Preparation of pellets containing a standardized Artemisia annua L. extract by extrusion-spheronization

Elviscley de Oliveira Silva
Ricardo Neves Marreto
Edemilson Cardoso da Conceição
Maria Teresa Bara

    Elviscley de Oliveira Silva

    Federal University of Goiás, Faculty of Pharmacy, 5th Avenue, Praça Universitária Setor Universitário, CEP 74000-000, Goiania, GO, Brazil.

    Farmacêutico Industrial. Especialista em Tratamento e Disposição Final de Resíduos Sólidos e Líquidos pela Escola de Engenharia da UFG. Mestre em Ciências Farmacêuticas pela Faculdade de Farmácia da UFG. Coordenador do Laboratório de Controle de Qualidade de Medicamentos (LCQM) da Faculdade de Farmácia da UFG e Responsável Técnico do lab. Físico-Químico. Responsável Técnico Substituto do Centro de Equivalência Farmacêutica do LCQM EQFAR-069.

    Ricardo Neves Marreto

    Federal University of Goiás, Faculty of Pharmacy, 5th Avenue, Praça Universitária Setor Universitário, CEP 74000-000, Goiânia, GO, Brazil.

    Graduated in Pharmacy from the Federal University of Goiás (1999), holds a PhD in Pharmaceutical Sciences from the University of São Paulo (2006). He is currently Associate Professor and Vice-Director of the Faculty of Pharmacy at the Federal University of Goiás. Member of the Graduate Programs in Pharmaceutical Sciences at UFG and the Pharmaceutical Innovation Program UFG / UFPA / UFAM / UFAP. He was vice-coordinator of UFG's University Pharmacy, vice-coordinator (2011-2013) and coordinator (2013-2015) of the Graduate Program in Pharmaceutical Sciences (FF / UFG). He is a member of the Thematic Technical Committee of Active Ingredients of the Brazilian Pharmacopoeia (ANVISA) and of the Sectorial Chamber of Medicines and Health Products of the State of Goiás (CASMED-GO). He is currently First Secretary of the Brazilian Association of Pharmaceutical Sciences (ABCF). He was associate editor of the journal INFARMA Ciências Farmacêuticas (CFF) and consultant at CAPES to evaluate graduate programs. Participated in technological development projects promoted by FINEP in association with the private sector. It has national and international patent patents. He is one of the coordinators of the Laboratory of Nanosystems and Modified Drug Release Devices at UFG (NanoSYS-UFG). He has cooperation with different national and international institutions, including the Universidad de Santiago de Compostela (Spain) and the Ashland Development Center. Pharmaceutical Specialties (USA). He works in the Pharmacy area, with an emphasis on preformulation, development of multiparticulate systems for drug release, extrusion, new granulation techniques and nanotechnology.

    Edemilson Cardoso da Conceição

    Federal University of Goiás, Faculty of Pharmacy, 5th Avenue, Praça Universitária Setor Universitário, CEP 74000-000, Goiânia, GO, Brazil.

    Graduated in Pharmacy from the Faculty of Pharmacy, UFG. Master, Doctorate and Post Doctorate in Pharmaceutical Sciences from the University of São Paulo. Full Professor at the Faculty of Pharmacy, UFG. Productivity Scholarship in Technological Development and Innovative Extension from CNPq, since 2012. He has experience in the areas of Pharmacy and Product Development, working mainly on the following topics: a) Bioproducts RD&I; b) Unit operations applied in the standardization of raw materials of vegetable, synthetic and biotechnological origin; c) Phytopharmaceutical and Phytocosmetic Technologies. He is a master's and doctoral advisor in the Graduate Programs in Pharmaceutical Sciences at UFG (Goiás) and the Graduate Program in Pharmaceutical Innovation of the network: UFG (Goiás), UFPA (Pará), UFAM (Amazonas) and UNIFAP (Amapá). Vice coordinator of the Graduate Program in Pharmaceutical Innovation at UFG (PhD level).

    Maria Teresa Bara

    UFG

Keywords

Phytopharmaceutical technology
Artemisinin
Herbal medicinal
Multiparticulate solid dosage form

Abstract

Artemisinin, the major substance with antimalarial activity of Artemisia annua L., is a poorly water-soluble drug. The development of pellets containing a standardized hydroethanolic extract of A. annua may overcome these drawbacks while offer an intermediate product with good technological properties for subsequent tablet manufacture. This work aimed to obtain and characterize A. annua pellets using the extrusion-spheronization technique. The extract was prepared by percolation and artemisinin content was determined using a validated HPLC method. The standardized extract was then used as a liquid binder in the preparation of pellets with different liquid: solid ratio. The formulation PF5 containing microcrystalline cellulose: A. annua extract (40:58) resulted in pellets with 1.49 ± 0.02 % (w/w) artemisinin, average size of approximately 500 µm and sphericity of 0.82 ± 0.08. These pellets were encapsulated in hard gelatin capsules and the percentage released was higher than 80% in 10 min using 0.1N HCl and phosphate buffer media. These data allow to suggest that the pelletizing strategy used made it possible to achieve the desired artemisinin dissolution and generates perspectives for the potential further use of the A. annua pellets as a solid dosage form for malaria treatment.

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Author(s)

  • Elviscley de Oliveira Silva
    Federal University of Goiás, Faculty of Pharmacy, 5th Avenue, Praça Universitária Setor Universitário, CEP 74000-000, Goiania, GO, Brazil.
  • Ricardo Neves Marreto
    Federal University of Goiás, Faculty of Pharmacy, 5th Avenue, Praça Universitária Setor Universitário, CEP 74000-000, Goiânia, GO, Brazil.
  • Edemilson Cardoso da Conceição
    Federal University of Goiás, Faculty of Pharmacy, 5th Avenue, Praça Universitária Setor Universitário, CEP 74000-000, Goiânia, GO, Brazil.
  • Maria Teresa Bara
    UFG

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Preparation of pellets containing a standardized Artemisia annua L. extract by extrusion-spheronization. Rev Fitos [Internet]. 2021 Mar. 31 [cited 2024 Nov. 21];15(1):84-92. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1063
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