Antidiabetic properties of medicinal plants of the genus Bauhinia: integrative review

Roberta Freitas Celedonio
OrcID
Anne Caroline Ferreira Queiroga
OrcID
Wilma Freitas Celedonio
OrcID
Janiel Ferreira Felício
OrcID
Bárbara Letícia de Queiroz Xavier
OrcID
Yara Santiago de Oliveira
OrcID
Maria do Socorro Moura Rufino
OrcID
Jeferson Falcão do Amaral
OrcID

    Roberta Freitas Celedonio

    Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB), Instituto de Educação à Distância (IEAD), Instituto de Ciências da Saúde (ICS), Curso de pós - graduação em Saúde da Família, Rodovia CE 060, Km 51, Campus dos Palmares, CEP 62785-000, Acarape, CE, Brasil.

    OrcID https://orcid.org/0000-0003-0787-8070

    Graduated in Nutrition from the Federal Institute of Education, Science and Technology ? IFCE (2016). At graduation she was a bromatology monitor, participated in the Food Science and Technology research group (2014-2016), and performed in-service training at Hospital de Messejana Dr. Carlos Alberto Studart Gomes ? HM (2015). Specialist by the Postgraduate Program in the Residency modality in Hospital Health Care, with an emphasis on Diabetes at the Walter Cantídio University Hospital/Federal University of Ceará - UFC. Preceptor of the Multiprofessional Residency in Diabetes Care - Walter Cantídio University Hospital/UFC. Preceptor of the Bachelor's Degree in Nutrition at Faculdade Metropolitana de Fortaleza - FAMETRO. Extensionist of the EM DIA Nucleus Project (Multiprofessional Nucleus for Studies, Integrated Care and Permanent Education in Diabetes, Obesity, Arterial Hypertension, Dyslipidemia and Atherosclerosis) at the Walter Cantídio University Hospital/UFC. Specialist in Family Health from the University of International Integration of Afro-Brazilian Lusophony (UNILAB) and in Clinical and Sports Nutrition from the Faculty of Quixeramobim (UNIQ). Master's student in Nutrition and Health at the State University of Ceará (UECE). Area of ​​interest for study/research: Nutritional assessment; Educational technologies; Chronic non-communicable diseases.

    Anne Caroline Ferreira Queiroga

    University of International Integration of Afro-Brazilian Lusofonia (UNILAB), Institute of Rural Development. Liberty Campus. Avenida da Abolição, 3, downtown, CEP 62790-000, Redenção, CE, Brazil.

    OrcID https://orcid.org/0000-0002-7958-2247

    Master in Nursing from the International University for the Integration of Afro-Brazilian Lusophony-UNILAB- Research line: Technologies in Health Care in the scenario of Lusophone countries. Diabetologist Nurse at the Multiprofessional Residency in Hospital Health Care (RESMULTI) - Walter Cantídio University Hospital (HUWC) - Federal University of Ceará (UFC). Diabetes educator certified by the Juvenile Diabetes Association (ADJ)- Brazilian Society of Diabetes (SBD)- International Diabetes Federation (IDF)/Latin American Network of Diabetes Educators (RELAD).

    Wilma Freitas Celedonio

    Federal University of Paraíba (UFPB), Center for Agricultural Sciences-CCA-Campus II, 12 Rodovia, PB-079, CEP 58397-000, Areia, PB, Brazil.

    OrcID https://orcid.org/0000-0002-6292-8299

    Eng. Agronomist graduated from the Federal Rural University of Semi-Arid (Ufersa). Master's student in Agronomy, with emphasis on Fruit Fruit, from the Federal University of Paraíba (UFPB)

    Janiel Ferreira Felício

    Universidade Federal do Rio Grande do Norte (UFRN), Laboratório de Pesquisa em Saúde e Enfermagem no Cuidado às pessoas em Condições Agudas e Crônicas (LAPAC - UFRN), campus Universitário, Lagoa Nova, CEP 59078-970, Natal, RN, Brasil

