Interactions of medicinal plants and drugs in patients with systemic arterial hypertension and Diabetes mellitus

Tiago Agostinho Ferreira
OrcID
Ydia Mariele Valadares
OrcID
Jullyana Bicalho Costa
OrcID
Andressa Barros Paschoalim
OrcID
Jéssica Aline Silva Soares
OrcID
Mariana Cristina de Assis Ramos
OrcID
Port.
OrcID

    Tiago Agostinho Ferreira

    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.

    OrcID https://orcid.org/0000-0001-6758-1805

    He is graduating from the 9th period of the Pharmacy course at the Federal University of Juiz de Fora, Advanced Campus of Governador Valadares (UFJF-GV). He worked as a volunteer monitor in the discipline of Physiology IV and a fellow monitor in the discipline of Medical Parasitology and in the research area, promoting screening of antimicrobial activity of plant extracts and interactions between medicinal plants and allopathic medicines used in the treatment of systemic arterial hypertension and diabetes. .

    Ydia Mariele Valadares

    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.

    OrcID https://orcid.org/0000-0001-6028-551X

    Graduated in Pharmacy from the Federal University of Minas Gerais (1998), Master's in Pharmaceutical Sciences from the Federal University of Minas Gerais (2000). PhD in Pharmaceutical Sciences from the Federal University of Minas Gerais (2009) with a sandwich internship at the University of Salamanca, Spain. He has experience in the area of natural products, with emphasis on phytochemistry, quality control of phytotherapics and organic synthesis, working mainly on the following subjects: chromatography, isolation and identification of natural products; standardization of methods for quality control of herbal medicines and synthesis of derivatives from natural products. Interactions between medicinal plants and medicines.

    Jullyana Bicalho Costa

    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.

    OrcID https://orcid.org/0000-0002-7137-9359

    Graduated in Pharmacy, she has experience in fire safety, work safety and technical instructions.

    Andressa Barros Paschoalim

    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.

    OrcID https://orcid.org/0000-0001-7875-2761

    She is currently a bacteriology monitor at the Federal University of Juiz de Fora- Campus Governador Valadares and participates in the extension project "evaluation of the use of medicinal plants and drug interactions with allopathic therapy in patients with arterial hypertension and diabetes mellitus users of Hiperdia Minas in Governador Valadares-Mg. Has experience in Pharmacy.

    Jéssica Aline Silva Soares

    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.

    OrcID https://orcid.org/0000-0002-7311-6122

    Pharmacist (2019) graduated from the Federal University of Juiz de Fora Governador Valadares campus and Master's student at the Graduate Program in Medicines and Pharmaceutical Assistance (PPGMAF) at the Faculty of Pharmacy of the Federal University of Minas Gerais. Researcher at the Center for Studies in Pharmaceutical Care (CEAF-UFMG). He has a specialization in Health and Wellness Phytotherapy (2020) from Faculdade dos Vales Elbira Dayrell (FAVED). He is currently a professor of the undergraduate and graduate courses in pharmacy at Faculdade Pitágoras, Governador Valadares/MG and Ipatinga/MG. She performs care as a clinical pharmacist and herbalist in a private office. Pharmacist advisor to the Phytotherapy Technical Group of the Minas Gerais Regional Pharmacy Council (CRF-MG). She was a substitute professor for 2 years in the pharmacy department of the Federal University of Juiz de Fora, Governador Valadares campus (UFJF-GV). She worked as a Clinical Pharmacist at Hospital Bom Samaritano in Governador Valadares / MG with the implementation of the pharmaceutical clinical service of pharmacotherapeutic follow-up in intensive care units (ICUs) and for broad-spectrum antimicrobials. Experience in clinical and pharmaceutical services in community pharmacy. Founder and collaborator of the Academic League of Drug Therapy Management (LAGTM) at UFJF-GV. She works mainly in the following subjects: pharmaceutical care, clinical pharmacy, clinical pharmaceutical services, pharmacotherapy and clinical phytotherapy.

    Mariana Cristina de Assis Ramos

    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.

    OrcID https://orcid.org/0000-0001-8830-6570

    Graduated in Pharmacy, Federal University of Juiz de Fora, Governador Valadares Campus

    Port.

