Produtos Naturais Ativos em Leishmaniose

B. Gilbert; R. Favoreto

doi:10.32712/2446-4775.2005.6

Produtos Naturais Ativos em Leishmaniose

v. 1 n. 01 (2005)
43-51
30/09/2013
30/06/2005
https://doi.org/10.32712/2446-4775.2005.6

B. Gilbert
R. Favoreto

Palavras-chave

Resumo

Uma variedade surpreendente de substâncias naturais inibe o crescimento experimental de parasitos do gênero Leishmania responsáveis pelas três principais formas da doença leishmaniose – a tegumentar, a muco-tegumentar e a visceral. Resultados obtidos com extratos de plantas, às vezes in vivo, mais freqüentemente in vitro, demonstram que a atividade pode ser encontrada numa extensa diversidade de familias, das quais se destacam, entre muitas outras, Crassulaceae (gênero Kalanchoe), Annonaceae (muitos gêneros). Piperaceae (especialmente o gênero Piper), Rutaceae (com destaque para o gênero Galipea) e Apocynaceae (gênero Peschiera entre outros). Classes químicas que se distinguem incluem alcalóides e chalconas que foram em alguns casos demonstradas agir diretamente sobre o parasito, enquanto outras classes que abrangem uma variedade de substâncias fenólicas, terpênicas, inclusive di- e triterpenóides, e polissacarídeos, agem, ou parecem agir, sobre o macrófago, célula hospedeira do parasito, estimulando-o a produzir óxido nítrico, mediadores como TNFa e INFs ou outros fatores da reação imunológica letais à Leishmania sem ser prejudiciais ao próprio macrófago. Os resultados, às vezes, confirmam usos tradicionais das plantas e, em conjunto, formam uma base sólida para o desenvolvimento de novos medicamentos para este grupo de doenças.

Referências

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B. Gilbert
Instituto de Tecnologia em Fármacos, Far-Manguinhos, Fundação Oswaldo Cruz Rua Sizenando Nabuco 100, Manguinhos, 21041-250 Rio de Janeiro, RJ, Brasil
R. Favoreto

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Produtos Naturais Ativos em Leishmaniose. Rev Fitos [Internet]. 30º de junho de 2005 [citado 28º de novembro de 2024];1(01):43-51. Disponível em: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/6

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

[1] ABREU, P.M.; MARTINS, E.S.; KAYSER, O., BINDSEIL, K.U.; SIEMS, K.; SEEMANN, A.; FREVERT, J. Antimicrobial, antitumor and antileishmania screening of medicinal plants from Guinea-Bissau. Phytomedicine, v.6, n.3, p.187-195, 1999.

[2] ARAUJO, C.A.; ALEGRIO, L.V.; GOMES, D.C.; LIMA, M.E.; GOMES-CARDOSO, L; LEON, L.L. Studies on the effectiveness of diarylheptanoid derivatives against Leishmania amazonens. Memórias do Instituto Oswaldo Cruz, v 94, n.6, p.791-794, 1999.

[3] BARATA, L.E.; SANTOS, L.S.; FERRI, P.H.; PHILLIPSON, J.D.; PAINE, A; CROFT, S.L. Anti-leishmanial activity of neolignans from Virola species and synthetic analogues. Phytochemistry, v.55, n.6, p.589-595, 2000.

[4] CARMONA, D.; SAEZ, J. GRANADOS, H.; PEREZ, E.; BLAIR, S., ÂNGULO, A., FIGADERE, B. Antiprotozoal 6-substituted-5,6-dihydro-alpha-pyrones from Raimondia cf. monoica. Natural Product Research, v.17, n.4, p.275-280, 2003.

[5] CHRISTENSEN, S.B.; MING, C.; ANDERSEN, L.; HJORNE, U.; OLSEN, C.E.; CORNETT, C.; THEANDER, T.G.; KHARAZMI, A. An antileishmanial chalcone from Chinese licorice roots. Planta Medica, v.60, n.2, p.121-123, 1994.

[6] DA SILVA, S.A.; COSTA, S.S.; MENDONÇA, S.C.; SILVA, E.M.; MORAES, V.L.; ROSSI-BERGMANN, B. Therapeutic effect of oral Kalanchoe pinnata leaf extract in murine leishmaniasis. Acta Tropica, v.60, n.3, p.201-210, 1995.

[7] DA-SILVA, S.A.; COSTA, S.S.; ROSSI-BERGMANN, B. The anti-leishmanial effect of Kalanchoe is mediated by nitric oxide intermediates. Parasitology. v. 118, n.6, p.575-282, 1999.

[8] DELMAS, F; DI GIORGIO, C.; ELIAS, R.; GASQUET, M.; AZAS, N.; MSHVILDADZE, V.; DEKANOSIDZE, G.; KEMERTELIDZE, E.; TIMON-DAVID, P. Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro Planta Medica, v.66, n.4, p.343-347, 2000.

[9] DELORENZI; J.C.; ATTIAS, M.; GATTASS, C.R.; ANDRADE, M.; REZENDE, C.; PINTO, A. C.; HENRIQUES, A.T.; BOU-HABIB; D.C.; SARAIVA, E.M.;. Antileishmanial activity of na indole alkaloid from Peschiera australis. Antimicrobial Agents Chemotherapy, v.45, n.5, p.1349-1354, 2001.

[10] DELORENZI, J.C.; FREIRE-DE-LIMA, L.; GATTASS, C.R.; DE ANDRADECOSTA, D.; HE, L.; KUEHNE, M.E.; SARAIVA, E.M.. In vitro activities of iboga alkaloid congeners coronaridine and 18-methoxycoronaridine against Leishmania amazonensis. Antimicrobial Agents Chemotherapy, v.46, n.7, p.2111-2115, 2002.

[11] FEVRIER, A.; FERREIRA, M.E.; FOURNET, A.; YALUFF, G.; INCHAUSTI, A.; ROJAS-DE-ARIAS, A.; HOCQUEMILLER, R.; WAECHTER, A.I. Acetogenins and other compounds from Rollinia emarginata and their antiprotozoal activities..Planta Med. v.65, n.1, p.47-9, 1999.

[12] FOURNET, A.; ANGELO, A.; MUNOZ, V.; ROBLOT, F.; HOCQUEMILLER, R.; CAVE, A. Biological and chemical studies of Pera benensis, a Bolivian plant used in folk medicine as a treatment of cutaneous leishmaniasis. J Ethnopharmacology, v. 37, n. 2, p.159-164, 1992.

[13] FOURNET, A.; BARRIOS, A.A. MUÑOZ, V.; HOCQUEMILLER, R.; ROBLOT, F.; CAVE, A. Antileishmanial activity of a tetralone isolated from Ampelocera edentula, a Bolivian plant used as a treatment for cutaneous leishmaniasis. Planta Medica, v.60, n.1, p.8-12, 1994.

[14] FOURNET, A.; FERREIRA, M.E.; ROJAS-DE-ARIAS, A.; TORRES-DE-ORTIZ, S.; FUENTES, S.; NAKAYAMA, H.; SCHININI, A.; HOCQUEMILLER, R. In vivo efficacy of oral and intralesional administration of 2-substituted quinolines in experimental treatment of new world cutaneous leishmaniasis caused by Leishmania amazonensis. Antimicrobial Agents Chemotherapy, v.40, n.11, p.2447-2451, 1996.

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