Potential therapeutic effect of Moringa oleifera Lamarck (Moringaceae) leaves: a revision of its role in glycemic control in vivo studies

Francker Duarte de Castro
OrcID
Larissa Marina Pereira Silva
OrcID
Renata Borges de Oliveira
OrcID
Silvana Maria Zucolotto
OrcID

    Francker Duarte de Castro

    Federal University of Rio Grande do Norte (UFRN), Health Sciences Center, Department of Pharmacy, Av. General Cordeiro de Farias, s/n, Petrópolis, CEP 59012-570, Natal, RN, Brazil.

    OrcID https://orcid.org/0000-0001-8173-1654

    Master in Development and Environment (PRODEMA) from the Federal University of Rio Grande do Norte (UFRN). Bachelor in Pharmacy (UFRN) and Degree in Geography from the Federal Institute of Education, Science and Technology of Rio Grande do Norte (IFRN). He is currently a professor at the State Public Education Network of Rio Grande do Norte. Its study topics include: Pharmacognosy, medicinal plants, environmental perception, environmental issues, artisanal fishing, and cultural geography.

    Larissa Marina Pereira Silva

    Federal University of Rio Grande do Norte (UFRN), Health Sciences Center, Department of Pharmacy, Av. General Cordeiro de Farias, s/n, Petrópolis, CEP 59012-570, Natal, RN, Brazil.

    OrcID https://orcid.org/0000-0002-7480-1412

    Visiting Scholar no Plants for Human Health Institute, North Carolina State University, NC, EUA. Doctoral student in Development and Technological Innovation in Medicines (UFRN, 2018). Master in Pharmaceutical Sciences by the Pharmaceutical Sciences program at the Federal University of Rio Grande do Norte (UFRN, 2017). Graduated in Pharmacy from UFRN (2014). She worked as a Scientific Initiation student and monitor in Medicines Quality Control, with the LCQMed team under the guidance of Professor Dr. Cícero Flávio Aragão (2013). She has professional experience in the Commercial/Community Pharmacy area (UniFarma and Santa Fé Drugstore Networks, 2013-2014). She did an internship in the area of ​​Biochemical Analysis (PAPI, 2014). Intern at the Food and Drug Research Center - (NUPLAM, 2013). She worked at NUPLAM (2016-2017). She participated in the organization of the event: ''Safe and rational use of medicinal plants and phytotherapics: guidance for future professionals in the health area'', together with the PNBio team, under the coordination of Professor Dr. Silvana Maria Zucolotto Langassner (2016). She held a teaching internship in the Pharmacy Graduation course (UFRN), teaching a class with the theme ''Phenolic Compounds'' (2017). She has research experience with classical chromatography and chromatographic techniques such as

     

    HPLC-DAD, CLUE-DAD and LC-MS; development of analytical methodologies; pharmacological evaluation in vivo (nociceptive and anti-inflammatory) of synthetic compounds and in vitro (anthelmintic and anti-fungal) of plant derivatives; elucidation and structural characterization by NMR and MS of substances of natural origin. She acted as Substitute Professor in the Pharmacognosy discipline-UFRN (2018-2019). She is interested in research, mainly related to the prospection of natural products and chromatographic techniques. She intends to pursue an academic career, seeking to apply active methodologies such as the OSCE (Organization for Security and Co-operation in Europe) that encourage students to pursue active learning.

    Renata Borges de Oliveira

    Federal University of Rio Grande do Norte (UFRN), Health Sciences Center, Department of Pharmacy, Av. General Cordeiro de Farias, s/n, Petrópolis, CEP 59012-570, Natal, RN, Brazil.

    OrcID https://orcid.org/0000-0001-6655-205X

    Graduating in Pharmacy at UFRN, she is part of the Research Group on Bioactive Natural Products (GPNBio) as a Scientific Initiation Scholar, where she evaluates the antiviral activity of free and nanoencapsulated extracts of Spondias mombin. Participates in the Group of Studies and Practices in Pharmaceutical Assistance (GEPRAF), working on the project Development and validation of a clinical questionnaire to assess the predisposition to adherence to immunosuppressive treatment in kidney transplant patients, performed in 6 transplant centers and 5 dialysis clinics in the northeast Brazilian. Currently, she is a monitor in the Applied Pharmacology and Pharmaceutical Care disciplines. She is interested in research, bioactive natural products, pharmaceutical care, pharmacology and pharmaceutical care.

