. Essential and fatty oils from Croton sonderianus. Revista Latinoamericana de Química, v.9, n.2, p.95-97, 1978b.
50. CRAVEIRO, A.A.; LEMOS, T.L.G. Interconversion of arylpropanoids in the essential oil of Croton aff. Zehntneri. Journal of Natural Products, v.43, n.5, p.634-636, 1980.
51. CRAVEIRO, A.A.; ANDRADE, C.H.S.; MATOS, F.J.A.; ALENCAR, J.W.; DANTAS, T.N.C. Fixed and volatile constituents of Croton aff. nepetaefolius. Journal of Natural Products, v.43, n.6, p.756-757, 1980.
52. CRAVEIRO, A.A.; SILVEIRA, E.R.; BRAZ FILHO, R.; MASCARENHAS, I.P. Sonderianin, a furanoid diterpene from Croton sonderianus. Phytochemistry, v.20, n.4, 852-854, 1981.
53. CRAVEIRO, A.A.; SILVEIRA, E.R. Two cleistanthane type diterpenes from Croton sonderianus. Phytochemistry, v.21, n.10, p.2571-2574, 1982.
54. DE-EKNAMKUL, W.; POTDUANG, B. Biosynthesis of â-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. Phytochemistry, v.62, n.3, p.389-398, 2003.
55. DESMARCHELIER, C.; SCHAUS, F.W.; COUSSIO, J.; CICCA, G. Effects of Sangre de Drago from Croton lechleri Muell.-Arg. on the production of active oxygen radicals. Journal of Ethnopharmacology, v.58, n.2, p.103-108, 1997.
56. DEV, S. CRC Handbook of Terpenoids: Diterpenoids. Florida: CRC Press, 1985.
57. DI STASI, L.C.; SANTOS, E.M.G.; SANTOS, C.M.; HIRUMA, C.A. Plantas Medicinais na Amazônia. São Paulo: UNESP, p.127, 1989.
58. ELLIGER, C.A.; ZINKEL, D.F.; CHAN, B.G.; WAISS JR., A.C. Diterpene acids as larval growth inhibitors. Cellular and Molecular Life Sciences, v.32, n.11, p.1364-1366, 1976.
59. EL-MEKKAWY, S.; MESELHY, M.R.; NAKAMURA, N.; HATTORI, M.; KAWAHATA, T.; OTAKE, T. 12-O-acetylphorbol-13-decanoate potently inhibits cytopathic effects of human immunodeficiency virus type 1 (HIV-1), without activation of protein kinase C. Chemical & Pharmaceutical Bulletin, v.47, n.9, p.1346-1347, 1999.
60. EL-MEKKAWY, S.; MESELHY, M.R.; NAKAMURA, N.; HATTORI, M.; KAWAHATA, T.; OTAKE, T. Anti-HIV-1 phorbol esters from the seeds of Croton tiglium. Phytochemistry, v.53, n.4, p.457-464, 2000.
61. ERDELMEIER, C.A.J.; VAN LEEUWEN, P.A.S.; KINGHORN, A.D. Phorbol diester constituents of Croton oil: separation by two-dimensional TLC and rapid purification utilizing reversedphase overpressure layer chromatography (RP-OPLC). Planta Medica, v.54, n.1, p.71-75, 1988.
62. ESMERALDINO, L.E.; SOUZA, A.M.; SAMPAIO, S.V. Evaluation of the effect of aqueous extract of Croton urucurana Baillon (Euphorbiaceae) on the hemorrhagic activity induced by the venom of Bothrops jararaca, using new techniques to quantify hemorrhagic activity in rat skin. Phytomedicine, v.12, n.8, p.570-576, 2005.
63. ESTEVES-SOUZA, A.; ECHEVARRIA, A.; PINTO, A.C.; MACIEL, M.A.M. Síntese e Avaliação Citotóxica de Derivados da trans-Desidrocrotonina, 26ª Reunião Anual-SBQ, 2003.
64. FARIAS, R.A.F.; NETO, M.F.O.; VIANA, G.S.B.; RAO, V.S.N. Effects of Croton cajucara extract on serum lipids of rats fed a high fat diet. Phytotherapy Research, v.10, n.8, p.697-699, 1996.
65. FARIAS, R.A.F.; RAO, V.S.N.; VIANA, G.S.B.; SILVEIRA, E.R.; MACIEL, M.A.M.; PINTO, A.C. Hypoglycemic effect of transdehydrocrotonin, a nor-clerodane diterpene from Croton cajucara. Planta Medica, v.63, n.6, p.558-560, 1997.
66. FARIAS, R.A.F.; GONZÁLEZ, R.P.; LEYVA, A.; MAIA, L.S.; MACIEL, M.A.M.; PINTO, A.C.; VEIGA JR., V.F.; PESSOA, C.; MORAES, M.O. Chromatographic fractions from Croton cajucara inhibit cell proliferation and induce differation in a human leukemia cell line. Journal of Cancer Integrative Medicine, v.3, n.2, p.75-80, 2005.
67. FATTORUSSO, E.; TAGLIALATELA-SCAFATI, O.; CAMPAGNUOLO, C.; SANTELIA, F.U.; APPENDINO, G.; SPAGLIARDI, P. Diterpenoids from Cascarilla (Croton eluteria Bennett). Journal of Agricultural and Food Chemistry, v.50, n.18, p.5131-5138, 2002.
68. FISCHER, H.; MACHEN, T.E.; WIDDICOMBE, J.H.; CARLSON, T.J.S.; STEVEN, R.K.; CHOW, J.W.S.; ILLEK, B. A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells. Journal of Ethnopharmacology, v.93, n.2-3, p.351-357, 2004.
69. FIGUEIREDO, M.R. Significado quimiossistemático de diterpenos. Universidade de São Paulo: São Paulo, p. 125, 1992.
70. FREIRE, A.C.G.; ASSIS, C.F.; FRICK, A.O.; MELO, P.S.; HAUN, M.; AOYAMA, H.; DURÁN, N.; SAUER, M.M.; KALLÁS, E.G.; FERREIRA, C.V. Influence o f protein phosphatase inhibitors on HL60 cells death induction by dehydrocrotonin. Leukemia Research, v.27, n.9, p.823-829, 2003a.
71. FREIRE A.C.G.; SILVA M.P.; AOYAMA H.; HAUN M.; DURAN N.; FERREIRA C.V. Cytotoxic effect of the diterpene lactone dehydrocrotonin from Croton cajucara on human promyelocytic leukemia cells. Planta Medica, v.69, n.1, p.67- 69, 2003b.
