Impacto do consumo de Melissa officinalis L. (Lamiaceae) em ratos wistar alimentados com dieta de cafeteria

Jéssica  Priscila Zampieri Da Silva; Letícia  Marcon Borges; Pierre  Augusto Piva; Gustavo  Moreno Frederico; Fernanda  Guimarães Drummond e Silva; Flavia  Maria Netto; Sóstenez Alexandre Vessaro Silva; Daniela Miotto Bernardi

doi:10.32712/2446-4775.2022.1321

Impact of Melissa officinalis L. (Lamiaceae) consumption on wistar rats fed a cafeteria diet

Vol. 16 No. 4 (2022)
479-489
19/08/2021
20/12/2022
https://doi.org/10.32712/2446-4775.2022.1321

Jéssica Priscila Zampieri Da Silva
Letícia Marcon Borges
Pierre Augusto Piva
Gustavo Moreno Frederico
Fernanda Guimarães Drummond e Silva
Flavia Maria Netto
Sóstenez Alexandre Vessaro Silva
Daniela Miotto Bernardi

State University of Campinas (UNICAMP), Faculty of Food Engineering. Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, Barão Geraldo, CEP 13083862, Campinas, SP, Brazil.

OrcID https://orcid.org/0000-0002-0289-6424

He holds a degree in Food Engineering from the State University of Campinas (1980), a Master's in Food Technology from the State University of Campinas (1984), a PhD in Food Science from the State University of Campinas (1992) and a postdoctoral degree from the University of Minnesota System(1996). He is currently Associate Professor at the State University of Campinas, Journal Reviewer for Food Science and Technology (0101-2061), Journal Reviewer for Food and Nutrition Security at NEPA, Journal Reviewer for the International Dairy Journal (0958-6946), Journal Reviewer Food Hydrocolloids Journal Reviewer (0268-005X), Journal Reviewer for the International Dairy Journal, Journal Reviewer for Pesquisa Agropecuária Brasileira, Journal Reviewer for Bioresource Technology, Journal Reviewer for the African Journal of Marine Science, Journal Reviewer for Brazilian Archives of Biology and Technology, Reviewer of Food Chemistry, Reviewer of Química Nova, Reviewer of Journal of Agricultural and Food Chemistry, Reviewer of Food and Nutrition (UNESP), Reviewer of Food Science and Technology International , Reviewer of a journal at Nutrire (São Paulo), Reviewer of a support project at the Fundação de Amparo à Pesquisa do Estado from São Paulo, reviewer of the development project of the National Council for Scientific and Technological Development and reviewer of the funding project of the National Agency for Scientific and Technological Promotion. He has experience in the field of Food Science and Technology, with an emphasis on Food Science. Acting mainly on the following topics: protein hydrolysates, enzymatic hydrolysis, soy protein isolate, peptides, clinical nutrition

Keywords

Abstract

Melissa officinalis (Lamiaceae) is recognized for different phytotherapeutic and physiological-functional properties. The aim of this study was to evaluate the effect of Melissa officinalis on growth parameters, liver histology and biochemical tests of wistar rats fed a cafeteria diet. Thirty-two animals were used, divided into four groups (n=8): C - control group, fed with commercial feed and water; DC - group fed with cafeteria diet and water; DCMD - fed with cafeteria diet with 2% Melissa officinalis and water; DCMI - fed with cafeteria diet and 10% Melissa officinalis infusion. Daily feed intake, daily liquid consumption, daily weight gain, feed conversion, organ weights, and serum tests for glucose, cholesterol, triglycerides, lipid oxidation, and antioxidant activity were evaluated. Results showed that Melissa officinalis administered in infusion form acted on the reduction of the animals' body weight, on the decrease in the efficiency of the cafeteria diet to promote body weight gain and had a protective effect on the liver tissue producing less cytoplasmic vacuolization. Melissa officinalis administered in the diet promoted a protective effect on the serum glucose levels of the animals. Therefore, Melissa officinalis presents potential use as a dietary and phytotherapeutic agent.