    OrcID https://orcid.org/0000-0002-5601-0086

    Nurse from the University of International Integration of Afro-Brazilian Lusophony (UNILAB)-2021. He is currently a master's degree in Collective Health by the Postgraduate Program in Collective Health (PPSAC) of UECE. Participant of the Research and Extension Group Classification Systems of Nursing Practice, registered in the CNPq Directory. Developed projects promoted by the Cearense Foundation for Support for Scientific and Technological Development-FUNCAP (2018-2019), (2019-2020), (2020-2021) focusing on the health profile of children of a specialized service (2018-2019), Application of an instrument of nursing intervention for prevention against falls in elderly with arterial hypertension (2019-2020) and dissemination of Covid-19 in Ceará (2020-2021). He acts on the following subjects: nursing taxonomies; chronic diseases. Email: janielfelicio1@gmail.com

    Bárbara Letícia de Queiroz Xavier

    Federal University of Rio Grande do Norte (UFRN), Research Laboratory in Health and Nursing in the Care of People with Acute and Chronic Conditions (LAPAC - UFRN), University Campus, Lagoa Nova, CEP 59078-970, Natal, RN, Brazil.

    OrcID https://orcid.org/0000-0003-1622-9128

    Doctoral student and master in collective health from the Postgraduate Program in Collective Health of the Federal University of Rio Grande do Norte. EXTERNAL STUDENT (Master level) of the National School of Public Health - FIOCRUZ. Bachelor of Nursing from the Federal University of Campina Grande (2010-2015). Specialist in Public Health from the School of Public Health, Family Health, Nursing in Intensive Care Unit and Surgical Instrumentation, Surgical Center, and Material and Sterilization Center. She has experience as a teacher at undergraduate, postgraduate and technical level. She acts as an evaluator of scientific events and undergraduate stalls. She teaches courses and lectures in companies and hospitals. Event Organizer, Reviewer and Book Organizer in the Health area. Member of the Health and Nursing Research Laboratory in the care of people in acute and chronic conditions (LAPAC - UFRN). She acted at the HIV / AIDS Studies Center and Associated Diseases (Neaids-UFC). He served as a care nurse in the public and private network in the following sectors: medical and surgical clinics (adult and pediatric), maternity, operating room and obstetric center, translated and psychiatry, risk classification, adult and pediatric emergency. During graduation she served as extensionist of the Extension Scholarship Program (Probex-UFCG). She developed teaching initiation activities, as a fellow monitor in Clinical Nursing Discipline II-Transmissible Diseases. Areas of action: public health, focusing on health promotion, infectious diseases and social vulnerabilities.

    Yara Santiago de Oliveira

    Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB), Instituto de Ciências da Saúde (ICS), Rua José Franco de Oliveira, s/n, Zona Rural, Campus das Auroras, CEP 62790-970, Redenção, CE, Brasil

    OrcID https://orcid.org/0000-0001-8812-948X

    Graduated in Pharmacy from the Federal University of Ceará (2013), Master and Doctorate in Pharmaceutical Sciences UFC (2015 and 2019, respectively). Doctorate Sandwich at the University of Limerick - Ireland (2015), with emphasis on crystallography. She is currently an adjunct professor at the Institute of Health Sciences at the University of International Integration of Afro-Brazilian Lusophony in the Pharmacy course and acts as a permanent member of the Postgraduate Program in Pharmaceutical Sciences (PPGCF). She published 10 works in indexed magazines. Has experience in the area of control and quality guarantee of medicines, pharmaceutical and physical equivalence of solid state, with emphasis on drug applications, mainly acting on drugs related to drugs, crystal engineering, vibrational spectroscopy, thermal analysis and diffraction of x-rays of dust and monocrystal.

    Maria do Socorro Moura Rufino

    Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB), Mestrado Acadêmico em Sociobiodiversidade e Tecnologias Sustentáveis (MASTS), Rua José Franco de Oliveira, s/n, Zona Rural, Campus das Auroras, CEP 62790-970, Redenção, CE, Brasil