72. GIORGI, R.; BATATINHA, M.J.M.; BERNARDI, M.M.; SOUZASPINOSA, H.; SPINOSA, F.R.N.; PALERMO-NETO, J. Effects of Croton zehntneri aqueous extracts on some cholinergicand dopaminergic-related behaviours of laboratory rodents. Journal of Ethnopharmacology, v.34, n.2-3, p.189-193, 1991.
73. GOLDSMITH, D.J.; DESHPANDE, R. Total synthesis of ajugarin-IV and annonene: a Diels-Alder approach. Synlett, special issue, p.495-497, 1995.
74. GONZÁLES, A.G.; LUIS, J.G.; RAVELO, A.G. Plantas Iberoamericanas Fuentes de Moleculas Bioactivas. Tenerife: Litografia A. Romero, 1990.
75. GRASSI-KASSISSE, D.M.; WOLF-NUNES, V.; MIOTTO, A.M.; FARIAS-SILVA, E.; SOUZA-BRITO, A.R.M.; NUNES, D.S.; SPADARI-BRATFISCH, R.C. Sensitivity to β-adrenoceptor agonists of adipocytes from rats treated with an aqueous extract of Croton cajucara Benth. Journal of Pharmacy and Pharmacology, v.55, n.2, p.253-257, 2003.
76. GROSSMAN, R.B.; RASNE, R.M. Short Total Synthesis of Both the Putative and Actual Structures of the Clerodane Diterpenoid (±)-Sacacarin by Double Annulation. Organic Letters, v.3, n. 25, p.4027-4030, 2001.
77. GRYNBERG, N.F.; ECHEVARRIA, A.; LIMA, J.E.; PAMPLONA, S.G.S.R.; PINTO, A.C.; MACIEL, M.A.M. Anti-tumour activity of two 19-nor-clerodane diterpenes, trans-dehydrocrotonin and trans-crotonin, from Croton cajucara. Planta Medica, v.65, n.8, p.687-689, 1999.
78. GUERRERO. M.F.; CARRÓN, R.; MARTÍN, M.L.; SAN ROMÁN, L.; REGUERO, M.T. Antihypertensive and vasodilator effects of aqueous extracts from Croton schiedeanus Schlecht in rats. Journal of Ethnopharmacology, v.75, n.1, p.33-36, 2001.
79. GUERRERO. M.F.; PUEBLA, P.; CARRÓN, R.; MARTÍN, M.L.; ARTEAGA, L.; SAN ROMÁN, L. Assessment of the antihypertensive and vasodilator effects of ethanolic extracts of some Colombian medicinal plants. Journal of Ethnopharmacology, v.80, n.1, p.37-42, 2002a.
80. GUERRERO, M.F.; PUEBLA, P.; CARRÓN, R.; MARTÍN, M.L.; SAN ROMÁN, L. Quercetin 3,7-dimethyl ether: a vasorrelaxant flavonoid isolated from Croton schiedeanus. Journal of Pharmacy and Pharmacology, v.54, n.10, p.1373-1378, 2002b.
81. GUERRERO, M.F.; PUEBLA, P.; MARTÍN, M.L.; CARRÓN, R.; SAN ROMÁN, L; REGUERO, M.T.; ARTEAGA, L. Inhibitory effect of N(G)-nitro-L-arginine methyl ester on the antiadrenergic response elicited by ayanin in the pithed rat. Planta Medica, v.68, n.4, p.322-325, 2002c.
82. GUERRERO. M.F.; PUEBLA, P.; CARRÓN, R.; MARTÍN, M.L.; SAN ROMÁN, L. Vasorrelaxant effect of new neo-clerodane diterpenoids isolated from Croton schiedeanus. Journal of Ethnopharmacology, v.94, n.1, p.185-189, 2004.
83. GURGEL, L.A.; SILVA, R.M.; SANTOS, F.A.; MARTINS, D.T.; MATTOS, P.O.; RAO, V.S. Studies on the antidiarrhoeal effect of dragon’s blood from Croton urucurana. Phytotherapy Research, v.15, n.4, p.319-322, 2001.
84. GURGEL, L.A.; SIDRIM, J.J.C.; MARTINS, D.T.; CECHINEL FILHO, V.; RAO, V.S. In vitro antifungal activity of dragon’s blood from Croton urucurana against dermatophytes. Journal of Ethnopharmacology, v.97, n.2, p.409-412, 2005.
85. HAGEDORN, M.L.; BROWN, S.M. The constituents of cascarilla oil (croton eluteria Bennett). Flavour and Fragrance Journal, v.6, n.3, p.193-204, 1991.
86. HAGIWARA, H.; INOME, K.; UDA, H. A total synthesis of an antibacterial clerodane, 16-hydroxycleroda-3,13(14)Z-dien-15,16-olide. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry, v.7, p.757-764, 1995.
87. HANSON, J.R. Terpenoids. In: The Chemistry of Natural Products. Ed. Thompson, R. H., Glasgow: Blackie and Son Ltd., v.4, p.154, 1985.
88. HARUYAMA, H.; HATA, T.; OGISO, A.; TAMURA, C.; KITAZAWA, E. Structure of plaunolide, a new furanoid diterpene from Croton sublyratus, C20H20O5. Acta Crystallographica, v.C39, n.2, p.255-257, 1983.
89. HECKER, E.; KUBINYI, H.; SZCZEPANSKI, Ch.V.; HAERLE, E.; BRESCH, H. Phorbol, a new tetracyclic diterpene from Croton tiglium. Tetrahedron Letters, v.6, n.23, p.1837-1842, 1965.
90. HECKER, E.; BARTSCH, H.; BRESCH, H.; GSCHWENDT, M.; HAERLE, E.; KUBINYI, H.; SCHAIRER, H.U.; SZCZEPANSKI, Ch.V.; THIELMANN, H.W.; KREIBICH, G. Structure and stereochemistry of the tetracyclic diterpene phorbol from Croton tiglium L. Tetrahedron Letters, v.8, n.33, p.3165-3170, 1967.
91. HIRUMA-LIMA, C.A.; SPADARI-BRATFISCH, R.C.; GRASSIKASSISSE, D.M.; SOUZA-BRITO, A.R.M. Antiulcerogenic mechanisms of dehydrocrotonin, a diterpene lactone obtained from Croton cajucara. Planta Medica, v.65, n.4, p.325-330, 1999a.
