Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats

Filipe Jonas Federico da Cruz
Daniel Ferreira Almeida de Souza
Samila Fernandes dos Santos Anjos
Ana Paula Fernandes Barbosa
Juliana Pedrosa de Holanda Marques
Svetlana Maria Wanderley de Barros
Antonio Euzebio Goulart Santana
Magna Suzana Alexandre Moreira
Mario Jorge Jucá

    Filipe Jonas Federico da Cruz

    Federal University of Sergipe (UFSE), Graduate Program in Biotechnology Renorbio, Avenida Marechal Rondon Jardim, s/n, Rosa Elze, São Cristóvão, CEP 49100-000, SE, Brazil.

    http://lattes.cnpq.br/7350480557402747

    Geriatric Doctor at the Hospital das Clínicas of the Federal University of Pernambuco (2019-2021). Specialized Complementation in Cognitive Disorders by Hospital das Clínicas, Faculty of Medicine, University of São Paulo (2021-2022). Residency in Internal Medicine at the Real Hospital Português de Pernambuco (2017 - 2019). Graduated in Medicine from the Federal University of Alagoas (2015). PhD in Health Biotechnology from the Federal University of Sergipe (in progress). During his academic training, he was a fellow in Technological Innovation by CNPQ, Founding Member and President of the Integrated Academic League of Neurology and Psychiatry and Monitor of the discipline of Cellular and Molecular Biology.

    Daniel Ferreira Almeida de Souza

    Emergency Hospital of Sergipe, Avenida Presidente Tancredo Neves, 7501, Capucho, CEP 49095-000, Aracaju, SE, Brazil.

    https://orcid.org/0000-0003-4444-444X

    Graduating in Medicine at the Federal University of Alagoas. He was a monitor of the Human Anatomy discipline during the year 2012. He was the founder and member of the Integrated Academic League of Neurology and Psychiatry at FAMED / UFAL. He is a member of the Uncisal Academic Trauma League linked to the State General Hospital (HGE) and a member of the Uncisal Academic League of Applied Clinical Anatomy (LACA).

    Samila Fernandes dos Santos Anjos

    Women's Hospital, Avenida Comendador Leão, 1213, Poço, CEP 57025-000, Maceió, AL, Brazil

    https://orcid.org/0000-0002-0494-6106

    Gynecologist and Obstetrician from the University of Pernambuco-CISAM/PE. Physician graduated from the Federal University of Alagoas-UFAL. Pharmacist- Biochemistry graduated from the Federal University of Alagoas-UFAL.

    Ana Paula Fernandes Barbosa

    Federal University of Alagoas (UFAL), Faculty of Medicine, Avenida Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP 5707-290, Maceió, AL, Brazil

    https://orcid.org/0000-0002-5835-0359

    He holds a degree in Medicine from the School of Medical Sciences of Alagoas (1990), a Master's in Pathology (Pathological Anatomy) from the Fluminense Federal University (1999) and a PhD in Pathology (Pathological Anatomy) from the Fluminense Federal University (2004). She is currently an adjunct professor at the Federal University of Alagoas (UFAL), effective partner and director-president of the Association for Supporting Cancer Carriers (AAPC) and physician at the pathological anatomy laboratory Nucleus for Cancer Prevention and Diagnosis (NPDC). She is a retired professor at the State University of Health Sciences of Alagoas (UNCISAL)

    Juliana Pedrosa de Holanda Marques

    Federal University of Alagoas (UFAL), Faculty of Medicine, Avenida Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP 5707-290, Maceió, AL, Brazil

    https://orcid.org/0000-0002-7614-5252

    Graduated in Medicine from the Federal University of Alagoas (2002), Medical Residency in Pathology (2005) at the University Hospital Professor Alberto Antunes/Alagoas and Master's degree from the Federal University of Pernambuco (2011). She is currently an assistant professor at the Federal University of Alagoas and a pathologist at the Cancer Prevention and Diagnosis Center (NPDC) and at the Internal Medicine and Physical Conditioning Clinic (MEDICOR).

    Svetlana Maria Wanderley de Barros

    State University of Health Sciences of Alagoas, Rua Dr. Jorge de Lima, 113, Trapiche da Barra, CEP 57010-300, Maceió, AL, Brazil

    https://orcid.org/0000-0002-4109-8636

    He has a degree in Veterinary Medicine, has experience in the area of health sciences with an emphasis on laboratory animals, working on the following topics: bioterism, production, nutritional, genetic and sanitary management of conventional laboratory animals, mice, rats, rabbits, also working with experimental endovascular surgery in swine.

