Estudo de Revisão da Eficácia Clínica do Vitex agnus-castus na Saúde Feminina

Isaia, C.F. Perini

doi:10.32712/2446-4775.2007.73

Study Review of the Clinical Effectiveness of Vitex agnus-castus in Female Health Condition

Vol. 3 No. 02 (2007)
43-50
18/10/2013
01/06/2007
https://doi.org/10.32712/2446-4775.2007.73

Isaia, C.F. Perini

Keywords

Vitex agnus-castus

Premenstrual Syndrome

Hyperprolactenemia

Mastodynia

Menopause

Abstract

Extract of the chaste tree Vitex agnus-castus (VAC) is common used in treatments related to premenstrual symptoms, as well as mastodynia cyclic and hyperprolactenemia, and also other somatic symptoms and physic of Premenstrual Syndrome (PMS), in addition there also are reports about its usage in the luteal phase disorders of menstrual cycle and on menopausal symptoms. There are not many data regarding the effects of VAC available in PMS syndromes and other female conditions. Hence, this bibliographical review has aimed to search for an enhanced insight about the action mechanism of extracts of the fruits of VAC, its clinical effectiveness and pharmacological effects besides the action relief of severe symptoms of Premenstrual Syndrome, primarily in hyperprolactenemia and mastodynia, including the menopause itself and the luteal phase disorders. Therefore, we have verified a greater amount of studies related to the usage and effectiveness of the extract of the chaste tree regarding the relief in cyclical mastodynia and hyperprolactemia of PMS, which it has proven its valid endurance and inhibition against mild pain by dopaminergic principles of VAC.