92. HIRUMA-LIMA, C.A.; GRACIOSO, J.S.; NUNES, D.S.; SOUZA-BRITO, A.R.M. Effects of an essential oil from the bark of Croton cajucara Benth. on experimental gastric ulcer models in rats and mice. Journal of Pharmacy and Pharmacology, v.51, n.3, p.341-346, 1999b.
93. HIRUMA-LIMA, C.A.; GRACIOSO, J.S.; RODRÍGUEZ, J.A.; HAUN M.; NUNES, D.S.; SOUZA-BRITO, A.R.M. Gastroprotective effect of essential oil from Croton cajucara Benth. (Euphorbiacae). Journal of Ethnopharmacology, v.69, n.3, p.229-234, 2000.
94. HIRUMA-LIMA, C.A.; TOMA, W.; GRACIOSO, J.S.; ALMEIDA, A.B.A.; BATISTA, L.M.; MAGRI, L.; PAULA, A.C.B.; SOARES, F.R.; NUNES, D.S.; SOUZA-BRITO, A.R.M. Natural transCrotonin: The Antiulcerogenic Effect of Another Diterpene Isolated from the Bark of Croton cajucara Benth. Biological and Pharmaceutical Bulletin, v.25, n.4, p.452-456, 2002a.
95. HIRUMA-LIMA, C. A.; GRACIOSO, J. S.; BIGHETTI, E. J. B.; GRASSI-KASSISSE, D. M.; NUNES, D. S.; SOUZA-BRITO, A. R. M. Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa. Phytomedicine, v.9, n.6, p.523-529, 2002b.
96. ICHIHARA, Y.; TAKEYA, K.; HITOTSUYANAGI, Y.; MORITA, H.; OKUYAMA, S.; SUGANUMA, M.; FUJIKI, H.; MOTIDOME, M.; ITOKAWA, H. Cajucarinolide and isocajucarinolide: antiinflammatory diterpenes from Croton cajucara. Planta Medica, v.58, n.6, p.549-551, 1992.
97. IIO, H.; MONDEN, M.; OKADA, K.; TOKOROYAMA, T. Asymetric synthesis of clerodane diterpenoids. Total synthesis of (-)-methyl kolavenate. Journal of the Chemical Society: Chemical Communications, v.5, p.358-359, 1987.
98. ITO, Y.; KAWANISHI, M.; HARAYAMA, T.; TAKABAYASHI, S. Combined effect of the extracts from Croton tiglium, Euphorbia lathyris or Euphorbia tirucalli and n-butyrate on Epstein-Barr virus expression in human lymphoblastoid P3HR-1 and Raji cells. Cancer Letters, v.12, n.3, p.175-180, 1981.
99. ITOKAWA, H.; ICHIHARA, Y.; KOJIMA, H.; WATANABE, K.; TAKEYA, K. Nor-clerodane diterpenes from Croton cajucara. Phytochemistry, v.28, n.6, p.1667-1679, 1989.
100. ITOKAWA, H.; ICHIHARA, Y.; SHIMIZU, M.; TAKEYA, K.; MOTIDOME, M. Cajucarins A and B, new clerodane diterpenes from Croton cajucara, and their conformations. Chemical & Pharmaceutical Bulletin, v.38, n.3, p.701-705, 1990.
101. JONES, P.S.; LEY, S.V.; SIMPKINS, N.S.; WHITTLE, A.J. Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes. Tetrahedron, v.42, n.23, p.6519-6534, 1986.
102. KIM, J.H.; LEE, S.J.; HAN, Y.B.; MONN, J.J.; KIM, J.B. Isolation of isoguanosine from Croton tiglium and its antitunour activity. Archives of Pharmacal Research, v.17, n.2, p.115-118, 1994.
103. KINGHORN, A.D.; ERDELMEIER, C.A.J.. Analysis of croton oil by reversed-phase overpressure layer chromatography. Modern Methods of Plant Analysis, v.12, p.175-184, 1991.
104. KITAZAWA, E.; OGISO, A.; TAKAHASHI, S.; SATO, A.; KURABAYASHI, M.; KUWANO, H.; HATA, T.; TAMURA, C. Plaunol A and B, new antiulcer diterpene lactones from Croton sublyratus. Tetrahedron Letters, v.20, n.13, p.117-120, 1979.
105. KITAZAWA, E.; SATO, A.; TAKAHASHI, S.; KUWANO, H.; OGISO, A. Novel diterpene lactones with anti-peptic ulcer activity from Croton sublyratus. Chemical & Pharmaceutical Bulletin, v.28, n.1, p.227-234, 1980.
106. KITAZAWA, E.; OGISO, A. Two diterpene alcohols from Croton sublyratus. Phytochemistry, v.20, n.2, p.287-289, 1981.
107. KUBO, I.; ASAKA, Y.; SHIBATA, K. Insect growth inhibitory nor-diterpenes, cis-dehydrocrotonin and transdehydrocrotonin from Croton cajucara. Phytochemistry, v.30, n.8, p.2545-2546, 1991.
108. KUPCHAN, S.M.; UCHIDA, I.; BRANFMAN, A.R.; DAILEY Jr., R.G.; FEI, B.Y. Antileukemic principles isolated from Euphorbiaceae plants. Science, v.194, n.4227, p.571-572, 1976.
109. LAHLOU, S.; CARDOSO, J.H.L.; MAGALHÃES, P.J.C.; SOUZA, A.N.C.; DUARTE, G.P. Cardiovascular effects of the essential oil of Croton nepetaefolius in rats. Role of the autonomic nervous system. Planta Medica, v.65, n.6, p.553-557, 1999.
110. LAHLOU, S.; CARDOSO, J.H.L.; MAGALHÃES, P.J.C. Essential oil of Croton nepetaefolius decreases blood pressure through an action upon vascular smooth muscle: studies in DOCA-salt hypertensive rats. Planta Medica, v.66, n.2, p.138-143, 2000.
111. LAZARINI, C.A.; UEMA, A.H.; BRANDÃO, G.M.S.; GUIMARÃES, A.P.C.; BERNARDI, M.M. Croton zehntneri essential oil: effects on behavioral models related to depression and anxiety. Phytomedicine, v.7, n.6, p.477-481, 2000.
112. LIU, H.J.; HO, Y.L.; WU, J.D.; SHIA, K.S. An efficacious synthetic strategy for cis-clerodane diterpenoids. Application to the total synthesis of (±)-6â-acetoxy-2-oxokolavenool. Synlett, v.11, p.1805-1807, 2002.
113. LEMOS, T.L.G.; MACHADO, M.I.L.; MENEZES, J.E.S.A.; SOUSA, C.R. Essential oil of Croton cajucara. Journal of Essential Oil Research, v.11, n.4, p.411-412, 1999.