References

Myles IA. Fast food fever: reviewing the impacts of the Western diet on immunity. Nutr J. 2014; 13(61): 1-17. ISSN 1475-2891 [https://doi.org/10.1186/1475-2891-13-61].
Statovci D, Aguilera M, MacSharry J, Melgar S. The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces. Front Immunol. 2017; 8(838): 1-21. ISSN 1664-3224 [https://doi.org/10.3389/fimmu.2017.00838].
Basho SM, Bin MC. Propriedades dos alimentos funcionais e seu papel na prevenção e controle da hipertensão e diabetes. Interbio. 2010; 4(1): 48-59. ISSN 1981-3775.
Falzon CC, Balabanova A. Phytotherapy: An Introduction to Herbal Medicine. Prim Care. 2017; 44 (2): 217-227. ISSN: 1558-299X [https://doi.org/10.1016/j.pop.2017.02.001].
Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L. - A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2016; 188: 204-28. ISSN 1872-7573 [https://doi.org/10.1016/j.jep.2016.05.010].
Campión J, Martinez JA. Ketoconazole, and Antifungal Agent, Protects Against Adiposity Induced by a Cafeteria Diet. Horm Metab Res. 2004; 36 (7): 485-491. ISSN 1439-4286 [https://doi.org/10.1055/s-2004-825729].
Brasil. Constituição Federal. Lei n° 11.794, de 8 de outubro de 2008. Regulamenta o inciso VII do § 1o do art. 225 da Constituição Federal, estabelecendo procedimentos para o uso científico de animais; revoga a Lei no 6.638, de 8 de maio de 1979. Diário Oficial da União. Brasília, 9 out. 2008; Seção 1, p1.
Beçak W, Paulete J. Técnicas de citologia e histologia (Vol. I). Rio de Janeiro: Livros Técnicos e Científicos. 1979.
Junqueira LC Junqueira LMMS. Técnicas básicas de citologia e histologia. São Paulo: Santos. 1983. ISBN 857288178.
Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of â€œantioxidant powerâ€: the FRAP assay. Anal Biochem. 1996; 239(1): 70-76. ISSN 1096-0309. [https://doi.org/10.1006/abio.1996.0292].
Vyncke, W. Direct determination of the thiobarbituric acid value in trichloracetic acid extracts of fish as a measure of oxidative rancidity. Eur J Lipid Sci Tech. 1970; 72(12): 1084-1087. ISSN 1438-9312. [https://doi.org/10.1002/lipi.19700721218].
Faria HG. Considerações sobre dietas experimentais para animais de Laboratório: formulações, aplicações, fornecimento e efeitos experimentais. In: Anais do I Simpósio de bioterismo da Fiocruz-PE; 2010 nov.; 11-12. Pernambuco, Brasil. Recife: Fiocruz; 2010.
Westerpep-Platenga MS. Effects of energy density of daily food intake on long-term energy intake. Physiol Behav. 2004; 81(5): 765-771. ISSN 1873-507X. [https://doi.org/10.1016/j.physbeh.2004.04.030].
Weisberg SP, Mccann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112(12): 1796-1808. ISSN 1558-8238. [https://doi.org/10.1172/JCI19246].
Bolkent S, Yanardag R, Karabulut-Bulan O, Yesilyaprak B. Protective role of Melissa officinalis L. extract on liver of hyperlipidemic rats: A morphological and biochemical study. J Ethnopharmacol. 2005; 99(3): 391-398. ISSN 1872-7573. [https://doi.org/10.1016/j.jep.2005.02.038].
Asadi A, Shidfar F, Safari M, Hosseini AF, Fallah Huseini H, Heidari I, Rajab A. Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double-blind, clinical trial. Phytother Res. 2019; 33(3): 651-659. ISSN 1099-1573. [https://doi.org/10.1002/ptr.6254].
Hasanein P, Riahi H. Antinociceptive and Antihyperglycemic Effects of Melissa officinalis L. Essential Oil in an Experimental Model of Diabetes. Med Princ Pract. 2015; 24: 47-52. ISSN 1423-0151. [https://doi.org/10.1159/000368755].
Nayebi N, Esteghamati A, Meysamie A, Khalili N, Kamalinejad M, Emtiazy M et al. The effects of a Melissa officinalis L. based product on metabolic parameters in patients with type 2 diabetes mellitus: A randomized double-blinded controlled clinical trial. J Compl Integr Med. 2019; 16(3): 1-12. ISSN 1553-3840. [https://doi.org/10.1515/jcim-2018-0088].
Heshmati J, Morvaridzadeh M, Sepidarkish M, Fazelian S, Rahimlou M, Omidi A et al. Effects of Melissa officinalis L. (Lemon Balm) on cardio-metabolic outcomes: a systematic review and meta-analysis. Phytother Res. 2020; 34(12): 3113-3123. ISSN 1099-1573. [https://doi.org/10.1002/ptr.6744].
Miraj S, Rafieian-Kopaei, Kiani S. Melissa officinalis L.: a review study with an antioxidant prospective. J Evid Based Compl Altern Med. 2017; 22(3): 385-394. ISSN 2156-5899. [https://doi.org/10.1177/2156587216663433].
Ghazizadeh J, Hamedeyazdan S, Torbati M, Farajdokht F, Fakhari A, Mahmoudi J et al. Melissa officinalis L. hydro-alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis. Exp Physiol. 2020; 105(4): 707-720. ISSN 1469-445X. [https://doi.org/10.1113/EP088254].