    OrcID https://orcid.org/0000-0003-3450-9481

    Since graduation (Agronomic Engineering) he has been dedicated to the study of bioactive compounds present in tropical fruits and their adjacent subjects. The subject of his master's degree was the study of nutritional compounds present in cashew fruit. In 2008 she completed her PhD, including a Doctoral Internship Abroad in Biochemistry of Nutrition at the Dept. of Metabolism and Nutrition (ICTAN/CSIC), Madrid (ES). In 2010 she was recognized with the Capes de Tese / 2009 Prize, for her unprecedented research on bioactive compounds, dietary fiber and antioxidant activity in tropical fruits. In 2010 she held a Post-Doctorate (PNPD / CAPES) in Food Science and Technology at UFC. She is currently an Associate Professor (entry in 2012) at the University of International Integration of Afro-Brazilian Lusofonia (UNILAB), a federal public institution whose mission is international cooperation with CPLP countries. She is a Permanent Professor in the MASTS/Unilab Graduate Program. From 2012 to 2014, she participated in the management of the University, assuming Management Positions, among them the Coordination of Research and Graduate Studies, Pro-Rectory of Research, Graduate Studies and Extension and Pro-Rectory of Institutional Relations. Leader of the research group POLIFIBAN/CNPq (Polyphenols, antioxidants and dietary fiber in health). Among recent works, the following stand out: participation as author of a book chapter by the Royal Society of Chemistry, Cambridge (UK); participation as author of a book chapter by Elsevier (RJ); Luis Noé Fernández Award, Antioxidantes-Fibra group, Alimerka Foundation, Spain; lectures and courses given in Brazil and abroad. She has experience in the area of ​​Food Science and Technology (Biochemistry of Food and Nutrition), working mainly on the following topics: bioactive compounds, antioxidant activity and macroantioxidants in foods of plant and animal origin. Effective member of the FUNCAP Chamber of Agricultural and Veterinary Sciences (2021-2023). She is currently part of the Bank of Evaluators of the National Higher Education Assessment System-BASis / INEP. Lab Manager. Food Analysis (IDR-Unilab).

    Jeferson Falcão do Amaral

    Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB), Mestrado Acadêmico em Sociobiodiversidade e Tecnologias Sustentáveis (MASTS), Rua José Franco de Oliveira, s/n, Zona Rural, Campus das Auroras, CEP 62790-970, Redenção, CE, Brasil

    OrcID https://orcid.org/0000-0003-0426-0347

    Adjunct Professor Class C3 at the University of International Integration of Afro-Brazilian Lusophony (UNILAB). He holds a degree in Pharmacy from the Federal University of Ceará (2000), a Master's in Pharmacology from the Federal University of Ceará (2004) and a PhD in Pharmacology from the same University (2010). Specialist in Strategic Management of Higher Education Institutions-IES (FAMETRO). Specialist in Pharmaceutical Care and Clinical Pharmacy (IPOG). Specialization in Phytotherapy and Prescription of Phytotherapics in progress (Faculty Metropolitana). Specialization in Mental Health in progress (FAVENI). Training Course in Clinical Psychoanalysis in progress (Brazilian Institute of Clinical Psychoanalysis - IBPC). Professor of the Pharmacy Course (Applied Pharmacology, Pharmaceutical Semiology, Clinical Pharmacy, Internship in Pharmaceutical Assistance and Introduction to the Pharmacy Course). Permanent Professor of the Master in Sociobiodiversity and Sustainable Technologies (MASTS/UNILAB). Advisory Professor TCCs of the Uni/Multiprofessional Residency at ESP-CE (TOPIC: Mental/Collective Health). Coordinator of the Research and Extension Group on Drug Use (GPUMed - UNILAB). Vice-Coordinator of the Pharmacy Course at UNILAB. Coordinator of the EAD Pole of Redenção-CE (IEAD/UNILAB). Clinical Pharmacist at the Comprehensive Health Care Center (CAIS/ICS/UNILAB). Member of the Technical Advisory Committee on Community Pharmacy and Pharmaceutical Services (CRF-CE). Member of the Pharmaceutical Assistance Technical Advisory Commission (CRF-CE). He has experience in Academic Management and Distance Learning Management. He has experience in the area of ​​Health (Pharmaceutical Assistance, Pharmaceutical Care and Teaching). He works as a Researcher and Extensionist in the following lines of study: Clinical Pharmacy; Mental Health and Neuropsychopharmacology; Rational Use of Medicines/Medicinal Plants/Phytotherapics, Education/Health Promotion and Pharmaceutical Assistance.