114. LOPES, M.T.; PERES, P.; PIZZOLATTI, M.G.; YUNES, R.A.; MONACHE, F.D. Clerodane diterpenes of Croton ururucana. Phytochemistry, v.49, n.1, p.171-174, 1998.
115. LOPES, D.; BIZZO, H.R.; SA, A.F.S.; PEREIRA, M.V.G. Linaloolrich essential oil from leaves of Croton cajucara Benth. Journal of Essential Oil Research, v.12, n.6, p.705-708, 2000.
116. LOPES, M.I.L.; SAFFI, J.; ECHEVERRIGARAY, S.; HENRIQUES, J.A.P.; SALVADOR, M. Mutagenic and antioxidant activities of Croton lechleri sap in biological systems. Journal of Ethnopharmacology, v.95, n.2-3, p.437-445, 2004.
117. LOURENÇO, A.; DE LA TORRE, M.C.; RODRÍGUEZ, B. Transformation of montanin A into isocrotocaudin. A revision of structures of crotocaudin and isocrotocaudin. Tetrahedron Letters, v.32, n.49, p.7305-7308, 1991.
118. LUNA-COSTA, A.M.; SILVA, J.C.R.; CAMPOS, A.R.; RAO, V.S.N.; MACIEL, M.A.M.; PINTO, A.C. Antiestrogenic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara. Phytotherapy Research, v.13, n.8, p.689-691, 1999.
119. MACIEL, M.A.M. Croton cajucara: Uma Escolha Etnobotânica, Tese de Doutorado em Química, Rio de Janeiro, IQ, UFRJ, 1997.
120. MACIEL, M.A.M.; PINTO, A.C.; BRABO, S.N.; ARRUDA, A.C. Estudo da variação dos teores de terpenóides bioativos isolados das cascas do caule de Croton cajucara, nativos e cultivados no estado do Pará. Revista da Universidade Rural, Série Ciências Exatas e da Terra, v.18/20, n.1/2, p.17-34, 1998a.
121. MACIEL, M.A.M.; PINTO, A.C.; BRABO, S.N.; SILVA, M.N. Terpenoids from Croton cajucara. Phytochemistry, v.49, n.3, p.823-828, 1998b.
122. MACIEL, M.A.M.; PINTO, A.C.; ARRUDA, A.C.; PAMPLONA, S.G.S.R.; VANDERLINE, F.A.; LAPA, A.J.; ECHEVARRIA, A.; GRYNBERG, N.F.; CÔLUS, I.M.S.; FARIAS, R.A.F.; LUNA COSTA, A.M.; RAO, V.S.N. Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara. Journal of Ethnopharmacology, v.70, n.1, p.41-55, 2000.
123. MACIEL, M.A.M., PINTO, A.C., VEIGA JR., V.F., MARTINS, J.R., GRYNBERG, N.F., ECHEVARRIA, A., LAPA, A.J.; VANDERLINDE, F.A Croton cajucara as an alternative to traditional medicine in a modern health system, Phytochem. Pharmacol. II Ser. Recent Prog. Med. Plants, v.8, p.502-517, 2002a.
124. MACIEL, M.A.M.; PINTO, A.C.; VEIGA JR., V.F. Plantas Medicinais: a necessidade de estudos multidisciplinares. Química Nova, v.25, n.3, p.429-438, 2002b.
125. MACIEL, M.A.M.; DANTAS, T.N.C.; PINTO, A.C.; ESTEVES-SOUZA, A.; GRYNBERG, N.F.; Pissinati, K.; ECHEVARRIA, A. Cytotoxic effects of natural and semi-syntetic cajucarinolides from Croton cajucara. Revista Brasileira de Ciências Farmacêuticas, v.39, p.212, 2003a. Como parte do 4th Congress Pharmaceutical Sciences-CIFARP, Ribeirão Preto, São Paulo, SP.
126. MACIEL, M.A.M.; PINTO, A.C.; KAISER, C.R. NMR and structure review of some natural fluroclerodanes. Magnetic Resonance in Chemistry, v.41, n.4, p.278-282, 2003b.
127. MACIEL, M.A.M., DANTAS, T.N.C., CÂMARA, J.K.P., PINTO, A.C., VEIGA JR., V.F., KAISER, C.R., PEREIRA, N.A., CARNEIRO, C.M.T.S., VANDERLINDE, F.A., LAPA A.J., AGNER, A.R., CÓLLUS, I.M.S., ECHEVARRIA-LIMA, J., GRYNBERG, N.F., ESTEVES-SOUZA, A., PISSINATE, K., ECHEVARRIA A. Pharmacological and biochemical profiling of lead compounds from traditional remedies: the case of Croton cajucara. In: Advances in Phytomedicine (Lead molecules from natural products, Discovery and New Trends), Eds. Khan, M.T.H.; Ather, A., v.2, chapter 14, p.229-257, 2006.
128. MAGALHÃES, P.J.C.; CRIDDLE, D.N.; TAVARES, R.A.; MELO, E.M.; MOTA, T.L.; CARDOSO, J.H.L. Intestinal myorelaxant and antispasmodic effects of the essential oil of Croton nepetaefolius and its constituents cineole, methyl-eugenol and terpineol. Phytotherapy Research, v.12, n.3, p.172-177, 1998.
129. MAGALHÃES, P.J.C.; LAHLOU, S.; SANTOS, M.A.V.; PRADINES, T.L.; CARDOSO, J.H.L. Myorrelaxant effects of the essential oil of Croton nepetaefolius on the contractile activity of the guinea-pig tracheal smooth muscle. Planta Medica, v.69, n.9, p.874-877, 2003.
130. MAGALHÃES, P.J.C.; LAHLOU, S.; CARDOSO, J.H.L. Antispasmodic effects of the essential oil of Croton nepetaefolius on guinea-pig ileum: A myogenic activity. Fundamental & Clinical Pharmacology, v.18, n.5, p.539-546, 2004.
131. MEKKAWI, A.G. The essential oil of Croton zambesicus. Fitoterapia, v.56, n.3, p.181-183, 1985.
132. MALDONADO, E.; ORTEGA, A. Polystachynes A-E, five cisneo-clerodane diterpenoids from Salvia polystachya. Phytochemistry, v.53, n.1, p.103-109, 2000.
133. MELO, P.S.; DURÁN, N.; HAUN M. Cytotoxicity of derivatives from dehydrocrotonin on V79 cells and Escherichia coli. Toxicology, v.159, n.3, p.135-141, 2001.
