Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities

Maria de Fátima Simão Jucá Cruz
OrcID
Gabriela Moysés Pereira
OrcID

    Maria de Fátima Simão Jucá Cruz

    Federal University of Rio de Janeiro, Health Sciences Center/CCS - Block H. Avenida Carlos Chagas Filho, 373, Cidade Universitária, Galeão, CEP 21941-590, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0000-0002-6611-3388

    Graduada em Química (modalidade Bacharelado) com titulação de Química Industrial pela Universidade Federal Rural do Rio de Janeiro (2012). Complementação pedagógica com equivalência a Licenciatura em Química pela Instituição A Vez do Mestre-Cândido Mendes (2021). Mestra (2015) e Doutora (2019) em Química de Produtos Naturais pela Universidade Federal do Rio de Janeiro - Instituto de Pesquisas de Produtos Naturais, onde atuou desenvolvendo pesquisas na área de fitoquímica, tendo como foco a Investigação de Princípios Ativos em Plantas Medicinais. Possui experiência em técnicas espectroscópicas como Ressonância Magnética Nuclear (R.M.N.), Espectroscopia na Região do Infravermelho (I.V.), Espectroscopia na Região do Ultravioleta (U.V.), técnicas Cromatográficas e ensaios biológicos in vivo e in vitro. Possui experiência como professora de Química I do estabelecimento de ensino superior da Academia de Bombeiro Militar Dom Pedro II (ABMDPII).

    Gabriela Moysés Pereira

    Federal University of Rio de Janeiro, Health Sciences Center/CCS - Block H. Avenida Carlos Chagas Filho, 373, Cidade Universitária, Galeão, CEP 21941-590, Rio de Janeiro, RJ, Brazil.

    OrcID https://orcid.org/0000-0002-0307-1547

    Graduated in Industrial Chemistry from the Federal Rural University of Rio de Janeiro (2011), Degree in Chemistry from AVM Educacional (2017), Master (2014) and Doctor (2018) in Chemistry of Natural Products from the Federal University of Rio de Janeiro. She has worked mainly on the following research topics: medicinal plants, phytochemical investigation, structural characterization, bioactive macromolecules, saponins, polysaccharides, Nuclear Magnetic Resonance and chromatography. She worked as a science teacher at the Seropédica Municipal Secretary of Education, as a content writer for Sagah Educacional and Faculdade Única, producing chemistry teaching materials for higher education. She currently works as a census analyst at the Research Directorate / Technical Coordination of the Demographic Census (DPE / CTD) of the Brazilian Institute of Geography and Statistics (IBGE).

Keywords

Triterpenoid saponins
Medicinal chemistry
Therapeutics properties
Vaccine
COVID-19

Abstract

Saponins are plant-derived non-ionic surfactants and widely applied in many products, such as cosmetics, cleansers, medicines, vaccine, as additives by therapeutic properties and chemical characteristics theirs. These substances are of growing interest for drug research as they’re active constituents of several folk medicines, in addition to comprising an important class of medicinal chemistry. Triterpenoid saponins are secondary metabolites, these’re largely distributed in plant species and they’re characterized as one of the active principles of these. These saponins have potent anti-viral, adjuvant, hemolytic, cytotoxic and anti-angiogenic activities that are relationship with the presence of characteristics chemical moiety. In this work was summarized the studies found in the scientific literature on the therapeutic properties of triterpenoid saponins, as well as commercial applicability theirs. Recent works have suggested some triterpenoid saponins like candidates for treatment of patients with COVID-19.

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Author(s)

  • Maria de Fátima Simão Jucá Cruz
    Federal University of Rio de Janeiro, Health Sciences Center/CCS - Block H. Avenida Carlos Chagas Filho, 373, Cidade Universitária, Galeão, CEP 21941-590, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0000-0002-6611-3388
  • Gabriela Moysés Pereira
    Federal University of Rio de Janeiro, Health Sciences Center/CCS - Block H. Avenida Carlos Chagas Filho, 373, Cidade Universitária, Galeão, CEP 21941-590, Rio de Janeiro, RJ, Brazil.
    https://orcid.org/0000-0002-0307-1547

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Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities. Rev Fitos [Internet]. 2023 Jun. 30 [cited 2024 Nov. 14];17(2):295-316. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351
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