    Antonio Euzebio Goulart Santana

    Federal University of Alagoas (UFAL), Faculty of Medicine, Avenida Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP 5707-290, Maceió, AL, Brazil.

    http://lattes.cnpq.br/8895697287739745

    He holds a degree in Pharmacy and Biochemistry from the Federal University of Minas Gerais (1975) and a PhD in Chemistry from the Federal University of Minas Gerais (1984). He is currently a professor at the Center for Engineering and Agricultural Sciences-CECA at the Federal University of Alagoas, a partner at Interacta Química Ltda. Has experience in Chemistry, with emphasis on Organic Synthesis, Chemical Ecology and Chemistry of Natural Products, working mainly on the following topics: synthesis, application and formulation of pheromones, chemistry of natural plant products, mollucicidal bioassay, against Biomphalaria glabrata, larvicides against Aedes aegypti. He was awarded the FAPEAL Merit Commendation - 20 years, and Merit Honor - UFAL - 50 years, received the Roberto Alves de Lima Prize in 2016 for the Graduate Program in Chemistry and Biotechnology of the Institute of Chemistry and Biotechnology of UFAL and in 2017 the National Prize in Chemical Ecology Prof. José Tércio Barbosa Ferreira, by the Brazilian Society of Chemical Ecology. Member of the National Technical Commission on Biosafety - CTNBio since 2020. Advises graduate students in the PPGQB, PPP and RENORBIO programs

     

    Magna Suzana Alexandre Moreira

    Federal University of Alagoas (UFAL), Faculty of Medicine, Avenida Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP 5707-290, Maceió, AL, Brazil.

    http://lattes.cnpq.br/1313843948155733

    Full Professor at the Institute of Biological and Health Sciences of the Federal University of Alagoas of the Institute of Biological and Health Sciences - UFAL. Graduated in Pharmacy from the Federal University of Paraíba (1994), Master's in Natural and Synthetic Bioactive Products from the Federal University of Paraíba (1997), PhD in Science (Microbiology and Immunology) from the Federal University of Rio de Janeiro (2001) and Post-doc in Medicinal Chemistry-UFRJ (2001-2002) and in Immunoparasitology-IBCCF-UFRJ (2003-2005). She coordinated the Graduate and Health Sciences Program, Chief Representative of the Pharmacology Sector, coordinated numerous projects Pro-equipment-CAPES and CT-INFRA (BIOCEN)-FINEP. She is accredited in 3 Postgraduate programs in the areas of Pharmacy, Health and in the RENORBIO network. He founded in 2004 and coordinates the Laboratory of Pharmacology and Immunity-LAFI, where he develops a project in the areas of immunopharmacology, with an emphasis on pharmacology of inflammatory diseases, neglected diseases (Leishmaniasis), immunoparasitology, medicinal chemistry and development of leishmanicidal drugs. She is currently Research Coordinator-CPQ at the Dean of Research and Graduate Studies at UFAL-PROPEP-UFAL.

    Mario Jorge Jucá

    Universidade Federal de Alagoas (UFAL), Faculdade de Medicina, Avenida Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP 5707-290, Maceió, AL, Brasil.