134. MELO P.S.; DURAN N.; HAUN M. Derivatives of dehydrocrotonin, a diterpene lactone isolated from Croton cajucara: cytotoxicity in rat cultured hepatocytes and in V79 cells. Human & Experimental Toxicology, v.21, n.5, p.281-288, 2002.
135. MELO, P.S.; DURÁN, N.; HIRUMA-LIMA, C.A.; SOUZA BRITO, A.R.M.; HAUN, M. Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives. Journal of Ethnopharmacology, v.87, n.2-3, p.169-174, 2003.
136. MELO, P.S.; JUSTO, G.Z.; DURÁN, N.; HAUN, M. Natural killer cell activity and anti-tumor effects of dehydrocrotonin and its synthetic derivatives. European Journal of Pharmacology, v.487, n.1-3, p.47-54, 2004.
137. MERRITT, A.T.; LEY, S.V. Clerodane diterpenoids. Natural Products Reports, v.9, p.243-287, 1992. McCHESNEY, J.D.; SILVEIRA, E.R.; CRAVEIRO, A.A.; SHOOLERY, J.N. The use of carbon-carbon connectivity in the structure determination of marmelerin, a novel benzofuran sesquiterpene from Croton sonderianus. Journal of Organic Chemistry, v.49, n.26, p.5154-5157, 1984.
138. McCHESNEY, J.D.; SILVEIRA, E.R. 12-Hydroxyhardwickic acid and sonderianial, neo-clerodanes from Croton sonderianus. Phytochemistry, v.28, n.12, p.3411-3414, 1989.
139. McCHESNEY, J.D.; SILVEIRA, E.R. Ent-clerodanes of Croton sonderianus. Fitoterapia, v.61, n.2, p.172-175, 1990.
140. McCHESNEY, J.D.; CLARK, A.M.; SILVEIRA, E.R. Antimicrobial diterpenes of Croton sonderianus. I. Hardwickic and 3,4-secotrachylobanoic acids. Journal of Natural Products, v.54, n.6, p.1625-1633, 1991a.
141. McCHESNEY, J.D.; CLARK, A.M.; SILVEIRA, E.R. Antimicrobial diterpenes of Croton sonderianus. I. ent-Beyer-15-en-18-oic acid. Pharmaceutical Research, v.8, n.10, p.1243-1247, 1991b.
142. MILANOWSKI, D.J.; WINTER, R.E.K.; ELVIN-LEWIS, M.P.F.; LEWIS, W.H. Geographic distribution of three alkaloid chemotypes of Croton lechleri. Journal of Natural Products, v.65, n.6, p.814-819, 2002.
143. MILO, B.; RISCO, E.; VILA, R.; IGLESIAS, J.; CANIGUERAL, S. Characterization of a fucoarabinogalactan, the main polysaccharide from the gum exudate of Croton urucurana. Journal of Natural Products, v.65, n.8, p.1143-1146, 2002.
144. MONGELLI, E.; DESMARCHELIER, C.; GIULIETTI, A.; COUSSIO, J.; CICCIA, G. Bioactivity of certain medicinal latexes used by the Ese’ejas. Journal of Ethnopharmacology, v.47, n.3, p.159-163, 1995.
145. MORAIS, S.M.; CATUNDA Jr., F.E.A.; SILVA, A.R.A.; MARTINS NETO, J.S.; RONDINA, D.; CARDOSO, J.H.L. Atividade antioxidante de óleos essenciais de espécies de Croton no nordeste do Brasil. Química Nova, v.29, n.5, p.907-910, 2006a.
146. MORAIS, S.M.; CAVALCANTI, E.S.B.; BERTINI, L.M.; OLIVEIRA, C.L.L.; RODRIGUES, J.R.B.; CARDOSO, J.H.L. Larvicidal activity of essential oils from Brazilian Crotons species against Aedes aegypti L. Journal of the American Mosquito Control Association, v.22, n.1, p.161-164, 2006b.
147. MOTL, O.; AMIN, M.; SEDMERA, P. Structure of cascarillic acid from cascarilla essential oil. Phytochemistry, v.11, n.1, p.407-408, 1972.
148. MUKHERJEE, R.; AXT, E.M. Cyclitols from Croton celtidifolius. Phytochemistry, v.23, n.11, p.2682-2684, 1984.
149. MOULIS, C.; BON, M.; JAUD, J.; FOURASTE, I. Crovatin, a furanoid diterpene from Croton levatii. Phytochemistry, v.31, n.4, p.1421-1423, 1992a.
150. MOULIS, C.; FOURASTE, I.; BON, M. Levatin, an 18-norclerodane diterpene from Croton levatii. Journal of Natural Products, v.55, n.4, p.445-449, 1992b.
151. MOURA, V.L.A.; MONTE, F.J.O.; BRAZ FILHO, R. A new casbane-type diterpenoid from Croton nepetaefolius. Journal of Natural Products, v.53, n.6, p.1566-1571, 1990.
152. NABETA, K.; ISHIKAWA, T.; OKUYAMA, H. Sesqui- and diterpene biosynthesis from 13C labelled acetate and mevalonate in cultured cells of Heteroscyphus planus. Journal of Chemical Society, Perkin Transactions I, p.3111-3115, 1995.
153. NGADJUI, B.T.; FOLEFOC, G.G.; KEUMEDJIO, F.; DONGO, E.; SONDENGAM, B. L.; CONNOLLY, J.D. Crotonadiol, a labdane diterpenoid from the stem bark of Croton zambesicus. Phytochemistry, v.51, n.1, p.171-174, 1999.
154. NGADJUI, B.T.; ABEGAZ, B.M.; KEUMEDJIO, F.; FOLEFOC, G.N.; KAPCHE, G.W.F. Diterpenoids from the stem bark of Croton zambesicus. Phytochemistry, v.60, n.4, p.345-349, 2002.
155. NORTE, M.C.B.; COSENTINO, R.M.; LAZARINI, C.A. Effects of methyl-eugenol administration on behavioral models related to depression and anxiety, in rats. Phytomedicine, v.12, n.4, p.294-298, 2005.
156. OHUCHI, K.; LEVINE, L. á -tocopherol inhibits 12-Otetradecanoyl-phorbol-13-acetate-stimulated deacylation of cellular lipids, prostaglandin production, and changes in cell morphology of Madin-Darby canine kidney cells. Biochimica et Biophysica Acta, Lipids and Lipid Metabolism, v.619, n.1, p.11-19, 1980.