References

BLUMENTHAL, M.; RUSSE, W.R.; GOLDBERG, A.; GRUENWALD, J.; HALL, T.; RIGGINS, C.W.; RISTER, R.S.; The Complete German Commission E Monographs - Therapeutic Guide to Herbal Medicines. Austin (TX): Americal Botanical Concil, Boston: Intregrative Medicine Communication; 1998.
BRUGISSER, R.; BURKARD, W.; SIMMEN, U.; SCHAFFNER, W. Untersuchungen an opioid-rezeptoren mit Vitex agnus-castus L. Zeitschrift fÃ¼r Phytotherapy, v.20, p.154, 1999 apud Complementary Therapies in Nursing & Midwifery, v.8, p.148-154, 2002.
DANIELE, C.; COON, J.T.; PITTLER, M.H.; ERNST. E. Vitex agnus castus: A Systematic Review of Adverse Events. Drug Safety, v.28, n.4, p.319-332, 2005.
FORD, O.; MOL, B.; ROBERTS, H. Progesterone for premenstrual syndrome [protocol]. The Cochrane Library, v.1, 2006.
GERHARD, I.; PATEK, A.; MANGA, B. et al. MastodynonÂ® bei weiblicher SterilitÃ¤t - Randomisierte, plazebokontollierte, klinische Doppelblindstudie. Forsch Komplementarmed, v.5, p.272-278, 1998.
HALASKA, M.; RAUSS, K.; BELES P. et al. Treatment of cyclical mastodynia using an extract of Vitex agnus-castus: results of a double-blind comparison with a placebo. Česká Gynekologie, v.63, p.388-392, 1998.
HALASKA, M.; BELES, P.; GORKOW, C.; SIEDER, C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus-castus extract: results of a placebo-controlled double-blind study. The Breast, v.8, p.175-181, 1999.
JARRY, H.; LEONHARDT, S.; GORKOW, C.; WUTTKE W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Experimental and Clinical Endocrinology, v.102, n.6, p.448-54, 1994.
LUCKS, B.C.; SORENSEN, J.; VEAL, L. Vitex agnus-castus essential oil and menopausal balance: a self-care survey. Complementary Therapies in Nursing & Midwifery, v.8, p.148-154, 2002.
LUCKS, B.C. Vitex agnus castus essential oil and menopausal balance: a research update. Complementary Therapies in Nursing and Midwifery, v.8, p.148-154, 2003.
MERZ P. G.; GORKOW, C.; SCHRODTER, A. et al. The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects. Experimental and Clinical Endocrinology & Diabetes, v.104, n.6, p.447-53, 1996.
MILEWICZ, A.; GEJDEL, E.; SWOREN, H. et al. Vitex agnus-castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study. Arzneimittelforschung, v.43, p.752-756, 1993.
MILEWICZ, A.; JEDRZEJUK, D. Premenstrual syndrome: From etiology to treatment. Maturitas, v.55, p.47-54, 2006.
NEUMANN-KUHNELT, B.; STIEF, G.; SCHMIADY, H.; KENTENICH, H. Investigations on possible effects of the phytotherapeutic agent Agnus-castus on the follicular and corpus luteum phases. Human Reproduction, v.8, p.110, 1993.
PETERS F, SCHUTH W, SCHEURICH B, BRECKWOLDT M. Serum prolactina levels in patients with fibrocystic breast disease. Obstetrics and Gynecology v.64, n.3, p.381-385, 1984.
PRILEPSKAYA, V.N.; LEDINA, A.V.; TAGIYEVA, A.V.; REVAZOVA, F.S. Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome. Maturitas, v.55, p.55-63, 2006.
ROEMHELD-HAMM, B. Chasteberry. American Family Physician, v.72, n.5, p.1, 2005.
SCHELLENBERG, R. Treatment for the premenstrual syndrome with Agnus Castus fruit extract: prospective, randomised, placebo controlled study. British Medical Journal: BMJ, v.322, p.134-137, 2001.
SLIUTZ, G.; SPEISER, P.; SCHULTZ, A. M. et al. Agnus-castus extracts inhibit prolactin secretion of rat pituitary cells. Hormone and Metabolic Research, v.25, p.253-255, 1993.
TESCH, B.J. Herbs commonly used bywomen. An evidence-based review. American Journal of Obstetrics & Gynecology, v.188, n.5, p.44-55, 2003.
WEBSTER, D.E.; LU, J.; CHEN, S.-N.; FARNSWORTH, N.R.; WANG, Z.J. Activation of the Âµ-opiate receptor by Vitex agnus-castus methanol extracts: Implication for its use in PMS. Journal of Ethnopharmacology v.106, p.216-221, 2006.
WUTTKE, W.; JARRY, H.; CHRISTOFFEL, B. et al. Chaste tree (Vitex agnus-castus) Pharmacology and clinical indications. Phytomedicine, v.10, p.348-357, 2003.

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Author(s)

Isaia, C.F. Perini
Unidade de Pesquisa Clínica Carlos Isaia Filho, Rua Padre Chagas 66, Sala 704, Bairro Moinhos de Vento, 90570-080 Porto Alegre, RS, Brasil

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How to Cite

Study Review of the Clinical Effectiveness of Vitex agnus-castus in Female Health Condition. Rev Fitos [Internet]. 2007 Jun. 1 [cited 2024 Nov. 28];3(02):43-50. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/73

This work is licensed under a Creative Commons Attribution 4.0 International License.

[1] BLUMENTHAL, M.; RUSSE, W.R.; GOLDBERG, A.; GRUENWALD, J.; HALL, T.; RIGGINS, C.W.; RISTER, R.S.; The Complete German Commission E Monographs - Therapeutic Guide to Herbal Medicines. Austin (TX): Americal Botanical Concil, Boston: Intregrative Medicine Communication; 1998.

[2] BRUGISSER, R.; BURKARD, W.; SIMMEN, U.; SCHAFFNER, W. Untersuchungen an opioid-rezeptoren mit Vitex agnus-castus L. Zeitschrift fÃ¼r Phytotherapy, v.20, p.154, 1999 apud Complementary Therapies in Nursing & Midwifery, v.8, p.148-154, 2002.

[3] DANIELE, C.; COON, J.T.; PITTLER, M.H.; ERNST. E. Vitex agnus castus: A Systematic Review of Adverse Events. Drug Safety, v.28, n.4, p.319-332, 2005.