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Author(s)

Jéssica Priscila Zampieri Da Silva
Fundação Assis Gurgacz University Center (FAG), Clinical Analysis Laboratory, Avenida das Torres, 500, Fag Loteamento, , CEP 85806-095, Cascavel, PR, Brazil.
https://orcid.org/0000-0003-4469-1782
Letícia Marcon Borges
Fundação Assis Gurgacz University Center (FAG), Clinical Analysis Laboratory, Avenida das Torres, 500, Fag Loteamento, CEP 85806-095, Cascavel, PR, Brazil.
https://orcid.org/0000-0003-2715-3413
Pierre Augusto Piva
Fundação Assis Gurgacz University Center (FAG), Clinical Analysis Laboratory, Avenida das Torres, 500, Fag Loteamento, CEP 85806-095, Cascavel, PR, Brazil.
https://orcid.org/0000-0002-0974-4538
Gustavo Moreno Frederico
Fundação Assis Gurgacz University Center (FAG), Clinical Analysis Laboratory, Avenida das Torres, 500, Fag Loteamento, CEP 85806-095, Cascavel, PR, Brazil.
https://orcid.org/0000-0002-7982-1551
Fernanda Guimarães Drummond e Silva
State University of Campinas (UNICAMP), Faculty of Food Engineering. Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, Barão Geraldo, CEP 13083862, Campinas, SP, Brazil.
https://orcid.org/0000-0002-9615-5415
Flavia Maria Netto
State University of Campinas (UNICAMP), Faculty of Food Engineering. Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, Barão Geraldo, CEP 13083862, Campinas, SP, Brazil.
https://orcid.org/0000-0002-0289-6424
Sóstenez Alexandre Vessaro Silva
Fundação Assis Gurgacz University Center (FAG), Clinical Analysis Laboratory, Avenida das Torres, 500, Fag Loteamento, CEP 85806-095, Cascavel, PR, Brazil.
https://orcid.org/0000-0002-2114-7277
Daniela Miotto Bernardi
State University of Western Paraná (UNIOESTE), Rodovia Vitório Traiano, Km2, Água Branca, CEP 85601-970, Francisco Beltrão, PR, Brazil
https://orcid.org/0000-0001-9019-3835

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Impact of Melissa officinalis L. (Lamiaceae) consumption on wistar rats fed a cafeteria diet. Rev Fitos [Internet]. 2022 Dec. 20 [cited 2025 Jan. 31];16(4):479-8. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1321

This work is licensed under a Creative Commons Attribution 4.0 International License.

[1] Myles IA. Fast food fever: reviewing the impacts of the Western diet on immunity. Nutr J. 2014; 13(61): 1-17. ISSN 1475-2891 [https://doi.org/10.1186/1475-2891-13-61].

[2] Statovci D, Aguilera M, MacSharry J, Melgar S. The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces. Front Immunol. 2017; 8(838): 1-21. ISSN 1664-3224 [https://doi.org/10.3389/fimmu.2017.00838].

[3] Basho SM, Bin MC. Propriedades dos alimentos funcionais e seu papel na prevenção e controle da hipertensão e diabetes. Interbio. 2010; 4(1): 48-59. ISSN 1981-3775.

[4] Falzon CC, Balabanova A. Phytotherapy: An Introduction to Herbal Medicine. Prim Care. 2017; 44 (2): 217-227. ISSN: 1558-299X [https://doi.org/10.1016/j.pop.2017.02.001].

[5] Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L. - A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2016; 188: 204-28. ISSN 1872-7573 [https://doi.org/10.1016/j.jep.2016.05.010].

[6] Campión J, Martinez JA. Ketoconazole, and Antifungal Agent, Protects Against Adiposity Induced by a Cafeteria Diet. Horm Metab Res. 2004; 36 (7): 485-491. ISSN 1439-4286 [https://doi.org/10.1055/s-2004-825729].