157. OLIVEIRA, A.C.; LEAL-CARDOSO, J.H.; SANTOS, C.F.; MORAIS, S.M.; SOUZA, A.N.C. Antinociceptive effects of the essential oil of Croton zehntneri in mice. Revista Brasileira de Pesquisas Médicas e Biológicas, v.34, n.11, p.1471-1474, 2001.
158. OGISO, A.; KITAZAWA, E.; KURABAYASHI, M.; SATO, A.; TAKAHASHI, S.; NOGUCHI, H.; KUWANO, H.; KOBAYASHI, S.; MISHIMA, H. Isolation and structure of antipeptic ulcer diterpene from a Thai medicinal plant. Chemical & Pharmaceutical Bulletin, v.26, n.10, p.3117-3123, 1978.
159. ORTEGA, A.; GARCÍA, P.E.; CÁRDENAS, J.; MANCERA, C.; MARQUINA, S.; GARDUÑO, M.L.C.; MALDONADO, E. Methyl dodonates, a new type of diterpenes with a modified clerodane skeleton from Dodonaea viscosa. Tetrahedron, v.57, n.15, p.2981-2989, 2001.
160. PAULA, A.C.; TOMA, W.; GRACIOSO, J.S.; HIRUMA-LIMA, C.A.; CARNEIRO, E.M.; SOUZA-BRITO, A.R. The gastroprotective effect of the essential oil of Croton cajucara is different in normal rats than in malnourished rats. The British Journal of Nutrition, v.96, n.2., p.310-315, 2006.
161. PANDEY, R.; VERMA, R.K.; GUPTA, M.M. Neo-clerodane diterpenoids from Clerodendrum inerme. Phytochemistry, v.66, n.6, p.643-648, 2005.
162. PAX, F.; HOFFMAN, H. Die natürlichen Pflanzenfamilien. Ed. Engler, A., Prantil, K., Leipzig: Engelmann, 2ed., v.19C, p.208, 1931.
163. PERAZZO, F.F.; RODRIGUES, M.; CARVALHO, J.C.T.; MACIEL, M.A.M.; PINTO, A.C.; ARRUDA, A.C.; PAMPLONA, S.G.S.R. II World Congress on Medicinal and Aromatic Plants for Human Welfare, ICMAP-ISHS-SAIPA, Mendoza, República Argentina, p.378, 1997.
164. PERDUE, G.P.; BLOMSTER, R.N.; BLAKE, D.A.; FARNSWORTH, N.R. South America plants. II: Taspine isolation and anti-inflammatory activity. Journal of Pharmaceutical Sciences, v.68, n.1, p.124-126, 1979.
165. PERES, M.T.L.P.; MONACHE, F.D.; CRUZ, A.B.; PIZZOLATTI, M.G.; YUNES, R.A. Chemical composition and antimicrobial activity of Croton urucurana Baillon (Euphorbiaceae). Journal of Ethnopharmacology, v.56, n.3, p.223-226, 1997.
166. PERES, M.T.L.P.; MONACHE, F.D.; PIZZOLATTI, M.G.; SANTOS, A.R.S.; BEIRITH, A.; CALIXTO, J.B.; YUNES, R.A. Analgesic compounds of Croton urucurana Baillon. Pharmaco-chemical criteria used in their isolation. Phytotherapy Research, v.12, n.3, p.209-211, 1998a.
167. PERES, M.T.L.P.; PIZZOLATTI, M.G.; YUNES, R.A.; MONACHE, F.D. Clerodane diterpenes of Croton urucurana. Phytochemistry, v.49, n.1, p.171-174, 1998b.
168. PHILLIPSON, J.D. A matter of some sensitivity. Phytochemistry, v.38, n.6, p.1319-1343, 1995.
169. PIETERS, L.A.C.; VLIETINCK, A.J. Rotation locular countercurrent chromatography and quantitative protonnuclear magnetic resonance spectroscopy of the phorbol ester constituents of Croton oil. Planta Medica, n.6, p.465-468, 1986.
170. PIETERS, L.A.C.; VLIETINCK, A.J. Carbon-13 NMR spectroscopy of phorbol esters. Magnetic Resonance in Chemistry, v.25, n.4, p.368-370, 1987.
171. PIETERS, L.A.C.; VANDEN BERGHE, D.A.; VLIETINCK, A.J. A dihydrobenzofuran lignan from Croton erythrochilus. Phytochemistry, v.29, n.1, p.348-349, 1990.
172. PIETERS, L.; De BRUYNE, T.; CLAEYS, M.; VLIETINCK, A.; CALOMME, M.; VAN DEN BERGHE, D. Isolation of a dihydrobenzofuran lignan from South American dragon’s blood (Croton ssp.) as an inhibitor of cell proliferation. Journal of Natural Products, v.56, n.6, p.899-906, 1993.
173. PUEBLA, P.; LÓPEZ, J.L.; GUERRERO. M.F.; CARRÓN, R.; MARTÍN, M.L.; SAN ROMÁN, L.; SAN FELICIANO, A. Neoclerodane diterpenoids from Croton schiedeanus. Phytochemistry, v.62, n.4, p.551-555, 2003.
174. PUEBLA, P.; CORREA, S.X.; GUERRERO, M.; CARRÓN, R.; SAN FELICIANO, A. New cis-clerodane diterpenoids from Croton schiedeanus. Chemical & Pharmaceutical Bulletin, v.53, n.3, p.328-329, 2005a.
175. PUEBLA, P.; CORREA, S.X.; GUERRERO, M.F.; SAN FELICIANO, A. Phenylbutanoid derivatives from Croton schiedeanus. Biochemical Systematics and Ecology, v.33, n.8, p.849-854, 2005b.
176. RISCO, E.; GHIA, F.; VILA, R.; IGLESIAS, J.; ALVAREZ, E.; CANIGUERAL, S. Immunomodulatory activity and chemical caracterisation of sangre de dagro (dragon’s blood) from Croton lechleri. Planta Medica, v.69, n.9, p.785-794, 2003.
177. RODRÍGUEZ, B.; DE LA TORRE, M.C.; PERALES, A.; MALAKOV, P.J.; PAPANOV, G.Y.; SIMMONDS, M.S.J.; BLANEY, W.M. Oxirane-opening reactions of some 6,19-oxygenated 4á,18-epoxy-neo-clerodanes isolated from Teucrium. Biogenesis and antifeedant activity of their derivatives. Tetrahedron, v.50, n.18, p.5451-5468, 1994.
