Relação estrutura-atividade de saponinas triterpenoidais: propriedades biológicas e aplicabilidades comerciais

Maria de Fátima Simão Jucá Cruz
OrcID
Gabriela Moysés Pereira
OrcID

    Maria de Fátima Simão Jucá Cruz

    Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde/CCS - Bloco H. Avenida Carlos Chagas Filho, 373, Cidade Universitária, Galeão, CEP 21941-590, Rio de Janeiro, RJ, Brasil.

    OrcID https://orcid.org/0000-0002-6611-3388

    Graduated in Chemistry (Bachelor's Degree) with a degree in Industrial Chemistry from the Federal Rural University of Rio de Janeiro (2012). Pedagogical complementation with equivalence to a Degree in Chemistry from the Institution A Vez do Mestre-Cândido Mendes (2021). Master (2015) and PhD (2019) in Chemistry of Natural Products from the Federal University of Rio de Janeiro - Instituto de Pesquisas de Produtos Naturais, where she worked developing research in the area of phytochemistry, focusing on the Investigation of Active Principles in Medicinal Plants. She has experience in spectroscopic techniques such as Nuclear Magnetic Resonance (NMR), Infrared Region Spectroscopy (I.V.), Ultraviolet Region Spectroscopy (U.V.), Chromatographic techniques and in vivo and in vitro biological assays. She has experience as a teacher of Chemistry I at the higher education establishment of the Dom Pedro II Military Firefighter Academy (ABMDPII).

    Gabriela Moysés Pereira

    Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde/CCS - Bloco H. Avenida Carlos Chagas Filho, 373, Cidade Universitária, Galeão, CEP 21941-590, Rio de Janeiro, RJ, Brasil.

    OrcID https://orcid.org/0000-0002-0307-1547

    Graduada em Química Industrial pela Universidade Federal Rural do Rio de Janeiro (2011), Licenciada em química pela AVM Educacional (2017), Mestra (2014) e Doutora (2018) em Química de Produtos Naturais pela Universidade Federal do Rio de Janeiro. Atuou principalmente nos seguintes temas de pesquisa: plantas medicinais, investigação fitoquímica, caracterização estrutural, macromoléculas bioativas, saponinas, polissacarídeos, Ressonância Magnética Nuclear e cromatografia. Atuou como professora de ciências na Secretária Municipal de educação de Seropédica, como conteudista para a Sagah Educacional e Faculdade Única produzindo materiais didáticos de química para o ensino superior . Atualmente exerce a função de analista censitária na Diretoria de Pesquisa/ Coordenação Técnica do Censo Demográfico (DPE/CTD) do Instituto Brasileiro de Geografia e Estatística (IBGE).

Palavras-chave

Triterpenoid saponins
Medicinal chemistry
Therapeutics properties
Vaccine
COVID-19

Resumo

As saponinas são tensoativos não iônicos derivados de plantas e amplamente aplicados em diversos produtos, como cosméticos, desinfetantes, medicamentos, vacinas, como aditivos por propriedades terapêuticas e características químicas próprias. Essas substâncias são de crescente interesse para a pesquisa de medicamentos, pois são constituintes ativos de diversos medicamentos populares, além de comporem uma importante classe da química medicinal. As saponinas triterpenoidais são metabólitos secundários, amplamente distribuídos nas espécies vegetais e caracterizam-se como um dos princípios ativos destas. Estas saponinas possuem potentes atividades antiviral, adjuvante, hemolítica, citotóxica e antiangiogênica que estão relacionadas com a presença de fração química característica. Neste trabalho foram resumidos os estudos encontrados na literatura científica sobre as propriedades terapêuticas das saponinas triterpenoidais, bem como a sua aplicabilidade comercial. Trabalhos recentes sugeriram algumas saponinas triterpenoidais como candidatas ao tratamento de pacientes com COVID-19.

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Autor(es)

  • Maria de Fátima Simão Jucá Cruz
    Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde/CCS - Bloco H. Avenida Carlos Chagas Filho, 373, Cidade Universitária, Galeão, CEP 21941-590, Rio de Janeiro, RJ, Brasil.
    https://orcid.org/0000-0002-6611-3388
  • Gabriela Moysés Pereira
    Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde/CCS - Bloco H. Avenida Carlos Chagas Filho, 373, Cidade Universitária, Galeão, CEP 21941-590, Rio de Janeiro, RJ, Brasil.
    https://orcid.org/0000-0002-0307-1547

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Relação estrutura-atividade de saponinas triterpenoidais: propriedades biológicas e aplicabilidades comerciais. Rev Fitos [Internet]. 30º de junho de 2023 [citado 15º de novembro de 2024];17(2):295-316. Disponível em: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351
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