    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.

    OrcID https://orcid.org/0000-0002-1694-1556

    She has a Nursing Technician at the José Rodrigues da Silva Technical School (Governador Valadares-MG/2014). Currently a student of the pharmacy course at the Federal University of Juiz de Fora Advanced Campus of Governador Valadares - MG, fellow in the scientific initiation project "Pharmacist's clinical performance in the management of rheumatoid arthritis: scoping review", volunteer in the extension project "Microbial World in Action: Concepts of Microbiology and Parasitology in Elementary and Secondary Education" and founding participant of the Interdisciplinary Study Group in Pharmaceutical Care (GEICF). She was an undergraduate monitor in the discipline "Analytical Chemistry IV" between 04/2018 to 12/2018, volunteer collaborator in the extension project "Evaluation of the use of medicinal plants and drug interactions with allopathic therapy in patients with Systemic Arterial Hypertension and Diabetes Mellitus users from Hiperdia Minas in Governador Valadares - MG" between 04/2019 to 12/2019, volunteer in the extension project "The importance of the Pharmacy and Therapeutics Commission in the development of Pharmaceutical Assistance in Governador Valadares - MG" between 04/2019 to 12/ 2019, extension project that presented continuity with the name "Implementation of the Pharmacy and Therapeutics Commission in the development of Pharmaceutical Assistance in Governador Valadares - MG" between 04/2020 to 06/2021 and volunteer in the professional training "Application of chemical-analytical techniques of forensic toxicology to support the activities of the criminal expertise of the Civil Police of the State of Minas Gerais in Governador Valadares" en from 10/2019 to 10/2020.

Keywords

Plant-drug interactions
Rational use of medicinal plants
Systemic arterial hypertension
Diabetes mellitus tipo 2

Abstract

The prevalence of chronic diseases such as Systemic Arterial Hypertension (SAH) and Diabetes Mellitus (DM) encourages the search for alternative treatments in addition to conventional pharmacotherapy, with emphasis on medicinal plants. However, the lack of information about medicinal plants, their interactions with drugs and self-medication are worrying factors. The objectives of the study were to identify medicinal plants and pharmacological classes used by patients with SAH and/or DM registered in the Hiperdia program in Governador Valadares, MG, to characterize these users and possible interactions between medicinal plants and a pharmacotherapy. A cross-sectional study was carried out with a semi-structured questionnaire. Of the respondents, 66.2% have SAH, 9% DM and 24.8% both pathologies. The majority (52.4%) use medicinal plants and 46.2% are subject to some type of plant-drug interaction, such as the use of Baccharis trimera, Allium sativum, Rosmarinus officinalis and Plectranthus barbatus with antihypertensives or Allium sativum and Matricaria chamomilla with oral antidiabetics. In this sense, an assessment of plant-drug interactions, adequacy of therapy and patient guidance are fundamental tools for preventing undesirable effects, contributing to the rational use of medicinal plants and improving the quality of life of patients with SAH and DM.

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Author(s)

  • Tiago Agostinho Ferreira
    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.
    https://orcid.org/0000-0001-6758-1805
  • Ydia Mariele Valadares
    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.
    https://orcid.org/0000-0001-6028-551X
  • Jullyana Bicalho Costa
    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.
    https://orcid.org/0000-0002-7137-9359
  • Andressa Barros Paschoalim
    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.
    https://orcid.org/0000-0001-7875-2761
  • Jéssica Aline Silva Soares
    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.
    https://orcid.org/0000-0002-7311-6122
  • Mariana Cristina de Assis Ramos
    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.
    https://orcid.org/0000-0001-8830-6570
  • Port.
    Universidade Federal de Juiz de Fora (UFJF), Faculdade de Farmácia e Bioquímica. Avenida Israel Pinheiro, nº 2000, Universitário, CEP 35020-070, Governador Valadares, MG, Brasil.
    https://orcid.org/0000-0002-1694-1556

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Interactions of medicinal plants and drugs in patients with systemic arterial hypertension and Diabetes mellitus. Rev Fitos [Internet]. 2022 Dec. 20 [cited 2024 Nov. 22];16(4):490-507. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1341
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