178. RODRÍGUEZ, J.A.; HAUN M. Cytotoxicity of transdehydrocrotonin from Croton cajucara on V79 cells and rat hepatocytes. Planta Medica, v.65, n.6, p.522-525, 1999.
179. RODRÍGUEZ, J.A.; HIRUMA-LIMA, C.A.; SOUZA BRITO, A.R.M. Antiulcer activity and subacute toxicity of transdehydrocrotonin from Croton cajucara. Human and Experimental Toxicology, v.23, n.9, p.455-461, 2004.
180. ROHMER, M.; KNANI, M.; SIMONIN, P.; SUTTER, B.; SAHM, H. Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isoprenyl diphosphate. Biochemical Journal, v.295, n.2, p.517-524, 1993.
182. ROSSI, D.; BRUNI, R.; BIANCHI, N.; CHIARABELLI, C.; GAMBARI, R.; MEDICI, A.; LISTA, A.; PAGANETTO, G. Evaluation of the mutagenic, antimutagenic and antiproliferative potential of Croton lechleri (Muell. Arg.) latex. Phytomedicine, v.10, n.2-3, p.139-144, 2003.
183. RUZICKA, L. The isoprene rule and the biogenesis of terpenic compounds. Experientia, v.9, n.10, p.357-367, 1953.
184. RUZICKA, L. Perspectives of the biogenesis and chemistry of terpenes. Pure and Applied Chemistry, v.6, p.493-495, 1963.
185. SAMPSON, J.H.; PHILLIPSON, J.D.; BOWERY, N.G.; O’NEILL, M.J.; HOUSTON, J.G.; LEWIS, J.A. Ethnomedicinally selected plants as sources of potential analgesic compounds: indication of in vitro biological activity in receptor binding assays. Phytotherapy Research, v.14, n.1, p.24-29, 2000.
186. SANTOS, F.A.; JEFERSON, F.A.; SANTOS, C.C.; SILVEIRA, E.R.; RAO, V.S.N. Antinociceptive effect of leaf essential oil from Croton sonderianus in mice. Life Sciences, v.77, n.23, p.2953-2963, 2005.
187. SANTOS, F.V.; MESQUITA, S.F.P.; FARIA, M.J.S.S.; POERSH, A.; MACIEL, M.A.M.; PINTO, A.C.; MORIMOTO, H.K.; CÓLUS, I.M.S. Absence of mutagenicity in somatic and germ cells of mice submitted to subchronic treatment with an extract of Croton cajucara Benth. (Euphorbiacae). Genetic and Molecular Biology, v.29, n.1, p.159-165, 2006.
188. SATO, A.; KURABAYASHI, M.; OGISO, A.; KUWANO, H. Poilaneic acid, a cembranoid diterpene from Croton poilanei. Phytochemistry, v.20, n.8, p.1915-1918, 1981.
189. SILVA, R.M.; SANTOS, F.A.; RAO, V.S.N.; MACIEL, M.A.M.; PINTO, A.C. Blood glucose- and triglyceride-lowering effect of trans-dehydrocrotonin, a diterpene from Croton cajucara Benth., in rats. Diabetes, Obesity and Metabolism, v.3, n.6, 452-456, 2001a.
190. SILVA, R.M.; SANTOS, F.A.; MACIEL, M.A.M.; PINTO, A.C.; RAO, V.S.N. Effect of trans-dehydrocrotonin, a 19-norclerodane diterpene from Croton cajucara on experimental hypertriglyceridaemia and hypercholesterolaemia induced by triton WR 1339 (tyloxapol) in mice, Planta Medica, v.67, n.8, p.763-765, 2001b.
191. SILVA, R.M.; SANTOS, F.A.; RAO, V.S.N.; MACIEL, M.A.M.; PINTO, A.C. The lipid-lowering effect of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara Benth. in mice fed on high-fat diet. (2001c) Journal of Pharmacy and Pharmacology, v.53, n.4, p.535-539, 2001c.
192. SILVA, R.M.; OLIVEIRA, F.M.; CUNHA, K.M.A; MAIA, J.L.; MACIEL, M.A.M.; PINTO, A.C.; NASCIMENTO, N.R.F.; SANTOS, F.A.; RAO, V.S.N. Cardiovascular effects of transdehydrocrotonin, a diterpene from Croton cajucara in rats. Vascular Pharmacology, v.43, n.1, p.11-18, 2005.
193. SILVEIRA, E.R. Biological Evaluation and Chemical Constitution of “Marmeleiro Preto” (Croton sonderianus Muell. Arg.), Dissertação de mestrado. The University of Mississippi, M.S., EUA, 1985.
194. SILVEIRA, E.R.; McCHESNEY, J.D. 6,7-oxygenated neoclerodane furan diterpenes from Croton sonderianus. Phytochemistry, v.36, n.6, p.1457-1463, 1994.
195. SIMÕES, J.C.; SILVA, A.J.R.; SERRUYA, H.; BENTES, M.H.S. Desidrocrotonina, um nor-diterpeno de Croton cajucara Benth. Ciência e Cultura, v.31, n.10, p.1140-1141, 1979.
196. SIQUEIRA, R.J.B.; CARDOSO, J.H.L.; COUTURE, R.; LAHLOU, S. Role of capsaicin-sensitive sensory nerves in mediation of the cardiovascular effects of the essential oil of Croton zehntneri leaves in anaesthetized rats. Clinical and Experimental Pharmacology & Physiology, v.33, n.3, p.238-247, 2006a.
197. SIQUIERA, R.J.B.; MAGALHÃES, P.J.C.; CARDOSO, J.H.L.; DUARTE, G.P.; LAHLOU, S. Cardiovascular effects of the essential oil of Croton zehntneri leaves and its main constituents, anethole and estragole, in normotensive conscious rats. Life Sciences, v.78, n.20, p.2365-2372, 2006b.
198. SIVAK, A.; VAN DUUREN, B.L. Studies with carcinogens and tumor-promoting agents in cell culture. (1968) Experimental Cell Research, v.49, n.3, p.572-583, 1968.
199. SMITT, O.; HÖGBERG, H.E. Synthesis of a prenylbisabolane diterpene, a natural insecticide from Croton linearis, and of the bisabolane sesquiterpenes (-)-delobane and (-)-epidelobane. Tetrahedron, v.58, n.38, p.7691-7700, 2002.
200. SOARES, M.P. Would sacaca, Croton cajucara Benth. (Euphorbiaceae) be an hepatotoxic plant like Germander, Teucrium chamaedrys L. (Labiatae)? Revista da Sociedade Brasileira de Medicina Tropical, v.37, n.2, p.96-97, 2004.
