Medicinal plants with potential for treating anxiety and depression disorders: an integrative review

Tanea Maria Bisognin Garlet
OrcID
Bettina Monika Ruppelt
OrcID

    Tanea Maria Bisognin Garlet

    Universidade Federal de Santa Maria

    OrcID https://orcid.org/0000-0003-1188-5804

    He has a degree in Biological Sciences - Full Degree from the Federal University of Santa Maria, a master's degree in Botany from the Federal University of Rio Grande do Sul and a doctorate in Agronomy: Plant Production from the Federal University of Santa Maria. Associate Professor at the Federal University of Santa Maria in the area of Botany and Plant Physiology. It develops projects that aim to insert students into basic education schools and the community. Her work includes actions that encourage teacher training, interdisciplinarity and interprofessionality. Her projects include medicinal plants, ethnobotany and phytotherapy.

    Bettina Monika Ruppelt

    Universidade Federal Fluminense

    OrcID https://orcid.org/0000-0003-1472-6948

    Graduated in Pharmacy from the Federal University of Rio de Janeiro (1988), graduated in Industrial Pharmacy from the Federal University of Rio de Janeiro (1992), specialization in Pharmacology of Natural Products from the Federal University of Pernambuco (1988), specialization in the Training of Professors in the Distance Education Modality from the Federal University of Paraná (2000), Master's degree in Sciences (Pharmacology and Experimental Therapeutics) from the Federal University of Rio de Janeiro (1991) and PhD in Natural Products Chemistry from the Federal University of Rio de Janeiro ( 1996). She worked as a professor at the Federal University of Paraná-Campus Palotina (1997-2018), where she held the positions of Deputy Director of the Palotina Campus, Deputy Director of the Veterinary Hospital of the Palotina Campus, Coordinator of the Veterinary Medicine Course-Palotina. Did she participate in the Implementation Committee of the Support Program for the Restructuring and Expansion Plan of Federal Universities? REUNI, on the Palotina Campus. She received the 2005 Model Employee Award: Public Sector from the Rotary Club of Palotina, PR. She received a Vote of Commendation for the Medicinal Plants Extension Project from the Legislative Assembly of the State of Paraná. She is currently Associate Professor IV at Universidade Federal Fluminense. She co-supervised 2 master's projects. She supervised 10 monographs for the completion of an improvement/specialization course, 3 work for the conclusion of an undergraduate course, 1 work for junior scientific initiation and 53 extension and teaching initiation students. She published 18 articles in journals, 4 published books, 1 published book chapter, 8 articles in newspapers and magazines and developed 12 teaching materials. She has experience in the area of Pharmacology, with an emphasis on Pharmacology of Natural Products, working mainly on the following topics: medicinal plants, ethnopharmacology, pharmacology of medicinal plants with antivenom activity in rodent and zebrafish models. She coordinated the Medicinal Plants University Extension Program, awarded with the 2011 and 2013 PROEXT Notices. In the 2013 PROEXT Notice, the Medicinal Plants Program was placed first in the health area. She was a member of the Thematic Technical Committee on Blood Derivatives and Blood Components of the Brazilian Pharmacopoeia in the period 2014-2020. She is currently a member of the Thematic Committee on Medicinal Plants of the Brazilian Pharmacopoeia and a member of the Thematic Committee on Natural Products of the Brazilian Academic Consortium for Integrative Health. She received the UFF Award for Excellence in Innovation for Social Development,

Keywords

Phytotherapy
Biodiversity
Mental health
Insomnia
Clinical trials

Abstract

Sociobiodiversity can contribute to innovation in medicines from Brazilian plant diversity. This work sought to gather evidence from clinical studies on the effectiveness of using medicinal plants and herbal medicines in treating anxiety disorders and depression. Thus, an integrative review was carried out with a selection of plants from the work of Pio Corrêa (1926 - 1978) and through the PubMed, Lilacs and Cochrane databases. After applying the selection criteria, 43 articles were listed, and 12 plants were investigated. It was possible to demonstrate anxiolytic effects for saffron (Crocus sativus), cimicífuga (Actaea racemosa), dill (Anethum graveolens), orange (Citrus x aurantium), hops (Humulus lupulus), melissa (Melissa officinalis), passion fruit (Passiflora incarnata) and valeriana (Valeriana officinalis); antidepressants for saffron, curcuma (Curcuma longa), hops and melissa; sedatives for saffron, lettuce (Lactuca sativa), citron (Aloysia citriodora), hops, melissa, passion fruit and valeriana (Valeriana officinalis). Therefore, phytotherapy can help treat anxiety disorders and depression in mental health care, using plants from Brazilian sociobiodiversity. However, further investigations with clinical trials and investments in biotechnology are necessary to ensure the development of innovation in medicines of plant origin.

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Medicinal plants with potential for treating anxiety and depression disorders: an integrative review. Rev Fitos [Internet]. 2024 May 30 [cited 2024 Nov. 20];18(Suppl. 3):e1572. Available from: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1572
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