    http://lattes.cnpq.br/1658529783248624

    Graduated in Medicine from the Federal University of Alagoas (1986), Master in Medicine (Surgical Gastroenterology) from the Federal University of São Paulo (1991) and Doctorate in Medicine (Surgical Gastroenterology) from the Federal University of São Paulo (1997). Postdoctoral fellow in Coloproctology from the University of Texas at Dallas. He is currently Full Professor at FAMED / UFAL and Coordinator of the Discipline of Coloproctology at the Federal University of Alagoas. Professor of Medicine at Centro Universitário Cesmac. He is currently Head of the Management Sector of Research and Technological Innovation in Health (2020...); General Coordinator of the HUPAA-Ufal Permanent Education Nucleus. Titular Member of the State Health Council, where he is a member of the Permanent Education Commission; Member of the Management Committee PIBIC-Hupaa-Ufal. Technical Coordinator of the Proposal for Implementation of the Clinical Research Center of Hpaa-Ufal. Specialist in Higher Education Didactics, Specialist in Academic Management, Specialist in Health Teaching. He was Dean of Postgraduate Studies at UFAL (1999-2000). Titular Member of the Superior Council of FAMED at the Federal University of Alagoas as Coordinator of Graduate Studies and Research at FAMED/UFAL. He coordinated the Specialization Course in Pedagogical Management PROPEP / FAMED / UFAL. Titular Member of the Collegiate of the Postgraduate Program in Health Sciences. Professor of the Postgraduate Program at Master's Level in Health Sciences of the Mandatory Discipline of Scientific Methodology (2006-2010). Professor of the Elective Discipline of Higher Education Didactics at PPGCS/UFAL (2010), He was Professor of the Mandatory Discipline of Scientific Methodology of the Professional Master's Program in Health Education - MPES/UFAL). Coordinated the Internship in Surgery at the UFAL Medical School, Coordinated the Residency in General Surgery at HUPAA (2006 to 2010). Professor with monitoring of Residents and Interns at HUPAA by the Department of Surgery of the UFAL Medical School, in the areas of General Surgery and Coloproctology. Chair of the HUPAA Medical Residency Commission. Installed and Chaired the State Medical Residency Commission. Coordinated by the Federal Council of Medicine/UFAL Agreement for Specialized Training (Lato Senso Postgraduate with a workload similar to Medical Residencies) for Cape Verdean Physicians. Second Vice-President of the Brazilian Society of Medical Writers - Regional Alagoas and Effective Member of the Academia Maceioense Letras. Master of the Alagoas Chapter of the Brazilian College of Surgery (2012-2014), President of the Alagoas Chapter of the Brazilian College of Digestive Surgery (2017-2019). Has experience in Medicine, with emphasis on Digestive and Coloproctological Surgery, working mainly on the following topics: Colorectal cancer (experimental, prevention, screening and follow-up), Cellular Aging and elderly patients.

Keywords

Colorectal cancer
Chemoprevention
da cordifolia L
Aberrant crypt
1,2-dymethylhydrazine

Abstract

Search for new therapeutic agents and alternative strategies for chemoprevention of colorectal cancer is needed to reduce morbidity and mortality resulting from this disease. This study aimed to compare the effect of aqueous extract of Sida cordifolia L. and 5- fluorouracil (5-FU) on colon carcinogenesis induced by 1,2- dimethylhydrazine (1,2-DMH). The extract reduced the frequency of aberrant crypts to regarding the positive control, but there was no significant difference among the positive control animals, those who received the extract and those receiving standard anticancer drug. Thus, the aqueous extract of Sida cordifolia L. 800 mg/kg showed no statistical impact on carcinogenesis in animal models, but showed a significant anti-inflammatory effect on the colon mucosa.

References

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Author(s)

  • Filipe Jonas Federico da Cruz
    Federal University of Sergipe (UFSE), Graduate Program in Biotechnology Renorbio, Avenida Marechal Rondon Jardim, s/n, Rosa Elze, São Cristóvão, CEP 49100-000, SE, Brazil.
  • Daniel Ferreira Almeida de Souza
    Emergency Hospital of Sergipe, Avenida Presidente Tancredo Neves, 7501, Capucho, CEP 49095-000, Aracaju, SE, Brazil.
  • Samila Fernandes dos Santos Anjos
    Women's Hospital, Avenida Comendador Leão, 1213, Poço, CEP 57025-000, Maceió, AL, Brazil
  • Ana Paula Fernandes Barbosa
    Federal University of Alagoas (UFAL), Faculty of Medicine, Avenida Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP 5707-290, Maceió, AL, Brazil
  • Juliana Pedrosa de Holanda Marques
    Federal University of Alagoas (UFAL), Faculty of Medicine, Avenida Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP 5707-290, Maceió, AL, Brazil
  • Svetlana Maria Wanderley de Barros
    State University of Health Sciences of Alagoas, Rua Dr. Jorge de Lima, 113, Trapiche da Barra, CEP 57010-300, Maceió, AL, Brazil
  • Antonio Euzebio Goulart Santana
    Federal University of Alagoas (UFAL), Faculty of Medicine, Avenida Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP 5707-290, Maceió, AL, Brazil.
  • Magna Suzana Alexandre Moreira
    Federal University of Alagoas (UFAL), Faculty of Medicine, Avenida Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP 5707-290, Maceió, AL, Brazil.
  • Mario Jorge Jucá
    Universidade Federal de Alagoas (UFAL), Faculdade de Medicina, Avenida Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP 5707-290, Maceió, AL, Brasil.

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1.
Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats. Rev Fitos [Internet]. 2022 Jun. 30 [cited 2024 Nov. 21];16(2):169-80. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1085
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