201. SOUSA, E.M.B.D.; MARTÍNEZ, J.; CHIAVONE-FILHO, O.; ROSA, P.T.V.; DOMINGOS, T.; MEIRELES, M.A.A. Extraction of volatile oil from Croton zehntnetri Pax et Hoffm. with pressurized CO2: Solubility, composition and kinetics. Journal of Food Engineering, v.69, n.3, p.325-333, 2005.
202. SOUZA-BRITO, A.R.M.; RODRÍGUEZ, J.A.; HIRUMA-LIMA, C.A.; HAUN, M.; NUNES, D.C. Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara. Planta Medica, v.64, n.2, p.126-129, 1998.
203. SOUZA, A.N.C.; BARATA, E.L.; MAGALHÃES, P.J.C.; LIMA, C.C.; CARDOSO, J.H.L. Effects of the essential oil of Croton zehntneri and its constituent estragole on intestinal smooth muscle. Phytotherapy Research, v.11, n.4, p.299-304, 1997.
204. SOUZA, A.N.C.; CRIDDLE, D.N.; CARDOSO, J.H.L. Selective modulatory effects of the essential oil of Croton zehntneri on isolated smooth muscle preparations of the guinea-pig. Phytotherapy Research, v.12, n.3, p.189-194, 1998.
205. STIRPE, F.; PESSION-BRIZZI, A.; LORENZONI, E.; STROCCHI, P.; MONTANARO, L.; SPERTI, S. Studies on the proteins from the seeds of Croton tiglium and of Jatropha curcas. Toxic properties and inhibition of protein synthesis in vitro. Biochemical Journal, v.156, n.1, p.1-6,
207. STUART, K.L.; GRAHAM, L. Alkaloids from Croton species. XIV. Alkaloid biosynthesis in Croton linearis. Phytochemistry, v.12, n.8, p.1973-1975, 1973.
208. TACHIBANA, Y.; KATO, A.; NISHIYAMA, Y.; KAWANISHI, K.; TOBE, H.; JUMA, F.D.; OGETO, J.O.; MATHENGE, S.G. Mitogenic activities in African traditional herbal medicines. Planta Medica, v.59, n.4, p.354-358, 1993.
209. TAKAHASHI, S.; KURABAYASHI, M.; KITAZAWA, E.; HARUYAMA, H.; OGISO, A. Plaunolide, a furanoid diterpene from Croton sublyratus. Phytochemistry, v.22, n.1, p.302-303, 1983.
210. TANSAKUL, P.; DE-EKNAMKUL, W. Geranylgeraniol-18-hydroxylase: the last enzyme on the plaunotol biosynthetic pathway in Croton sublyratus. Phytochemistry, v.47, n.7, p.1241-1246, 1998.
211. TIEPPO, M.; PORAWSKI, M.; SALVADOR, M.; MOREIRA, A.J.; COLLADO, P.S.; GONZÁLEZ-GALLEGO, J.; MARRONI, N.P. Croton cajucara Benth. leaf extract scavenges the stable free radical DPPH and protects against oxidative stress induced by paraquat. Biological & Pharmaceutical Bulletin, v.29, n.1, p.161-165, 2006.
212. TORSSELL, K.G.B. The Mevalonic Acid Pathway. New York: Jonh Wiley & Sons, p.189, 1983.
213. TSAI, J.C.; TSAI, S.; CHANG, W.C. Effect of ethanol extracts of three Chinese medicinal plants with laxative properties on ion transport of the rat intestinal epithelia. Biological & Pharmaceutical Bulletin, v.27, n.2, p.162-165, 2004.
214. UBILLAS, R.; JOLAD, S.D.; BRUENING, R.C.; KERNAN, M.R.; KING, S.R.; SESIN, D.F.; BARRET, M.; STODDART, C.A.; FLASTER, T. SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago). Phytomedicine, v.1, n.2, p.77-106, 1994.
215. VAISBERG, A.J.; MILLA, M.; PLANAS, M.C.; CORDOVA, J.L.; AUGUSTI, E.R.; FERREYRA, R.; MUSTIGA, M.C.; CARLIN, L.; HAMMOND, G.B. Taspine is the cicatrizant principle in Sangre de Drago extracted from Croton lechleri. Planta Medica, v.55, n.2, p.140-143, 1989.
216. VAN DEN BERG, M.E. Plantas Medicinais na Amazônia: Contribuição ao seu conhecimento sistemático. Belém: Falangola, p.159, 1982.
217. VEIGA Jr., V.F.; PINTO, A.C.; MACIEL, M.A.M. Plantas Medicinais: Cura segura? Química Nova, v.28, n.3, p.519-528. 2005.
218. VIGOR, C.; FABRE, N.; FOURASTÉ, I.; MOULIS, C. Three clerodane diterpenoids from Croton eluteria Bennett. Phytochemistry, v.57, n.8, p.1209-1212, 2001.
219. VIGOR, C.; FABRE, N.; FOURASTÉ, I.; MOULIS, C. Neoclerodane diterpenoids from Croton eluteria. Journal of Natural Products, v.65, n.8, p.1180-1182, 2002.
220. VONGCHAREONSATHIT, A.; DE-EKNAMKUL, W. Rapid TLCdensitometric analysis of plaunotol from Croton sublyratus leaves. Planta Medica, v.64, n.3, p.279-280, 1998.
221. WEBSTER, G.L. The genera of the Euphorbiaceae in the South-Eastern United States. J. Arnold Arbor, v.48, p.303, 1967.
222. WEBSTER, G.L. Systematics of the Euphorbiaceae. Annals of the Missouri Botanical Garden, v.81, n.1, p.1-144, 1994.
223. WECKERT, E.; HÃœMMER, K.; ADDAE-MENSAH, I.; ACHENBACH, H. Constituents of tropical medicinal plants. 50. The absolute configuration of chiromodine. Phytochemistry, v.31, n.6, p.2170-2172, 1992.
224. WILSON, S.R.; NEUBERT, L.A.; HUFFMAN, J.C. The Chemistry of the Euphorbiaceae. A new diterpene from Croton californicus. Journal of the American Chemical Society, v.98, n.12, p.3669-3674, 1976.
225. YANASE, S.; ITO, Y. Heat durability of Epstein-Barr virusactivating substances of plant origin: 12-Otetradecanoylphorbol 13-acetate, 12-O-hexadecanoyl-16-hydrophorbol 13-acetate, croton oil, tung oil and Croton megalocarpus extract. Cancer Letters, v.22, n.2, p.183-186, 1984.