Antimicrobial activity of sesquiterpene lactones from yacon leaves (Smallanthus sonchifolius, Asteraceae)

Perla Raquel Nogueira Vieira
OrcID
Débora Raquel Mergen Lima Reis
OrcID
Cledes Teresinha de Oliveira
OrcID
Carolina Ribeiro Noronha de souza
OrcID

    Perla Raquel Nogueira Vieira

    Federal Institute of Paraná (IFPR), Campus Palmas, Av. Bento Munhoz da Rocha Neto s / nº, PRT-280, Trevo da Codapar, CEP 85555-000, Palmas, PR, Brazil.

    OrcID https://orcid.org/0000-0002-5925-7391

    Graduated in Biological Sciences from the Federal Institute of Paraná (2017).

    Débora Raquel Mergen Lima Reis

    Federal Institute of Paraná (IFPR), Campus Palmas, Av. Bento Munhoz da Rocha Neto s / nº, PRT-280, Trevo da Codapar, CEP 85555-000, Palmas, PR, Brazil.

    OrcID https://orcid.org/0000-0002-5884-0681

    She is currently Research and Extension Coordinator at IFPR - Campus Palmas, works at COPE - Campus Research and Extension Committee, is a member of NIT- Technological Innovation Center at Campus Palmas and a member of CEP / IFPR - Research Ethics Committee at IFPR. He is part of the faculty of the Collegiate of Biological Sciences of IFPR - Campus Palmas, teaching the disciplines of Human Anatomy and Physiology in the Undergraduate courses in Pharmacy, Nursing and Biological Sciences. He holds a Master's Degree in Education from the Pontifical Catholic University of Paraná, a Postgraduate Degree in Biology, Education and Health and a Degree in Biological Sciences from the Catholic University Center of Southwest Paraná. He has experience in the areas of Human Anatomy, Human Physiology, Cytology, Histology, Embryology and Genetics, working mainly in the areas of human health and in the disciplines aimed at the pedagogical practice of university professors. His research mainly involves the following topics: yacon, diabetes mellitus, genetics, education in higher education, teaching approaches and methodologies in the complexity paradigm.

    Cledes Teresinha de Oliveira

    Federal Institute of Paraná (IFPR), Campus Palmas, Av. Bento Munhoz da Rocha Neto s / nº, PRT-280, Trevo da Codapar, CEP 85555-000, Palmas, PR, Brazil.

    OrcID https://orcid.org/0000-0002-2759-1002

    Possui graduação em Farmácia pelo Instituto Federal de Educação, Ciência e Tecnologia do Paraná/Campus Palmas(2014), graduação em Ciências Licenciatura com Habilitação em Biologia pelo Centro Pastoral Educacional e Assistência Dom Carlos(2003), especialização em Biologia Geral pelo Centro Pastoral Educacional e Assistência Dom Carlos(2004) e mestrado em Tecnologia de Processos Químicos e Bioquímicos pela Universidade Tecnológica Federal do Paraná(2016). Atualmente é Técnica de laboratório/Biologia do Instituto Federal de Educação, Ciência e Tecnologia do Paraná/Campus Palmas. Atuando principalmente nos seguintes temas:Produtos Naturais, Cromatografia a gás, Disco difusão, microdiluição, Radical livre. (Texto gerado automaticamente pela aplicação CVLattes)

    Carolina Ribeiro Noronha de souza

    Federal University of Jataí, Campus Jatobá, Rodovia BR-364, km 195, nº 3800, Cidade Universitária, CEP 75801615, GO, Brazil.

    OrcID https://orcid.org/0000-0002-1403-9964

    Graduated and Bachelor of Biological Sciences from the University of São Paulo, with an exchange program at Eberhard-Karls-Universität Tübingen (Germany; 2006-2007). Master and PhD in Comparative Biology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto (USP), with sandwich internship at Arizona State University. He did a postdoctoral internship at the Federal University of Pará (2015), and began his professional practice at the Federal Institute of Paraná (2016-2018). He is currently a professor in the area of Human and Comparative Anatomy at the Federal University of Goiás (UFG), in Jataí, and postdoctoral fellow at the Ecology and Evolution program at UNIFESP, Diadema (SP). Has experience in Anatomy and Physiology, with emphasis on Comparative Physiology of reptiles and amphibians.

Keywords

Antimicrobial activity
Yacon
Sesquiterpene lactones
Smallanthus sonchifolius

Abstract

Yacon (Smallanthus sonchifolius) is a native plant from the Andes belonging to the Asteraceae family. Its tubers and leaves are consumed mainly for the control of hyperglycemia. In addition, the glandular trichomes present in the leaves are rich in sesquiterpene lactones such as enyndrine, uvedalina and sonchifolin, which present antimicrobial activity against different strains of fungi and gram-positive bacteria. The antimicrobial activity of the sesquiterpene lactones extracted from leaves was evaluated against Candida albicans, Candida tropicalis, Staphylococcus aureus and Salmonella enterica Typhimurium by the disc diffusion method. Results show antimicrobial activity only against S. aureus. Minimum inhibitory concentration against S. aureus, calculated after the microdilution method, was 0.09 mg/ml. Results confirm the antimicrobial activity of sesquiterpene lactones against gram-positive bacteria.

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Author(s)

  • Perla Raquel Nogueira Vieira
    Federal Institute of Paraná (IFPR), Campus Palmas, Av. Bento Munhoz da Rocha Neto s / nº, PRT-280, Trevo da Codapar, CEP 85555-000, Palmas, PR, Brazil.
    https://orcid.org/0000-0002-5925-7391
  • Débora Raquel Mergen Lima Reis
    Federal Institute of Paraná (IFPR), Campus Palmas, Av. Bento Munhoz da Rocha Neto s / nº, PRT-280, Trevo da Codapar, CEP 85555-000, Palmas, PR, Brazil.
    https://orcid.org/0000-0002-5884-0681
  • Cledes Teresinha de Oliveira
    Federal Institute of Paraná (IFPR), Campus Palmas, Av. Bento Munhoz da Rocha Neto s / nº, PRT-280, Trevo da Codapar, CEP 85555-000, Palmas, PR, Brazil.
    https://orcid.org/0000-0002-2759-1002
  • Carolina Ribeiro Noronha de souza
    Federal University of Jataí, Campus Jatobá, Rodovia BR-364, km 195, nº 3800, Cidade Universitária, CEP 75801615, GO, Brazil.
    https://orcid.org/0000-0002-1403-9964

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Antimicrobial activity of sesquiterpene lactones from yacon leaves (Smallanthus sonchifolius, Asteraceae). Rev Fitos [Internet]. 2021 Mar. 31 [cited 2025 Jan. 20];15(1):108-14. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/864
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