Effect of spray drying process parameters on Uncaria tomentosa (Willd. ex Schult.) DC. dried extracts

Lucas Oliveira Rodrigues
OrcID
Rachel Andrade de Faria
OrcID
Marcos Martins Gouvêa
OrcID
Carlos Augusto de Freitas Peregrino
Elizabeth Valverde Macedo
Samanta Cardozo Mourão

    Lucas Oliveira Rodrigues

    1Federal Fluminense University, Faculty of Pharmacy, Applied Sciences to Health Products Graduate Program, Rua Mário Viana nº 523, Postal code: 24241-000, Niterói, RJ, Brazil.

    OrcID https://orcid.org/0000-0001-9463-6488

    Bachelor of Pharmacy from Universidade Federal Fluminense (UFF) on 07/22/2019. He was an intern intern at UFF, a Technological Initiation fellow at CNPq and a UFF Extension fellow, working at the Rodolpho Albino University Laboratory - LURA. He was a scholarship scholar at the Vital Brazil Institute for 2 years, working in the New Formulation Development (LDNF) sector, in partnership with LURA. He is currently a Master's student in Sciences Applied to Health Products at UFF.

    Rachel Andrade de Faria

    Federal Fluminense University, Faculty of Pharmacy, Applied Sciences to Health Products Graduate Program, Rua Mário Viana nº 523, Postal code: 24241-000, Niterói, RJ, Brazil.

    OrcID https://orcid.org/0000-0001-9748-8193

    Graduated in Pharmacy from Universidade Federal Fluminense (UFF). He has experience with medicinal plants aiming at better extraction characteristics of bioactive compounds and in obtaining dry extracts for the development of new uncoated oral solid formulations. In addition to having experience in the development of nanoemulsions from plant extracts.

    Marcos Martins Gouvêa

    Federal Fluminense University, Department of Analytical Chemistry, Outeiro de São João Batista s/n, Campus do Valonguinho, Postal code: 24020-141, Niterói, RJ, Brazil.

    OrcID https://orcid.org/0000-0003-0262-9462

    Substitute professor in the Analytical Chemistry department (GQA) at Universidade Federal Fluminense (UFF) since July 2019. Master in Chemistry (2018) and graduated in Pharmacy from UFF (2015). PhD student in the graduate program in Chemistry at UFF. He has experience in Pharmaceutical Technology, Chemistry of Natural Products and Quality Control of medicinal plants, medicines and food. Currently, he develops projects in the area of Molecular Pharmacology applied to the Central Nervous System.

    Carlos Augusto de Freitas Peregrino

    Federal Fluminense University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Rua Mario Viana nº 523, Postal code: 24241-000, Niterói, RJ, Brazil.

    Graduated in Industrial Pharmacy and Biochemistry from Universidade Federal Fluminense (1986), Master in Pharmaceutical Sciences from Federal University of Rio de Janeiro (1999) and PhD in Collective Health from Rio de Janeiro State University (2006). He is currently Associate Professor at Universidade Federal Fluminense, was Assistant Professor at Universidade Estácio de Sá, Director of the Pharmacy Course and National Pedagogical Coordinator of the Pharmacy Course at Estácio de Sá University from 2000 to 2014. He serves as Director of the Rodolpho Albino University Laboratory LURA, linked to the Dean of Extension of Universidade Federal Fluminense. Has experience in the Pharmacy area, with emphasis on Pharmacotechnics, acting mainly on the following themes: Pharmacotechnics, herbal medicine legislation, Pharmaceutical technology applied to Medicines and Herbal medicines, Quality control of herbal medicines and intellectual property law. Coordinator of the New Formulation Development Laboratory - LDNF, linked to LURA, and to the Vital Brazil Institute / IVB. Responsible for creating the Pharmacy course at Universidade Estácio de Sá in Rio de Janeiro. Professor of the Latu Sensu Postgraduate Courses in Drug and Food Science, Postgraduate Latu Sensu Course in Pharmaceutical Technology, both at the UFF Pharmacy School, and Professor of the Stricto Sensu Postgraduate Course in Biotechnology at the Institute of Biology of UFF. Extensive experience in Management in Higher Education, in the area of ​​Pharmacy and Development of formulations for the Pharmaceutical area.

    Elizabeth Valverde Macedo

    Federal Fluminense University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Rua Mario Viana nº 523, Postal code: 24241-000, Niterói, RJ, Brazil.