    Silvana Maria Zucolotto

    Federal University of Rio Grande do Norte (UFRN), Health Sciences Center, Department of Pharmacy, Av. General Cordeiro de Farias, s/n, Petrópolis, CEP 59012-570, Natal, RN, Brazil.

    OrcID https://orcid.org/0000-0002-2768-0793

    He holds a degree in Pharmacy from the Federal University of Santa Catarina (UFSC) (2003), a master's degree (2005) and a doctorate (2009) in Pharmacy from the UFSC, with a sandwich period at the Universidad Nacional de Colombia (UNAL). He is currently Associate Professor at the Department of Pharmacy, Federal University of Rio Grande do Norte (UFRN). Permanent member of the Graduate Programs in Pharmaceutical Sciences, Graduate Program in Health Sciences and Graduate Program in Development and Technological Innovation in Medicines. He has been a CNPq Research Productivity Scholar 2 since March 2021. He develops Research Projects in the area of ​​Pharmacognosy / Natural Products and advises Scientific Initiation, Master's and Doctoral students, in addition to Postdoctoral supervision. He coordinates the Research Group on Bioactive Natural Products (PNBio). He has experience in Pharmacy, with emphasis on Chemical investigation of natural products, working mainly on the following subjects: Passiflora and Kalanchoe species; plant species of interest to the SUS and occurring in the Northeast region of Brazil; development and validation of analytical methodologies for the determination of markers, flavonoids and phytotherapics. Founder of the Instagram profile @fitoterapia.com.ciencia. She was on maternity leave from November 2010 to May 2011 and from May to November 2013. She is currently doing postdoctoral work at the Plants for Human Health Institute at North Carolina State University (NCSU)-Kannapolis, US.

Keywords

Moringa
Toxicity
Antioxidant
Antihyperglycemic
Diabetes

Abstract

Moringa oleifera Lamarck (Moringaceae) has been highlighted in Brazil due to its high nutritional content and is widely used in food supplementation. Lately, many studies have been published about its actions in the treatment of diabetes mellitus and in several other properties, such as antioxidant, tissue protector and antihypertensive and immunomodulator effect. However, its growing irrational use by the population has triggered the prohibition of its use and commercialization of products in Brazil by the National Health Surveillance Agency (ANVISA). In this context, this study aimed to conduct a literature review to assess the potential antidiabetic action of M. oleifera leaves. For this purpose, 43 non-clinical studies (12 - in vitro; 31 - in vivo) were analyzed. The studies analyzed pointed to a promising antidiabetic activity. However, the lack of methodological standardization of the process and chemical characterization of products added to some methodological biases in studies weakened the scientific evidence on their efficacy, and the understanding of their mechanism of action.

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Author(s)

  • Francker Duarte de Castro
    Federal University of Rio Grande do Norte (UFRN), Health Sciences Center, Department of Pharmacy, Av. General Cordeiro de Farias, s/n, Petrópolis, CEP 59012-570, Natal, RN, Brazil.
    https://orcid.org/0000-0001-8173-1654
  • Larissa Marina Pereira Silva
    Federal University of Rio Grande do Norte (UFRN), Health Sciences Center, Department of Pharmacy, Av. General Cordeiro de Farias, s/n, Petrópolis, CEP 59012-570, Natal, RN, Brazil.
    https://orcid.org/0000-0002-7480-1412
  • Renata Borges de Oliveira
    Federal University of Rio Grande do Norte (UFRN), Health Sciences Center, Department of Pharmacy, Av. General Cordeiro de Farias, s/n, Petrópolis, CEP 59012-570, Natal, RN, Brazil.
    https://orcid.org/0000-0001-6655-205X
  • Silvana Maria Zucolotto
    Federal University of Rio Grande do Norte (UFRN), Health Sciences Center, Department of Pharmacy, Av. General Cordeiro de Farias, s/n, Petrópolis, CEP 59012-570, Natal, RN, Brazil.
    https://orcid.org/0000-0002-2768-0793

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Potential therapeutic effect of Moringa oleifera Lamarck (Moringaceae) leaves: a revision of its role in glycemic control in vivo studies. Rev Fitos [Internet]. 2022 Dec. 20 [cited 2025 Dec. 8];16(4):508-40. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1315
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