Optimization of the extraction of phenolic compounds from agroindustrial residue of Cupuaçu (Theobroma grandiflorum (Wild. ex. spreng) K. Schum) from the Amazon

Haroldo Araujo Lourenço da Silva
OrcID
Debora Kono Taketa Moreira
OrcID
Alessandra da Silva Santos
OrcID
Alciene Ferreira da Silva Viana
OrcID
Kelliane Silva de Oliveira
OrcID
Bruno Alves Cândido
OrcID
Bruno Alexandre da Silva
OrcID
Lauro Euclides Soares Barata
OrcID

    Haroldo Araujo Lourenço da Silva

    Federal University of Rio de Janeiro (UFRJ), Department of State Law, Rua Moncorvo Filho, 8, Centro, CEP 20211-340, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0000-0002-2455-6586

    Lawyer specializing in Real Estate Law for 17 years. Postdoctoral degree in Arbitration with Public Authorities (UERJ). Doctor and Master in Law (PPGD/UNESA). Adjunct Professor Doctor I at UFRJ Graduation and guest professor at FGV and EMERJ. Coordinator of the LEMASC/UFRJ research group (Laboratory for the Study of Appropriate Conflict Resolution Means). Member of IBDP, IAB, ABDPC and ABA, acting on the Real Estate and Condominium Law Commission. Author of several legal works and articles, especially on Civil Procedural Law and Real Estate.

    Debora Kono Taketa Moreira

    Federal Institute of Brasilia - IFB, Campus Gama. Rodovia DF-480 SMA Lote 1, Gama, CEP 72429-005, Brasília, DF, Brazil.

    OrcID https://orcid.org/0000-0002-1405-227X

    He holds a degree in Food Technology from the State University of Pará (2007), specialization in Food Quality and Safety (2008), a Master's Degree in Food Science from the Federal University of Lavras (2010) and a PhD in Food Science from the State University of Campinas (2016). She worked as a substitute teacher at IFSuldeminas and UFOPA. She is currently a professor at the Federal Institute of Brasília. She has experience in the area of Food Science and Technology, with an emphasis on Technology of Products of Plant Origin, researching the following topics: Functional foods, modification of oils and fats and development of new products.

    Alessandra da Silva Santos

    Federal University of Western Pará (UFOPA). Rua Vera Paz, Salé, CEP 68040-255, Santarém, PA, Brazil.

    OrcID https://orcid.org/0000-0003-2698-4135

    Graduated in Agronomy from the Federal University of Western Pará (2019) and high school education from Madre Imaculada (2011). She has experience in the area of Agronomy, with an emphasis on Agronomy.

    Alciene Ferreira da Silva Viana

    Federal University of Western Pará (UFOPA). Rua Vera Paz, Salé, CEP 68040-255, Santarém, PA, Brazil.

    OrcID https://orcid.org/0000-0001-7893-205X

    Graduated in Pharmacy from Instituto Esperanca de Ensino Superior (2016). Postgraduate degree in Pharmacology and Drug Interactions from Uninter. She is currently a clinical analysis technician at the Federal University of Western Pará at the Pharmacognosy Laboratory. She has experience in the area of Clinical Analysis, with an emphasis on Pharmacy.

    Kelliane Silva de Oliveira

    Federal University of Western Pará (UFOPA). Rua Vera Paz, Salé, CEP 68040-255, Santarém, PA, Brazil.

    OrcID https://orcid.org/0000-0002-2808-8951

    Technician in Nursing, with an interest in the health sector of the population, seeking, in the academy, to acquire knowledge to act as a professional who will promote changes in the context of regional health, turning attention to the lack that the population of Western Pará is going through.

    Bruno Alves Cândido

    Federal University of Rio de Janeiro (UFRJ), Department of State Law, Rua Moncorvo Filho, 8, Centro, CEP 20211-340, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0009-0005-3787-9906

    Graduating in Licentiate in Chemistry from the Federal Institute of Brasília (IFB). CNPq Scientific Initiation Scholar, has two research projects completed in the field of Food Sciences. She has experience in the area of Food Science and Technology, with emphasis on evaluation of bioactive properties.