[7] Brasil. Constituição Federal. Lei n° 11.794, de 8 de outubro de 2008. Regulamenta o inciso VII do § 1o do art. 225 da Constituição Federal, estabelecendo procedimentos para o uso científico de animais; revoga a Lei no 6.638, de 8 de maio de 1979. Diário Oficial da União. Brasília, 9 out. 2008; Seção 1, p1.

[8] Beçak W, Paulete J. Técnicas de citologia e histologia (Vol. I). Rio de Janeiro: Livros Técnicos e Científicos. 1979.

[9] Junqueira LC Junqueira LMMS. Técnicas básicas de citologia e histologia. São Paulo: Santos. 1983. ISBN 857288178.

[10] Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of â€œantioxidant powerâ€: the FRAP assay. Anal Biochem. 1996; 239(1): 70-76. ISSN 1096-0309. [https://doi.org/10.1006/abio.1996.0292].

[11] Vyncke, W. Direct determination of the thiobarbituric acid value in trichloracetic acid extracts of fish as a measure of oxidative rancidity. Eur J Lipid Sci Tech. 1970; 72(12): 1084-1087. ISSN 1438-9312. [https://doi.org/10.1002/lipi.19700721218].

[12] Faria HG. Considerações sobre dietas experimentais para animais de Laboratório: formulações, aplicações, fornecimento e efeitos experimentais. In: Anais do I Simpósio de bioterismo da Fiocruz-PE; 2010 nov.; 11-12. Pernambuco, Brasil. Recife: Fiocruz; 2010.

[13] Westerpep-Platenga MS. Effects of energy density of daily food intake on long-term energy intake. Physiol Behav. 2004; 81(5): 765-771. ISSN 1873-507X. [https://doi.org/10.1016/j.physbeh.2004.04.030].

[14] Weisberg SP, Mccann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112(12): 1796-1808. ISSN 1558-8238. [https://doi.org/10.1172/JCI19246].

[15] Bolkent S, Yanardag R, Karabulut-Bulan O, Yesilyaprak B. Protective role of Melissa officinalis L. extract on liver of hyperlipidemic rats: A morphological and biochemical study. J Ethnopharmacol. 2005; 99(3): 391-398. ISSN 1872-7573. [https://doi.org/10.1016/j.jep.2005.02.038].

[16] Asadi A, Shidfar F, Safari M, Hosseini AF, Fallah Huseini H, Heidari I, Rajab A. Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double-blind, clinical trial. Phytother Res. 2019; 33(3): 651-659. ISSN 1099-1573. [https://doi.org/10.1002/ptr.6254].

[17] Hasanein P, Riahi H. Antinociceptive and Antihyperglycemic Effects of Melissa officinalis L. Essential Oil in an Experimental Model of Diabetes. Med Princ Pract. 2015; 24: 47-52. ISSN 1423-0151. [https://doi.org/10.1159/000368755].

[18] Nayebi N, Esteghamati A, Meysamie A, Khalili N, Kamalinejad M, Emtiazy M et al. The effects of a Melissa officinalis L. based product on metabolic parameters in patients with type 2 diabetes mellitus: A randomized double-blinded controlled clinical trial. J Compl Integr Med. 2019; 16(3): 1-12. ISSN 1553-3840. [https://doi.org/10.1515/jcim-2018-0088].

[19] Heshmati J, Morvaridzadeh M, Sepidarkish M, Fazelian S, Rahimlou M, Omidi A et al. Effects of Melissa officinalis L. (Lemon Balm) on cardio-metabolic outcomes: a systematic review and meta-analysis. Phytother Res. 2020; 34(12): 3113-3123. ISSN 1099-1573. [https://doi.org/10.1002/ptr.6744].

[20] Miraj S, Rafieian-Kopaei, Kiani S. Melissa officinalis L.: a review study with an antioxidant prospective. J Evid Based Compl Altern Med. 2017; 22(3): 385-394. ISSN 2156-5899. [https://doi.org/10.1177/2156587216663433].

[21] Ghazizadeh J, Hamedeyazdan S, Torbati M, Farajdokht F, Fakhari A, Mahmoudi J et al. Melissa officinalis L. hydro-alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis. Exp Physiol. 2020; 105(4): 707-720. ISSN 1469-445X. [https://doi.org/10.1113/EP088254].