Combatting COVID-19 by stimulating the immune system with natural products

Roberta Ghilosso-Bortolini
Priscilla Christina Olsen
Benjamin Gilbert

    Roberta Ghilosso-Bortolini

    Oswaldo Cruz Foundation (FIOCRUZ), Pharmaceuticals-Farmanguinhos Institute of Technology, Biodiversity and Health Innovation Center (CIBS), Avenida Comandante Guaranys, 447, Jacarepaguá, CEP 22775-903, Rio de Janeiro, RJ, Brazil.

    Pharmacist with specialization in Clinical Analysis from the Pontifical Catholic University of Rio Grande do Sul (2000), Doctorate in Sciences with emphasis in Immunology and Pharmacology from the postgraduate course in Cellular and Molecular Biology at Instituto Oswaldo Cruz/FIOCRUZ-RJ (2018), Master's Degree in Biology, emphasis in Biomedicine by the postgraduate degree in Nuclear Biosciences at the State University of Rio de Janeiro (2005). Specialization in Homeopathic Pharmacy by Instituto Hahnemanniano do Brasil (2005), Training Course in Pharmacology by the Brazilian Association of Pharmacology (2008) and, currently, Specialization in Innovation in Phytomedicines (Farmanguinhos-Fiocruz - 2019-2021) and Specialization in Pharmaceutical Industrial Technologies (TIF - Farmanguinhos-Fiocruz - 2021-2022). She has experience in the following areas: Pharmacology, Herbal Medicine, Homeopathy, Biostatistics.

    Priscilla Christina Olsen

    Federal University of Rio de Janeiro (UFRJ), Health Sciences Center - CCS, Block A 2, room 7, Cidade Universitária, CEP 21941-902, Ilha do Fundão, Rio de Janeiro, RJ, Brazil.

    Graduated in Microbiology and Immunology at UFRJ (2006), Master (2007) and Ph.D. (2011) in Cellular and Molecular Biology at FIOCRUZ, with an emphasis on pharmacology and immunology. During her doctorate, she was a professor in the Social Pre-Entrance Exam at CEDERJ. She completed her postdoctoral studies at FIOCRUZ in 2013, when she became Adjunct Professor at the Faculty of Pharmacy at UFRJ. She is a permanent professor at the Postgraduate Course in Immunology and Inflammation and head of the Laboratory of Studies in Immunology at UFRJ. In 2016 she was named Pew Latin American Fellow, developing a scientific mission at Rockefeller University. She has experience in the field of immunopharmacology, focusing on the study of therapies for inflammatory lung diseases, allergic diseases and arboviruses. During postdoctoral research at Rockefeller University, she specialized in understanding the humoral response against flaviviruses and immunotherapy with human monoclonal antibodies. She is a member of the Brazilian Society of Immunology, of the Latin American and Caribbean Association for Immunology (ALACI), of ALACI's Women in Immunology and of the Brazilian Society for the Advancement of Science. She is a Young Scientist from Our State (JCNE / FAPERJ), acts as a member of the Research Ethics Committee of the HUCFF at UFRJ and is Lucas' mother (2 years old).

    Benjamin Gilbert

    Oswaldo Cruz Foundation (FIOCRUZ), Pharmaceuticals-Farmanguinhos Institute of Technology, Biodiversity and Health Innovation Center (CIBS), Avenida Comandante Guaranys, 447, Jacarepaguá, CEP 22775-903, Rio de Janeiro, RJ, Brazil.

    Graduated in Organic Chemistry - University of Bristol (1950) and Ph.D. in Organic Chemistry - University of Bristol (1954). She is currently a senior technologist at the Institute of Pharmaceutical Technology at the Oswaldo Cruz Foundation. She has experience in Chemistry, with an emphasis on Chemistry of Natural Products, acting on the following topics: chemical standardization of medicinal plants, implementation of phytotherapy in SUS, production of monographs on medicinal plants. She has been part of expert groups at the World Health Organization writing books on Medicinal Plants Monographs and Guides on Good Agricultural Production and Quality Control Practices, and Monographs on Environmental Health Criteria. He served on the Biology and Vector Control Committee of the Pan American Health Organization for a number of years and on the Board of Directors of the International Organization for the Development of Chemistry.

Keywords

SARS-CoV-2
COVID-19
Natural product
Innate and adaptive immune systems
Recognition of virus

Abstract

The innate immune system recognizes chemical structures of the virus and activates cells capable of blocking viral infection, it also activates the adaptive immune system that develops antibodies that can destroy or immobilize viruses. Analogously, chemical components of plants and yeasts in natural products can act as activators of the immune system, which could provide a defence against infection. Herein we examine various natural products from food and medicinal plants whose chemical components can possibly contribute in the defence against SARS-CoV-2, the virus that causes COVID-19.

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Author(s)

  • Roberta Ghilosso-Bortolini
    Oswaldo Cruz Foundation (FIOCRUZ), Pharmaceuticals-Farmanguinhos Institute of Technology, Biodiversity and Health Innovation Center (CIBS), Avenida Comandante Guaranys, 447, Jacarepaguá, CEP 22775-903, Rio de Janeiro, RJ, Brazil.
  • Priscilla Christina Olsen
    Federal University of Rio de Janeiro (UFRJ), Health Sciences Center - CCS, Block A 2, room 7, Cidade Universitária, CEP 21941-902, Ilha do Fundão, Rio de Janeiro, RJ, Brazil.
  • Benjamin Gilbert
    Oswaldo Cruz Foundation (FIOCRUZ), Pharmaceuticals-Farmanguinhos Institute of Technology, Biodiversity and Health Innovation Center (CIBS), Avenida Comandante Guaranys, 447, Jacarepaguá, CEP 22775-903, Rio de Janeiro, RJ, Brazil.

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Combatting COVID-19 by stimulating the immune system with natural products. Rev Fitos [Internet]. 2021 Dec. 17 [cited 2025 Feb. 1];15(4):523-37. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1108
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