    Bruno Alexandre da Silva

    Federal University of Western Pará (UFOPA). Rua Vera Paz, Salé, CEP 68040-255, Santarém, PA, Brazil.

    OrcID https://orcid.org/0000-0001-8801-0761

    Pharmacist-Biochemist, Specialist in Higher Education, Master in Food Science and Technology, PhD in Organic Chemistry. Professor of Pharmacognosy of the Pharmacy course at the Instituto de Saúde Coletiva of the Federal University of Western Pará, where he works in RD&I with natural products, medicinal plants and natural bioactive food compounds. Researcher and disseminator of body and mind healing technologies through integrative and complementary health practices. Specialist in Positive Psychology, Science of Well-being and Self-realization, he has a special interest in studies in the field of self-care and in Traditional Chinese Medicine and its therapeutic resources.

    Lauro Euclides Soares Barata

    Federal University of Western Pará (UFOPA). Rua Vera Paz, Salé, CEP 68040-255, Santarém, PA, Brazil.

    OrcID https://orcid.org/0000-0003-0909-769X

    Degree in Industrial Chemistry from the Federal University of Pará, Master's Degree in Chemistry of Natural Products from the Federal University of Rio de Janeiro, PhD in Chemistry from the State University of Campinas, Post-Doctorate at the Center National de la Recherche Scientifique - CNRS, Institut de Chimie des Natural Substances. Visiting Professor at the University of London, School of Pharmacy. He was National and International Relations Advisor at the Federal University of Oeste do Pará (2017) and Associate Researcher at the Thomson Mass Spectrometry Laboratory at UNICAMP until 2017) and Associate Researcher at the Chromatography Lab at IQ-UNICAMP. Professor of master's and doctorate at UFOPA. Consultant - SEBRAE-PA, FINEP; FAPESP, FAPESP and INCT-Climate Change Supervised by Prof. Carlos Nobre. He has experience in the area of Chemistry, with emphasis on Organic Chemistry and Phytochemistry, Essential Oils and Extracts of Aromatic Plants and Medicinal Plants applied to Medicines and Cosmetics. Cooperation with Companies in the Cosmetics sector in Brazil. Consultant for Companies in the Pharmaceutical and Cosmetic area. He is a Director of the Amazon Natural Products Consultancy Company.

Keywords

Waste
Western Pará
Bioactive compounds
DCCR

Abstract

The Amazon has a great diversity of edible fruits, which originate several food products. This commercial exploitation generates a necessary amount of waste, which has a potential for biological activity, as it contains phenolic compounds in matrices. Thus, this study aimed to employ the response surface methodology to optimize the treatment of ethanol (X1 = 25 to 75%) and the solvent: solute ratio (X2: 30 to 90%) in the recovery of phenolic compounds (CFT) to from agribusiness residues from cupuaçu. Process time was fixed at 1 h of extraction at 37°C using the assisted ultrasound bath. The results suggested that the optimal conditions were 50% ethanol concentration and the solute:solvent ratio was 1:100. Under the optimal conditions, the experimental CFT was 18.08 ± 2.37 µg GAE / mg of dry cupuaçu peel, which was very close to the predicted value. The second order polynomial model fits the experimental data satisfactorily with an adapted R2 of 89.70, implying a good agreement between the predicted and experimental values, which indicates acceptability in the optimization of the conditions for the extraction of CFT from the cupuaçu peel.

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Optimization of the extraction of phenolic compounds from agroindustrial residue of Cupuaçu (Theobroma grandiflorum (Wild. ex. spreng) K. Schum) from the Amazon. Rev Fitos [Internet]. 2023 Sep. 30 [cited 2026 Jan. 17];17(3):376-87. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1383
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