[4] FORD, O.; MOL, B.; ROBERTS, H. Progesterone for premenstrual syndrome [protocol]. The Cochrane Library, v.1, 2006.

[5] GERHARD, I.; PATEK, A.; MANGA, B. et al. MastodynonÂ® bei weiblicher SterilitÃ¤t - Randomisierte, plazebokontollierte, klinische Doppelblindstudie. Forsch Komplementarmed, v.5, p.272-278, 1998.

[6] HALASKA, M.; RAUSS, K.; BELES P. et al. Treatment of cyclical mastodynia using an extract of Vitex agnus-castus: results of a double-blind comparison with a placebo. Česká Gynekologie, v.63, p.388-392, 1998.

[7] HALASKA, M.; BELES, P.; GORKOW, C.; SIEDER, C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus-castus extract: results of a placebo-controlled double-blind study. The Breast, v.8, p.175-181, 1999.

[8] JARRY, H.; LEONHARDT, S.; GORKOW, C.; WUTTKE W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Experimental and Clinical Endocrinology, v.102, n.6, p.448-54, 1994.

[9] LUCKS, B.C.; SORENSEN, J.; VEAL, L. Vitex agnus-castus essential oil and menopausal balance: a self-care survey. Complementary Therapies in Nursing & Midwifery, v.8, p.148-154, 2002.

[10] LUCKS, B.C. Vitex agnus castus essential oil and menopausal balance: a research update. Complementary Therapies in Nursing and Midwifery, v.8, p.148-154, 2003.

[11] MERZ P. G.; GORKOW, C.; SCHRODTER, A. et al. The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects. Experimental and Clinical Endocrinology & Diabetes, v.104, n.6, p.447-53, 1996.

[12] MILEWICZ, A.; GEJDEL, E.; SWOREN, H. et al. Vitex agnus-castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study. Arzneimittelforschung, v.43, p.752-756, 1993.

[13] MILEWICZ, A.; JEDRZEJUK, D. Premenstrual syndrome: From etiology to treatment. Maturitas, v.55, p.47-54, 2006.

[14] NEUMANN-KUHNELT, B.; STIEF, G.; SCHMIADY, H.; KENTENICH, H. Investigations on possible effects of the phytotherapeutic agent Agnus-castus on the follicular and corpus luteum phases. Human Reproduction, v.8, p.110, 1993.

[15] PETERS F, SCHUTH W, SCHEURICH B, BRECKWOLDT M. Serum prolactina levels in patients with fibrocystic breast disease. Obstetrics and Gynecology v.64, n.3, p.381-385, 1984.

[16] PRILEPSKAYA, V.N.; LEDINA, A.V.; TAGIYEVA, A.V.; REVAZOVA, F.S. Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome. Maturitas, v.55, p.55-63, 2006.

[17] ROEMHELD-HAMM, B. Chasteberry. American Family Physician, v.72, n.5, p.1, 2005.

[18] SCHELLENBERG, R. Treatment for the premenstrual syndrome with Agnus Castus fruit extract: prospective, randomised, placebo controlled study. British Medical Journal: BMJ, v.322, p.134-137, 2001.

[19] SLIUTZ, G.; SPEISER, P.; SCHULTZ, A. M. et al. Agnus-castus extracts inhibit prolactin secretion of rat pituitary cells. Hormone and Metabolic Research, v.25, p.253-255, 1993.

[20] TESCH, B.J. Herbs commonly used bywomen. An evidence-based review. American Journal of Obstetrics & Gynecology, v.188, n.5, p.44-55, 2003.

[21] WEBSTER, D.E.; LU, J.; CHEN, S.-N.; FARNSWORTH, N.R.; WANG, Z.J. Activation of the Âµ-opiate receptor by Vitex agnus-castus methanol extracts: Implication for its use in PMS. Journal of Ethnopharmacology v.106, p.216-221, 2006.

[22] WUTTKE, W.; JARRY, H.; CHRISTOFFEL, B. et al. Chaste tree (Vitex agnus-castus) Pharmacology and clinical indications. Phytomedicine, v.10, p.348-357, 2003.