Keywords

Bauhinia
Diabetes mellitus
Hyperglycemia
Hypoglycemia

Abstract

Diabetes mellitus (DM) is a heterogeneous group of metabolic disorders that result in hyperglycemia due to defects in insulin action and/or secretion, and it is possible to find in the literature several plants with reports of antidiabetic activity, including those of the Bauhinia genus. Thus, the purpose of this article is to approach through the literature the antidiabetic properties of medicinal plants of the Bauhinia genus, which are popularly known as pata-de-vaca, unha-de-vaca, unha de boi or bauínia. Thus, a bibliographic survey was carried out in the LILACS and PubMed/MEDLINE databases, which covered national and international publications, from 2000 to 2021, totaling 20 articles. It was evidenced through the articles that the Bauhinia genus would be an adjunct to the treatment of Diabetes mellitus, presenting antidiabetic properties, and that its use helps in the control of the pathology and damage prevention. However, even though it is a plant widely used by the population, it has not yet been regulated by the National Agency of Sanitary Vigilance of Brazil and has no therapeutic indication, as more studies are still needed to prove its safety and efficacy, especially in humans. 

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Author(s)

  • Roberta Freitas Celedonio
    Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB), Instituto de Educação à Distância (IEAD), Instituto de Ciências da Saúde (ICS), Curso de pós - graduação em Saúde da Família, Rodovia CE 060, Km 51, Campus dos Palmares, CEP 62785-000, Acarape, CE, Brasil.
    https://orcid.org/0000-0003-0787-8070
  • Anne Caroline Ferreira Queiroga
    University of International Integration of Afro-Brazilian Lusofonia (UNILAB), Institute of Rural Development. Liberty Campus. Avenida da Abolição, 3, downtown, CEP 62790-000, Redenção, CE, Brazil.
    https://orcid.org/0000-0002-7958-2247
  • Wilma Freitas Celedonio
    Federal University of Paraíba (UFPB), Center for Agricultural Sciences-CCA-Campus II, 12 Rodovia, PB-079, CEP 58397-000, Areia, PB, Brazil.
    https://orcid.org/0000-0002-6292-8299
  • Janiel Ferreira Felício
    Universidade Federal do Rio Grande do Norte (UFRN), Laboratório de Pesquisa em Saúde e Enfermagem no Cuidado às pessoas em Condições Agudas e Crônicas (LAPAC - UFRN), campus Universitário, Lagoa Nova, CEP 59078-970, Natal, RN, Brasil
    https://orcid.org/0000-0002-5601-0086
  • Bárbara Letícia de Queiroz Xavier
    Federal University of Rio Grande do Norte (UFRN), Research Laboratory in Health and Nursing in the Care of People with Acute and Chronic Conditions (LAPAC - UFRN), University Campus, Lagoa Nova, CEP 59078-970, Natal, RN, Brazil.
    https://orcid.org/0000-0003-1622-9128
  • Yara Santiago de Oliveira
    Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB), Instituto de Ciências da Saúde (ICS), Rua José Franco de Oliveira, s/n, Zona Rural, Campus das Auroras, CEP 62790-970, Redenção, CE, Brasil
    https://orcid.org/0000-0001-8812-948X
  • Maria do Socorro Moura Rufino
    Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB), Mestrado Acadêmico em Sociobiodiversidade e Tecnologias Sustentáveis (MASTS), Rua José Franco de Oliveira, s/n, Zona Rural, Campus das Auroras, CEP 62790-970, Redenção, CE, Brasil
    https://orcid.org/0000-0003-3450-9481
  • Jeferson Falcão do Amaral
    Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB), Mestrado Acadêmico em Sociobiodiversidade e Tecnologias Sustentáveis (MASTS), Rua José Franco de Oliveira, s/n, Zona Rural, Campus das Auroras, CEP 62790-970, Redenção, CE, Brasil
    https://orcid.org/0000-0003-0426-0347

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Antidiabetic properties of medicinal plants of the genus Bauhinia: integrative review. Rev Fitos [Internet]. 2023 Jun. 30 [cited 2025 Dec. 19];17(2):274-9. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1399
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