    Graduated in Pharmacy from the Federal Fluminense University (UFF), Master in Organic Chemistry from the Chemistry Institute of the Federal Fluminense University (UFF) and PhD in Sanitary Surveillance from the National Institute for Quality Control (INCQS) of the Oswaldo Cruz Foundation (FIOCRUZ). She is currently Deputy Director of the Rodolpho Albino University Laboratory (LURA) at UFF, where she develops research and extension projects to monitor the quality of medicines available for use in SUS and Development of herbal medicines. Adjunct professor and coordinator of the disciplines: Pharmaceutical Technology, Internship in Regulatory Affairs and Validation, all at UFF. He was President of the Brazilian Pharmaceutical Association (ABF). The Brazilian Pharmacopeia (2010) collaborated for the elaboration of the 5th edition. He is a professor in the Pharmaceutical Technology specialization course at the same University. Has experience in the areas of Health Surveillance, Validation and Pharmaceutical Technology, with an emphasis on the development of risk analysis applied to processes and design of experiments? Design of experiments?

    Samanta Cardozo Mourão

    Federal Fluminense University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Rua Mario Viana nº 523, Postal code: 24241-000, Niterói, RJ, Brazil.

    Graduated in Pharmacy-Biochemistry - mod. Pharmaceuticals and Medicines by Universidade Estadual Paulista Júlio de Mesquita Filho (1998), master's degree in Pharmaceutical Sciences by Universidade Estadual Paulista Júlio de Mesquita Filho (2001) and doctorate in Pharmaceutical Sciences by Universidade de São Paulo (2009). She is currently an adjunct professor IV at Universidade Federal Fluminense, working at the Faculty of Pharmacy in the disciplines of Pharmacotechnics and Cosmetics Technology. He has experience in the Pharmacy area, with an emphasis on Pharmacotechnics, working in the development, production and control of conventional or modified release formulations as well as in biopharmaceutical evaluation.

Keywords

Traditional medicine
Design of experiments
Spray drying
Phytomedicine Development

Abstract

Uncaria tomentosa (Willd. ex Schult.) DC. (Cat's claw) is a plant member of the Rubiaceae family, from the Amazon region, and used in traditional medicine as raw material for phytomedicines indicated for arthritis and osteoarthritis. This study aimed to evaluate the spray drying process parameters on the properties of different extracts obtained from Uncaria tomentosa. A reduced 24-1 multifactorial design was applied to evaluate the importance of the equipment variables (pump speed, spray nozzle diameter, air inlet temperature, and atomization airflow rate) in the process. Maltodextrin and acacia gum were used as carriers in a 1:1 (m/m) ratio, considering the solid residue content of the liquid plant extract. Process yield, moisture, and hygroscopicity were evaluated as dependent variables. Higher atomization airflow rate led to higher process yield for powdered dried extracts with maltodextrin. Higher temperature led to lower moisture contents regarding powdered dried extracts with acacia gum. No variable, for any carrier, was considered significant for hygroscopicity. The best spray drying configuration for the desired characteristics (i.e. lower hygroscopicity and moisture) used the larger spray nozzle with a diameter of 1.2 mm and the higher temperature of 150 °C, with both carriers.

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Author(s)

  • Lucas Oliveira Rodrigues
    1Federal Fluminense University, Faculty of Pharmacy, Applied Sciences to Health Products Graduate Program, Rua Mário Viana nº 523, Postal code: 24241-000, Niterói, RJ, Brazil.
    https://orcid.org/0000-0001-9463-6488
  • Rachel Andrade de Faria
    Federal Fluminense University, Faculty of Pharmacy, Applied Sciences to Health Products Graduate Program, Rua Mário Viana nº 523, Postal code: 24241-000, Niterói, RJ, Brazil.
    https://orcid.org/0000-0001-9748-8193
  • Marcos Martins Gouvêa
    Federal Fluminense University, Department of Analytical Chemistry, Outeiro de São João Batista s/n, Campus do Valonguinho, Postal code: 24020-141, Niterói, RJ, Brazil.
    https://orcid.org/0000-0003-0262-9462
  • Carlos Augusto de Freitas Peregrino
    Federal Fluminense University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Rua Mario Viana nº 523, Postal code: 24241-000, Niterói, RJ, Brazil.
  • Elizabeth Valverde Macedo
    Federal Fluminense University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Rua Mario Viana nº 523, Postal code: 24241-000, Niterói, RJ, Brazil.
  • Samanta Cardozo Mourão
    Federal Fluminense University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Rua Mario Viana nº 523, Postal code: 24241-000, Niterói, RJ, Brazil.

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Effect of spray drying process parameters on Uncaria tomentosa (Willd. ex Schult.) DC. dried extracts. Rev Fitos [Internet]. 2020 Dec. 18 [cited 2026 Mar. 15];14(4):469-75. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/969
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